• Proceedings of the Korean Nuclear Society Conference
• /
• 1995.05b
• /
• pp.853-858
• /
• 1995

$^{152}$EU, $^{241}$Am 및 $^{241}$Np를 선정하여 추출제 di-(2-ethylhexyl)phosphoric acid (DEHPA)로 이들 세가지 핵종의 상호 분리공정에 대해 연구하였다. 추출공정에서 질산농도는 0.IM이고 추출 제DEHPA/n-dodecane 농도가 IM 일때, $^{152}$Eu 및 $^{241}$Am, $^{241}$Np 핵종 모두 99.9% 이상 추출되었다. $^{241}$Am 핵종의 역추출을 위한 제 1 역추출공정에서 역추출제인 0.05M di-ethylenetriamine pentaacetic acid (DTPA)와 1.5M 젖산 (lactic acid) 혼합용액의 pH가 3.6 일때 $^{152}$Eu과 $^{241}$Am의 상호분리비와 역추출율이 가장 좋았다. $^{152}$Eu의 역추출을 위한 제 2 역추출단계에서 역추출제인 질산용액의 최적농도는 6M이며, 이때 $^{152}$Eu은 99%가 역추출되었다.$^{241}$Np 핵종의 역추출을 위한 제 3 역추출공정에서 역추출제는 0.5M 옥살산이며, 이때 $^{241}$Np은 92%가 역추출되었다.

• Journal of The Korean Radiological Technologist Association
• /
• v.29 no.1
• /
• pp.152-152
• /
• 2003

• Biomolecules & Therapeutics
• /
• v.21 no.2
• /
• pp.114-120
• /
• 2013

Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma cells to B-Raf inhibitor, we used chronic selection to establish B-Raf (V600E) melanoma clones with acquired resistance to the new oncogenic B-Raf inhibitor UI-152. Whereas the parental A375P cells were highly sensitive to UI-152 ($IC_{50}$ < $0.5{\mu}M$), the resistant sub-line (A375P/Mdr) displayed strong resistance to UI-152 ($IC_{50}$ < $20{\mu}M$). Immunofluorescence analysis indicated the absence of an increase in the levels of P-glycoprotein multidrug resistance (MDR) transporter in A375P/Mdr cells, suggesting that resistance was not attributable to P-glycoprotein overexpression. In UI-152-sensitive A375P cells, the anti-proliferative activity of UI-152 appeared to be due to cell-cycle arrest at $G_0/G_1$ with the induction of apoptosis. However, we found that A375P/Mdr cells were resistant to the apoptosis induced by UI-152. Interestingly, UI-152 preferentially induced autophagy in A375P/Mdr cells but not in A375P cells, as determined by GFP-LC3 puncta/cell counts. Further, autophagy inhibition with 3-methyladenine (3-MA) partially augmented growth inhibition of A375P/Mdr cells by UI-152, which implies that a high level of autophagy may protect UI-152-treated cells from undergoing growth inhibition. Together, our data implicate high rates of autophagy as a key mechanism of acquired resistance to the oncogenic B-Raf inhibitor, in support of clinical studies in which combination therapy with autophagy targeted drugs is being designed to overcome resistance.

• 대한생식의학회:학술대회논문집
• /
• 2006.06a
• /
• pp.152.1-152.1
• /
• 2006

• 대한생식의학회:학술대회논문집
• /
• 2006.06a
• /
• pp.152.2-152.2
• /
• 2006

• Proceedings of the SAREK Conference
• /
• 2005.11a
• /
• pp.256-261
• /
• 2005

In the present experimental study, condensation heat transfer coefficients between R404A and R152a flow in a horizontal smooth tube were compared. The outer and inner diameters of the tube were 9.52 mm and 7.55 mm, respectively, and the heated length was 1045 mm. The mass flux ranged from 150 to 400 $kg/m^{2}s$ and the test section were uniformly heated from 8 to 12. $kW/m^2$. The quality range was from 0.2 to 0.8 at the saturation temperature from 27.3 to $34^{\circ}C$. Experimental condensation heat transfer coefficients increased as the quality and mass flux increased. Modified Dobson and Chato correlation reduced the mean deviation of 5.1% for R404A and 9.4% for R152a than the original correlation$^{(2)}$.

• Journal of Oral Medicine and Pain
• /
• v.34 no.4
• /
• pp.363-369
• /
• 2009

Erosive oral lichen planus (EOLP) and recurrent aphthous stomatitis (RAS) are T-cell mediated inflammatory immune disorders. It was investigated mRNA expression pattern of several regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, which influence T lymphocyte in unstimulated whole saliva (UWS) of EOLP and RAS patients. It was collected unstimulated whole saliva during 10 minute in EOLP 18 people, RAS patients 12 people, healthy control 8 people. We investigated mRNA expression of T lymphocyte regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, with real time reverse transcription polymerase chain reaction. In EOLP group, CD45, CD279 expressed higher and CD154 expressed lower than control. In RAS, CD45, CD270 expressed higher and CD28, CD154 expressed lower than control. In addition CD152 salivary mRNA expression of EOLP is higher than that of RAS. The above results were suggested that the mRNA expression of T lymphocyte regulatory factors in unstimulated whole saliva of EOLP and RAS contributes to diagnosis of diseases.

• Proceedings of the Korean Magnestics Society Conference
• /
• 2009.12a
• /
• pp.152-152
• /
• 2009

• Journal of Korean Physical Therapy Science
• /
• v.8 no.2
• /
• pp.997-1003
• /
• 2001

The purpose of this study is to know the average of pint range of motion and difference according to the aging for the elderly, This study consisted of elder male(n=75) and elder female(n=l09), The result of assessment and analysis in shoulder pint range of motion are as follows: 1) The average shoulder flexion pint range of motion in 60-69(from sixty to sixty-nine)years old are 163.04(Left-Male), 162.91(Right-Male), 158.74 (Left-Female), 158.74 (Right-Female). 70-79years old are 149.40(L-M), 152.38(R-M), 153,37(L-F), 153.37(R-F). 80-89 years old are 149.57(L-M), 147.93(R-M), 151.17(L-F), 150.33(R-F). There was no significant difference among group, 2) The average shoulder extension pint range of motion in 60-69years old are 48.15(L-M), 47.20(R-M), 45.16(L-F), 44.23(R-F), 70-79years old are 37.l1(L-M), 38.70(R-M), 35.17(L-F), 36.71(R-F), 80-89 years old are 34.46(L-M). 36.71(R-M), 33.90(L-F), 33.09(R-F). There was significant difference among group(p<.05). 3) The average shoulder abduction pint range of motion in 60-69years old are 164.22(L-M), 165.96(R-M), 159.34(L-F), 159.97(R-F), 70-79years old are 152.27(L-M), 155.05(R-M), 152.32(L-F), 53.66(R-F), 80-89 years old are 152.17(L-M), 153.76(R-M), 147.53(L-F), 147.37(R-F). There was significant difference in right shoulder abduction among group(p<05). 4) The average shoulder internal rotation pint range of motion in 60-69years old are 63.52(L-M), 65.70(R-M), 64.16(L-F), 64.61(R-F), 70-79years old are 64.50(L-M), 65.81(R-M) 61.10(L-F), 61.83(R-F). 80-89 years old are 61.60(L-M), 61.66(R-M), 57.53(L-F), 57.53(R-F). There was no significant difference among group. 5) The average shoulder external rotation pint range of motion in 60-69years old are 50.87(L-M), 50.22(R-M), 51.03(L-F), 50.42(R-F), 70-79years old are 50.91(L-M), 50.20(R-M) 48.37(L-F), 50.20(R-F). 80-89 years old are 46.83(L-M), 47.93(R-M), 43.43(L-F), 43.72(R-F).There was significant difference in left shoulder external rotation among group(p<.05).

• Proceedings of the Korean Vacuum Society Conference
• /
• 1995.06a
• /
• pp.152-152
• /
• 1995