• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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• pp.980-981
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• 2008

This study was carried out to research antimicrobial agents from medicinal plants, Lonicera japonica, Pinellia ternata, Dictamnus albus, Cryptotympana pustulata, Pinus densiflora, Bupleurum falcatum, Forsythia saxatilis, Castanea crenata, Hovenia dulcis, Prunus sargentii. The ethanol extracts of 10 medicinal plants were tested for the antimicrobial activity against Streptococcus mutans. The extracts of Pinus densiflora showed significant antimicrobial activity against Streptococcus mutans. These results suggested that the extract from Pinus densiflora could be a candidate for new antimicrobial agents against Streptococcus mutans.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 춘계학술발표회
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• pp.140-141
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• 2008

• 한국식물병리학회지
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• 제10권3호
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• pp.181-191
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• 1994

Occurrence of diseases in economic resource plants in Korea is poorly known. This paper reports short descriptions on symptom, occurrence condition, pathogen, and some phytopathological notes for each 10 fungal plant diseases new to Korea; leaf spot of Rosa multiflora with Seimatosporium discosioides causing leaf spot and defoliation, leaf blight of Equisetum arvense with Titaeospora equiseti causing leaf spot to leaf blight, leaf blight of Setaria viridis with Phyrenochaeta setariae causing leaf spot of Aster tataricus with Septoria astericola causing leaf spot and black spot, powdery mildew of Clematis fusca var. coreana with Erysiphe ranunculi causing powdery mildew and dwarfing, powder mildew of Ligularia stenocephala with Erysiphe galeopsidis causing powdery mildew and dwarfing, powdery mildew of Phlox subulata with Erysiphe cichoracearum causing powdery mildew and defoliation tar spot of Lonicera japonica with Rhytisma lonicericola causing tar spot and dwarfing, white rust of Pharbitis nil with Albugo ipomoeae-pandulatae causing white rust and deformation, and white rust of Achyranthes japonica with Albugo achyranthis causing white rust and defoliation.

• 한국식품영양학회지
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• 제34권5호
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• pp.545-552
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• 2021

HAE-06 extract is a mixture of four medicinal plants, namely Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), and Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum). The HAE-06 extract demonstrated a concentration-dependent relaxing effect and enhanced cAMP production in bronchial smooth muscle that had been stimulated to contract with acetylcholine. Using a blocker, it was confirmed that the effect was through the β2-adrenergic receptor/cAMP/PKA pathway. In addition, it is thought that the HAE-06 extract has a bronchial smooth muscle relaxation effect by reducing the inflow of Ca²⁺ through the K⁺ and Ca²⁺ channels present in the sarcoplasmic membrane. If research continues in the future, it is believed that it will be possible to use it as a material for pharmaceuticals and functional foods.

• 동의생리병리학회지
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• 제24권4호
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• pp.630-637
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• 2010

The object of this study was to evaluate the effect of Lonicerae Flos, aqueous extracts of the dried flower bud part of Lonicera japonica on the 6-n-propyl-2-thiouracil (PTU)-induced rat hypothyroidism. Aqueous extracts of Lonicerae Flos (LF yield = 23.80%) were administered, once day for 42 days from 2 weeks before start of PTU treatment as an oral dose of 500 and 250 mg/kg (body weight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for 28 days. The changes on the body weight, thyroid gland weights, serum thyroid hormone - thyroid stimulating hormone (TSH), tri-iodothyronine ($T_3$) and thyroxine ($T_4$), serum lipid profiles - total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride were observed with liver antioxidant defense system - lipid peroxidation, $H_2O_2$, superoxide dismutase (SOD) and catalase (CAT) and serum asparte aminotransferase (AST) and alanine aminotransferase (ALT) analysis. Results were compared with Levothyroxine ($LT_4$) 0.5 mg/kg treated rats. As results of PTU treatment, marked decreases of body weights, serum thyroid hormone levels and triglyceride contents, liver $H_2O_2_3$ and SOD activities were observed with increases of serum AST and HDL contents, liver CAT activities, thyroid gland weight. However, these PTU induced hypothyroidism were dose-dependently inhibited by treatment of LF extracts, and LF extracts effectively regulated the hypothyroidism related changes on the antioxidant defense system. The results obtained in this study suggest that LF extracts have favorable effects on the thyroid hormone productions with beneficial effects on the hypothyroidism mediated by the modulatory effects on the antioxidant defense system.

• 한국응용곤충학회지
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• 제39권1호
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• pp.5-12
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• 2000

임의증폭 다형 DNA(RAPD)와 미토콘드리아 12S, 16S rRNA 유전자의 제한단편 DNA 표식자에 의해 한국에서 발생하는 담배가루이 개체군들의 biotype을 판별하였다. 진천의 장미 온실과 서울 내곡동의 포인세티아 온실에서 발생한 담배가루이는 일본, 이스라엘, 호주의 B biotype 과 동일한 DNA 단편들을 보유하였다. 여러 지역의 노지 콩 (Glycine max), 고구마 (Ipomea batatas), 들깨 (Perilla frutescens)에서 채집된 담배가루이 개체군들은 일본 시코쿠의 인동덩굴(Lonicera japonica)에서 채집된 담배가루이와 같은 DNA로 표식되었다. 이들 non-B biotype은 한국, 일본 등 극동아시아 지역에 고유한 계통으로 보인다. 최근 한국에서 발견된 담배가루이 Bemisia tabaci(Gennadius)의 주사전자현미경 관찰에 의한 형태적 특정을 온실 원예작물의 주요해충인 온실가루이 Trialeurodes vaporariorum (Westwood)와 비교하여 기재하였다.

• Archives of Pharmacal Research
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• 제29권4호
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• pp.282-286
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• 2006

Ochnaflavone is a medicinal herbal product isolated from Lonicera japonica that inhibits cyclooxygenase-2 (COX-2) dependent phases of prostaglandin $D_2(PGD_2)$ generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with $IC_{50}$ values of $0.6{\mu}M$. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the $PGD_2$ product was accompanied by a decrease in the COX-2 protein level. In addition, this compound consistently inhibited the production of leukotriene $C_4 (LTC_4)$ in a dose dependent manner, with an $IC_{50}$ value of $6.56 {\mu}M$. These results demonstrate that ochnaflavone has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound strongly inhibited degranulation reaction in a dose dependent manner, with an $IC_{50}$ value of $3.01{\mu}M$. Therefore, this compound might provide a basis for novel anti-inflammatory drugs.

• 동의생리병리학회지
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• 제36권2호
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• pp.66-72
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• 2022

Flos Lonicerae Japonicae (the flower buds of Lonicera japonica Thunberg) has been used as an antibacterial and antiviral drug in Korean Medicine. The aim of this study is to evaluate the effect of Flos Lonicerae Japonicae water extract (FL) on the production of cytokines in RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS). After 24 h treatment, the production of various cytokines from RAW 264.7 was measured with multiplex cytokine assay using Bio-Plex 200 suspension array system. FL at concentrations of 50, 100, and 200 ㎍/mL significantly inhibited productions of tumor necrosis factor-α, macrophage inflammatory protein (MIP)-1β, and MIP-2 in LPS-stimulated RAW 264.7 cells; FL at concentrations of 100 and 200 ㎍/mL significantly inhibited productions of leukemia inhibitory factor, LIX (CXCL5), and RANTES in LPS-stimulated RAW 264.7 cells; FL at concentrations of 200 ㎍/mL significantly inhibited productions of granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor in LPS-stimulated RAW 264.7 cells; FL at concentrations of 50 and 100 ㎍/mL significantly increased productions of interleukin (IL)-10 in LPS-stimulated RAW 264.7 cells; FL at concentrations of 50, 100, and 200 ㎍/mL significantly increased productions of IL-6 and interferon gamma-induced protein-10 in LPS-stimulated RAW 264.7 cells; FL at concentrations of 100 and 200 ㎍/mL significantly increased productions of monocyte chemoattractant protein-1 in LPS-stimulated RAW 264.7 cells. Taken together, these data mean that FL might modulate productions of cytokines, chemokines, and growth factor in LPS-stimulated macrophages. Further study needs to verify the exact mechanism for modulatory activities of FL with macrophages.

• 한국가금학회지
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• 제35권1호
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• pp.1-7
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• 2008

Coptis japonica Makino (황련, 48.5%), Lonicera japonica Thunb (금은화, 48.5%), Morus alba L. (상엽, 3%)를 혼합한 복합 한약재의 급여가 생산된 계란의 냉장 저장 중 일반 성분 및 물리적 특성에 미치는 영향을 조사하였다. 28주령의 Lohmann Brown 108수를 3가지 처리(복합 한약재 0, 0.3 및 1%), 6반복으로 완전 임의 배치한 후 6주간 급여하고 생산된 계란을 수거하여 $4^{\circ}C$ 냉장 저장하면서 일반 성분, 색도 및 조직감 등을 관찰하였다. 복합 한약재를 급여하여 생산된 계란은 수분, 단백질, 지방 및 무기물의 함량 차이가 없었으며 삶은 계란에서 3일차 적색도($a^*$-value) 및 황색도($b^*$-value)를 제외하고는 처리간 색도의 차이가 없었다. 그러나 저장 기간동안 처리구와 상관없이 적색도와 황색도가 증가하였다. 전체적인 조직감 측정에서도 복합 한약재 급여 처리는 14일차 탄성(springness)을 제외하고는 차이가 나타나지 않았다. 다만 계란의 저장기간에 따른 조직감의 차이는 보여 탄성과 검성(gumminess)는 저장기간이 늘어나면서 감소하는 것으로 나타났다. 결과적으로 복합 한약재의 급여는 생산된 계란의 일반 성분이나 색도, 조직감 특성에서 대조구와 큰 차이가 없는 것으로 판단되며, 이는 합성 항생제를 대체를 위한 복합 한약재의 첨가를 산업적으로 적용할 때 계란의 물리화학적 품질에 큰 영향이 없을 것으로 사료된다.

• The Korean Journal of Ecology
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• 제27권6호
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• pp.335-345
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• 2004

우리나라 공업단지 중 화학비료를 생산하고 있는 온산공단주변의 해송림이 쇠퇴된 이후 그곳에 덩굴식물류의 우점현상을 평가하기 위하여 식생조사를 실시하였다. 하층식생에 덩굴식물류의 중요치는 청미래덩굴(Smilax china)이 13.2로 가장 높았으며, 인동(Lonicera japonica)이 11.7, 계요등(Paederia scandens) 11.5, 댕댕이덩굴(Cocclus trilobus)이 7.7의 순으로 높아 대기오염으로 인한 생태계 훼손지역의 1차 식생으로 나타남을 알 수 있었다. 각 조사지별 목본류의 종수와 종다양도, 최대종다양도, 균재도, 우점도를 층위별로 나타낸 결과상층, 중층 식생에서는 종수, 종다양도, 최대종다양도, 균재도, 우점도가 산림지역이 공단지 역보다 높게 나타나 공단 주변 식생의 단순함을 보였으며, 하층 식생에서는 공단지역이 산림지역보다 높게 나타났는데 이는 덩굴식물이 차지하고 있는 비율이 높은 것이 원인인 것 같다. 초본류 조사에서는 총 59종이 출현하였으며, 고사리, 기름새, 닭의장풀, 미국자리공, 멍석딸기, 억새, 실새풀 등에서 중요치가 높아 대기오염지역의 우점종으로 나타났으며, 종수, 종다양도, 최대종다양도, 균재도, 우점도에서는 지역간의 구분이 뚜렷하게 나타나지는 않았지만 공단지역이 산림지역보다는 덩굴식물의 분포가 높게 나타났다. 이는 인접한 경기화학의 영향으로 상층식생의 쇠퇴에 따른 광조건에 의하여 열대성 식물인 덩굴식물이 우점종으로 나타나 생태계의 교란으로 인한 사막화 현상에 응용할 수 있을 것으로 생각된다.