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http://dx.doi.org/10.6114/jkood.2015.28.3.001

Study on the Anti-inflammatory Effects of the Remedy Prescripted with Lonicera japonica and Scutellaria baicalensis Radix in U937 cells  

Lee, Yong-Suk (College of Korean Medicine, Wonkwang University)
Jung, Myung (Professional Graduate School of Korean Medicine, Wonkwang University)
Lim, Kyu-Sang (Professional Graduate School of Korean Medicine, Wonkwang University)
Yun, Yong-Gab (College of Korean Medicine, Wonkwang University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.28, no.3, 2015 , pp. 1-13 More about this Journal
Abstract
Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.Methods : We investigated the anti-inflammatory effects of water extracts fromLonicera japonicaandScutellaria baicalensisin lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1${\beta}$, TNF-${\beta}$, and PGE2) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-${\kappa}B$-DNA complex of NF-${\kappa}B$ binding activity and translocation of NF-${\kappa}B$ from cytosol to nucleus.Conclusions : Our study suggest that the combination of water-extractable components ofL. japonicaandS. baicalensismay be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
Keywords
Lonicera japonica; Scutellaria baicalensis; Tumor necrosis factor-alpha(TNF-α); prostaglandin E2(PGE2); nitric oxide(NO);
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