• The Journal of the Acoustical Society of Korea
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• v.37 no.4
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• pp.181-187
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• 2018

In this paper, sound absorption of micro-perforated elastic plates installed in an impedance tube of a circular cross-section is discussed using an analytic method. Vibration of the plates and sound pressure fields inside the duct are expressed in terms of an infinite series of modal functions, where modal functions in the radial direction is given in terms of the Bessel functions. Under the plane wave assumption, a low frequency approximation is derived by including the first few plate modes, and the sound absorption coefficient is given in terms of an equivalent impedance of a single surface. The sound absorption coefficient using the proposed formula is in excellent agreement with the result by the FEM (Finite Element Method), and shows dips and peaks at the natural frequencies of the plate. When the perforation ratio is very small, the sound absorption coefficient is dominated by the vibration effect. However, when the perforation ratio reaches a certain value, the sound absorption is mainly governed by the rigid MPP (Micro-Perforated Plate), while the vibration effect becomes very small.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.3 s.345
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• pp.111-117
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• 2006

Developing a home network and a ubiquitous infrastructure requires various communication techniques and devices with more advanced hardware. With this development, increasing realtime access to multimedia data results in rapid degradation of qualify for multimedia playback. This paper presents a traffic allocation technique based on MPP(Media Preference for Presentation) that can steadily maintain multimedia playback quality by adaptively allocating streaming traffic requested from clients with different playback performances. Media preference is defined in accordance with content popularity and playback performance of client devices. Through experiments when requested stream data exceeds processing ability of a midea server, the proposed allocation technique shows 10% quality improvement comparing to the system without applying the proposed allocation technique.

• Journal of Internet Computing and Services
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• v.11 no.4
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• pp.1-10
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• 2010

As recent fusion industry and ubiquitous technology have grown fast, network contents, which require high load, are provided in various infrastructures and facilities such as u-city and smart phones. Therefore, it is anticipated that the playback quality of multimedia compared to network loads degrades dramatically due to the drastic increment of real-time reference of conventional high load contents (eg. multimedia data). In this paper, we improved the method of the traffic assignment based on MPP which elevated the playback quality of multimedia by assigning discriminately the possible traffic of MMS with TP coefficients. When the TP coefficient which combines content preference with media preference was applied to a real-time traffic assignment scheduler, the simulation results showed that the multimedia playback stream was assigned within the possible traffic of a server. The real-time scheduling algorithm was improved by using the TP coefficient that combines the time-dependent image contents and the weighted value of media preference. It was observed from the experiment that the loss of the possible traffic decreases to 3.91% and 3.88% for three and four clients respectively.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.397-400
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• 2015

In this paper a solar energy harvesting system with low-cost MPPT control for low duty-cycled sensor nodes is proposed. The targeted applications are environment, structure monitoring sensor nodes that are not required successively to operate, and MPPT(Maximum Power point Tracking) control using simple circuits is low-cost differently than existing MPPT control. The proposed MPPT control is implemented using linear relationship between the open-circuit voltage of a solar cell. The designed MPPT circuit traces the maximum power point by sampling periodically the open circuit voltage of the solar cell and delivers the maximum available power to the load. The proposed circuit is designed in 0.35um CMOS process. The designed chip area is $975um{\times}1025um$ including pads. Measured results show that the designed system can track the MPP voltage by sampling periodically the open circuit voltage of solar cell.

• Physical Therapy Rehabilitation Science
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• v.10 no.3
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• pp.311-319
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• 2021

Objective: To investigate the effect of emphasized initial contact by using a wearable air-pressure insole to provide auditory-feedback with variations of maximum peak pressure (MPP) of the affected side on spatiotemporal gait parameters and gait symmetry of stroke patients Design: A cross-sectional study Methods: Eighteen stroke patients participated in this study. All subjects walked five trials using an air-pressure insole that provides auditory feedback with different thresholds set on the insole. First, subjects walked without any auditory feedback. Then, the MPP threshold on the affected side was set from 70% and increase threshold by 10% after each trial until 100%. They walked three times or more on the gait analyzer for each trial, and the average values were measured. Before starting the experiment, subjects measured body weight, initial gait abilities and affected side MPP without auditory feedback. Results: Temporal and spatial variables were significantly increased in trials with auditory feedback from air-pressure insole except for non-paralyzed single support time and spatial gait symmetry compared to trials without auditory feedback(p<0.05). Among the four different thresholds, the walking speed, unaffected side single support time, affected and unaffected side stride, and affected side step length were greatest at 80% threshold of maximum peak, while affected single support time, temporal gait symmetry, and unaffected step length were greatest at the maximum peak of 100% threshold. Conclusions: These results indicate that auditory feedback gait using air-pressure insoles can be an effective way to improve walking speed, single support time, step length, stride, and temporal gait symmetry in stroke patients.

• Biomolecules & Therapeutics
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• v.27 no.5
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• pp.442-449
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• 2019

This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine ($MPP^+$)-induced SH-SY5Y cells, to investigate the potential anti-inflammatory mechanisms of Asiatic acid in Parkinson's disease (PD). SH-SY5Y cells were induced using $MPP^+$ to establish as an in vitro model of PD, so that the effects of Asiatic acid on dopaminergic neurons could be examined. The NLRP3 inflammasome was activated in BV2 microglia cells to explore potential mechanisms for the neuroprotective effects of Asiatic acid. We showed that Asiatic acid reduced intracellular production of mitochondrial reactive oxygen species and altered the mitochondrial membrane potential to regulate mitochondrial dysfunction, and suppressed the NLRP3 inflammasome in microglia cells. We additionally found that treatment with Asiatic acid directly improved SH-SY5Y cell viability and mitochondrial dysfunction induced by $MPP^+$. These data demonstrate that Asiatic acid both inhibits the activation of the NLRP3 inflammasome by downregulating mitochondrial reactive oxygen species directly to protect dopaminergic neurons from, and improves mitochondrial dysfunction in SH-SY5Y cells, which were established as a model of Parkinson's disease. Our finding reveals that Asiatic acid protects dopaminergic neurons from neuroinflammation by suppressing NLRP3 inflammasome activation in microglia cells as well as protecting dopaminergic neurons directly. This suggests a promising clinical use of Asiatic acid for PD therapy.

• Journal of Integrative Natural Science
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• v.15 no.3
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• pp.99-110
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• 2022

Solar photovoltaic (PV) system shows a non-linear current (I) -voltage (V) characteristics, which depends on the surrounding environment factors, such as irradiance, temperature, and the wind. Solar PV system, with current (I) - voltage (V) and power (P) - Voltage (V) characteristics, specifies a unique operating point at where the possible maximum power point (MPP) is delivered. At the MPP, the PV array operates at maximum power efficiency. In order to continuously harvest maximum power at any point of time from solar PV modules, a good MPPT algorithms need to be employed. Currently, due to its simplicity and easy implementation, Perturb and Observe (P&O) algorithms are the most commonly used MPPT control method in the PV systems but it has a drawback at suddenly varying environment situations, due to constant step size. In this paper, to overcome the difficulties of the fast changing environment and suddenly changing the power of PV array due to constant step size in the P&O algorithm, least mean Square (LMS) methods is proposed together with P&O MPPT algorithm which is superior to traditional P&O MPPT. PV output power is predicted using LMS method to improve the tracking speed and deduce the possibility of misjudgment of increasing and decreasing the PV output. Simulation results shows that the proposed MPPT technique can track the MPP accurately as well as its dynamic response is very fast in response to the change of environmental parameters in comparison with the conventional P&O MPPT algorithm, and improves system performance.

• The Korea Journal of Herbology
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• v.28 no.5
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• pp.21-28
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• 2013

Objectives : The aim of this study was to investigate the neuroprotective effects and mechanisms of Cyperi Rhizoma extracts (CRE) using in vitro and in vivo models of Parkinson's disease (PD). Methods : We evaluated the neuroprotective effect of CRE against 1-methyl-4-phenylpyridinium (MPP+) toxicity using tyrosine hydroxylase immunohistochemistry (IHC) in primary rat mesencephalic dopaminergic neurons. In addition, the effect of CRE was evaluated in mice PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). For evaluations, C57bl/6 mice were orally treated with CRE 50 mg/kg for 5 days and were injected intraperitoneally with MPTP (20 mg/kg) at 2 h intervals on the last day. To identify the CRE affects on MPTP-induced neuronal loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) and striatum of mice, the behavioral tests and IHC analysis were carried out. Also, we conducted nitric oxide (NO) and tumor necrosis factor-alpha (TNF-${\alpha}$) assay in dopaminergic neurons and IHC using glial markers in SNpc of mice to assess the anti-inflammation effects. Results : In primary mesencephalic culture system, CRE protected dopaminergic cells against $10{\mu}M$ MPP+-induced toxicity at 0.2 and $1.0{\mu}g/mL$. In the behavior tests, CRE treated group showed improved motor deteriorations than those in the MPTP only treated group. CRE significantly protected striatal dopaminergic damage from MPTP-induced neurotoxicity in mice. Moreover, CRE inhibited productions of NO and TNF-${\alpha}$ in dopaminergic culture system and activation of astrocyte and microglia in SNpc of the mice. Conclusion : We concluded that CRE shows anti-parkinsonian effect by protecting dopaminergic neurons against MPP+/MPTP toxicities through anti-inflammatory actions.

• Journal of Interdisciplinary Genomics
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• v.5 no.2
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• pp.35-41
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• 2023

Background: Ca²⁺ signaling plays a vital role in neuronal signaling and altered Ca²⁺ homeostasis in Parkinson's disease (PD). Overexpression of αSYN significantly promote the Ca²⁺-Calmodulin (CaM) activity and subsequent nuclear translocation of nuclear factor of activated T cells (NFAT) transcription factor in dopaminergic neurons of midbrain. However, the exact role of Ca²⁺-CaM and NFAT in PD pathology is yet to be elucidated. Methods: We designed the CaM-NFAT-oligodeoxynucleotide (ODN), a synthetic short DNA containing complementary sequence for NFAT transcription factor and CaM mRNA. Then, the effect of CaM-NFAT-ODN on 1-methyl-4-phenylpyridinium (MPP⁺)-mediated neurotoxicity was investigated in mimic PD model in vitro. Results: First, the expression of αSYN and CaM was strongly increased in substantia nigra (SN) of PD and the expression of tyrosine hydroxylase (TH) was strongly increased in control SN. Additionally, the expression of apoptosis marker proteins was strongly increased in SN of PD. Transfection of CaM-NFAT-ODN repressed CaM and pNFAT, the target genes of this ODN in rat embryo primary mesencephalic neurons. It also reduced ERK phosphorylation, a downstream target of these genes. These results demonstrated that CaM-NFAT-ODN operated successfully in rat embryo primary mesencephalic neurons. Transfection of CaM-NFAT-ODN repressed TH reduction, αSYN accumulation, and apoptosis by MPP⁺-induced neurotoxicity response through Ca²⁺ signaling and mitogen-activated protein kinases (MAPK) signaling. Conclusion: Synthetic CaM-NFAT-ODN has substantial therapeutic feasibility for the treatment of neurodegenerative diseases.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.2
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• pp.15-21
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• 2011

In this paper, an energy management circuit for solar energy harvesting system is designed in $0.35{\mu}m$ CMOS technology. The solar energy management system consists of an ISC(Integrated Solar Cell), a voltage booster, and an MPPT(Maximum Power Point Tracker) control unit. The ISC generates an open circuit voltage of 0.5V and a short circuit current of $15{\mu}A$. The voltage booster provides the following circuit with a supply voltage about 1.5V. The MPPT control unit turns on the pMOS switch to provide the load with power while the ISC operates at MPP. The SEMU(Solar Energy Management Unit) area is $360{\mu}m{\times}490{\mu}m$ including pads. The ISC area is $500{\mu}m{\times}2000{\mu}m$. Experimental results show that the designed SEMU performs proper MPPT control for solar energy harvested from the ISC. The measured MPP voltage range is about 370mV∼420mV.