• 한국산림과학회지
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• 제99권3호
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• pp.432-438
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• 2010

인공산성비 처리와 목초액 처리가 토양 화학적 성질, 인동덩굴(Lonicera japonica)의 뿌리와 엽내 이온함량 변화 및 생장에 미치는 영향을 알아보기 위하여 다양한 수준의 인공산성비(pH 5.6, 4.5, 3.5, 2.5)와 대조구(pH 6.3)로 구분하여 6월에서 10월까지 150일간 주 2회씩 총 30회에 걸쳐 처리하였고, 목초액을 500배로 희석하여 2주 1회씩 총 10회에 걸쳐 처리하였다. 인공산성비의 pH가 낮아질수록 토양 pH는 감소하였고, 유기물함량, 전 질소, 유효인산은 증가하는 경향이었지만, 목초액을 처리하였을 때 토양 개선효과는 미비한 것으로 나타났다. 식물체의 성분은 인공산성비 처리에 의해 $SO_4{^2}$와 $NO_3{^-}$가 증가하였으며 목초액 처리구에서는 증가 폭이 감소하였다. 또한 양이온은 인공산성비의 pH 에 따라 증가하는 경향이 나타났으며, 뿌리 보다는 잎에서 더 높게 나타났다. 인공산성비 처리 후 조기 낙엽과 생장저해가 나타났으나 목초액 처리 후 생장량이 증가하였다.

• 대한본초학회지
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• 제23권2호
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• pp.51-58
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• 2008

Objectives : Trimellitic anhydride (TMA), a sensitizer that induces occupational asthma and atopic dermatitis, is widely used industrially to make epoxy and alkyd resins, plasticizers, high temperature polymer, and surfactants. The aim of this study was to investigative the effects of aqueous extracts of Lonicera japonica Flower(LJFAE) on TMA-induced contact hypersensitivity (CHS) in Balb/c mice. Methods : The dried flowers of L. japonica were extracted with distilled water at $100^{\circ}C$ for 7 h. The extract was freeze-dried following filteration through 0.45 ${\mu}m$ filter. Mice were orally administrated with or without LJFE of a different doses(25-100 mg/kg) for 28 days. In the challenge period, mice were externally applied at difference doses of LJFAE one time per day 30 min before TMA treatment. We examined the effects of LJFAE on the the serum levels of IgE and prostagladin E2 (PGE2), the Thl/Th2 cytokine production of spleen cells, ear swelling responses, and the leukocyte infiltration induced by TMA. Results : The orally and externally administration of LJFAE dose-dependently reduced the serum levels of IgE and PGE2 production as well as ear swelling responses and leukocyte infiltration in TMA-induced Balb/c mice. Furthermore, the levels of Thl (TNF-${\alpha}$, IFN-${\gammer}$, IL-2)/Th2 (IL-4, IL-5, IL-13) cytokine production from spleen cells stimulated with anti-CD3 and CD28 mAbs was markedly suppressed by the orally and externally treatment with LJFAE in a concentration dependent manner. Conclusions : These results suggest that LJFAE suppresses the inflammatory mediators and regulates the Thl/Th2 cytokines. Therefore, these properties may contribute to the strong anti-CHS response effect of LJFAE.

• Biomolecules & Therapeutics
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• 제21권1호
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• pp.66-71
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• 2013

Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and L. japonica was found to exert strong anti-inflammatory activity against several animal models of inflammation, especially against an animal model of acute bronchitis. In the present investigation, the effects of BL on animal models of septic inflammation and chronic bronchitis are examined. Against lipopolysaccharide (LPS)-induced septic inflammation in mice, BL (200-400 mg/kg) reduced the induction of some important proinflammatory cytokines. At 1 h after LPS treatment, BL was found to considerably inhibit TNF-${\alpha}$ production when measured by cytokine array. At 3 h after LPS treatment, BL inhibited the induction of several proinflammatory cytokines, including IFN-${\gamma}$ and IL-$1{\beta}$, although dexamethasone, which was used as a reference, showed a higher inhibitory action on these biomarkers. Against chronic bronchitis induced by LPS/elastase instillation in rats for 4 weeks, BL (200-400 mg/kg/day) significantly inhibited cell recruitment in bronchoalveolar lavage fluid. Furthermore, BL considerably reduced lung injury, as revealed by histological observation. Taken together, these results indicate that BL may have a potential to treat systemic septic inflammation as well as chronic bronchitis.

• 농약과학회지
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• 제4권2호
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• pp.18-20
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• 2000

민들레(Teraxacum platycerpum leaf), 소나무(Pinus densiflora leaf), 쑥(Artemisia prinseps, leaf), 부추(Allium tuberosum leaf), 결명초(Cassia obtussifolia, whole plant), 고삼(Sophora angestifolia, root), 백부근(Stemonae sessilifolia, root), 인동(Lonicera japonica, stem, leaf, flower) 및 귤(Clivia miniata, left)등 9종의 자생식물(시료11종)의 메탄올 추출물이 흰줄숲모기와 바퀴에 대한 기피효과 실험을 실행하였다. 그결과 흰줄숲모기에 대해서는 소나무잎 민들레잎 부추 잎 및 인동꽃 등의 메탄올 추출물이 기피효과가 우수하였다. 한편 바퀴에 대한 이들의 기피효과에서는 인동잎이 좋았으나 일반적으로 흰줄숲모기에 비해 기피효과가 떨어졌다.

• 한방안이비인후피부과학회지
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• 제28권3호
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• pp.1-13
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• 2015

Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.Methods : We investigated the anti-inflammatory effects of water extracts fromLonicera japonicaandScutellaria baicalensisin lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1${\beta}$, TNF-${\beta}$, and PGE₂) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-${\kappa}B$-DNA complex of NF-${\kappa}B$ binding activity and translocation of NF-${\kappa}B$ from cytosol to nucleus.Conclusions : Our study suggest that the combination of water-extractable components ofL. japonicaandS. baicalensismay be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.

• 동의생리병리학회지
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• 제21권5호
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• pp.1087-1091
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• 2007

In order to obtain practical application of Yiyiren-tang against gout disease, water extract of modified Gami-Yiyiren-tang(GYYT) added with Lonicera japonica is prepared through decoction and freeze drying. The effects were evaluated with blood sample from ICR mice treated with MSU intra-peritoneal injection 1 time a day, 3 days consecutively. The results were as follows. GYYT decreased C-reactive protein level and HDL cholesterol levels. But the creatinine, the LDL cholesterol levels, triglyceride and uric acid levels were not changed were decreased significantly. These results show that GYYT can be used effectively against the urate-related gout disease. But not better than effects of the Gami-daehwangmokdan-tang.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.256.2-257
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• 2002

Intestinal epithelial cells can produce cytokines and chemokines that play an important role in the mucosal immune response. Regulation of this secretion is important to prevent inflammatory tissue damage. Lonicera japonica have been shown to inhibit inflammation. We tested the effect of luteolin, a major ingredient of Lonicera japonica, on TNF-${\alpha}$-stimulated IL-8 secretion from lntestinal epithelial cells. (omitted)

• 동의생리병리학회지
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• 제21권2호
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• pp.399-403
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• 2007

In order to obtain practical application of Daehwangmokdan-tang gout disease, water extract of Gami-daehwangmokdan-tang(GDMT) added with Lonicera japonica is prepared through decoction and freeze drying. The effects were evaluated with blood sample from ICR mice treated with MSU intra-peritoneal injection 1 time a day, 3 days consecutively. The results were as follows. GDMT decreased BUN, creatinine and C-reactive protein level in serum significantly. But the HDL and LDL cholesterol levels were not changed in spite of positive tendency in HDL cholesterol. Triglyceride and uric acid levels were decreased significantly too. These results show that GDMT can be used effectively against the urate-related gout disease.

• Archives of Pharmacal Research
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• 제8권1호
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• pp.42-44
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• 1985

Polysaccharides were isolated with alkaline extraction method from twelve pharmaceutical plants, which have been used against the various tumors in the oriental herb medicine, and examined for their antitumor activities. When the polysaccharides were administered i. p. at the dose of 10mg/kg/day for ten consecutive days to the male ICR mice, which had been implanted with $1{\times}10^{6}$ cells of sarcoma 180 twentyfour hours before the first injection of polysaccharides, those from Forsythia Corea, Curcuma, Zedoaria, Albizzia Julibrissin, Prunuts Persica, Foeniculum Vlugare and Daphne Pseudogenkwa showed inhibition ratios of 88.0%, 61.1%m 73.0%, 72.8% 55.1% and 71.7%. The significant prolongation of life span was observed only in the case of Forsythia Corea (18.1%). Other six polysaccharide fractions from Olibanum, Lonicera Japonica, Rheum Coreanum, Scirpus Maritimus, Gleditchia Officinalis and Brassica Juncea showed negligible inhibition ratios.

• 한국환경과학회지
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• 제14권8호
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• pp.719-722
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• 2005

This study is to find the effective way to green perpendicular wall spaces as soon as possible and to get basic data for activating the perpendicular greening on high story building through the experiment of container-type planting ground in which lightened artificial soil mixed with rock wool was put. Comparative studies of the sizes of containers and soil were carried out but separate management was not performed. Four plants(Euonymus fortunei var. radicans, Lonicera japonica, Parthenocissus quinquefolia, Parthenocissus tricuspidata) which have the capability to cover and screen perpendicular spaces were used in the experiment. In result, a container must be equipped with over 15cm depth soil mixed with less than $30\%$ of rock wool.