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http://dx.doi.org/10.9799/ksfan.2021.34.5.545

Effect of Natural Product Complex Extract (HAE-06) on Bronchial Dilation  

Kim, Dae Sung (Dept. of Research, Hanpoong Pharm & Foods Co.)
Kim, Hye Yoom (Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University)
Publication Information
The Korean Journal of Food And Nutrition / v.34, no.5, 2021 , pp. 545-552 More about this Journal
Abstract
HAE-06 extract is a mixture of four medicinal plants, namely Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), and Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum). The HAE-06 extract demonstrated a concentration-dependent relaxing effect and enhanced cAMP production in bronchial smooth muscle that had been stimulated to contract with acetylcholine. Using a blocker, it was confirmed that the effect was through the β2-adrenergic receptor/cAMP/PKA pathway. In addition, it is thought that the HAE-06 extract has a bronchial smooth muscle relaxation effect by reducing the inflow of Ca2+ through the K+ and Ca2+ channels present in the sarcoplasmic membrane. If research continues in the future, it is believed that it will be possible to use it as a material for pharmaceuticals and functional foods.
Keywords
natural product complex extract; HAE-06; bronchial dilation;
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