The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Natural Product Complex Extract (HAE-06) on Bronchial Dilation

천연물 복합 추출물 (HAE-06)의 기관지 확장에 미치는 영향

  • Kim, Dae Sung (Dept. of Research, Hanpoong Pharm & Foods Co.) ;
  • Kim, Hye Yoom (Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University)
  • 김대성 (한풍제약 연구부) ;
  • 김혜윰 (원광대학교 한방심신증후군연구센터)
  • Received : 2021.09.10
  • Accepted : 2021.10.14
  • Published : 2021.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

HAE-06 extract is a mixture of four medicinal plants, namely Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), and Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum). The HAE-06 extract demonstrated a concentration-dependent relaxing effect and enhanced cAMP production in bronchial smooth muscle that had been stimulated to contract with acetylcholine. Using a blocker, it was confirmed that the effect was through the β2-adrenergic receptor/cAMP/PKA pathway. In addition, it is thought that the HAE-06 extract has a bronchial smooth muscle relaxation effect by reducing the inflow of Ca2+ through the K+ and Ca2+ channels present in the sarcoplasmic membrane. If research continues in the future, it is believed that it will be possible to use it as a material for pharmaceuticals and functional foods.

Keywords

Acknowledgement

본 논문은 (유)한풍제약을 통하여 HEA-06 시료 및 분석자료를 제공받아 실험을 진행 했으며, 한국연구재단(NRF-2019R1I1A3A01062432)의 연구비를 지원을 받았습니다.

References

  1. Al-Majed AA, Bakheit AHH, Abdel Aziz HA, Alajmi FM, AlRabiah H. 2017. Propranolol. In Brittain HG (Ed.), Profiles of Drug Substances, Excipients and Related Methodology, volume 42. pp.287-338
  2. Akopov AL, Aleksandrova EB, Il'kovich MM, Petrov DV, Trofimov VI. 2015. Rengalin, a new efficacious and safe antitussive agent. Results of a randomized, com- parative, multicenter clinical trial in patients with acute respiratory tract infections. Antibiot Khimioter 60:19-26
  3. Bae J, Lee M, Lee S. 2005. Antimicrobial effect of Cutellaria baicalensis George extracts on food-borne pathogens. Kor J Micribiol Biotechnol 33:35-40
  4. Barisione G, Baroffio M, Crimi E, Brusasco V. 2010. Beta-adrenergic agonists. Pharmaceuticals 3:1016-1044 https://doi.org/10.3390/ph3041016
  5. Brandsma CA, Van den Berge M, Hackett TL, Brusselle G, Timens W. 2020. Recent advances in chronic obstructive pulmonary disease pathogenesis: From disease mechanisms to precision medicine. J Pathol 250:624-635 https://doi.org/10.1002/path.5364
  6. Cazzola M, Page CP, Calzetta L, Matera MG. 2012. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev 64:450-504 https://doi.org/10.1124/pr.111.004580
  7. Coultrap SJ, Bayer KU. 2014. Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII). J Biol Chem 289:19458-19465 https://doi.org/10.1074/jbc.M114.558254
  8. Dasgupta A, Neighbour H, Nair P. 2013. Targeted therapy of bronchitis in obstructive airway diseases. Pharmacol Ther 140:213-222 https://doi.org/10.1016/j.pharmthera.2013.07.001
  9. Delmotte P, Sieck GC. 2015. Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca2+ regulation in airway smooth muscle (ASM). Can J Physiol Pharmacol 93:97-110 https://doi.org/10.1139/cjpp-2014-0361
  10. Ehlert FJ. 2003. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci 74:355-366 https://doi.org/10.1016/j.lfs.2003.09.023
  11. Farah OR, Li D, McIntyre BAS, Pan J, Belik J. 2009. Airway epithelial-derived factor relaxes pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol 296:L115-L120 https://doi.org/10.1152/ajplung.90391.2008
  12. Ishii M, Kurachi Y. 2006. Muscarinic acetylcholine receptors. Curr Pharm Des 12:3573-3581 https://doi.org/10.2174/138161206778522056
  13. Insel PA, Ostrom RS. 2003. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol 23:305-314 https://doi.org/10.1023/A:1023684503883
  14. Jeong YT, Jeong SC, Hwang JS, Kim JH. 2015. Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis. Chem Biol Interact 238:33-39 https://doi.org/10.1016/j.cbi.2015.05.022
  15. Kim SH. 2010. Antitussives, mucolytic agents and expectorants in clinical practice. Korean J Med 78:682-686
  16. Kim V, Criner GJ. 2013. Chronic bronchitis and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 187:228-237 https://doi.org/10.1164/rccm.201210-1843CI
  17. Kitsiopoulou E, Hatziefthimiou AA, Gourgoulianis KI, Molyvdas PA. 2007. Resting tension affects eNOS activity in a calcium-dependent way in airways. Mediators Inflamm 2007:024174
  18. Kume H, Nishiyama O, Isoya T, Higashimoto Y, Tohda Y, Noda Y. 2018. Involvement of allosteric effect and KCa channels in crosstalk between β2-adrenergic and muscarinic M2 receptors in airway smooth muscle. Int J Mol Sci 19:1999 https://doi.org/10.3390/ijms19071999
  19. Lee SG, Jeong HJ, Lee EJ, Kim JB, Choi SW. 2011. Antioxidant and anti-inflammatory activities of ethanol extracts from medicinal herb mixtures. Korean J Food Sci Technol 43:200-205 https://doi.org/10.9721/KJFST.2011.43.2.200
  20. Lourenco LO, Ramos Lopes AC, Zavan B, Soncini R. 2020. Vagotomy influences the lung response to adrenergic agonists and muscarinic antagonists. Respir Physiol Neurobiol 274:103358 https://doi.org/10.1016/j.resp.2019.103358
  21. Matera MG, Page CP, Calzetta L, Rogliani P, Cazzola M. 2020. Pharmacology and therapeutics of bronchodilators revisited. Pharmacol Rev 72:218-252 https://doi.org/10.1124/pr.119.018150
  22. Rabe KF, Watz H. 2017. Chronic obstructive pulmonary disease. Lancet 389:1931-1940 https://doi.org/10.1016/S0140-6736(17)31222-9
  23. Ritchie AI, Wedzicha JA. 2020. Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations. Clin Chest Med 41:421-438 https://doi.org/10.1016/j.ccm.2020.06.007
  24. Semenov I, Brenner R. 2018. Voltage effects on muscarinic acetylcholine receptor-mediated contractions of airway smooth muscle. Physiol Rep 6:e13856 https://doi.org/10.14814/phy2.13856
  25. Shin HY, Kim H, Shin JY, Lee SJ, Yu KW. 2021. The physiological activity of crude polysaccharide solvent extracted from herbal medicine mixture. Korean J Food Nutr 34:36-46 https://doi.org/10.9799/KSFAN.2021.34.1.036
  26. Stamatiou K, Pierris N. 2013. Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study. Arch Ital Urol Androl 85:190-196 https://doi.org/10.4081/aiua.2013.4.190
  27. Taouil K, Hinnrasky J, Hologne C, Corlieu P, Klossek JM, Puchelle E. 2003. Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway. J Biol Chem 278:17320-17327 https://doi.org/10.1074/jbc.M212227200
  28. Townsend EA, Sathish V, Thompson MA, Pabelick CM, Prakash YS. 2012. Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A. Am J Physiol Lung Cell Mol Physiol 303:L923-L928 https://doi.org/10.1152/ajplung.00023.2012
  29. Vanhoutte PM. 2013. Airway epithelium-derived relaxing factor: Myth, reality, or naivety? Am J Physiol Cell Physiol 304:C813-C820 https://doi.org/10.1152/ajpcell.00013.2013
  30. Wasilewski NV, Lougheed MD, Fisher JT. 2014. Changing face of β2-adrenergic and muscarinic receptor therapies in asthma. Curr Opin Pharmacol 16:148-156 https://doi.org/10.1016/j.coph.2014.05.007
  31. Williams DM, Rubin BK. 2018. Clinical pharmacology of bronchodilator medications. Respir Care 63:641-654 https://doi.org/10.4187/respcare.06051
  32. Woo IT, Park KN, Lee SH. 2007. Antimicrobial activities of Scutellaria baicalensis Georgi against various pathogens and spoilage bacteria isolated from Tofu. J Korean Soc Food Sci Nutr 36:470-475 https://doi.org/10.3746/JKFN.2007.36.4.470
  33. Yoon WH. 2013. Genotoxicological safety evaluation of the solvent extracts for medicinal herbs that are of highly domestic spendings. Korean J Food Nutr 26:814-823 https://doi.org/10.9799/KSFAN.2013.26.4.814
  34. Zhang WC, Peng YJ, Zhang GS, He WQ, Qiao YN, Dong YY, Gao YQ, Chen C, Zhang CH, Li W, Shen HH, Ning W, Kamm KE, Stull JT, Gao X, Zhu MS. 2010. Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J Biol Chem 285:5522-5531 https://doi.org/10.1074/jbc.M109.062836