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Effects of Palmul-Tang on the Change of Cerebral Hemodynamics in Rats  

Park Cheol Hun (Department of Pathology, College of Oriental Medicine, Dongshin University)
Bae In Tae (Department of Pathology, College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.4, 2004 , pp. 1014-1020 More about this Journal
Abstract
The study was designed to investigate the effects of Palmul-Tang(PMT) on the change of cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD) and mean arterial blood pressure(MABP)] in normal and cerebral ischemic rats. The change of rCBF and MABP were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows ; PMT significantly increased rCBF and PAD in a dose-dependent, and PMT increased MABP in a dose-dependent. This results were suggested that PMT significantly increased rCBF by dilating PAD. The results in cerebral ischemic rats were as follows ; Both rCBF and PAD were significantly and stably increased by PMT(10㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. The present authors thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics.
Keywords
Palmul-Tang; regional cerebral blood flow; pial arterial diameter; mean arterial blood pressure; cerebral ischemia;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
연도 인용수 순위
1 /
[ 虞搏 ] / 醫學正傳
2 /
[ 許浚 ] / 東醫寶鑑
3 /
[ 康舜洙;盧昇鉉;李尙仁 ] / 方劑學
4 /
[ 汪昻 ] / 醫方集解
5 /
[ 李載熙 ] / 圖說韓方診療要方
6 /
[ 鄭遇悅;安圭錫 ] / 韓方臨床病理學
7 /
[ 朴贊國 ] / 病因病機學
8 /
[ 柯雪帆 ] / 中醫辨證學
9 Glutamate neurotoxicity and disease of the nervous system /
[ Choi, D.W. ] / J. Neuron   ScienceOn
10 /
[ 朴英培;金泰熙 ] / 辨證診斷學
11 The nitrous oxide method for the man ; theory, procedure and normal values /
[ Kety, S.S.;Schmidt, C.F. ] / J. Clin Invest
12 /
[ 의학교육연구원 ] / 물리요법
13 /
[ 대한신경외과학회 ] / 신경외과학
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[ Harris, R.J.;Symon, L.;Branston, N.M.;Bayhan, M. ] / J. Cereb Blood Flow Metab.
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[ Wieloch, T.;Siesjo, B.K. ] / Pathol Biol(Paris).
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[ 이경은;김경환 ] / 大韓神經科學會誌
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[ Hallenbeck, J.M.;Dutka, A.J.;Tanishima, T.;Kochanek, P.M.;Kumaroo, K.K.;Thompson, C.B.;Obrenovich, T.P.;Contreras, T.J. ] / Stroke
18 Influx of leukocytes and platelets in an evolving brain infarct(Wistar rat) /
[ Garcia, J.H.;Liu, K.F.;Yoshida, Y.;Lian, J.;Chen, S.;del Zoppo, G.J. ] / Am J. Pathol.
19 최근 뇌졸중에 대한 역학적 고찰 /
[ 나영설;윤상협;민병일 ] / 경희의학
20 /
[ 中國中醫硏究院廣安門醫院 ] / 實用中醫腦病學
21 /
[ 全國韓醫科大學 本草學敎授(編) ] / 本草學
22 A model of focal ischemic stoke in the rat ; reproducible extension cortical infarction /
[ Chen, S.T.;Hsu, C.Y.;Hogan, E.L.;Maricque, H.;Balentine, J.D. ] / Stroke
23 Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide ; with detailed description of the closed cranial window technique in rats /
[ Morii, S.;Ngai, A.C.;Winn, H.R. ] / J. Cereb Blood Flow Metab.
24 /
[ 歐陽忠興(主編) ] / 心腦病證治精要
25 祛風導痰湯이 白鼠의 腦血流變化에 미치는 機轉硏究 /
[ 宋政錫;鄭鉉雨 ] / 東醫生理病理學會誌
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[ 金天中;趙秀仁;鄭鉉雨 ] / 東醫生理病理學會誌
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[ Joseph, E.;Lebasseur, M.S.;Wei, E.P.;Raper, A.J.;Kontos, H.A.;Patterson, J.L. ] / Stroke
28 Reversible middle cerebral artery occlusion without craniectomy in rats /
[ Longa, E.Z.;Weinstein, P.R.;Carlson, S.;Cummins, R. ] / Stroke
29 /
[ Snedecor, G.H.;Cocharn, W.G. ] / Statistical Methods
30 /
[ 沙圖穆蘇 ] / 瑞竹堂經驗方(欽定四庫全書 卷 十四)
31 /
[ 공廷賢 ] / 萬病回春
32 Correlation of continnous electroencephalograms with cerebral blood flow measurments during carotid endarterectomy /
[ Sharbrough, F.W.;Messick, M.K. Jr.;Sundt, T.M. Jr. ] / Stroke
33 /
[ 方廣 ] / 丹溪心法附錄(上)
34 Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy /
[ Trojaborg, W.;Boysen, G. ] / Electroencephalogr Clin Neurophysiol.   ScienceOn
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[ 李文鎬;金鍾暉;許仁穆 ] / 內科學(上)
39 /
[ 金祐謙 ] / 인체의 생리
40 Mechanisms of disease : oxygen-derived free radicals in postischemic tissue injury /
[ McCord, J.M. ] / New Eng J. Med.   ScienceOn
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[ Choi, D.W. ] / J. Neurobiology
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[ Halliwell, B. ] / Acta Neurol. Scand Suppl.
43 Reactive oxygen species and the central nervous system /
[ Halliwell, B. ] / J. Neurochem.
44 /
[ 劉完素 ] / 素問玄機原病式
45 /
[ 李東垣 ] / 東垣十種醫書
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