• Investigative Magnetic Resonance Imaging
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• v.12 no.1
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• pp.1-7
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• 2008

Purpose : To compare Multi Echo Data Image Combination (MEDIC) and fast SE T2-weighted images with fat saturation (T2FS) to suggest more accurate evaluation of the histologic components of soft-tissue tumors. Materials and Methods : The experimental group included 25 histologic tissues (5 vascular, 4 neural, 4 fibrous, 4 hypercellular, 2 hemorrhagic necroses, 2 cystic, 2 lipoid, 1 myxoid stroma, and 1 thrombus) in 10 patients who had pathologically confirmed schwannoma (n = 3), hemangioma (n = 2), lipoma (n = 1), angiokeratoma (n = 1), synovial sarcoma (n = 1), liposarcoma (n = 1), and malignant fibrous histiocytoma (n = 1). The inhomogeneity values were measured using the standard deviation value (SD) divided by the mean value as SD presents an error amount similar to that of imaging heterogeneity. Results : The inhomogeneity values of 25 histologic components were lower on MEDIC than those on T2FS (p < .001). Conclusion : We conclude that MEDIC is more accurate than T2FS for evaluating the tissue components of soft-tissue tumors using digitalized data because MEDIC images have far lower inhomogeneity.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2006.11a
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• pp.191-195
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• 2006

국내와 북미 지역에서 ATSC DTV 방송 서비스가 시작된 이래 수신 성능을 개선하기 위한 계속적인 노력이 경주되어 왔다 [1]-[6]. 본 논문에서는 2005 년 8 월 캐나다 CRC (Communications Research Center) 센터의 테스트 결과를 토대로 최신 ATSC 수신기의 성능을 고찰해 보고자 한다 [4]. CRC 테스트는 수신 감도, 다중 경로 환경에서의 수신 성능, 간섭 신호에 대한 강건성 등 다양한 항목에 걸려 실시되었으며, A/74 권고안에 기술된 난시청 지역의 50 개 신호 샘플에 대한 성능 평가를 포함하고 있다. 테스트에 사용된 ATSC 수신기는 당사에서 개발한 최신 칩 (GEMINI)을 탑재한 것으로 파일럿 (pilot) 신호가 손상된 경우에도 안정적인 동기 획득이 가능하며 현존 수신기 중 가장 넓고 강력한 반사파 (ghost) 제거 성능을 보유하고 있다. CRC 테스트 결과와 국내외 필드테스트 결과는 최신 ATSC 수신기가 A/74 권고안뿐만 아니라 각종 성능 지표에서 이전 수신기에 비해 대폭 개선되었음을 확인시켜 준다.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.149-154
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• 2006

Selective inhibition of phosphodiesterase (PDE) 5 opened a new therapeutic approach for cardiovascular disorders. Therefore, the effect of PDE5 inhibition on the cardiac function should thoroughly be defined. The purpose of the present study was to define the effects of sildenafil, a selective inhibitor of PDE5, on the atrial cGMP efflux, atrial dynamics, and the release of atrial natriuretic peptide (ANP). By perfusing rabbit left atria to allow atrial pacing, changes in atrial stroke volume and pulse pressure, transmural extracellular fluid translocation, cGMP efflux, and ANP secretion were measured. SIN-I, an NO donor and soluble (s) guanylyl cyclase (GC) activator, and C-type natriuretic peptide (CNP), an activator of particulate (p) GC activator, were used. Sildenafil increased basal levels of cGMP efflux slightly but not significantly. Sildenafil in a therapeutic dose increased atrial dynamics (for atrial stroke volume, $2.84{\pm}1.71%$, n=12, vs $-0.71{\pm}0.86%$, n=21; p<0.05) and decreased ANP release ($-9.02{\pm}3.36%$, n=14, vs $1.35{\pm}3.25%$, n=23; p < 0.05), however, it had no effect on the SIN-1- or CNP-induced increase of cGMP levels. Furthermore, sildenafil in a therapeutic dose accentuated SIN-1-induced, but not CNP-induced, decrease of atrial pulse pressure and ANP release. These data indicate that PDE5 inhibition with sildenafil has a minor effect on cGMP levels, but has a distinct effect on pGC-cGMP- and sGC-cGMP-induced contractile and secretory function.

• Journal of Korean Medical classics
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• v.19 no.1 s.32
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• pp.1-15
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• 2006

UNGI(運氣) theory is one of the most important theory in Oriental medicine. But it's so difficult to adapt to real medic. Long time ago many Oriental Physicians disscussed this with other physicians, UNGI to Oriental Medicine, and so still now. Remarkably, it is important as a basic theory itself, UNGI exist as a special medic. We can see that in the book of ‘五運六氣韓醫學寶鑑’, ‘運氣演繹方藥篇’ and other such kind of books. The special thing is we can predict each man's disease through the date of his birth. And more, we can make out prescription for each person's health. In addition, by knowing his date of birth, we can calculate his date of pregnancy, and with the same way, we can also predict and prescript that he can be protected from his fateful disease. But, the way like this can make Oriental medic an astrology and a superstition. So I studied on this and concluded as follow, 1. UNGI theory is important in the Oriental Medicine not only in basic but on diagnosis and attendance. 2. Mechanical abuse in the past, make UNGI theory unbelievable. But Liu Ha-gan(劉河間) studied so deeply, and knew the right way to applicate UNGI theory on Oriental medic. 3. It is not logical the pregnant day counted thru birthday, so we have to percept this an abstract idea. And it founded detail way to count the pregnant day. 'UNGI' as a medical system, by knowing his birthday we can predict and prevent his fateful disease. Of course, I cannot find such substances in Neijing, and classic books on Oriental medicine. So queer at a glance, but clinically it has some valuable meanings. However, There's little to prove its foundation. It is similar to astrology, we cannot define its base. The problems we have to trace and find out.

• Korean Journal of Oriental Medicine
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• v.12 no.2 s.17
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• pp.31-45
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• 2006

Bioinformatics and medical informatics have moved to make its knowledge more systematically and computationally using ontology. These ontologies help querying ring and analyzing data and used to develop application in biomedical. However, no research about ontology of oriental medical exists. Thus, to maximize the power of transitional knowledge, it is necessary to construct the ontology for oriental medical. This paper compares the ontologies of bio and medic by an objective point of view to guide the construction of oriental medic ontologies.

• Investigative Magnetic Resonance Imaging
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• v.6 no.2
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• pp.152-157
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• 2002

Purpose : The differential diagnosis between Modic type I degenerative spine and infectious spondylitis sometimes is difficult, because the affected bone marrows in both disease show similar signal intensity on conventional MR imaging. We evaluate the usefulness of diffusion-wighted MR imaging for differential diagnosis between Modic type I degenerative spine and infectious spondylitis. Materials and methods : The spin-echo and diffusion-weighted MR images of eight patients with Modic type I degenerative spines and 14 patients with infectious spondylitis diagnosed by clinical findings or CT-guided biopsies we re analyzed. The diffusion-weighted imaging sequence was based on reversed fast imaging with steady-state precession (PSIF). Signal intensity changes of the vertebral bone marrow on conventional spin-echo and diffusion-weighted MR imaging were compared between degenerative spine and infectious spondylitis. Results : On T1-weighte d images, the affeted bone marrow in both disease showed hypointense signals. On T 2-weighted images, all of type I degenerative spine and 11 of infectious spondylitis showed hyperintensity, and three of infectious spondylitis showed heterogeneo us mixed signal intensity. On diffusion-weighted MR images, all of type I degenerative spine were hypointense with peripheral high signal intensity to normal vertebral body, but infectious spondylitis was hyperintense (n = 11) and hypointense (n=3). Conclusion : Diffusion-weighted MR imaging is useful to differentiate Modic type I degenerative spine from infectious spondylitis. On diffusion-weighted images, the high singal intensity of bone marrow suggests infectious spondylitis, whereas the low signal intensity of bone marrow with peripheral focal high signal intensity suggests type I degenerative spine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.499-508
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• 2018

This research aimed to determine what male nursing students experienced in the course of serving in a medical care unit in the military and how this experience affected the nursing curriculum after they returned to school. This study was intended to provide basic information on nursing education for male nursing students. This qualitative research conducted a focus group interview to gather comprehensive data that are common among the subjects, in which 15 male nursing college students who experienced serving in a medical unit were divided into three focus groups. The results of this study identified five themes: 'recognition of the various role of a medic', 'caring ability and management of rare diseases', 'adaptation to different works in each military ranks', 'recognition of health care networks', and 'prerequisite learning of school subjects'. It was concluded that experience as a medic during military service helped to develop various capabilities, and these competencies were shown to guide students to demonstrate their abilities in a school environment or help accomplish their given tasks with confidence and establish interpersonal relationships as nurses in the future. The results of this study provide a theoretical basis for demonstrating that male nursing student's experience as a medic during military service aids to reinforce not only personal and academic capabilities but also the skills needed as a nurse.

• Applied Biological Chemistry
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• v.22 no.2
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• pp.101-108
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• 1979

The viscosity of mucilage of Abelmoschus Manihot, Medic root decreased by the influence of various mechanical, physical and chemical conditions. It was experimented by viscosity decrease of mucilage connected with hydrogen ion concentration, bacterial multiplication, disinfection with 70% ethanol, some antibiotics, such as streptomycin, penicillin, ganamycin and chloramphenicol and mucilage derived from autoclaved Abelmoschus Manihot, Medic root. The results obtained were as follows: 1. It was clear that the viscosify of mucilage decreased notably under the influence of infected bacteria and bacterial multiplication. 2. By the inoculation of Bacillus subtilis ATCC 6633 and Escherichia coli ML 1410 to the mucilage the viscosify decrease fast but the viscosity of mucilage derived from autoclaved, Abelmoschus Manihot, Medic root. 3. The small quantity of reducing sugar in the mucilage was detected. 4. Hydrogan ion concentration in the mucilage remained $6.5{\sim}8.0$ in spite of the viscosity decrease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1135-1148
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• 2006

The effect of heat on the cancer have been keen since ancient orint medic. Quantitative biologic techniques were applied to the investigation of heat, and the resulting studies have defined a firm rationale for the expectation that hypertherima will be useful in the treatment of cancer. This promise led to activity in developing physical means to produce and measure hyperthermia in patients. Hyperthermic treatments for cancer are grouped into two categories according two the amount of tissue bing heated during the treatments. The categories commonly used are localized, regional, and whole body hyperthermia. Hyperthermia is a situation referring to yang-heat. In orient medic, It refers to vital-qi and the driving force of life activities. Our paper reviewed the present state of the the hyperthemia, outline some major impediments to progress at this time, and suggest researching approches in order to define the role of hyperthermia in the treatment of cancer.

• Tuberculosis and Respiratory Diseases
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• v.85 no.2
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• pp.111-121
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• 2022

Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB drugs (i.e., linezolid and bedaquiline). In 2018, the World Health Organization revised the groupings of TB medicines and reclassified linezolid as a group A drug for the treatment of MDR-TB. Linezolid is a synthetic antimicrobial agent in the oxazolidinone class. Although linezolid has a good efficacy, it can cause substantial adverse events, especially hematologic toxicity. In both TB infection and linezolid mechanism of action, mitochondrial dysfunction plays an important role. In this concise review, characteristics of linezolid as an anti-TB drug are summarized, including its efficacy, pathogenesis of hematologic toxicity highlighting mitochondrial dysfunction, and the monitoring and management of hematologic toxicity.