• International Journal of Concrete Structures and Materials
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• v.10 no.2
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• pp.237-247
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• 2016

Progressive collapse resistance of RC buildings can be analyzed by considering column loss scenarios. Using finite element analysis and a static test, the progressive collapse process of a RC frame under monotonic vertical displacement of a side column was investigated, simulating a column removal scenario. A single-story 1/3 scale RC frame that comprises two spans and two bays was tested and computed, and downward displacement of a side column was placed until failure. Our study offers insight into the failure modes and progressive collapse behavior of a RC frame. It has been noted that the damage of structural members (beams and slabs) occurs only in the bay where the removal side column is located. Greater catenary action and tensile membrane action are mobilized in the frame beams and slabs, respectively, at large deformations, but they mainly happen in the direction where the frame beams and slabs are laterally restrained. Based on the experimental and computational results, the mechanism of progressive collapse resistance of RC frames at different stages was discussed further. With large deformations, a simplified calculation method for catenary action and tensile membrane action is proposed.

• Molecules and Cells
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• v.40 no.9
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• pp.613-620
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• 2017

The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.41
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• pp.293-319
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• 2009

This paper aims to find the differences between the trading company of Korea and Japan, by analyzing the development history of Corporate Governance and Internal Control System in Korea and Japan. And this paper studies about that on the legal site. A corporate governance has the tremendous influence on the value of the company, and a company's system of internal control has a key role in the management of risks that are significant to the fulfillment of its business objectives. On the other hand, many companies in the every industry have suffered several times from fatal loss or damage resulted from miss or malfeasance late in the 20th century. And the result of that, starting the Sarbanese-Oxley Act in America, a government established the financial laws and corporate laws in the a lot of countries including Korea and Japan. Japanese trading companies tend to be taking a serious view of internal control more than corporate governance against Korean trading companies. But this not means that Japanese are superior to Korean. The most important thing is the fact that Korean trading companies have to spend enough time finding suitable system of corporate governance and internal control as Japanese trading companies did.

• Archives of Plastic Surgery
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• v.33 no.2
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• pp.263-267
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• 2006

In both cosmetic and functional aspects, loss of digital pulp is a common problem. Compound or composite defects of the hand and fingers with exposed denuded tendon, bone, joint, or neurovascular structures may require flap coverage. Most often these lesions can be repaired by using simple local flap, neurovascular flap, thenar flap, and cross-finger flap. But microvascular reconstruction is sometimes needed for large defects. But Authors do not recommend these procedures in case of severe crushing injuries involving multiple finger pulp losses because they have possibility of damage of the vascular network and infection. So we applied distant flaps such as chest flaps, groin flaps, abdominal flaps and etc. And then we applied surgical rubber gloves for remodeling the flap after cutaneous healing. We have acquired satisfactory results, after the simple molding method for distant flap finger by using surgical rubber gloves treatment.

• Advances in Traditional Medicine
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• v.7 no.3
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• pp.297-303
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• 2007

The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieri aerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanol-induced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both the fractions were endowed with significant hepatoprotective activity. EAF and NBF were investigated for hepatoprotective activity in albino rats at 300 mg/kg, p.o. dose and compared with standard drug Silymarin (25 mg/kg, p.o.). Results show that both the fractions were effective in blunting ethanol-induced enhanced activities of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, level of serum bilirubin (both total and direct), liver weight loss and was also effective in reducing ethanol-induced lipid peroxidation both in vitro and in vivo. Furthermore, the fractions could also enhance ethanol-induced suppressed activities of superoxide dismutase, catalase and decreased level of reduced glutathione. Results of hepatocellular damage caused by ethanol and its recovery by EAF and NBF, suggest that they might be considered as a potential source of natural hepatoprotective agents, which could be related to the free radical scavenging properties of saponins present in high concentration in the fractions.

• Proceedings of the Korean Vacuum Society Conference
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• 1999.07a
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• pp.109-109
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• 1999

Recently, low energy ion beam irradiation has been adopted for surface modification. Low energy ion beam irradiation has many advantages in polymer engineering such as weak damage, good adhesion, noticeably-enhanced wettability(less than 15 degree), good reproducibility and so on. In this experiment, chemical reactions between free radicals and environment gas species have been investigated using angle-resolved XPS and TRIM code. In the case of low ion beam energy (around 1 keV), energy loss in polymer is mainly originated from atomic collisions instead of electronic interference. Atomic collisions could generated displaced atoms and free radicals. Cold cathode-ion source equipped with 5cm convex grid was used in an O2 environment. Base and working pressure were 5$\times$10-6 and 2.3$\times$10-4 Torr. Flow rates of argon and oxygen were fixed at 1.2 and 8 sccm. target materials are polyethylene polyvinyidenefluoride and polytetrafluoroethylene.

• Structural Engineering and Mechanics
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• v.73 no.4
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• pp.447-454
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• 2020

Seismic isolation technology has a wide application to protect bridges from earthquake damage, a new designed bridge pier with seismic isolation are provided for railways in seismic regions of China. The pier with rocking isolation is a self-centering system under small and moderate earthquakes, and the unbonded prestressed tendons are used to prevent overturning under strong earthquakes. A numerical model based on pseudo-static testing results is presented to evaluate the seismic performance of isolation bridge piers, and is validated by the shaking table test. It is found that the rocking response and the loss of prestressing for the bridge pier increase with the increase of earthquake intensity. Besides, the intensity and spectral characteristics of input ground motion have great influence on displacement of the top and bottom of the bridge pier, while have less influence on the bending moment of the pier bottom. Experimental and numerical results show that the rocking-isolated piers presented in this study have good seismic performance, and it provides an alternative way for the railway bridge in the regions with high occurrence of earthquakes. Therefore, we provide the detailed procedures for seismic design of the rocking-isolated bridge pier, and a case study of the seismic isolation design with rocking piers is carried out to popularize the seismic isolation methods.

• Journal of the Society of Naval Architects of Korea
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• v.47 no.5
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• pp.719-724
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• 2010

Thousands of passengers and crews are onboard a cruise ship and there are many cabins and large public spaces such as atria and theaters. Therefore it is easy to cause a huge loss of life and damage to property when accidents happen at sea. To improve the safety of passenger ships, in October 2007, IMO proposed MSC.1/Circ.1238 on guidelines for evacuation analysis and recommended its use. However, this guideline is difficult to apply because ship designers need to get many pieces of information from CAD drawings such as width and length of stairs and corridors and manually calculate the evacuation time. In this paper, for practical application of the guidelines, an evacuation time calculation program is developed using AutoCAD .NET API library and C Sharp language.

• Nutrition Research and Practice
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• v.17 no.4
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• pp.641-659
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• 2023

BACKGROUND/OBJECTIVES: The skin is the outermost organ of the human body and plays a protective role against external environmental damages, such as sunlight and pollution, which affect anti-oxidant defenses and skin inflammation, resulting in erythema or skin reddening, immunosuppression, and epidermal DNA damage. MATERIALS/METHODS: The present study aimed to investigate the potential protective effects of red orange complex H extract (ROC) against ultraviolet (UV)-induced skin photoaging in Skh:HR-2 mice. ROC was orally administered at doses of 20, 40, and 80 mg/kg/day for 13 weeks, along with UV irradiation of the mice for 10 weeks. RESULTS: ROC improved UV-induced skin barrier parameters, including erythema, melanin production, transepidermal water loss, elasticity, and wrinkle formation. Notably, ROC inhibited the mRNA expression of pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor α) and melanogenesis. In addition, ROC recovered the UV-induced decrease in the hyaluronic acid and collagen levels by enhancing genes expression. Furthermore, ROC significantly downregulated the protein and mRNA expression of matrix metalloproteinases responsible for collagen degradation. These protective effects of ROC against photoaging are associated with the suppression of UV-induced phosphorylation of c-Jun NH2-terminal kinase and activator protein 1 activation. CONCLUSIONS: Altogether, our findings suggest that the oral administration of ROC exerts potential protective activities against photoaging in UV-irradiated hairless mice.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.27 no.5
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• pp.27-40
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• 2024

Mountain ranges are crucial not only as habitats for biodiversity but also as sources of diverse ecosystem services essential to human well-being. In South Korea, the Baekdudaegan mountain range is protected for its natural and cultural significance. However, the subsidiary mountain ranges, known as Jeongmaeks, remain vulnerable to urbanization due to inadequate protection and management plans. This study aims to assess the impact of urbanization on Jeongmaek areas, utilizing the 'Environmental Impact Assessment Guideline for Baekdudaegan and Jeongmaek' to inform future management strategies. Damage was identified urbanized areas in land cover maps and EIA target areas, and loss of ecological connectivity. The results indicate that the Jeongmaeks near densely populated regions, such as the Seoul Metropolitan Area (Hannam and Hankbuk Jeongmaek), have suffered significant fragmentation, primarily due to road and rail construction. These areas should be managed as recreational zones, integrating natural parks and entertainment facilities to promote sustainable use of natural resources. Conversely, the Jeongmaeks located both near and further from urban centers, such as Nakdong and Naknam Jeongmaek, exhibit a mix of severely damaged and well-preserved areas. For these regions, a balanced management approach that integrated both conservation and sustainable use in recommended to ensure ecological resilience.