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The Pharmaceutical Society of Korea (대한약학회)
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The Influences of Extremely Low Frequency Magnetic Fields on Drug-Induced Convulsion in Mouse

  • Sung, Ji-Hyun (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Jeong, Ji-Hoon (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kim, Jeong-Soo (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Choi, Tai-Sik (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Park, Joon-Hong (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kang, Hee-Yun (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kim, Young-Sil (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kim, Dong-Suk (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, Chung-Ang University)
  • Published : 2003.06.01
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Abstract

This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on the sensitivity of seizure response to bicuculline, picrotoxin and NMDA in mice. The mice were exposed to either a sham or 20 G ELF-MFs for 24 hours. Convulsants were then administered i.p. at various doses. The seizure induction time and duration were measured and lethal dose ($LD_{50$}) and convulsant dose ($CD_{50}$) of the clonic and tonic convulsion were calculated. The analysis of glutamate, glycine, taurine and GABA of mouse brain was accomplished by HPLC. The mice exposed to ELF-MFs showed moderately higher $CD_{50}.{\;}LD_{50}$ and onset time on the bicuculline-induced seizure. However, the ELF-MFs did not influence them in the NMDA and picrotoxin-induced seizures. After the exposure to MFs exposure, the glutamate level was increased and GABA was decreased significantly in NMDA and picrotoxin-induced seizure. The level of glutamate and GABA were not changed by MFs in bicuculline-induced seizure. These results suggest that ELF-MFs may alter the convulsion susceptibility through GABAergic mechanism with the involvement of the level of glutamate and GABA.

Keywords

References

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