• 대한화학회지
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• 제63권5호
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• pp.346-351
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• 2019

Mannich-type reactions of cyclic N-sulfimines with 2-trimethylsiloxyfuran and pyrazolin-5-one have been developed using phosphoric acid (PA) as an organocatalyst. 2-Trimethylsiloxyfuran underwent a vinylogous Mannich-type reaction with cyclic N-sulfimines in the presence of the PA catalyst to give sulfamidate ${\gamma}$-butenolides in good yields and with high diastereoselectivities (up to 90% yield and 7:1 dr). In addition, the reaction between pyrazolin-5-one and a diverse range of cyclic N-sulfimines provided access to sulfamidates in good to high yields (up to 94% yield).

• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1195-1200
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• 2011

The catalytic enantioselective Mannich-type reaction promoted by chiral binaphthyl-modified bifunctional organocatalysts is described. The treatment of ${\alpha}$-fluoro-${\beta}$-ketoesters with N-Boc imines under mild reaction conditions afforded the corresponding ${\beta}$-aminated ${\alpha}$-fluoro-${\beta}$-ketoesters with excellent enantioselectivities (up to 98% ee).

• 대한화학회지
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• 제66권1호
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• pp.9-14
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• 2022

An efficient method for the synthesis of 1-aminophthalans has been developed. The intramolecular oxa-Mannich reaction of 1,3-dihydro-2-benzofuran-1-ols with p-toluenesulfonylamine in the presence of Cs₂CO₃ as a base, without using any catalyst, provided the desired 1-aminophthalans in moderate to good yields.

• 대한화학회지
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• 제47권4호
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• pp.412-416
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• 2003

• Bulletin of the Korean Chemical Society
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• 제23권10호
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• pp.1367-1368
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• 2002

• 대한화학회지
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• 제45권1호
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• pp.51-60
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• 2001

치환된 하이드록시 방향족 화합물과 이차아민, paraformaldehyde를 비 양성자성 용매하에서 one-pot으로 반응시켜 기질에 따른 상대적인 반응성을 비교하였으며, Mannich반응이 일어난 자리도 조사하였다. 치환된 하이드록시 방향족 고리의 Mannich반응의 반응성과 위치선댁성은 기질의 친핵성도와 아민의 입체장애에 의존함을 알 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.635-638
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• 2011

A simple and efficient method for the synthesis of $\beta$-amino carbonyl compounds by one-pot three-component Mannich reaction of acetophenone, aromatic aldehydes and aromatic amines using a carbon-based solid acid (CBSA), as an effective and reusable catalyst, is described. The present methodology offers several advantages such as simple procedure with an easy work-up, shorter reaction times, and high yields.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3175-3176
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• 2012

• 대한화학회지
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• 제55권4호
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• pp.644-649
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• 2011

Polyaniline/$SiO_2$ 촉매를 이용하여, acetophenone, aromatic aldehydes와 aromatic amines을 에탄올 용매 속에서 반응시켜서 다양한 various ${\beta}$-amino ketones을 one-pot mannich 반응을 수행하였으며, 이 반응을 위해 silica가 충진된 여러 가지 종류의 wt% polyaniline을 화학적인 산화방법에 의해 합성하였다. 합성한 촉매는 thermal analysis(TG-DTA), X-ray diffraction (XRD), scanning electron microscopy(SEM) energy dispersive spectroscopy(EDS), 및 Fourier transform infrared spectroscopy (FT-IR) 방법으로 확인하였으며, 촉매의 용매에 대한 안정도 UV-Visible spectroscopy로 측정하였다. Polyaniline/$SiO_2$ 촉매를 이용하는 합성 방법은높은 수율로 얻어지며, work up이 쉽고, 독성이 없으며, 쉽게 회수하여 재사용이 가능하다.

• Bulletin of the Korean Chemical Society
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• 제23권1호
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• pp.137-139
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• 2002