• Title/Summary/Keyword: M&C

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Effects of Extracellular $Ca^{++}$ on PKC or cAMP-stimulated Increases in LH Release and $LH{\beta}$ Subunit mRNA Levels in Rat Anterior Pituitary Cells (흰쥐 뇌하수체 전엽세포에서 PKC나 cAMP에 의한 LH 분비 및 $LH{\beta}$ Subunit mRNA 증가에 미치는 $Ca^{++}$의 영향)

  • Park, Deok-Bae;Kim, Chang-Mee;Cheon, Min-Seok;Ryu, Kyung-Za
    • The Korean Journal of Pharmacology
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    • v.32 no.3
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    • pp.347-355
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    • 1996
  • We examined the effects of EGTA and verapamil on phorbol ester-and forskolin-stimulated LH releases and $LH{\beta}$ subunit mRNA levels in order to verify the role of extracellular $Ca^{++}$ on PKC- or cAMP-induced increases in LH release and $LH{\beta}$ subunit mRNA levels in cultured anterior pituitary cells of rat. Forskolin-stimulated $LH{\beta}$ subunit mRNA levels as well as LH release were all suppressed by prevention of $Ca^{++}$ mobilization from extracellular environment, after the treatment of EGTA as a $Ca^{++}$ chelator or verapamil as a $Ca^{++}$ channel blocker. PMA-stimulated $LH{\beta}$ subunit mRNA levels were also suppressed by the treatment of EGTA and verapamil, while PMA-induced LH release was not affected. From the present study, it is, therefore, suggested that PKC activation and cAMP elevation all stimulate $LH{\beta}$ subunit mRNA levels and these are extracellular $Ca^{++}$-dependent. However, LH releases by PKC activation and cAMP increase seem to be different each other. LH release by PKC activation is thought to be independent of extracellular $Ca^{++}$. On the other hand, cAMP stimulated-LH release is thought to be dependent on the entry of extracellular $Ca^{++}$.

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The Effect of Korean Mistletoe Extract M11C (Non-Lectin Components) on the Tumor Necrosis $Factor-{\alpha}$ Secretion from Mouse Splenic Macrophages and on the Inhibition of Sarcoma 180-Induced Tumor Growth in Mice (한국산 겨우살이 추출물 M11C(비렉틴 구성물질)의 생쥐 비장 대식세포로부터 Tumor Necrosis $Factor-{\alpha}$ 분비효과와 생쥐에 Sarcoma 180으로 유도된 육종암의 성장 억제효과)

  • Sung, Ki-Tai;Kang, Tae-Bong;Jun, Myung-Ha;Chang, Sung-Ho;Lee, Jun-Ho;Kim, Jong-Bae;Choi, Wahn-Soo;Yoo, Yung-Choon;Seong, Nak-Sul;Lee, Sung-Tae;Sung, Hyun-Jea;Her, Erk
    • Korean Journal of Pharmacognosy
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    • v.34 no.3 s.134
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    • pp.210-217
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    • 2003
  • Korean mistletoe (Viscum album) extract has been found to posses immunostimulatory activity. In this study, Korean mistletoe extract, M11C (non-lectin components), was used to know whether this extract might activate mouse splenic macrophages to produce tumor necrosis $factor-{\alpha}\;(TNF-{\alpha}$) and might play a role in anticancer. To know the effect of M11C on the production of $TNF-{\alpha}$, the splenic macrophages were treated by the M11C, and then collected the supernatant (M11C stimulated splenic macrophage-conditioned media; MSCM). MSCM was analyzed for the $TNF-{\alpha}$ secretion by means of ELISA and immunoblotting, and mRNA expression was analyzed by RT-PCR. The S-180 murine sarcoma model was established to know the effect of M11C on the inhibition of tumor growth. M11C had the effect of $TNF-{\alpha}$ production from splenic macrophages performed by ELISA technique. This ELISA data was reconfirmed by immunoblotting assay. The effects of M11C on the expression of $TNF-{\alpha}$ mRNA from the macrophages was also shown. M11C also had the inhibitory effect of S-180 tumor growth. These data suggest that Korean mistletoe extract M11C may be used for an immunomodulator.

Carbon Nanotube/Nafion Composites for Biomimetic Artificial Muscle Actuators

  • Lee, Se-Jong;Yoon, Hyun-Woo;Lee, Deuk-Yong
    • Journal of the Korean Ceramic Society
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    • v.44 no.4 s.299
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    • pp.198-201
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    • 2007
  • Multi-walled carbon nanotube (M-CNT)/Nafion nanocomposites were prepared by solution casting to elucidate the effect of M-CNT addition, from 0 to 7 wt%, on the viscoelastic behavior of the composites. The M-CNT bundles induced by the Nafion polymer were determined to be uniformly distributed for the 1 wt% M-CNT/Nafion nanocomposites. The 1 wt% M-CNT/Nafion composite exhibited the highest blocking stress of 2.3 kPa due to its high elastic modulus of 0.485 GPa. From a dynamic mechanical analysis, the 1 wt% M-CNT had the highest storage and loss moduli compared with the other samples in all frequency and temperature ranges. From the storage modulus data, the M-CNT loaded composites had similar $T_g$ values near $120^{\circ}C$. The glass transition temperatures of the M-CNT loaded composites were $120^{\circ}C$ (1 wt%), $117^{\circ}C$ (3 wt%), $117^{\circ}C$ (5 wt%), and $135^{\circ}C$ (7 wt%), suggesting that the effect of the M-CNTs on the Nafion film begins at 1 wt%. Thus, it has been concluded that the 1 wt% M-CNT disported composite is attractive for actuator applications.

ON A QUASI-POWER MODULE

  • PARK CHIN HONG;SHIM HONG TAE
    • Journal of applied mathematics & informatics
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    • v.17 no.1_2_3
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    • pp.679-687
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    • 2005
  • In this paper we shall give a new definition for a quasi-power module P(M) and discuss some properties for P(M). The quasi-power module P(M) is a direct sum of invertible quasi-submodules C(H)'s of P(M) and then the quasi-submodule C(H) is also a direct sum of strongly cyclic quasi-submodules of C(H). When M is a quasi-perfect right R-module, we shall see that the quasi-power module P(M) is invertible.

M/M/s/s + c Queueing System Revisited (M/M/s/s + c 대기시스템 재방문)

  • 김성철
    • Journal of the Korean Operations Research and Management Science Society
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    • v.21 no.2
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    • pp.49-58
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    • 1996
  • The generalized Erlang loss function, extensively studied in the literature, is revisited. We study the steady state loss probability in M/M/s/s + c queueing system and prove that it satisfies the first and second order properties in integral number of servers as well as integral queue capacities. Also we study the problem of allocating integral number of servers and queue capacities, and develop an algorithm to obtian an optimal allocation of them individually and jointly with the small number of computations.

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A Busy Period Analysis for the M/M/c/K Queueing System (M/M/c/K 대기행렬 시스템의 바쁜 기간 분석)

  • Lim Dae-Eun;Chae Kyung-Chul
    • Journal of the Korean Operations Research and Management Science Society
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    • v.31 no.1
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    • pp.83-90
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    • 2006
  • By defining the partial busy period of the M/M/c/K queueing system as the time interval during which at least one server is in service, we derive the first two moments of both the partial busy period and the number of customers served during it. All expressions are given in explicit forms.

Spatial Distribution Pattern of the Populations of Carex siderosticta at Mt. Geumjeong and Mt. Ahop (금정산과 아홉산의 대사초 집단의 공간적 분포 양상)

  • Huh, Man Kyu
    • Journal of Life Science
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    • v.25 no.4
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    • pp.369-375
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    • 2015
  • Data on the spatial distribution of a plant population among administrative areas is useful for various purposes. In this study, I analyzed the spatial distribution of the geographical distances of Carex siderosticta at Mt. Geumjeong and Mt. Ahop in Korea. The aim was to test a spatial structure within two populations of C. siderosticta. Most natural plots of C. siderosticta are not uniformly distributed in the forest community; for example, uniform plots were aggregately distributed within a space of 6.0 m $\times$ 6.0 m. When the sampling plots were larger than 6.0 m $\times$ 12.0 m, the individuals of C. siderosticta were aggregately distributed. The neighboring patches of C. siderosticta were predominantly 7.5 m to 9.0 m apart, on average; however, if the natural populations were disturbed by human activities, the aggregation occurred in shorter distances than a scale of 9.0 m. Moran's I of C. siderosticta significantly differed from the expected value in only 16 of 40 cases (40%). In conclusion, the geographical distribution of C. siderosticta is not even, with varying degrees of size in the plots, while human activities give rise to density effects in the plots at both Mt. Geumjeong and Mt. Ahop in Korea.

Bioassay Study on fresh Water Fish with PCP and DDT (PCP와 DDT의 독성이 담수어에 미치는 영향)

  • Byung Soo Yang
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.17 no.2
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    • pp.77-83
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    • 1981
  • Four-day bioassay method was used in this study to find out toxicity levels of DDT and PCP. From this study it was found that M. chrysophekadion was the most sensitive to DDT with a 96 h-TL sub(m) value of 0.0044 mg/l followed by P. Sutchi with a 96 h-TL sub(m) value of 0.0056 mg/l, and the most resistant was C. Siamensis with a 96 h-TL sub(m) value of 0.0133 mg/l. In the case of PCP, it was also found that M. Chrysophekadion and P. Sutchi were the first and second most sensitive to PCP with a 96 h-TL sub(m) value of 0.065mg/l PCP and 0.125mg/l PCP respectively, as in the case of DDT study. T. Nilotica was found to be the most resistant to PCP with a 96 h-TL sub(m) value of 0.264mg/l PCP. The resistant power of fish to pollution varies with the species of fish and the types of pollutants. In order of decreasing sensitivity of fish to DDT based on TL sub(m), the following sequence is obtained M. Chrysophekadion, P. Sutchi, T Nilotica, P. Gonionotus, K. Bicirrhis, L. Bicolor, C. Carpio, R. Heteromorpha, C. Siamensis while in the case of PCP, M. Chrysophekadion, P. sutchi, L. Bicolor, K. Bicirrhis, P. Gonionotus (R. Heteromorpha, R. Trilineata), C. Siamensis, C. Carpio, T. Nilotica.

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A Study on the Enhancement of Athletic Performance by Analyzing Lap Times in Kayak 1000m Sprint (카약 1000m 경기 랩타임 분석을 통한 경기력 향상 방안 모색)

  • Shin, Kwang-Taek;Sohn, Jee-Hoon
    • Journal of the Korea Convergence Society
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    • v.10 no.2
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    • pp.301-307
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    • 2019
  • The purpose of this study is to evaluate the lap time of K-1 sprint competition and compare the records of the best group and the other groups. Based on these data we are willing to provide them on pace control strategies for improving their performances. The analysis was conducted on 12 elite kayak players, measuring the lap time by every interval after dividing the entire 1,000-meter race into 10 sections of 100 meters. We divide the group A, B, C and D based on their final time records. Two-factor repeated measures ANOVA, One-way ANOVA, and correlation analysis were performed. There were no significant lap time differences in the section of first 200m and last 200m between A, B and C. But the C's lap time of 200m~600m were significantly later than group A and B. Non-superior athletes need to establish strategies to reduce lap time in the middle section.

Evaluation of Radiation Dose and Imaging of the QC Program in Mammography MLO View (MLO View의 유방촬영에서 QC 프로그램을 이용한 선량 및 영상 평가)

  • Lee, Seon-Hwa;Kim, Jung-Min;Kweon, Dae-Cheol
    • Journal of radiological science and technology
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    • v.38 no.3
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    • pp.221-228
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    • 2015
  • Purpose: In digital mammography QC program was used for the purpose of reducing low-dose and high-definition images of the radiation dose. Materials and Methods: In digital mammography using a QC phantom according to the average glandular dose in the exposure method MLO view $0^{\circ}C$, $30^{\circ}C$, $45^{\circ}C$, $50^{\circ}C$, $55^{\circ}C$, $70^{\circ}C$, was measured at $90^{\circ}C$ intervals, an image with Hologic QC program to the SNR and CNR was measured to evaluate. Results: The average dose in the MLO view was wired to $90^{\circ}C$ when the maximum was 1.75 mGy, it decreased approximately 6% was measured at $45^{\circ}C$ 1.65 mGy. In addition, 1.67 mGy, manual record, there were an average wired in accordance with the exposure dose and the dose of 1.52 mGy difference in the way auto filter. Image quality evaluation at every angular section SNR 50 ~ 52, shows a slight difference in CNR 11 ~ 12, it was included in the manufacturer's recommended value. Conclusion: The dose was lowest in MLO view $45^{\circ}C$, the difference between SNR and CNR were insignificant. The method of exposure will need a way to reduce the exposure of the patient's body or unnecessary patient by placing a difference in settings in which the characteristics.