• Preventive Nutrition and Food Science
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• 제8권3호
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• pp.278-283
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• 2003

Textural properties of tofu manufactured with micronized full-fat soyflour (MFS) were enhanced by the addition of soy protein isolate, whey protein concentrate, chitosan oligosaccharide and mushroom powder. The MFS solution (14.2% solid content) was converted to semi-solid tofu by a two-stage heat treatment with the addition of 4% coagulant mix. The MFS tofu was evaluated by a compression test as well as sensory evaluation. To produce the semi-solid gel (MFS tofu) with reasonably high strength and toughness, the MFS solution with 14.2% solid content and 7.0% protein had to be heat treated at 121$^{\circ}C$ for 3min. The relative toughness of MFS tofu was increased by the addition of SPI, showing a 144% increase. The toughness of MFS tofu prepared with the MFS/SPI mixture was greatly increased by the addition of WPC at the level of 0.7% and the water separation from MFS tofu was greatly reduced. Furthermore, the toughness and strength of MFS/SPI tofu was enhanced by the addition of 0.1% chitosan oligosaccharide and 0.2% mushroom powder. The sensory evaluation of the tofu fortified with SPI, chitosan oligosaccharide and mushroom powder was superior to that of MFS tofu, with a higher score for overall preference.

• 한국식품영양과학회지
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• 제32권1호
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• pp.75-81
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• 2003

전지활성 생대두미세분말(micronized full-fat soyflour, MFS)로부터 제조된 두유는 의가소성 의 비뉴턴성 유체로서, 고형분 증가와 응고제의 첨가 및 가열에 따라 점도가 증가하였다. MFS용액은 열처리에 따른 점도가 급격하게 증가되는 시점의 온도는 응고제의 첨가 및 단백질의 함량이 증가함에따라 낮아졌다 충진형 전두부제조에 적합한 응고제는 가열된 MFS용액에 응고제 첨가 후 MFS용액의 점도를 완만하게 변화시키는 GDL, MgSO$_4$가 적 합한 것으로 나타났으며 전두부용 응고제는 0.1% salt, 0.1% GDL, 0.2% MgSO$_4$ㆍ7$H_2O$로 조제되었다. 고형분과 물의 비율이 1 : 6.0인 MFS60용액을 121$^{\circ}C$에서 3분간 가열하여 응고제를 첨가하여 제조된 전두부는 견고성과 깨짐성이 양호한 조직감을 나타내었으며, 여기에 SPI를 첨가하여 총단백질이 7.1%인 MFSS60용액으로 제조된 전두부의 경도와 깨짐성(brittleness)은 각각 120 g, 176 g으로 조직감이 개선되었다.

• Archives of Pharmacal Research
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• 제28권2호
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• pp.238-242
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• 2005

Many reports demonstrate that extremely low frequency magnetic fields (ELF MFs, 60 Hz) may be involved in hyperalgesia. In a previous investigation, we suggested that MFs may produce hyperalgesia and such a response may be regulated by the benzodiazepine system. In order to further confirm this effect of MFs, we used diazepam and/or flumazenil with MFs exposure. When testing the pain threshold of rats using hot plate tests, MFs or diazepam ($0.5\;{\mu}g$, i.c.v.; a benzodiazepine receptor agonist) induced hyperalgesic effects with the reduction of latency. These effects were blocked by a pretreatment of flumazenil (1.5 mg/kg, i.p.; a benzodiazepine receptor antagonist). When the rats were exposed simultaneously to MFs and diazepam, the latency tended to decrease without statistical significance. The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil. However, the pretreatment of GABA receptor antagonists such as bicuculline ($0.1\;{\mu}g$, i.c.v.; a $GABA_A$ antagonist) or phaclofen ($10\;{\mu}g$, i.c.v.; a $GABA_B$ antagonist) did not antagonize the hyperalgesic effect of MFs. These results suggest that the benzodiazepine system may be involved in MFs-induced hyperalgesia.

• Biomolecules & Therapeutics
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• 제22권2호
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• pp.143-148
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• 2014

Marfan syndrome (MFS) is a dominantly inherited connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1) and is characterized by aortic dilatation and dissection, which is the primary cause of death in untreated MFS patients. However, disease progression-associated changes in gene expression in the aortic lesions of MFS patients remained unknown. Using a mouse model of MFS, FBN1 hypomorphic mouse (mgR/mgR), we characterized the aortic gene expression profiles during the progression of the MFS. Homozygous mgR mice exhibited MFS-like phenotypic features, such as fragmentation of elastic fibers throughout the vessel wall and were graded into mgR1-4 based on the pathological severity in aortic walls. Comparative gene expression profiling of WT and four mgR mice using microarrays revealed that the changes in the transcriptome were a direct reflection of the severity of aortic pathological features. Gene ontology analysis showed that genes related to oxidation/reduction, myofibril assembly, cytoskeleton organization, and cell adhesion were differentially expressed in the mgR mice. Further analysis of differentially expressed genes identified several candidate genes whose known roles were suggestive of their involvement in the progressive destruction of aorta during MFS. This study is the first genome-wide analysis of the aortic gene expression profiles associated with the progression of MFS. Our findings provide valuable information regarding the molecular pathogenesis during MFS progression and contribute to the development of new biomarkers as well as improved therapeutic strategies.

• 한국지반공학회논문집
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• 제39권11호
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• pp.7-22
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• 2023

최근 지하안전에 관한 특별법이 시행(2022년 1월)되었으며, 지하안전영향평가를 통해 계획단계부터 지하안전에 관한 사전검토가 실시되고 있다. 지하굴착을 위해서는 가설 흙막이의 구조 안전성을 확보하는 것이 중요하므로 지하안전 검토는 더욱 강화되고 있다. 본 연구에서는 토사지반에서 Soil-Cement 흙막이의 벽체 두께를 확대하고 H-pile의 선택과 설치간격을 자유롭게 할 수 있는 MFS(Multi-axis Flat Continuous Soil Cement Earth Retaining Wall) 흙막이 벽체 공법의 거동 특성을 분석하였다. 실내모형실험을 통해 MFS 공법의 H-pile 설치간격에 따른 벽체에 작용하는 하중-변위 거동을 확인하였으며, MFS 흙막이 벽체의 두께별 H-pile 설치간격 및 크기 변화에 따른 하중-변위를 3차원 수치해석으로 분석하여 벽체에 작용하는 아칭효과 높이를 산정하였다. MFS 공법에서 산정한 최대 아칭높이를 기존의 부재력 검토 방법에 적용하여 벽체에 작용하는 축력, 전단력을 정량적으로 분석하는 설계방법을 제시하였다. 그 결과 MFS 흙막이 벽체에 적용되는 H-pile 설치 간격 및 크기에 따른 축력 및 전단력이 24.6~62.9%가 저감하는 것을 확인하였다.

• Archives of Pharmacal Research
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• 제26권6호
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• pp.487-492
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• 2003

This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on the sensitivity of seizure response to bicuculline, picrotoxin and NMDA in mice. The mice were exposed to either a sham or 20 G ELF-MFs for 24 hours. Convulsants were then administered i.p. at various doses. The seizure induction time and duration were measured and lethal dose ($LD_{50$}) and convulsant dose ($CD_{50}$) of the clonic and tonic convulsion were calculated. The analysis of glutamate, glycine, taurine and GABA of mouse brain was accomplished by HPLC. The mice exposed to ELF-MFs showed moderately higher $CD_{50}.{\;}LD_{50}$ and onset time on the bicuculline-induced seizure. However, the ELF-MFs did not influence them in the NMDA and picrotoxin-induced seizures. After the exposure to MFs exposure, the glutamate level was increased and GABA was decreased significantly in NMDA and picrotoxin-induced seizure. The level of glutamate and GABA were not changed by MFs in bicuculline-induced seizure. These results suggest that ELF-MFs may alter the convulsion susceptibility through GABAergic mechanism with the involvement of the level of glutamate and GABA.

• 한국운동역학회지
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• 제33권4호
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• pp.164-174
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• 2023

Objective: The aim of this study was to quantitatively analyze the impact characteristics of the lower extremity on strike pattern during running. Method: 19 young subjects (age: 26.53 ± 5.24 yrs., height: 174.89 ± 4.75 cm, weight: 70.97 ± 5.97 kg) participated in this study. All subjects performed treadmill running with fore-foot strike (FFS), mid-foot strike (MFS), and rear-foot strike (RFS) to analyze the impact characteristics in the lower extremity. Impact variables were analyzed including vertical ground reaction force, lower extremity joint moments, impact acceleration, and impact shock. Accelerometers for measuring impact acceleration and impact shock were attached to the heel, distal tibia, proximal tibia, and 50% point of the femur. Results: The peak vertical force and loading rate in passive portion were significantly higher in MFS and FFS compared to FFS. The peak plantarflexion moment at the ankle joint was significantly higher in the FFS compared to the MFS and RFS, while the peak extension moment at the knee joint was significantly higher in the RFS compared to the MFS and FFS. The resultant impact acceleration was significantly higher in FFS and MFS than in RFS at the foot and distal tibia, and MFS was significantly higher than FFS at the proximal tibia. In impact shock, FFS and MFS were significantly higher than RFS at the foot, distal tibia, and proximal tibia. Conclusion: Running with 3 strike patterns (FFS, MFS, and RFS) show different impact characteristics which may lead to an increased risk of running-related injuries (RRI). However, through the results of this study, it is possible to understand the characteristics of impact on strike patterns, and to explore preventive measures for injuries. To reduce the incidence of RRI, it is crucial to first identify one's strike pattern and then seek appropriate alternatives (such as reducing impact force and strengthening relevant muscles) on that strike pattern.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 추계학술대회 논문집 학회본부 C
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• pp.921-923
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• 1999

비휘발성 메모리의 고집적화와 적응학습형 뉴럴 소자의 실현을 위하여 1-트랜지스터 구조 강유전체 비휘발성 메모리(MFS-FET)를 SOI 기판위에 제작하고 평가하였다. 먼저 SBT($Sr_{0.8}Bi_{2.2}Ta_{2}O_{9}$)를 직접 Si위에 증착하고 C-V를 측정하여 1V의 메모리 윈도우를 얻음으로써 비휘발성 메모리로써의 동작가능성을 확인하였다. 또한 다양하게 게이트의 W/L 비를 바꾸어서 MFS-FET를 제작하여 다양한 드레인 전압-드레인 전류 특성을 얻었고 실제로 쓰기와 읽기 동작을 수행하여 MFS-FET가 비휘발성 메모리로써 제대로 동작하고 있음을 확인하였다.

• Annals of Clinical Neurophysiology
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• 제8권1호
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• pp.71-73
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• 2006

Many neurologic signs are found in Miller Fisher syndrome (MFS) especially including pupillary abnormalities. But when internal ophthalmoparesis is first manifestation in MFS, diagnosis may be difficult in acute phase of illness. We report two cases of MFS presenting with internal ophthalmoplegia. Pupillary areflexia may be involved in acute phase of MFS. When acute bilateral internal ophthalmoparesis is encounted in clinical practice, initial manifestation of MFS should be included in differential diagnosis.

• 마이크로전자및패키징학회지
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• 제12권1호
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• pp.59-63
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• 2005

금속-강유전체-반도체 전계효과 트랜지스터 (MFS/MFISFET)의 동작 특성을 technology computer-aided design (TCAD)과 simulation program with integrated circuit emphasis (SPICE)를 결합하여 전산모사하는 방법을 제시하였다. 복잡한 강유전체의 동작 특성을 수치해석을 이용하여 해석한 다음, 이를 이용하여 금속-강유전체-반도체 구조에서 반도체 표면에 인가되는 표면 전위를 계산하였다. 계산된 TCAD 변수인 표면 전위를 전계효과 트랜지스터의 SPICE 모델에서 구한 표면 전위와 같다고 보고게이트 전압에 따른 전류전압 특성을 구할 수 있었다. 이와 같은 방법은 향후 MFS/MFISFET를 이용한 메모리소자의 집적회로 설계에 매우 유용하게 적용될 수 있을 것이다.