• Journal of Food Hygiene and Safety
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• v.33 no.4
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• pp.266-271
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• 2018

The Ministry of Food and Drug Safety (MFDS) is amending its test methods for health-functional foods (dietary food supplements) to establish regulatory standards and specifications in Korea. In this regard, we continue our research on developing analytical methods for the items. Octacosanol is the major component of polycosanol and is a high-molecular-mass primary fatty alcohol, obtained from sugar cane wax. Previous researchers have shown that octacosanol can lower cholesterol and has antiaggregatory properties, cytoprotective uses, and ergogenic properties for human health. Recently, octacosanol products have been actively introduced into the domestic market because of their functional biological activity. We have developed a sensitive and selective test method for octacosanol that the TMS derivatives by means of gas-chromatographic-tandem mass spectrometry (GC-MS). The trimethylsilyl ether derivative of the target analyte showed excellent chromatographic properties. The procedure was validated in the range of $12.5{\sim}200{\mu}g/L$. Standard calibration curves presented linearity with the correlation coefficient ($r^2$) > 0.999, and the limits of detection (LOD) and limits of quantitation (LOQ) were $4.5{\mu}g/L$ and $13.8{\mu}g/L$, respectively. The high recoveries (92.5 to 108.8%) and precision (1.8 to 2.4%) obtained are in accordance with the established validation criteria. Our research can provide scientific evidence to amend the octacosanol test method for the Health-Functional Food Code.

• International journal of advanced smart convergence
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• v.8 no.4
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• pp.47-57
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• 2019

We examine the weaknesses of the existing OOXML-based MS-Word file structure, and analyze how data concealment and forgery are performed in MS-Word digital documents. In case of forgery by including hidden information in MS-Word digital document, there is no difference in opening the file with the MS-Word Processor. However, the computer system may be malfunctioned by malware or shell code hidden in the digital document. If a malicious image file or ZIP file is hidden in the document by using the structural vulnerability of the MS-Word document, it may be infected by ransomware that encrypts the entire file on the disk even if the MS-Word file is normally executed. Therefore, it is necessary to analyze forgery and alteration of digital document through internal structure analysis of MS-Word file. In this paper, we designed and implemented a mechanism to detect this efficiently and automatic detection software, and presented a method to proactively respond to attacks such as ransomware exploiting MS-Word security vulnerabilities.

• Digital Contents
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• no.12 s.43
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• pp.66-70
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• 1996

이번호에는 지난달에 예고한 바와 같이 지금까지 해왔던 HTML Tag를 이용한 홈페이지 제작이 아니라 워드를 치는 것만으로도 홈페이지를 만들 수 있는 방법을 소개 하고자 한다. 이번호에는 MS Word와 Internet Assistant를 이용하는 방법을 소개하고 다음달에는 역시 MS의 제품중 하나로 다음버전의 Office package에 포함될 홈페이지 저작툴인 Frintpage를 이용한 방법을 소개하고자 한다.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.6
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• pp.1485-1494
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• 2015

Traditionally, data hiding has been done mainly in such a way that insert the data into the large-capacity multimedia files. However, the document files of the previous versions of Microsoft Office 2003 have been used as cover files as their structure are so similar to a File System that it is easy to hide data in them. If you open a compound-document file which has a secret message hidden in it with MS Office application, it is hard for users who don't know whether a secret message is hidden in the compound-document file to detect the secret message. This paper presents an analysis of Compound-File Binary Format features exploited in order to hide data and algorithms to detect the data hidden with these exploits. Studying methods used to hide data in unused area, unallocated area, reserved area and inserted streams led us to develop an algorithm to aid in the detection and examination of hidden data.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.755-758
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• 2011

분산된 데이터를 효율적으로 관리하기 위해 일반적으로 DBMS을 사용하고 있다. DBMS에는 여러 시스템들이 있지만 대부분 상용판매이기 때문에 시스템을 구축하는데 있어 비용적인 문제가 있을 뿐만 아니라 사용방법도 복잡하여 사용하기 어려운 면이 있다. 이에 본 연구에서는 전문적인 지식 없이도 조작과 관리가 쉽고 체계적이고 통합적으로 관리가 가능하며 MS Office 제품과의 호환성이 뛰어난 MS-Access를 이용한 시스템구축 사례를 제안한다. MS-Access를 이용하면 서버나 기타 시스템 없이도 기존에 사용하고 있는 컴퓨터에서 데이터베이스를 운영할 수 있고 따로 전문적인 DB관리자가 필요가 없다. 본 논문에서는 이러한 점을 이용하여 프로젝트를 관리할 수 있는 시스템을 구현하였다. 이 시스템은 비용투자에 열악한 중소기업이나 비영리 단체에서 효율적으로 사용할 수 있다.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.5
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• pp.558-562
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• 2006

Filtration experiments were conducted to determine the characteristics of manganese removal in filtration using 4 different filter media including sand and manganese sand(MS). Filtration velocity was 123 m/d and the flow rate was $3.9m^3/d$ per column. Duration of these experiments was about one year, and manganese dioxide accumulation, turbidity removal, manganese removal, and organic material removal were examined depending on filter media. When filter influent(residual chlorine 1.0 mg/L) with an average manganese concentration of 0.208 mg/L was fed through a filter column, the sand+MS and MS columns removed 98.9% and 99.2% of manganese respectively on an annual basis. When there is need to replace the sand filters with a MS filter to remove manganese, it was shown that the replacement of a partial sand filter with MS had adequate manganese removal.

• Analytical Science and Technology
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• v.23 no.6
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• pp.544-550
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• 2010

Mistaking pink colored thermal oil for grape wine, a victim drank the oil to death which was analyzed to contain 39% of ethylene glycol. Thermal oil could be used for heat transfer to prevent the malfunction due to the high pressure in the boiler operated at high temperature when using water. Main component of thermal oil is known to be mineral oil or ethylene glycol. From the blood and other tissue of the victim from autopsy, ethylene glycol and its metabolite were simultaneously analyzed by GC/MS after extraction under acidic condition with acetonitrile followed by derivatization with BSTFA. About 0.2 g of the specimens were pretreated with 50 uL of 0.5 M HCl solution to keep acidic condition, then dehydrated with anhydrous sodium sulfate followed by concentration under nitrogen stream. Ethylene glycol and glycolic acid concentration in blood was measured to be $2,755\;{\mu}g/mL$ and $174\;{\mu}g/mL$ respectively. In other specimen, the concentration of ethylene glycol and glycolic acid was $860\;{\mu}g/g\sim1,290\;{\mu}g/g$ and $93\;{\mu}g/g\sim134\;{\mu}g/g$. Especially, crystal appeared in kidney which was supposed xalate from the metabolite of ethylene glycol.

• Analytical Science and Technology
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• v.19 no.5
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• pp.441-448
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• 2006

11-nor-9-carboxy-${\Delta}^9$-tetrahydrocannabinol (THCCOOH) is the major metabolite of tetrahydrocannabinol (THC) which is the primary psychoactive component of marijuana. It is also the target analyte for the discrimination marijuana use. A method using solid-phase extraction (SPE) and gas chromatography/mass spectrometry (GC/MS) was developed for the determination of THCCOOH in human urine. Urine samples (3 mL) were extracted by SPE column with a cation exchange cartridge after basic hydrolysis. The eluents were then evaporated, derivatized, and injected into the GC/MS. The limits of detection (LOD) and quantitation (LOQ) were 0.4 and 1.2 ng/mL, respectively. The response was linear with a correlation coefficient of 0.999 within the concentration range of 1.2 (LLE 1.3)~50.0 ng/mL. The precision and accuracy were stable within 1.20% and the recovery was 83.6~90.7%. The recovery of SPE method was lower than that of liquid-liquid extraction (LLE), but there were no apparent differences in LOD, LOQ, precision and accuracy between the two methods. While SPE method is used as a very effective and rapid procedure for sample pretreatment, and clean extracts, LLE method was not suitable for the extraction procedure of THCCOOH in urine. The applicability of the method was proven by analyzing a urine samples from a marijuana abusers.

• Korean Journal of Veterinary Service
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• v.43 no.3
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• pp.189-196
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• 2020

This study was conducted to analyze feasibility of monitoring of fluoroquinolnes residual through feather analysis in broilers. The calibration curve showed good linearity (r²≥0.99) within the concentration range of 1~100 ㎍/kg. The limit of detection (LOD) and limit of quantification (LOQ) were validated at ≤0.66 and ≤1.99 ㎍/kg in broiler feather, respectively. The recoveries in feather samples ranged from 94.6 to 114.4% (5.1-15.8% RSD) at the 5 to 20 ㎍/kg spiking levels. The proposed new analytical method proved to be suitable and effective for fluoroquinolnes determination. We also monitored fluoroquinolones residue in 36 samples (broiler that were slaughtered in Gyonggi-do) using this method. Among tested feather samples, enrofloxacin and ciprofloxacin were detected in all samples. In muscle samples, enrofloxacin was detected in 20 (55.6%) samples and ciprofloxacin was not detected.

• Analytical Science and Technology
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• v.21 no.1
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• pp.41-47
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• 2008

Although liquid-liquid extraction (LLE) method has been used routinely for the analysis of amphetamine-like drugs (amphetamine; AP, methamphetamine; MA, 3,4-methylenedioxyamphetamine; MDA, 3,4-methylenedioxymethamphetamine; MDMA, 3,4-methylenedioxyethylamphetamine; MDEA), a solid-phase extraction (SPE) method, which can be automated, was applied for the simultaneous determination by GC/MS in human urine. Urine samples (3 mL) and 0.1 M phosphate buffer (1 mL, pH 7.0) were extracted by an automated SPE system. The eluent was evaporated, derivatized with trifluoroacetic anhydride (TFAA), and analyzed by GC/MS. The calibration curves was linear with correlation coefficient ($r^2$) above 0.994 in the ranges of 34.0 (AP), 28.0 (MDA)~1000.0 ng/mL for AP, MDA, and 50.0~2000.0 ng/mL for MA, MDMA, and MDEA. The limits of detection ranged from 4.0 to 10.0 ng/mL, and the limits of quantitation ranged from 12.0 to 34.0 ng/mL. The relative recoveries were 93.5~107.7 %. The precisions and accuracies were 1.9~14.8 % and -8.7~14.8 %, respectively. The present method was successfully applied to identify the MA or Ecstasy (MDMA) abusers in exact as well as rapid.