Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Palmul-Tang on the Change of Cerebral Hemodynamics in Rats

팔물탕이 뇌혈류역학 변화에 미치는 효과

  • Park Cheol Hun (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Bae In Tae (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
  • 박철훈 (동신대학교 한의과대학 병리학교실) ;
  • 배인태 (동신대학교 한의과대학 병리학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실)
  • Published : 2004.08.01
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Abstract

The study was designed to investigate the effects of Palmul-Tang(PMT) on the change of cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD) and mean arterial blood pressure(MABP)] in normal and cerebral ischemic rats. The change of rCBF and MABP were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows ; PMT significantly increased rCBF and PAD in a dose-dependent, and PMT increased MABP in a dose-dependent. This results were suggested that PMT significantly increased rCBF by dilating PAD. The results in cerebral ischemic rats were as follows ; Both rCBF and PAD were significantly and stably increased by PMT(10㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. The present authors thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics.

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References

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