Browse > Article

Effect of Cheonmabanhwa-Tang on the Changes in Cerebral Hemodynamics in Cerebral Ischemia of Rats  

Yang Gi Ho (Department of Pathology, College of Oriental Medicine, Dongshin University)
Yun Young Dae (Department of Pathology, College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.3, 2004 , pp. 783-788 More about this Journal
Abstract
Cheonmabanhwa- Tang (CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam, We reported that CBT had effects on the cerebral hemodynamics [regional cerebral blood flow (rCBF), pial arterial diameter (PAD), and mean arterial blood pressure (MABP)] in normal and cerebral ischemic rats. Therefor we designed to determine the mechanism of action of CBT. The changes of rCBF and MABP were determinated by laser-Doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results were as follows: The CBT-induced increase in rCBF was significnatly inhibited by pretreatment with indomethacin (IDN, 1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, or methylene blue (MTB, 10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The CBT-induced increase in PAD was also significantly inhibited by pretreatment with IDN or MTB. The CBT-induced increase in MABP was also significantly inhibited by pretreatment with IDN or MTB. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics via mediation of cyclooxygenase and guanylate cyclase.
Keywords
Cheonmabanhwa-Tang(天麻半夏湯); cerebral hemodynamics; indomethacin; cyclooxygenase; methylene blue; guanylate cyclase;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 /
[ 許浚 ] / 東醫寶鑑
2 /
[ 대한병리학회 ] / 병리학
3 /
[ 대한신경외과학회 ] / 신경외과학
4 /
[ 全國韓醫科大學 本草學敎授(共編) ] / 本草學
5 風의 病理的 意味糾明과 中風의 原因 및 治療에 대한 東西醫學的 比較 /
[ 金世吉 ] / 대한한의학회지
6 /
[ 上海中醫學院 ] / 中醫學基礎
7 Nitric oxiderelease accounts for the biology activity of endothelium derived relaxing factor /
[ Palmer, P.M.J.;Ferrige, A.G.;Monacada, S. ] / Nature
8 Nitric oxiderelease accounts for the biology activity of endothelium derived relaxing factor /
[ Palmer, P.M.J.;Ferrige, A.G.;Monacada, S. ] / Nature
9 Nitric oxide macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells /
[ Stuehr, D.J.;Nathan, C.F. ] / J. Exp. Med.
10 /
[ 神戶中醫學硏究會 ] / 漢方臨床入門
11 Changes in extracellular calcium activity in cerebral ischemia /
[ Harris, R.J.;Symon, L.;Branston, N.M.;Bayhan, M. ] / J. Cereb Blood Flow Metab.
12 Ischemic brain injury ; the importance of calcium, lipolytic activities and free fatty acids /
[ Wieloch, T.;Siesjo, B.K. ] / Pathol Biol
13 허혈, 재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성 /
[ 이경은;김경환 ] / 大韓神經科學會誌
14 천마반하탕이 뇌혈류역학에 미치는 영향 /
[ 양기호;정현우 ] / 東醫生理病理學會誌
15 /
[ 김경환 ] / 이우주의 약리학 강의(제4판)
16 Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide ; with detailed description of the closed cranial window technique in rats /
[ Morii, S.;Ngai, A.C.;Winn, H.R. ] / J. Cereb Blood Flow Metab
17 Detailed description of a cranial window technique for acute and chronic experimentals /
[ Joseph, E.;Lebasseur, M.S.;Wei, E.P.;Raper, A.J.;Kontos, H.A.;Patterson, J.L. ] / Stroke   ScienceOn
18 /
[ Snedecor, G.H. and Cocharn, W.G. ] / Statistical Methods
19 /
[ 성호경 ] / 생리학(제6판)
20 Nitric oxide as a secretory product of mammalian cells /
[ Nathan, C. ] / FASEB J.
21 Endothelium- derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the Brain /
[ Garthwaite, J.;Charles, S.L.;Chess-Williams, R. ] / Nature
22 Nitric oxide ; A cytotoxic and activated macrophage effector molecule /
[ Hibbs, J.B.;Taintor, R.R.;Vavrin, Z.;Rachlin, E.M. ] / Boichem Biophysic Res Commum
23 Niric oxide sythesis inhibition induced leukocyte adhesion via superoxide and master cell /
[ Kubes, P.;Kanwar, S.;Niu, X.;Gaboury, J.P. ] / FASEB J.
24 Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep /
[ Iwamoto, J.;Yoshinaga, M.;Yang, S.P.;Krasney, E.;Krasney, J. ] / J. Appl Physiol.
25 Comparison of the effects of NG-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats /
[ Wang, Q.;Pelligrino, D.A.;Paulson, O.B.;Lassen, N.A. ] / Brain Res.
26 Role of inducible nitric oxide synthase and cyclooxygenase-2 endotoxin-induced cerebral hyperemia /
[ Okamoto, H.;Ito, O.;Roman, R.J.;Hudetz, A.G. ] / Stroke   ScienceOn
27 ubarachnoid hemorrhage impairs cerebral blood flow response to nitric oxide but not to cyclic GMP in large cerebral arteries /
[ Yamamoto, S.;Nishizawa, S.;Yokoyama, T.;Ryu, H.;Uemura, K. ] / Brain Res.
28 痰飮에 관한 文獻的 考察 /
[ 李周姬;吳泰煥;鄭昇杞;李珩九 ] / 大田大學校 論文集
29 SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors /
[ Iadecola, C.;Zhang, F.;Xu, X. ] / Am J. Physiol.
30 The cyclooxygenase inhibitors indomethacin and Rofecoxib reduced regional cerebral blood flow evoked by somatosensory stimulation in rats /
[ Bakalova, R.;Matsuura, T.;Kanno, I. ] / Exp. Biol. Med.
31 A model of focal ischemic stoke in the rat : reproducible extension cortical infarction /
[ Chen, S.T.;Hsu, C.Y.;Hogan, E.L.;Maricque, H.;Balentine, J.D. ] / Stroke   ScienceOn
32 Endogenous nitric oxide release required for long term synatic depression in the cerebellum /
[ Shibuki, K.;Okada, D. ] / Nature