• Interdisciplinary Bio Central
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• v.4 no.3
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• pp.8.1-8.7
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• 2012

The motor neuron degeneration 2 (mnd2) mice carry a point mutation of A to T nucleotide transversion at the serine 276 residue of high temperature requirement A2 (HtrA2), resulting in losses of an AluI restriction enzyme site (5'AGCT3') and the HtrA2 serine protease activity. Moreover, dysfunctions of HtrA2 are known to be intimately associated with the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Thus, this mnd2 mouse is an invaluable model for understanding the physiological role of HtrA2 and its pathological role in neurodegenerative diseases. Nevertheless, many molecular and cellular biologists in this field have limited experience in working with mutant mouse models due to the necessity of acquired years of the special techniques and knowledges. Herein, using the mnd2 mouse model as an example, we describe easy-to-use standard protocols for web-based analyses of target genes, such as HtrA2, and a novel approach for simple and accurate PCR-AluI-RFLP-based genotype analysis of mnd2 mice. In addition, band resolution of AluI-RFLP fragments was improved in 12% polyacrylamide gel running in 1X Tris-Glycine SDS buffer. Our study indicates that this PCR-AluI-RFLP genotype analysis method can be easily applied by the molecular and cellular biologist to conduct biomedical science studies using the other mutant mouse models.

• The KIPS Transactions:PartD
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• v.11D no.2
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• pp.407-414
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• 2004

The US DoD architecture framework defines architecture Products according to three viewpoints : operational view, system view, and technical view. But, its coarse-grained development process causes leakage of the details In transforming among different views. It also uses different methods for architecture products development, so that the levels of those products are not consistent. So. we propose MND AF(Ministry of National Defense Architecture Framework) for military environment to solve those problems. We propose additional architecture products to achieve consistency, including “architecture disciplines definition description,”“organization-to-activity relationships matrix,” “system definition description,” and “technical reference model,” etc. We also propose the architecture development process in more detail through seven steps. In addition, we propose the applicability of those products to the life cycle processes of the acquisition management. MND AF can provide consistency and traceability of architecture products, provide the basis for sl·stem integration and interoperability. Also, architecture developers can construct architecture in a more effective and efficient way through MND AF.

• Journal of the Korean Society of Systems Engineering
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• v.16 no.2
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• pp.118-130
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• 2020

Modern weapon systems are composed of complex systems(System of Systems) and require a complex and advanced operational concept that performs missions through interoperability with various weapon systems. In order to derive the operational concept of the weapon system that the military wants to acquire (i.e., single mission, component operation, Joint and Alliance operations), it is necessary to identify the system related to the weapon system, environmental factors and restrictions of the weapon system to be developed. Through the derivation of the operational concept, the weapon system acquisition agency can reasonably and accurately extract various and complex requirements. In this paper, we propose a complementary method of using MND-AF to OCD and ORD required in weapon system acquisition process. MND-AF can increase the understanding and consensus of business stakeholders (users, acquirers, developers, etc.) by showing the results of weapon system analysis from various perspectives. We compare the items in the standard form of OCD and ORD with the MND-AF outputs.

• The KIPS Transactions:PartD
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• v.12D no.5 s.101
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• pp.729-736
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• 2005

MND(Ministry of National Defense) has developed MND AF(Ministry of National Defense Architecture Framework) and CADM(Core Architecture Data Model) to guarantee interoperability among defense information systems. TRM(Technical Reference Model) and SP(Standard Profile) product defined in MND AF is core part of Information Technology Architecture and core element of interoperability guarantee. In this paper, we proposed a method which manages technical service and standard of TRM and SP, and developed TRM and SP management system based on the method. TRM and SP management system provides the basis for interoperability among information systems and a more efficient development and management of TRM and SP product.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.535-538
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• 2008

국방에서 사용되는 소프트웨어는 미션 크리티컬(Mission Critical)한 고 품질의 소프트웨어가 요구된다. 이를 위해 많은 조직에서는 전체 개발 프로세스를 개선하기 위한 목적으로 CMMI를 적용하고 있으나 테스트 프로세스를 개선하는 데는 부족함이 있어 고 품질의 소프트웨어를 생산하는데 어려움이 따르고 있다. 더욱이 국방이라는 특수한 도메인에서는 그러한 현상이 빈번히 발생함에 따라 국방 도메인에 적합한 테스트 성숙도 모델의 필요성이 제기되었으며 이를 위해 국방 시험 성숙도 모델(MND-TMM)이 개발되었고 현재 시험 적용 중이다. 본 논문에서는 현재 무기체계 소프트웨어를 개발하는 조직에서 전체 개발 프로세스를 개선하기 위해 CMMI를 적용하고 있기에 테스트 프로세스를 개선하기 위한 모델인 MND-TMM과 CMMI를 비교 분석하여 두 모델의 강점과 약점을 제시하고 상호연계방안을 모색한다. 상호연계를 통해 국방 소프트웨어 개발 조직에서는 두 모델을 적용하는데 있어 비용 및 시간을 줄이고 소프트웨어의 품질을 향상시킬 것으로 기대한다.

• The KIPS Transactions:PartD
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• v.12D no.6 s.102
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• pp.857-862
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• 2005

MND(Ministry of National Defense) has developed MND AF(Ministry of National Defense Architecture Framework) and CADM(Core Architecture Data Model to guarantee interoperability among defense information systems. But, it is very difficult to manage architecture product documented through MND AF and CADM. So, there Is necessity for development of modeling tool and repository system which can develop architecture products and manage architecture product informations in common repository In this paper, we developed architecture product management system which supports development and management of meta model and architecture product of MND AF and CADM. Through architecture product management system architect of each agency can construct architecture product in a more effective and efficient way with modeling method and a user can search and refer useful architecture product informations using query function. Also, architecture product management system provides the basis for system integration and interoperability with integration, analysis and comparison of architecture product.

• Journal of the Korean Society of Systems Engineering
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• v.8 no.1
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• pp.41-49
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• 2012

Recently, the LISI(Level of Information System Interoperability) model has been used to measure level of interoperability in the Ministry of National Defense. This study is proposed for improvement of interoperability level measurement method. The MND has been devoting a lot of effort to ensure defense weapon system interoperability. They enacted related regulations and developed SITES for measuring the level of interoperability. However, the LISI model has problems with using just only DITA and applying MND-AF based on Architecture development. To overcome these problems, this paper proposes how to apply reference model to LISI Model and how to apply LISI Model to MND-AF architecture development.

• Journal of Electrical Engineering and Technology
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• v.2 no.4
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• pp.532-536
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• 2007

Carbon nanotube (CNT) properties, produced using a magnetic null discharge (MND) plasma production technology, were investigated. We firstly deposited the Fe layer 200 nm in thickness on Si substrate by the magnetic null discharge sputter method at the substrate temperature of $300도C$, and then prepared CNTs on the catalyst layer by using the magnetic null discharge (MND) based CVD method. CNTs were deposited in a gas mixture of CH4 and N2 at a total pressure of 1 Torr by the MND-CVD method. The substrate temperature and the RF power were $650^{\circ}C$ and 600W, respectively. The characterization data indicated that the proposed source could synthesize CNTs even under relatively severe conditions for the magnetic null discharge formation.

• Journal of Information Technology Services
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• v.7 no.3
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• pp.87-95
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• 2008

The Law of effective building and operation for the information systems took effect at Dec. 2005. Every government and public agency have to build own enterprise architecture(EA), sometimes it's called the Information Technology Architecture(ITA), by this law. The Ministry of National Defense(MND) built the enterprise architecture(EA) during 2006. 12$\sim$2007. 11 by this law too. We knew the specific characters of the public sector thru the EA project. The public sector is less active than commercial sector and most members of the public sector are just looking on the project as a spectator. So the most of key for the success of EA is how to catch the Sponsorship and Participation of members. In this paper we propose the effective building methodology for the Enterprise Architecture of public agency applying the MND-EA. The other governments and public agencies can build own the EA easily by the proposed methodology.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10d
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• pp.184-189
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• 2007

물류유통분야에서는 SCM(Supply Chain Management)의 효율을 위하여 RFID 기술의 적용을 날로 확대하고 있다. 시대흐름에 편승하여 국방에서는 군수분야에 이 기술을 적용하고 있다. 군수물자 관리에서 필요성을 인식하고 국방탄약관리 시스템 구축사업, 신무기체계 자산관리 시스템 구축사업 등에 RFID 기술을 적용하였다. u-군수정보체계를 구축하기 위해서는 탄약뿐만 아니라 물자, 장비정비 RFID 시스템이 국방차원의 ONS(Object Naming Service) 및 DS(Discovery Service)와 연계되어야 비로소 군수물자 전체에 대하여 실시간으로 흐름을 파악할 수 있게 된다. 그러나 시범사업을 통하여 구축된 탄약 RFID 시스템이나 신무기체계 자산관리 시스템은 기관간 정보를 공유할 수 있도록 하는 국방차원의 ONS가 구비되어 있지 않고, 향후 구축할 계획을 가지고 있다. 따라서 본 논문에서는 EPCglobal 네트워크의 시사점 및 향후 추진 방향을 정리해 보고, 국방분야에서 RFID 시스템 도입사례와 향후 국방 RFID 추진방향, 국방 군수지원 개념을 고찰하였다. 그리고 군에 적합하고 인트라넷 환경에서 운영이 가능한 MND-ONS(Military and Defense) 시스템 구축방안을 제시하였다.