• 제목/요약/키워드: MABP

검색결과 66건 처리시간 0.021초

당귀와 백수오 추출물이 뇌혈류 변화에 미치는 영향 (Effects of Angelicae Gigantis and Cynanchum wilfordii Hemsley Extract on the Changes of Cerebral Flow)

  • 정현우;양동혁;송민선;정종길;이상영;최찬헌
    • 동의생리병리학회지
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    • 제27권4호
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    • pp.446-452
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    • 2013
  • This study was designed to investigate the effects of Angelicae Gigantis and Cynanchum wilfordii Hemsley extract (AAC) on the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and in the rats with cerebral ischemia induced by middle cerebral artery occlusion, and further to determine the mechanisms. The results were as follows. AAC significantly increased rCBF but significantly decreased MABP in a dose-dependent manner in normal rats. The increase of AAC-induced rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, i.p.), an inhibitor of guanylate cyclase, and AAC-induced MABP was decreased by pretreatment with methylene blue. In cerebral ischemics, rCBF was stably improved by AAC (10 mg/kg, i.p.) during the period of cerebral reperfusion, which was contrasted with the findings of rapid and marked increase in the control group. These results suggest that AAC can increase rCBF in the normal state, as well as improve the stability of rCBF in cerebral ischemic state.

대나무 추출액과 죽력의 혼합물이 국소 뇌혈류량 및 평균 혈압에 미치는 영향 (Effects of Mixture of Bambusae Caulis in Liquamen and Bamboo Extract on the Regional Cerebral Blood Flow and Mean Blood Pressure in Rats)

  • 김천중;장경선;조수인;김계엽;정현우
    • 동의생리병리학회지
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    • 제20권3호
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    • pp.575-580
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    • 2006
  • This Study was designed to investigate the effects of Mixture of Bambusae Caulis in Liquamen and Bamboo Extract on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal and cerebral ischemic rats. Experimental materials were as follows ; BE- 1 was Bamboo Extract (BE) extracted with 70% ethyl alcohol, BE-11 was BE extracted with distilled water at $121^{\circ}C$ for 30 min, BE-111 was BE extracted with distilled water at $121^{\circ}C$ for 3 hrs, MLC was mixture of Bambusae Caulis in Liquamen (BCL) and BE-111 mixed at the ratio of 1 to 100 (MLC100), 1 to 50 (MLC50), 1 to 20 (MLC20), 1 to 10 (MLC10), 1 to 5 (MLC5). The results were as follows , The Changes of BE- 1 on the rCBF and MABP in normal rats were not showed, BE- 11 significantly decreased rCBF in a dose-dependent manner Dut increased MABP in a dose-dependent manner. BE-111 increased rCBF in a dose-dependent manner, MLC significantly increased rCBF in a dose-dependent manner and increased MABP in a dose-dependent manner. rCBF was significantly and stably increased by MLC5 (1 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. As results above ; The present author thought that BE- 111 and MLC increased rCBF by dilating pial arterial diameter.

가감총명탕이 흰쥐의 뇌혈류량 변화에 미치는 영향 (Efects of Gagam-ChongMeong-Tang on Changes in Cerebral Blood Flow in Rats)

  • 김형우;김경윤;차대연;이상영;김계엽;김행중;정현우
    • 동의생리병리학회지
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    • 제22권2호
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    • pp.302-306
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    • 2008
  • ChongMyeong-Tang(CMT) have been used clinically to treat patient with amnesia and dementia. In addition, CMT have been also used for examinee to improve learning ability in Korea. This experimental study was designed to investigate the effects of Gagam-ChongMeong-Tang(GCMT) to improve the retentive faculty and learning ability in terms of Cerebral blood flow(rCBF) and Mean Artery Blood Pressure(MABP) in rats. In our study, we investigated that increasing doses of GCMT (1 ug/ml, 10 ug/ml, 100 ug/ml, and 1000 ug/ml) affect the level of rCBF and MABP in rats. In our results, treatment with GCMT elevated level of rCBF in dose dependant manner. Cantraray, level of MABP was lowered by treatment with GCMT. The involved mechanisms in rCBF are guanylate cyclase pathway. During the period of cerebral re-perfusion, GCMT treated group showed stability of rCBF compared to control group. These results imply that GCMT increased rCBF through dilation of pial artery. And related mechanisms are involved in guanylate cyclase pathway.

위중(委中)과 족삼리(足三里)의 자침이 뇌혈류 역학에 미치는 영향 (Effects of Acupuncture at the Wijung(BL40) and Chok-Samni(ST 36) on the Cerebral Blood Flow and Blood Pressure)

  • 정현우;김진우;한양신;;최찬헌
    • 동의생리병리학회지
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    • 제28권6호
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    • pp.601-606
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    • 2014
  • The purpose of this study is to research the effects of acupuncturing BL40 and ST36 and to determine the mechanism of action of acupuncturing BL40 and ST36 by measuring the changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. To determine the mechanism of action of acupuncturing BL40 and ST36, pretreatment with indomethacine and methylene blue was performed. Acupuncturing BL40 and ST36 significantly increased rCBF, and the increased rCBF by acupuncturing BL40 and ST36 was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Acupuncturing BL40 and ST36 decreased MABP, and decreased MABP by acupuncturing BL40 and ST36 was not changed by pretreatment with indomethacin and methylene blue. This result suggested that acupuncturing BL40 and ST36 might significantly increase rCBF by dilating arterial diameter and mechanism of acupuncturing BL40 and ST36 might be mediated by cyclooxygenase and guanylate cyclase.

Calculus Bovis-Fel Uris-Moschus Pharmacopuncture's Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats

  • Park, Soo-Jung;Lee, Ho-Young;Choi, Na-Rae;Kwon, Young-Mi;Joo, Jong-Cheon
    • 대한약침학회지
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    • 제16권4호
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    • pp.30-35
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    • 2013
  • Objectives: This study was designed to investigate the effects of Calculus Bovis-Fel Uris-Moschus pharmacopuncture (BUM) on the regional cerebral blood flow (rCBF) and the mean arterial blood pressure (MABP) in normal and cerebral ischemic rats and to investigate a possible pathway involved in the effects of BUM. Methods: The changes in the rCBF and the MABP following BUM into Fengfu (GV16) were determined by using a laser-Doppler flow meter and a pressure transducer, respectively. Results: BUM significantly increased the rCBF and decreased the MABP in normal rats in a dose-dependent manner. The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhibitor of guanylate cyclase, but was not affected by pretreatment with indomethacin (1 mg/kg, intraperitoneal), an inhibitor of cyclooxygenase. The BUM-induced decrease of the MABP was changed neither by methylene blue nor by indomethacin pretreatment. In the cerebral ischemic rats, the rCBF was stably increased upon cerebral reperfusion in the BUM group in contrast to the rapid and marked increase in the control group. Conclusion: This study demonstrated that BUM into Fengbu (GV16) increased the rCBF in a dose-dependent manner in the normal state; furthermore, it improved the stability of the rCBF in the ischemic state upon reperfusion. Also, the effects of BUM on the rCBF were attenuated by inhibition of guanylate cyclase, suggesting that the effects involved the guanylate cyclase pathway.

천마반하탕이 뇌허혈로 인한 뇌혈류역학적 변동에 미치는 영향 (Effect of Cheonmabanhwa-Tang on the Changes in Cerebral Hemodynamics in Cerebral Ischemia of Rats)

  • 양기호;윤대영;정현우
    • 동의생리병리학회지
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    • 제18권3호
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    • pp.783-788
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    • 2004
  • Cheonmabanhwa- Tang (CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam, We reported that CBT had effects on the cerebral hemodynamics [regional cerebral blood flow (rCBF), pial arterial diameter (PAD), and mean arterial blood pressure (MABP)] in normal and cerebral ischemic rats. Therefor we designed to determine the mechanism of action of CBT. The changes of rCBF and MABP were determinated by laser-Doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results were as follows: The CBT-induced increase in rCBF was significnatly inhibited by pretreatment with indomethacin (IDN, 1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, or methylene blue (MTB, 10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The CBT-induced increase in PAD was also significantly inhibited by pretreatment with IDN or MTB. The CBT-induced increase in MABP was also significantly inhibited by pretreatment with IDN or MTB. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics via mediation of cyclooxygenase and guanylate cyclase.

팔물탕이 뇌혈류역학 변화에 미치는 효과 (Effects of Palmul-Tang on the Change of Cerebral Hemodynamics in Rats)

  • 박철훈;배인태;정현우
    • 동의생리병리학회지
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    • 제18권4호
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    • pp.1014-1020
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    • 2004
  • The study was designed to investigate the effects of Palmul-Tang(PMT) on the change of cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD) and mean arterial blood pressure(MABP)] in normal and cerebral ischemic rats. The change of rCBF and MABP were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows ; PMT significantly increased rCBF and PAD in a dose-dependent, and PMT increased MABP in a dose-dependent. This results were suggested that PMT significantly increased rCBF by dilating PAD. The results in cerebral ischemic rats were as follows ; Both rCBF and PAD were significantly and stably increased by PMT(10㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. The present authors thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics.

사군자탕합생강즙(四君子湯合生薑汁)이 정상 흰쥐의 뇌혈류역학에 미치는 기전 (Mechanism of Sagunja-tang Extract and Zingiberis rhizoma recens Juice on the Cerebral Hemodynamics in Normal Rats)

  • 김거웅;정현우
    • 동의생리병리학회지
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    • 제21권5호
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    • pp.1271-1277
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    • 2007
  • This study was designed to investigate the effects of Sagunja-tang Extract & Zingiberis rhizoma recens Juice (SEZJ) and Zingiberis rhizoma recens Juice (ZRJ) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. The results were as follows ; SEZJ and ZRJ significantly increased rCBF in a dose-dependent manner, while it did not change MABP. This results suggest that SEZJ and ZRJ significantly increased rCBF by dilating pial arterial diameter. Increase of SEZJ-induced rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase, and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. SEZJ-induced MABP was significantly increased by pretreatment with indomethacin but was not changed by methylene blue. These results suggested that the action of SEZJ was mediated by cyclic 3',5'-guanosine monophosphate.

소엽(蘇葉) 추출물이 백서(白鼠)의 뇌허혈에 미치는 효과 (Effects of Folium Perillae on Cerebral Ischemia in Rats)

  • 김형우;김부여;조수진;정현우;조수인
    • 대한한방내과학회지
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    • 제28권3호
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    • pp.502-509
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    • 2007
  • Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats. Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too. Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LD H activity in vitro Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.

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익모초(益母草) 추출액이 국소 뇌혈류량 및 평균혈압에 미치는 영향 (Effects of LEONURI HERBA Extract on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Normal Rats)

  • 배인태;정현우
    • 동의생리병리학회지
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    • 제19권6호
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    • pp.1599-1603
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    • 2005
  • The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.