Effects of Modified Gami-Yiyiren-tang on the Gout Induced ICR Mice

가마의이인탕이 통풍유발 흰쥐에 미치는 영향

  • Eom, Hyun-Sup (Department of Pathology, College of Oriental Medicine, Dongeui University)
  • 엄현성 (동의대학교 한의과대학 병리학교실)
  • Published : 2007.10.25

Abstract

In order to obtain practical application of Yiyiren-tang against gout disease, water extract of modified Gami-Yiyiren-tang(GYYT) added with Lonicera japonica is prepared through decoction and freeze drying. The effects were evaluated with blood sample from ICR mice treated with MSU intra-peritoneal injection 1 time a day, 3 days consecutively. The results were as follows. GYYT decreased C-reactive protein level and HDL cholesterol levels. But the creatinine, the LDL cholesterol levels, triglyceride and uric acid levels were not changed were decreased significantly. These results show that GYYT can be used effectively against the urate-related gout disease. But not better than effects of the Gami-daehwangmokdan-tang.

Keywords

References

  1. 林珮琴. 類證治裁. 서울, 성보사, p 336, 1980
  2. 林準圭,申鉉大 편저. 東洋物理療法科學. 서울, 고문사, pp 272-273, 1986
  3. Harrisons 내과학. 해리슨내과학편찬위원회. 도서출판정담, pp 2251-2261, 1997
  4. 이문호. 내과학. 서울 박애출판사, pp 2304-2317, 1977
  5. 김중배, 지규용, 엄현섭. 대황목단탕의 요산지표 개선효과와 관련 유전자 탐색. 동의생리병리학회지 19(6):1534-1540, 2005
  6. 엄현섭. 가미대황목단탕이 통풍유발 휜쥐에 미치는 영향. 동의생리병리학회지 21(2):3994-3403, 2007
  7. Talke, H., Schubert, G.E., Klin. Wschr. 43, p 1974, 1965
  8. Jaffe, M., Uber den Niederschlag, welchen pikrin saure in normalen harn erzeugt und Uber eine Reaktion eskreugtinines Hoppe seylers Z. Physio. Chem. pp 391-400, 1980
  9. Patterson, L.T., Higginbotham, R.D. Mouse C-Reactive Protein and Endotoxin-Induced Resistance. J Bacteriol. 90(6):1520-1524, 1965
  10. Allain, C.C., Poon, L.S., Chan. C.G.S., Richmond. W., Fu. P.C. Enzymatic determination of total serum cholesterol Cli. Chem. 20(4): 1974
  11. Nagele, U., Haaagele, E.O. et al, J. Chin. Chem. Biochem. 22: 165-174, 1984
  12. Trinder, P. Dertermination of glucose in blood using gluse oxidase with an alternativeoxy-gen-acceptor, Ann. clin. Biochem, 6: 24, 1969 https://doi.org/10.1177/000456326900600108
  13. Trinder, P. Dertermination of glucose in blood using gluse oxidase with an alternativeoxy-gen-acceptor, Ann, Clin. Biochem, 6: 24, 1969 https://doi.org/10.1177/000456326900600108
  14. 孫思邈. 千金要方. 서울, 대성문화사, p 418, 1989
  15. 薛己. 문연각사고전서 薛氏醫案. 서울, 여강출판사, 제736책, p 324, 1988
  16. 陳實功. 외과정종, 북경, 인민위생출판사, p 164, 1964
  17. 신민교. 임상본초학. 서울, 영림사, p 578, 1991
  18. 신민교. 임상본초학. 서울, 영림사, p 464, 1991
  19. 이상인. 본초학. 서울, 수서원, p 288, 304, 1982
  20. 전국한의과대학 본초학교수 공편저. 本草學. 영림사, p 243, 1998