• 방사선산업학회지
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• 제3권1호
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• pp.39-45
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• 2009

Three mineral phosphate solubilizing (MPS) bacteria where isolated from rhizosphere soil samples of common bean and weed plants. 16S rDNA analysis indicated that the isolate P2 and P3 are closely related to Pantoea dispersa while isolate P4 is closely related to Pantoea terrae. Isolates P2 and P3 recorded $381.60{\mu}g\;ml^{-1}$ and $356.27{\mu}g\;ml^{-1}$ of tricalcium phosphate (TCP) solubilization respectively on 3 days incubation. Isolate P4 recorded the TCP solubilization of $215.85{\mu}g\;ml^{-1}$ and the pH was dropped to 4.44 on 24 h incubation. Further incubation of P4 sharply decreased the available phosphorous to $28.94{\mu}g\;ml^{-1}$ and pH level was raised to 6.32. Gamma radiation induced mutagenesis was carried out at $LD_{99}$ dose of the wild type strains. The total of 14 mutant clones with enhanced MPS activity and 4 clones with decreased activity were selected based on solubilization index (SI) and phosphate solubilization assay. Mutant P2-M1 recorded the highest P-solubilizing potential among any other wild or mutant clones by releasing $504.21{\mu}g\;ml^{-1}$ of phosphorous i.e. 35% higher than its wild type by the end of day 5. A comparative evaluation of TCP solubilization by wild type isolates of Pantoea and their mutants, led to select three MPS mutant clones such as P2-M1, P3-M2 and P3-M4 with a potential to release >$471.67{\mu}g\;ml^{-1}$ of phosphorous from TCP. These over expressing mutant clones are considered as suitable candidates for biofertilization.

• 한국전기전자재료학회논문지
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• 제29권6호
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• pp.380-385
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• 2016

Thermal characteristics of 20 W LED module on light thermal conductive plastic (TCP) heat sink were investigated in comparison with that on aluminum die casting alloy (ADC-12). Thermal simulations of the heat sinks were conducted by using flow simulation of SolidWorks with the following input parameters: density is 1.70 and $2.82kg/m^2$, thermal conductivity is 20 and $92W/(m{\cdot}K)$ for TCP and ADC-12, respectively. The simulated and measured temperatures of the LED modules on TCP heat sink were consistent with its measured temperature, which was $3^{\circ}C$ higher that on ADC-12. The fabricated LED module on TCP heat sink with a weight of 120.5 g was 30% lighter in weight than that of the ADC-12 reference with 171.0 g.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권1호
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• pp.49-58
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• 2008

Objective: The Purpose of the study was to investigate the bone morphogenic protein expression of rhBMP-2(recombinant human bone morphogenic protein-2) as singnaling molecule and ${\beta}-TCP$(Tricalcium phosphate) as a bone substitute and carrier medium of rhBMP-2. Materials and Methods: 16 rabbits divided into 2 group of each 8 rabbit. Two standardized bone defect, round bilateral defect was made in the cranium of the 8 rabbit of first group, and was grafted with $150{\sim}500{\mu}m$ diameter ${\beta}-TCP$ 0.25g in one side, which was soaked with rhBMP-2, and autogenous bone was grafted on another side as a positive control. Second group of 8 rabbit, only ${\beta}-TCP$ was grafted with same size and same manner. After 2, 4, 8, and 12 weeks, specimen was taken for microscopic immunohiostochemical and histomorphometric analysis. Result: Grafting ${\beta}-TCP$ with rhBMP show the early formation of the bone regenerative factor (BMP-4) and more quantity of new bone formation than only use of ${\beta}-TCP$ (8,12 week), even show less new bone formation than autogenous bone. Conclusion : The experimental study result that ${\beta}-TCP$ graft combination with rhBMP-2 as a delivery system is an effective with osteoinductive capacity and biodegradable properties, so that provide clinical availibility of composite use in reconstruction of bony defect.

• 한국세라믹학회지
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• 제45권10호
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• pp.618-624
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• 2008

Various calcium phosphate bioceramics are distinguished by their excellent biocompatibility and osteoconductivity. Especially, the exceptional biodegradability of $\beta$-TCP makes it a bone graft substitute of choice in many clinical applications. The activation of osteoclasts, differentiated from macrophage precursor cells, trigger a cell-mediated resorption mechanism that renders $\beta$-TCP biodegradable. Based on this evidence, we studied the biodegradation process of granular-type $\beta$-TCP bone graft substitute through in vitro and in vivo studies. Raw 264.7 cells treated with RANKL and M-CSF differentiated into osteoclasts with macrophage-like properties, as observed with TRAP stain. These osteoclasts were cultured with $\beta$-TCP nano powders synthesized by microwave-assisted process. We confirmed the phagocytosis of osteoclasts by observing $\beta$-TCP particles in their phagosomes via electron microscopy. No damage to the osteoclasts during phagocytosis was observed, nor did the $\beta$-TCP powders show any sign of cytotoxicity. We also observed the histological changes in subcutaneous tissues of rats implanted with granule-type $\beta$-TCP synthesized by fibrous monolithic process. The $\beta$-TCP bone graft substitute was well surrounded with fibrous tissue, and 4 months after implantation, 60% of its mass had been biodegraded. Also, histological findings via H&E stain showed a higher level of infiltration of lymphocytes as well as macrophages around the granule-type $\beta$-TCP. From the results, we have concluded that macrophages play an important role in the biodegradation process of $\beta$-TCP bone graft substitutes.

• 대한전자공학회논문지SD
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• 제39권1호
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• pp.31-38
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• 2002

0.35㎛-비아(via) 식각공정을 개선하기 위하여 C₂F/sub 6/가스의 식각특성을 분석하였다. 실험한 재료는 TEOS/SOG/TEOS 막을 올린 8인치 웨이퍼이며, 실험의 기법은 직교행열(Orthogonal array matrix) 실험 방식을 활용하였다. 산화막 식각에 이용된 장비는 transformer coupled plasma(TCP) source 방식이며 고밀도 플라즈마(HDP)장비이다. 실험의 결과는, 실험변수의 범위 내에서 C₂F/sub 6/는 0.8㎛/min-1.l㎛/min 범위의 식각속도를 보이며 균일도(Uniformity)는 ±6.9%미만으로 측정되었다. CD 변화(skew)는 식각 전과 후를 비교하여 10% 미만이었고 그 결과 비등방성(anisotropic) 식각의 특성이 우수하였다. C₂F/sub 6/를.20sccm 공급할 때 문제점이 발견되지 않았지만 14sccm을 공급하면 SOG 막의 내벽이 침식당하는 문제점이 있었다. 결과적으로 C₂F/sub 6/는 HDP TCP에서 빠른 식각비와 넓은 공정창(process window)을 가진 식각특성을 나타내었다.

• Archives of Pharmacal Research
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• 제9권2호
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• pp.99-110
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• 1986

In order to use for metabolic studies of tranylcypromine (TCP), TCP-phenyl-$d_{5}$ was synthesized via the intermediates, 3-benzoylpropionic acid-$d_{5}$ and trans-2-phenylcyclopropanecarboxylic acid-$d_{5}$ -TCP(0.22 mmole/kg) and its deuterated analog were administered s. c. to the rats and GC/MS analyses of the urines led to the detection of N-acetyltranylcypromine (ATCP) and glucuronide conjugate of phenyl-hydroxylated ATCP. MAO activities in rat brain were measured using serotonin as the substrate. In vitro $IC_{50}$ of ATCP was determined to be $10^{-3}M$. The inhibitions by ATCP were not dependent on the preincubation time and were reversed by washing sedimented mitochondrial pellets after the preincubation. In vivo MAO inhibitions at various times of 0.5, 1.5, 3, 6, 12, and 23 hr after the administration of 0.4 mmole/kg (i. p. ) of ATCP were found to be 0.13, 73, 90, 89, and 74 %, respectively. Similarly, the inhibition percents by 0.015 mmole/kg (i. p. ) of TCP were 94, 99, 95, 91, 71 and 49%. The results strongly suggest that deacetylated product of ATCP may account for its in vivo MAO inhibition. The relationship between the metabolism via phenyl-hydroxylation and the in vivo potency of TCP was examined by QSAR study and it was found that groupings discriminating between the compounds with p-substituents and those without them only ensure high correlations, suggesting that ring-hydroxylation which occurs at the para position in most of the compounds is a determining factor to the potency of TCP.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2010년도 한국컴퓨터종합학술대회논문집 Vol.37 No.1(D)
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• pp.343-347
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• 2010

TFMCC(TCP-Friendly Multicast Congestion Control)방식은 equation 기반의 멀티캐스트 혼잡 제어 메커니즘으로 TFRC(TCP-Friendly Rate Control) 프로토콜을 유니캐스트에서 멀티캐스트 도메인으로 확장한 방식이다. TFMCC 방식은 현재 무선 환경에 적용 시 유선 환경에서의 혼잡에 의한 패킷 손실뿐만 아니라, 무선 환경에서 무선 링크 에러를 네트워크의 혼잡으로 인식하며, single-rate 멀티캐스트 혼잡제어의 특성인 가장 낮은 수신단의 성능으로 전체 네트워크 전송률이 급격히 저하된다. 이에 본 논문에서는 무선 환경에서의 TFMCC의 성능 향상을 위해 네트워크의 무선 환경의 손실률과 유선 환경 손실률을 모델링하여 구분한 ARC(Analytical Rate Control)의 TCP 전송률 equation 을 TFMCC에 맞게 적용하였으며, 멀티캐스트 도메인에서 전송률 제어 시 무선 손실률을 별도로 고려하는 방식(M-ARC)을 제안하였다. 또한 성능 평가를 위해서 시뮬레이션 한 결과 무선 환경을 고려한 M-ARC(Multicast-Analytical Rate Control)가 기존의 TFMCC에 비해 더 높은 전송률을 유지함을 볼 수 있었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1998년도 추계종합학술대회 논문집
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• pp.1029-1032
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• 1998

In this paper, a comparative study is presented to evaluate the addition architecture of the high-speed checksum module in TCP/IP processing. In order to speed up TCP/IP processing, H/W implementation offers concurrent and parallel processing to yield high speed computation, with respect to S/W implementation. This research aims at comparing two addition architectures of checksum module, which is the major botteleneck in TCP/IP processing. The 16-bit and 8-bit byte-by-byte addition architecture are implemented by the full custom design, and compared, in analytical and experimental manner, from standpoint of space and performance. For LG $0.6\mu\textrm{m}$ TLM process, the 8-bit addition implementation requires the area, 1.3 times larger than the 16-bit one, and it operates at 80MHz while the 16-bit one runs by 66MHz.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2008년도 춘계학술발표대회
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• pp.1003-1006
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• 2008

인터넷상에서 TCP 프로토콜은 사실상 표준으로써 널리 이용되고 있다. 그러나 네트워크 환경이 발전해 감에 따라서 무선 네트워크, CDMA, 3G 네크워크등 다양한 환경이 공존하게 되었고, 이러한 환경에서 TCP의 성능저하가 이슈가 되어 많은 연구가 진행되었으며, 많은 알고리즘들이 발표되었다. 본 논문에서는 무선환경에서 다양한 TCP 성능저하 원인 중에서 spurious RTO에 관한 문제를 해결하고자 한다. 이 전의 연구인 E-RTO는 delay spike문제를 효과적으로 다루고 있다 하지만 delay spike이후 혼잡 윈도우를 회복하는 과정을 효과적으로 다루고 있지 못하다. 우리는 BCR를 제안하여 이러한 문제를 해결하고자 한다. BCR의 성능평가는 NS2를 이용하여 이루어 졌으며 throughput, goodput에서 좋은 성능을 보여주고 있다.

• 한국세라믹학회지
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• 제53권6호
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• pp.670-675
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• 2016

Calcium phosphate crystallites were prepared by wet chemical method for use in artificial bone. In order to obtain ${\beta}$-tricalcium phosphate (TCP), nano-crystalline calcium phosphate (CaP) was precipitated at $37^{\circ}C$ and at $pH5.0{\pm}0.1$ under stirring using highly active $Ca(OH)_2$ in DI water and an aqueous solution of $H_3PO_4$. The precipitated nano-crystalline CaP solution was kept at $90^{\circ}C$ for the growth of CaP crystallites. Through the growing process of CaP crystallites, we were able to obtain various sizes of rectangular CaP crystallites according to the crystal growing times. Dry nano-crystalline CaP powders at $37^{\circ}C$ were mixed with dry macro-crystalline CaP crystallites and the shaped mixture sample was fired at $1150^{\circ}C$ to make a ${\beta}-TCP$ block. Several tens of nm powders were uniformly coated on the surface, which was comprised of powders of several tens of ${\mu}m$, using a vibrator. The mixing ratio between the nanometer powders and the micrometer powders greatly affected the mechanical strength of the mixture block; the most appropriate ratio of these two materials was 50 wt% to 50 wt%. The sintered block showed improved mechanical strength, which was caused by the solid state interaction between the nano-crystalline ${\beta}-TCP$ and the macro-crystalline ${\beta}-TCP$.