• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.1989-1992
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• 2014

Background: The aim of this study was to assess the response rates (clinical and pathological ) with docetaxel and epirubicin combination chemotherapy and its effect on outcome. Materials and Methods: We retrospectively analysed locally advanced breast cancer (LABC) patients who received NACT from January 2008 to December 2012 in our tertiary care centre. LABC constituted 37% of all breast cancer cases and 120 patients fulfilled the eligibility criteria. The regimens used for NACT were, six cycles of DEC (docetaxel $75mg/m^2$, epirubicin $75mg/m^2$, cyclophosphamide $50mg/m^2$ on Day 1, 3 weekly) and a sequential regimen (4 cycles of FEC, 5-flurouracil $600mg/m^2$, epirubicin $75mg/m^2$, cyclophosphamide $600mg/m^2$ followed by 4 cycles of docetaxel $85mg/m^2$). Results: The median age was 47 years (range 23-72). Ninety six ( 80 %) had T4 disease and 90% had clinically palpable lymph nodes at diagnosis. The median size of primary tumor at presentation was 5.9 cm. Hormone receptor positivity was seen in 55% and HER2/neu positivity, in 25%. Triple negative breast cancers constituted 25 % of the cases. The overall clinical response rate (complete or partial ) was 85% and pathological complete responses were obtained in 15%. Four cases defaulted, 5 patients died of treatment related toxicity and 15% developed febrile neutropenia on DEC. The median duration of follow up was 22 months. The median time to relapse was 20 months and the 3 year relapse free and overall survival rates were 50% and 70% respectively. Conclusions: LABC constituted 37% of all breast cancer cases at our institute. With NACT, pCR was seen in 15% of the cases. Sequential chemotherapy was better tolerated than concurrent anthracyline and taxane chemotherapy with a similar pCR.

• 품질경영학회지
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• 제47권3호
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• pp.437-451
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• 2019

Purpose: The purpose of this study is to improve the quality of the PGM system by improving the structure and production process of slip-ring rotary joint for radar. Methods: The improvement measures for each cause are established through failure analysis of broken items. Specifically, changing in the housing to improve the heating system. Changing the transportation method to prevent damage to equipment during transport. Changing work process of the attenuator ring to prevent damage. etc. Results: The results of this study are as follows; improving the heating system reduces heat generated by the attenuator by about 7 degrees and obtain additional temperature margins. Reduction of defect rate because of adding X-band rotary joint run-out measurement test, ESS of slip-ring rotary joint and Transportation improvement(reinforced flight boxes, tube protection, etc). Getting stable VSWR values by improving work process of attenuator overheating due to a bad bonding process. Conclusion: Through this study, improvements were made to slip-ring rotary joint that failed repeatedly for various reasons. As a result of the application of the improvements, the same fault does not occur until now, so we can see that the quality of PGM has improved.

• Journal of Biosystems Engineering
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• 제43권3호
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• pp.185-193
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• 2018

Purpose: The purpose of this study was to analyze the performance factors of a rotary impact-type thresher to develop a sesame and perilla thresher, specifically to analyze the cut length of the stems and the threshing rates based on the relationship between the blade velocity and feeding speed. Methods: The materials were dried within a range of 12.3-13.0% to test the impact cut by bending. The cut lengths of the perilla and sesame stems were categorized in 6 ranges (~7.0, 7.1-10.0, 10.1-13.0, 13.1-16.0, 16.1-20.0, 20.1- (cm)). For testing the cut length and threshing rate, the upward-rotating blade velocity was varied as 11.0 m/s, 13.5 m/s, and 22.3 m/s. Feeding speeds were changed from 0.1 m/s to 2.2 m/s by the inverter connected to the feed motor. The feed rate and threshing rates without cover-casing were evaluated with the factors of thresher testing. Results: The mean cut length of the stem decreased as the blade velocity increased and/or the feeding speed decreased. As the feed rate increased up to 17.5 g/s, the cut length distributions showed no significant difference. The threshing rate was 98.9% for sesame, and flexible according to the blade velocity and feeding speed of the perilla. Conclusion: Feeding material too fast could produce longer cut stem segments, therefore, a feeding speed less than 2.2 m/s is recommended. A blade velocity of 13.5 m/s is preferable for both sesame and perilla with regard to cut length and threshing rate.

• 농업과학연구
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• 제11권1호
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• pp.160-175
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• 1984

로우터리 경운(耕耘)날의 회전속도(回轉速度) 및 작업속도(作業速度)가 경운소요(耕耘所要)토오크에 미치는 영향을 분석(分析)하기 위(爲)하여, 형상각(形狀角) ${\theta}=30^{\circ}$, $40^{\circ}$인 2종(種)의 경운(耕耘)날로 로우터리축(軸)을 204, 243, 285, 360rpm 4단계로, 전진속도(前進速度)는 29.40cm/s, 46.93cm/s로 변화(變化)시키면서 인공토양조(人工土壤槽)에서 dynamic strain gage system을 이용(利用)하여 경운소요(耕耘所要)토오크를 측정분석(測定分析)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 경운(耕耘)날의 회전속도(回轉速度) 및 전진속도(前進速度)는 경운소요(耕耘所要)토오크에 교호작용(交互作用)으로 영향(影響)을 미치는 것으로 분석(分析)되었으며, response surface analysis를 통(通)하여 분석(分析)한 수학적(數學的)인 모형(模型)은 다음과 같다. $$T=a_0+a_1V+a_2R+a_3VR+a_4VR^2$$ 여기서 T=경운소요(耕耘所要)토오크 (kg-m) $a_0$=당(當)수(數) $a_1,\;a_2,\;a_3,\;a_4$= 계(係)수(數) V=경운장치(耕耘裝置)의 전진속도(前進速度) (cm/s) R=경운(耕耘)날의 회전속도(回轉速度) (rpm) 2. 최대경운소요(最大耕耘所要)토오크는 로우터리날 회전속도(回轉速度)가 증가(增加)함에 따라 ${\frac{{\partial}T}{{\partial}V}}$는 증가(增加)하였으며, 200~220rpm에서 증가율(增加率)이 최저(最低)가 되었고, 같은 조건(條件)에서 ${\frac{{\partial}T}{{\partial}R}}$은 감소(減少)하는 경향(傾向)이었으며, 전진속도(前進速度)가 증가(增加)함에 따라 감소율(減少率)은 증가(增加)되었다. 3. 평균경운소요(平均耕耘所要)토오크는 회전속도(回轉速度)가 320~360rpm에서 ${\frac{{\partial}T}{{\partial}R}}$의 變化가 적었으며, ${\frac{{\partial}T}{{\partial}R}}$은 회전속도(回轉速度)가 증가(增加)함에 따라 감소율(減少率)이 증가(增加)되었다. 4. 전진속도(前進速度)에 대(對)한 토양(土壤)의 단위체적당(單位體積當) 평균경운소요(平均耕耘所要)토오크의 변화율(變化率)${\frac{{\partial}T}{{\partial}R}}$는 270~300rpm에서 최저(最低)가 되었으며, ${\frac{{\partial}T}{{\partial}R}}$은 V=29.40cm/s와 V=46.93cm/s일때 변화율(變化率)이 280~290rpm에서 교착(交錯)하였다. 5. 로우터리날의 형상각(形狀角)이 증가(增加)함에 따라 순경운소요동력(純耕耘所要動力)은 증가(增加)하였다. 그러나 실제(實際) 이용면(利用面)에서는 형상각(形狀角)이 작으면 로우터리날에 검불이 감기게 되므로 소요동력(所要動力)이 크게 증가(增加)함을 보여주는 연구결과도 있다. 그러므로 형상각(形狀角) 변화(變化)에 대(對)해서는 계속 연구(硏究)되어야 할 과제(課題)라 인정(認定)된다.

• 소성∙가공
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• 제20권2호
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• pp.93-98
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• 2011

Electroforming is a kind of metal molding technology. After gilding on the possession object(conductivity, nonconductivity) separate it with possession object and produce a part or duplicate. This process has an excellent ability of duplicating detailed figure. To simplify the manufacturing process of a rotary screen, this study was adopted electroforming technology and produced silicon rubber mandrel. Furthermore, to indicate the optimal condition for the acquisition of high-qualified rotary screen product, the experiment was executed with pH, time, sulfamate nickel solution according to density which were the main factors to decide the condition, then compared it with the product made by original "S" company in Holland. As a result, the figure of hole was more obvious and correct. Also the open size increased by more than 2-3%.

• JSTS:Journal of Semiconductor Technology and Science
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• 제12권3호
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• pp.255-265
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• 2012

This paper presents a 15-GHz multiphase rotary traveling-wave voltage-controlled oscillator (RTW VCO) where a shielded coplanar stripline (CPS) is exploited to provide better shielding protection and lower phase noise at a moderate cost of characteristic impedance and power consumption. Test chips were implemented in a standard 90-nm CMOS process, demonstrating the measured results of 2-GHz frequency tuning range, -11.3-dBm output power, -109.6-dBc/Hz phase noise at 1-MHz offset, and 2-ps RMS clock jitter at 15 GHz. The chip core occupies the area of $0.2mm^2$ and dissipates 12 mW from a single 1.2-V supply.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.438-443
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• 2005

Handy paint rollers with simple or no patterns are generally used to transcribe its design to a wall just after painting. However, the types of the patterns are limited to several conventional ones, so that interior planners' or decorators' demands are gradually tending to getting attractive roller designs. In order to obtain abundant kinds of the roller designs, a new advanced 3D machining method should be established for cylindrical models. In this paper, a post-processor that can generate suitable NC data is proposed for multi-axis NC machine tools with a rotary unit. The 3D machining system with the post-processor is also presented for an attractive interior decorating. The machining system allows us to easily transcribe the relief designs from on a flat model to on a cylindrical model. The effectiveness of the proposed 3D machining system using the post-processor is demonstrated through some machining experiments.

• 한국안전학회지
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• 제33권1호
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• pp.135-141
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• 2018

Rotary that causes traffic delays and safety issues by high-speed entry vehicles is currently being improved to roundabout. The operational difference between rotary and roundabout can cause driver's confusion and traffic accident. The purpose of this study is to develop the accident rate models which explain the factors related to the accidents by land use and intersection type. The main results are as follows. First, the null hypotheses that the type of land use and two intersections do not affect the accident rate are rejected. Second, the conflicting factors such as the number of crosswalk and bicycle lane should be carefully considered to reduce traffic accident at rotary. In the case of roundabout, greater than 3.5 m in circulatory lane width and two circulatory lane are analyzed to be important to prevent the accidents. Finally, the commercial and mixed areas are evaluated to be weak to traffic accidents than residential area.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.88-89
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• 2013

A variety of influenza A viruses from animal hosts are continuously prevalent throughout the world which cause human epidemics resulting millions of human infections and enormous industrial and economic damages. Thus, early diagnosis of such pathogen is of paramount importance for biomedical examination and public healthcare screening. To approach this issue, here we propose a fully integrated Rotary genetic analysis system, called Rotary Genetic Analyzer, for on-site detection of influenza A viruses with high speed. The Rotary Genetic Analyzer is made up of four parts including a disposable microchip, a servo motor for precise and high rate spinning of the chip, thermal blocks for temperature control, and a miniaturized optical fluorescence detector as shown Fig. 1. A thermal block made from duralumin is integrated with a film heater at the bottom and a resistance temperature detector (RTD) in the middle. For the efficient performance of RT-PCR, three thermal blocks are placed on the Rotary stage and the temperature of each block is corresponded to the thermal cycling, namely $95^{\circ}C$ (denature), $58^{\circ}C$ (annealing), and $72^{\circ}C$ (extension). Rotary RT-PCR was performed to amplify the target gene which was monitored by an optical fluorescent detector above the extension block. A disposable microdevice (10 cm diameter) consists of a solid-phase extraction based sample pretreatment unit, bead chamber, and 4 ${\mu}L$ of the PCR chamber as shown Fig. 2. The microchip is fabricated using a patterned polycarbonate (PC) sheet with 1 mm thickness and a PC film with 130 ${\mu}m$ thickness, which layers are thermally bonded at $138^{\circ}C$ using acetone vapour. Silicatreated microglass beads with 150~212 ${\mu}L$ diameter are introduced into the sample pretreatment chambers and held in place by weir structure for construction of solid-phase extraction system. Fig. 3 shows strobed images of sequential loading of three samples. Three samples were loaded into the reservoir simultaneously (Fig. 3A), then the influenza A H3N2 viral RNA sample was loaded at 5000 RPM for 10 sec (Fig. 3B). Washing buffer was followed at 5000 RPM for 5 min (Fig. 3C), and angular frequency was decreased to 100 RPM for siphon priming of PCR cocktail to the channel as shown in Figure 3D. Finally the PCR cocktail was loaded to the bead chamber at 2000 RPM for 10 sec, and then RPM was increased up to 5000 RPM for 1 min to obtain the as much as PCR cocktail containing the RNA template (Fig. 3E). In this system, the wastes from RNA samples and washing buffer were transported to the waste chamber, which is fully filled to the chamber with precise optimization. Then, the PCR cocktail was able to transport to the PCR chamber. Fig. 3F shows the final image of the sample pretreatment. PCR cocktail containing RNA template is successfully isolated from waste. To detect the influenza A H3N2 virus, the purified RNA with PCR cocktail in the PCR chamber was amplified by using performed the RNA capture on the proposed microdevice. The fluorescence images were described in Figure 4A at the 0, 40 cycles. The fluorescence signal (40 cycle) was drastically increased confirming the influenza A H3N2 virus. The real-time profiles were successfully obtained using the optical fluorescence detector as shown in Figure 4B. The Rotary PCR and off-chip PCR were compared with same amount of influenza A H3N2 virus. The Ct value of Rotary PCR was smaller than the off-chip PCR without contamination. The whole process of the sample pretreatment and RT-PCR could be accomplished in 30 min on the fully integrated Rotary Genetic Analyzer system. We have demonstrated a fully integrated and portable Rotary Genetic Analyzer for detection of the gene expression of influenza A virus, which has 'Sample-in-answer-out' capability including sample pretreatment, rotary amplification, and optical detection. Target gene amplification was real-time monitored using the integrated Rotary Genetic Analyzer system.

• Restorative Dentistry and Endodontics
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• 제27권5호
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• pp.521-529
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• 2002

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used, which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination, the one group was prepared crown-down technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Glidden burs(#1, #2, and #3) to coronal preparation and GT rotary files .08/20 and .06/30 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows : Subgroup 1, obturated with single cone method Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, .06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were demineralized in 10% nitric acid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A)at $\times$8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany) The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows 1. In canal prepared with GT$^{TM}$ rotary file, shaphing time taked more than the group of using Gates Glidden drill to coronal preparation without statistical significance (p>0.05) 2. The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3 The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files and Gates Glidden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method, The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT$^{TM}$ rotary files and Gates Glidden drill showed more apical leakage than the group of lateral condensation using same shaping method with-out statistical significance (p＞0.05).