• Analytical Science and Technology
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• v.35 no.2
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• pp.60-68
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• 2022

In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r² of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49 %). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.

• Toxicological Research
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• v.32 no.1
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• pp.57-64
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• 2016

Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-${\beta}$-D-glucosaminidase (NAG) and ${\beta}_2$-microglobulin (${\beta}_2$-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and ${\beta}_2$-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was $2.21{\mu}g/dL$ (geometric $SD=1.49{\mu}g/dL$) and $1.08{\mu}g/g\;cr$ (geometric $SD=1.98{\mu}g/g\;cr$), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: ${\beta}=0.44$, p < 0.001; urinary ${\beta}_2$-MG: ${\beta}=0.13$, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of ${\beta}_2$-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.

• Journal of the Korea Convergence Society
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• v.11 no.3
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• pp.45-52
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• 2020

In this study, we propose a new Relative position pattern unlocking solution based on blind interaction, which is a new unlocking method, and compared it with existing unlocking methods to verify usability and security improvement. And verified the practical value of the proposed new unlocking solution. The relative position pattern unlock method is easily remembered than the numeric code method and is worth practical enough to show a degree of learning ease similar to the drawing pattern method. The new method is safer to steal than other two methods. It can be manufactured at a low cost and can also be used by special users such as blind people. Therefore, the practical value is relatively high.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.12
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• pp.986-993
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• 2018

Lateral thrust jet has better maneuverability performance than the control surface like the conventional fin for attitude control or orbital transition of guided weapons. However, in the supersonic region, a jet interaction flow occurs due to the lateral thrust jet during flight, and a complicated flow structure is exhibited by the interaction of the shock wave, boundary layer flow, and the vortex flow. Especially, hit-to-kill interceptors require precise control and maneuvering, so it is necessary to analyze the effect of jet interaction flow. Conventional jet interaction analyses were performed under low altitude conditions, but there are not many cases in the case of medium altitude condition, which has different flow characteristics. In this study, jet interaction flow analysis is performed on the lateral jet controlled interceptor operating at medium altitude. Based on the results, the structural characteristics of the flow field and the changes of aerodynamic coefficient are analyzed.

• International Journal of Precision Engineering and Manufacturing
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• v.3 no.4
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• pp.72-77
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• 2002

The load interaction effect can be best illustrated by the phenomenon of overload retardation. Some prediction methods for retardation are reviewed and the problems discussed in the present paper. The so-called under-load effect much of the retardation disappears if a very low level minimum stress follows the overload, is also of importance for a prediction model to work properly under random load spectrum. The concept of Interactive Zone (IZ) fully considering reversed plasticity during unloading was discussed. This IZ concept can be combined with existing models to derive some improved models that can naturally take account of the under-load effect. Some simulations by IZ improved models for test under complex load sequences including multiple overloads and both over/under loads are compared with test results. It is seen that the improvement by IZ concept greatly enhanced the ability of existing models to accommodate complex load interaction effects.

• Journal of Mechanical Science and Technology
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• v.19 no.3
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• pp.826-835
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• 2005

Exposed-type steel column bases are used widely in low-rise building construction. Numerous researchers have examined methods to identify their stiffness and strength, but those studies have heretofore been restricted to in-plane behaviors. This paper presents an experimental investigation of inelastic behaviors of square hollow section (SHS) steel column bases under biaxial bending. Two types of failure modes are considered : anchor bolt yielding and base plate yielding. Different pinching effects and interaction surfaces for biaxial bending are observed for these two modes during bi-directional quasi-static cyclic loading tests. Differences are elucidated using limit analyses based on a simple analytical model.

• Journal of The Korea Institute of Healthcare Architecture
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• v.15 no.3
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• pp.51-59
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• 2009

This study reviewed the background of the advent of and the concept of age-integrated facilities where elderly persons' facilities and children's facilities have been built in the same plot or building or established adjacent to each other. And also it examined the concept, necessity, effects, and kinds of intergenerational interactions. Ten age-integrated facilities in Japan, where it is reported that intergenerational interactions are now being implemented, were selected and visited for surveys. This study implemented interviews with staff members and analyses of the drawings of the facilities to grasp the present state of age-integrated facilities and their plan types, etc. Through analyses of relationships between intergenerational interactions and the spaces in which these take place, this study discusses guidelines for space arrangement and for developing interaction space plans for age-integrated facilities that would facilitate intergenerational interactions.

• 한국연소학회:학술대회논문집
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• 2002.06a
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• pp.68-75
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• 2002

The dynamic behaviors of the single vortex and flame-vortex interaction in a $CH_4/Air$ diffusion flame with addition of $CO_2$ were investigated numerically. The numerical method was based on a predictor-corrector for low Mach number flow. A two-step global reaction mechanism was adopted as a combustion model. Through comparison of results by effect of $CO_2$ added either on the fuel or oxidizer side, it was found that the growth of single vortex and entrainment of surrounding fluid by $CO_2$addition on the fuel side are larger than those by $CO_2$ addition on oxidizer side. Also, when $CO_2$ is added on fuel side, flame-vortex interaction becomes more significant than on air side.

• Korean Journal of Child Studies
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• v.26 no.3
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• pp.1-13
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• 2005

Subjects were 78 12- to 35- month old infants, their mothers, and their teachers. Instruments included the Revised Toddler Temperament Questionnaire(Y. H. Choi 1990) and the Assessment Profile for Early Childhood Programs(M. K. Hong 1997; S. K. Kim 1999). There was no significant difference in perceptions of infant temperament between mothers and teachers. Infant-mother interaction differed by infant temperament in that mothers had high scores with easy infants but low scores with difficult children. On the other hand teachers maintained high interactions with difficult infants in the case of infant's rhythmicity. Infant-teacher interaction correlated with such teacher variables as teacher-infant ratio, teachers' academic backgrounds and working hours.

• Asia pacific journal of information systems
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• v.13 no.2
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• pp.171-197
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• 2003

There have been quite many studies to identify factors affecting successful implementation of EDI systems. However, previous studies have investigated influencing factors independently. Given the complexity involved in the implementation of EDI systems, it might be quite necessary to investigate the interaction effects between influencing factors. The primary purpose of this study is to investigate the interaction effects of organizational characteristics as contextual variables on the relationship between managerial characteristics and EDI implementation. Analysis of 202 responses of survey questionnaire indicates the following: 1) Education/training and top management support has positive effect on the successful EDI implementation. 2) The degree of decentralization has strong, and management risk position has mild moderating effect on the relationship between managerial characteristics and EDI implementation. 3) The degree of formalization and organizational size have no moderating effect. 4) The subgroup analysis, conducted to determine the exact nature of interaction effect, reveals that the relationship between managerial characteristics and EDI implementation is significantly stronger with a high level of decentralization or management risk position than with a low level.