• Nuclear Engineering and Technology
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• 제54권5호
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• pp.1698-1711
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• 2022

A combined safety approach, which uses a best-estimate computer code and adopts conservative assumptions for safety systems availability, is developed and applied to the safety margin evaluation for the Loss of Condenser Vacuum (LOCV) of the 1000 MWe Korean Nuclear Power Plant. The Multi-dimensional Analysis of Reactor Safety-KINS standard (MARS-KS) code is selected as a best-estimate code and the PAPIRUS program is used to obtain different initial operational conditions through random sampling of control variables. During an LOCV event, fuel integrity is not threatened by the increase in Departure from Nuclear Boiling Ratio (DNBR). However, the high pressure in the primary coolant system and the secondary system might affect the system integrity. Thus, the peak pressure becomes a major safety concern. Transient analyses are performed for 124 cases of different initial conditions and the most conservative case, which results in the highest system pressure is selected. It is found the suggested methodology gives similar peak pressures when compared to those predicted from existing methodologies. The proposed approach is expected to minimize the time and efforts required to identify the conservative plant conditions in the existing conservative safety methodologies.

• 대한예방한의학회지
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• 제17권3호
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• pp.19-30
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• 2013

This study was aimed to develop a new formula for herbal medicine-safety classification in terms of evidence-based medicine. Recently, human equivalent dose(HED)-based therapeutic index was developed for herbal medicine-safety classification by transforming $LD_{50}$ to HED. However, the use of the $ED_{50}$ and $LD_{50}$ to derive the therapeutic index may be misleading as to safety, depending on the slope of the dose-response curves for therapeutic and lethal effects. To overcome this deficiency, HED-based MOS(Margin of Safety)was developed and suggested in this study. The HED-based MOS developed by using $LD_1$, changing to ALD(approximate lethal dose), and $ED_{99}$. The HED-based MOS seems to be more useful and safer than HED-based therapeutic index since its values for several herbal medicines are basically two times less than the values from HED-based therapeutic index. Thus, HED-based MOS can be a good example of Evidence-based approach for herbal medicine-safety classification.

• 한국지반공학회지:지반
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• 제4권2호
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• pp.5-14
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• 1988

균질토 사면에서 진행성 파괴에 대한 확를론적 모델이 제시되었다. 파괴면 위의 어떤 절편에 대한 국부적인 Safety Margin은 정규분포차 가정하였다. 파괴면을 따라 존재하는 전단강도의 불확실성은 1차원 Random Field Models로 표현되었다. 이 연구에서는 파괴가 Toe에서 시작되어 사면 정상까지 진행되는 경우만을 고려하였다. 파괴면위의 어느 두 인접 절편의 Safety Margin의 Joint Distribution은 Bivariate Normal로 가정하였다. 활동파괴의 전체적인 파괴확률은 일련의 Conditional events의 급으로 표현되었다. 최종적으로 개발된 절차가 절취사면의 신뢰도를 얻기 위하여 한 예에 적용되었다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1149-1154
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• 2007

Fluctuation of control rod was experienced when plant was operating in normal operation mode in WH type NPPs. In order to cope with increased control rod fluctuation, the lead-lag controller setpoint for rod control system was optimized and resulted in increasing the margin of operation and minimizing unnecessary control rod movement. By optimization of the time constant, the margin of operation was increased by $1.5^{\circ}F$ and the control rod movement was not occurred due to mitigation of temperature fluctuation in loop. According to the mitigation of time constant, the margin of operation was increased but safety margin can be affected badly, so that the influences to FSAR design reference was evaluated. As the result of this evaluation, it satisfied the design reference of the existing safety analysis and was applied to NPP after obtaining the approval.

• Nuclear Engineering and Technology
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• 제48권3호
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• pp.684-701
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• 2016

The Gaussian process model (GPM) is a flexible surrogate model that can be used for nonparametric regression for multivariate problems. A unique feature of the GPM is that a prediction variance is automatically provided with the regression function. In this paper, we estimate the safety margin of a nuclear power plant by performing regression on the output of best-estimate simulations of a large-break loss-of-coolant accident with sampling of safety system configuration, sequence timing, technical specifications, and thermal hydraulic parameter uncertainties. The key aspect of our approach is that the GPM regression is only performed on the dominant input variables, the safety injection flow rate and the delay time for AC powered pumps to start representing sequence timing uncertainty, providing a predictive model for the peak clad temperature during a reflood phase. Other uncertainties are interpreted as contributors to the measurement noise of the code output and are implicitly treated in the GPM in the noise variance term, providing local uncertainty bounds for the peak clad temperature. We discuss the applicability of the foregoing method to reduce the use of conservative assumptions in best estimate plus uncertainty (BEPU) and Level 1 probabilistic safety assessment (PSA) success criteria definitions while dealing with a large number of uncertainties.

• 환경위생공학
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• 제20권3호
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• pp.51-56
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• 2005

Allocation of water pollution load from loading capacity can be much essential, controversial, and its standards can be applied case-by-case to the various situations. Allocation methods to point sources are generally 'Equal effluent concentration', 'Equal percent Treatment', Loading capacity at planning stage consists of basic pollution load, development pollution load, reserved pollution load and margin of safety. But at the implementing stage loading capacity can be consisted of allocatable load and margin of safety to give more flexibility in the total water pollution load management plan. In that case, we can re-adjust and altogether use the pollution load of point sources of series and non-point sources at the implementing stage.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.264-267
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• 2004

Wall thinning of carbon steel pipe components due to Flow-Accelerated Corrosion (FAC) is one of the most serious threats to the integrity of steam cycle piping systems in Nuclear Power Plants (NPP). Since the mid-1990s, secondary side piping systems in Korean NPPs have experienced wall thinning, leakages and ruptures caused by FAC. Korea Electric power Research Institute (KEPRI) and Korea Hydro & Nuclear Power Co., LTD. (KHNP) have conducted a study to develop the methodology for systematic pipe management and established the Korean Thinned Pipe Management Program (TPMP). To effectively maintain the integrity of piping system, FAC engineer should understand the criterions of the structural integrity evaluation and the safety margin assessment for the thinned pipe component. This paper describes the technical items of TPMP, and shows the example of the integrity evaluation and safety margin assessment for three thinned pipe component of a NPP.

• 항공우주시스템공학회지
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• 제14권6호
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• pp.79-84
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• 2020

Cooler driver electronics (CDE) for maintaining low temperature of the satellite payload IR sensor consists of a compressor that has a pulsation current load condition when it is operated. This pulsation current produces large voltage fluctuation, which affects both load and regulated bus stability. Thus, CDE power conditioning system consists of a primary bus, infrared power distribution unit for battery charging and protection, reverse current protection diode, and battery, which is used as a buffer. In this study, the operational mode analysis is performed by each part with equivalent impedance modeling verified through system level simulation. From this mode analysis, the safety margin for state of charge and open circuit voltage of the battery is determined for satisfying the minimum operational voltage of the CDE load.

• Archives of Plastic Surgery
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• 제51권5호
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• pp.487-494
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• 2024

Background Basal cell carcinoma (BCC) is the most common type of nonmelanoma skin cancer. Typically, resection requires a safety margin of ≥4 mm. When removing tumor cells, achieving complete excision with minimal safety margins and reconstructing the defect to preserve the original appearance are important. In this study, we used a 3-mm resection margin to confirm recurrence and re-resection rates. Methods Electronic medical records and photographic data were obtained for patients with primary BCC lesions less than 2 cm in diameter who underwent wide excision with a 3-mm surgical margin from January 2015 to November 2021. We analyzed factors determining recurrence and re-resection rates, such as tumor size, location, age, sex, underlying diseases (including immunosuppression state), ethnicity, subtypes, tumor borders, etc. Results This study included 205 patients. The mean age and follow-up period were 73.0 ± 11.5 years and 10.2 ± 8.0 months, respectively. The recurrence and re-resection rates were 1.95% and 25.85%, respectively. A statistically significant correlation was found between recurrence rate and tumor border (p = 0.013) and the re-resection rate was correlated statistically with location (p = 0.022) and immunosuppressed patients (p = 0.006). Conclusion We found that a 3-mm excision margin provided sufficient safety in small facial BCC, resulting in ease of surgery and better aesthetic outcomes. However, surgical margins must be determined case by case by integrating various patient factors. In particular, a surgical margin of ≥4 mm is required for BCC in high-risk areas, immunosuppressed patients, or poorly defined border.

• Nuclear Engineering and Technology
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• 제34권1호
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• pp.68-79
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• 2002

The approach for evaluating the critical heat flux (CHF) margin using the departure from nucleate boiling ratio (DNBR) concept has been widely applied to PWR core design, while DNBR in this approach does not indicate appropriately the CHF margin in terms of the attainable power margin-to-CHF against a reactor core condition. The CHF power margin must be calculated by increasing power until the minimum DNBR reaches a DNBR limit. The Critical Power Ratio (CPR), defined as the ratio of the predicted CHF power to the operating power, is considered more reasonable for indicating the CHF margin and can be calculated by a CPR orrelation based on the heat balance of a test bundle. This approach yields directly the CHF power margin, but the calculated CPR must be corrected to compensate for many local effects of the actual core, which are not considered in the CHF test and analysis. In this paper, correction of the calculated CPR is made so that it may become equal to the DNB overpower margin. Exemplary calculations showed that the correction tends to be increased as power distribution is more distorted, but are not unduly large.