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http://dx.doi.org/10.5012/jkcs.2022.66.1.9

Intramolecular Oxa-Mannich Reaction of 1,3-Dihydro-2-benzofuran-1-ol for Efficient Synthesis of 1-Aminophthalan Derivatives  

Kim, Heebum (Department of Chemistry, Kyonggi University)
Kim, Sung-Gon (Department of Chemistry, Kyonggi University)
Publication Information
Journal of the Korean Chemical Society / v.66, no.1, 2022 , pp. 9-14 More about this Journal
Abstract
An efficient method for the synthesis of 1-aminophthalans has been developed. The intramolecular oxa-Mannich reaction of 1,3-dihydro-2-benzofuran-1-ols with p-toluenesulfonylamine in the presence of Cs2CO3 as a base, without using any catalyst, provided the desired 1-aminophthalans in moderate to good yields.
Keywords
1,3-Dihydroisobenzofuran; Phthalan; p-Toluenesulfonylamine; Mannich reaction;
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