• 분석과학
• /
• 제35권2호
• /
• pp.60-68
• /
• 2022

In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r² of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49 %). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.

• Toxicological Research
• /
• 제32권1호
• /
• pp.57-64
• /
• 2016

Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-${\beta}$-D-glucosaminidase (NAG) and ${\beta}_2$-microglobulin (${\beta}_2$-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and ${\beta}_2$-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was $2.21{\mu}g/dL$ (geometric $SD=1.49{\mu}g/dL$) and $1.08{\mu}g/g\;cr$ (geometric $SD=1.98{\mu}g/g\;cr$), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: ${\beta}=0.44$, p < 0.001; urinary ${\beta}_2$-MG: ${\beta}=0.13$, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of ${\beta}_2$-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.

• 한국융합학회논문지
• /
• 제11권3호
• /
• pp.45-52
• /
• 2020

본 연구에서는 현존하고 있는 잠금 해제 방식에서 보이는 문제점으로부터 출발해 보안성 및 사용성 측면에서 개선된 블라인드 인터랙션을 적용한 상대적 위치 기반 패턴 잠금 해제 방식을 제안하고 이론적 타당성을 고찰했다. 기존 숫자암호 잠금 해제 방식과 패턴 그리기 잠금 해제 방식과의 차이를 실험을 통해 확인하고 실용적 가치를 평가했다. 상대적 위치 패턴은 숫자 암호 보다 쉽게 기억되고 그리기 패턴과 비슷한 정도의 학습 용이성을 보여 주었고 타 방식에 비해 훔쳐보기 공격에 안전한 결과를 얻었다. 생체신호를 센싱 할 센싱 모듈을 사용할 필요 없이 터치스크린의 기본기능만으로 실현 가능하기에 적은 원가로 제작할 수 있다. 시각적 요소가 필요 없는 방식이기에 시각 장애인과 같은 특수 사용자들도 불편함 없이 사용할 수 있기에 실용적 가치도 상대적으로 높다.

• 한국항공우주학회지
• /
• 제46권12호
• /
• pp.986-993
• /
• 2018

측 추력 제트는 유도무기의 자세제어 및 궤도 천이 기동을 하는 데 있어 기존의 핀과 같이 제어 면을 이용한 방식보다 우수한 기동성을 갖는다. 하지만 초음속 영역에서 비행 시 측 추력 제트로 인한 제트 간섭 유동이 발생하며 충격파와 경계층 유동, 와류 유동의 상호 작용으로 인해 매우 복잡한 유동 구조를 나타낸다. 특히 직격 파괴(hit-to-kill) 방식의 요격체의 경우 정밀한 제어 및 기동이 요구되기 때문에 제트 간섭 유동이 미치는 영향에 대한 분석이 필요하다. 기존의 제트 간섭 해석은 저고도 운용 조건에서 주로 수행되었으나 중고도 운용 조건의 경우 해석 사례가 많지 않으며 대기 조건으로 인해 분사 제트 유동이 상대적으로 크게 발달하는 특징을 갖는다. 본 연구에서는 중고도에서 비행하는 요격체 형상에 대해 받음각 조건에 따라 제트 간섭 유동 해석을 수행하였다. 해석 결과를 바탕으로 유동장의 구조적인 변화 특성을 분석하였으며, 공력 계수의 변화를 비교하였다.

• International Journal of Precision Engineering and Manufacturing
• /
• 제3권4호
• /
• pp.72-77
• /
• 2002

The load interaction effect can be best illustrated by the phenomenon of overload retardation. Some prediction methods for retardation are reviewed and the problems discussed in the present paper. The so-called under-load effect much of the retardation disappears if a very low level minimum stress follows the overload, is also of importance for a prediction model to work properly under random load spectrum. The concept of Interactive Zone (IZ) fully considering reversed plasticity during unloading was discussed. This IZ concept can be combined with existing models to derive some improved models that can naturally take account of the under-load effect. Some simulations by IZ improved models for test under complex load sequences including multiple overloads and both over/under loads are compared with test results. It is seen that the improvement by IZ concept greatly enhanced the ability of existing models to accommodate complex load interaction effects.

• Journal of Mechanical Science and Technology
• /
• 제19권3호
• /
• pp.826-835
• /
• 2005

Exposed-type steel column bases are used widely in low-rise building construction. Numerous researchers have examined methods to identify their stiffness and strength, but those studies have heretofore been restricted to in-plane behaviors. This paper presents an experimental investigation of inelastic behaviors of square hollow section (SHS) steel column bases under biaxial bending. Two types of failure modes are considered : anchor bolt yielding and base plate yielding. Different pinching effects and interaction surfaces for biaxial bending are observed for these two modes during bi-directional quasi-static cyclic loading tests. Differences are elucidated using limit analyses based on a simple analytical model.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제15권3호
• /
• pp.51-59
• /
• 2009

This study reviewed the background of the advent of and the concept of age-integrated facilities where elderly persons' facilities and children's facilities have been built in the same plot or building or established adjacent to each other. And also it examined the concept, necessity, effects, and kinds of intergenerational interactions. Ten age-integrated facilities in Japan, where it is reported that intergenerational interactions are now being implemented, were selected and visited for surveys. This study implemented interviews with staff members and analyses of the drawings of the facilities to grasp the present state of age-integrated facilities and their plan types, etc. Through analyses of relationships between intergenerational interactions and the spaces in which these take place, this study discusses guidelines for space arrangement and for developing interaction space plans for age-integrated facilities that would facilitate intergenerational interactions.

• 한국연소학회:학술대회논문집
• /
• 한국연소학회 2002년도 제24회 KOSCO SYMPOSIUM 논문집
• /
• pp.68-75
• /
• 2002

The dynamic behaviors of the single vortex and flame-vortex interaction in a $CH_4/Air$ diffusion flame with addition of $CO_2$ were investigated numerically. The numerical method was based on a predictor-corrector for low Mach number flow. A two-step global reaction mechanism was adopted as a combustion model. Through comparison of results by effect of $CO_2$ added either on the fuel or oxidizer side, it was found that the growth of single vortex and entrainment of surrounding fluid by $CO_2$addition on the fuel side are larger than those by $CO_2$ addition on oxidizer side. Also, when $CO_2$ is added on fuel side, flame-vortex interaction becomes more significant than on air side.

• 아동학회지
• /
• 제26권3호
• /
• pp.1-13
• /
• 2005

Subjects were 78 12- to 35- month old infants, their mothers, and their teachers. Instruments included the Revised Toddler Temperament Questionnaire(Y. H. Choi 1990) and the Assessment Profile for Early Childhood Programs(M. K. Hong 1997; S. K. Kim 1999). There was no significant difference in perceptions of infant temperament between mothers and teachers. Infant-mother interaction differed by infant temperament in that mothers had high scores with easy infants but low scores with difficult children. On the other hand teachers maintained high interactions with difficult infants in the case of infant's rhythmicity. Infant-teacher interaction correlated with such teacher variables as teacher-infant ratio, teachers' academic backgrounds and working hours.

• Asia pacific journal of information systems
• /
• 제13권2호
• /
• pp.171-197
• /
• 2003

There have been quite many studies to identify factors affecting successful implementation of EDI systems. However, previous studies have investigated influencing factors independently. Given the complexity involved in the implementation of EDI systems, it might be quite necessary to investigate the interaction effects between influencing factors. The primary purpose of this study is to investigate the interaction effects of organizational characteristics as contextual variables on the relationship between managerial characteristics and EDI implementation. Analysis of 202 responses of survey questionnaire indicates the following: 1) Education/training and top management support has positive effect on the successful EDI implementation. 2) The degree of decentralization has strong, and management risk position has mild moderating effect on the relationship between managerial characteristics and EDI implementation. 3) The degree of formalization and organizational size have no moderating effect. 4) The subgroup analysis, conducted to determine the exact nature of interaction effect, reveals that the relationship between managerial characteristics and EDI implementation is significantly stronger with a high level of decentralization or management risk position than with a low level.