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http://dx.doi.org/10.5012/bkcs.2011.32.2.635

Carbon-based Solid Acid Catalyzed One-pot Mannich Reaction: A Facile Synthesis of β-Amino Carbonyl Compounds  

Davoodnia, Abolghasem (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Tavakoli-Nishaburi, Afsaneh (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Niloofar, Tavakoli-Hoseini (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Publication Information
Bulletin of the Korean Chemical Society / v.32, no.2, 2011 , pp. 635-638 More about this Journal
Abstract
A simple and efficient method for the synthesis of $\beta$-amino carbonyl compounds by one-pot three-component Mannich reaction of acetophenone, aromatic aldehydes and aromatic amines using a carbon-based solid acid (CBSA), as an effective and reusable catalyst, is described. The present methodology offers several advantages such as simple procedure with an easy work-up, shorter reaction times, and high yields.
Keywords
Carbon-based solid acid; Mannich reaction; $\beta$-Amino carbonyl compounds;
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