• Biomolecules & Therapeutics
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• v.2 no.3
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• pp.247-255
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• 1994

As a series of safety studies of DA-3030, a new rhO-CSF, its local irritancy was examined in the rabbits after the following treatment; application into the conjunctival sac of the eye(single), subcutaneous injection(single), intramuscular injection(single), and intravenous injection(8-day repeated). In addition, paravenous irritation of DA-3030 was investigated in mice. The results obtained were as follows. 1. In the result of ocular irritation test, 0.03% solution of DA-3030 could be considered as a non-irritating material. 2. The local irritation of DA-3030 by an injection of 0.5mι of its solution subcutaneously or intramuscularly was negligible and not so much different from that of saline. 3. In the vascular irritancy test, macro- and microscopic observations revealed that the irritating activity of DA-3030 in blood vessels was not different from that of saline when they were injected once a day into vein retroauricularis of rabbits for 8 days.4. The paravenous administration of DA-3030 did not induce any abnormal changes at injection sites except mild swelling in 1 mouse at 3 hours after injection which was thought to be due to slow absorption. The above-mentioned results suggest that DA-3030 has no irritating activity when injected through intravenous or subcutaneous route for clinical practice as 0.03% solution.

• Journal of Advanced Marine Engineering and Technology
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• v.15 no.4
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• pp.46-53
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• 1991

In the present study, Navier-Stokes equation is numerically solved by use of a Finite analytic method to obtain the 2-dimensional flow field in the square cavity. The basic idea of F.A.M. is the incorporation of local analytic solutions in the numerical solution of linear or non-linear partial differential equations. In the F.A.M., the total problem is subdivided into a number of all elements. The local analytic solution is obtained for the small element in which the governing equation, if non-linear, to be linearized. The local analytic solutions are then expressed in algebraic form and are overlapped to cover the entire region of the problem. The assembly of these local analytic solutions, which still preserve the overall nonlinearity of the governing equations, results in a system of linear algebraic equations. The system of algebraic equations is then solved to provide the numerical solutions of the total problem. The computed flow field shows the same characteristics to physical concept of flow phenomena.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.8 s.185
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• pp.89-99
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• 2006

In this paper a new shape reconstruction method that allows us to construct surface models from very large sets of points is presented. In this method the global domain of interest is divided into smaller domains where the problem can be solved locally. These local solutions of subdivided domains are blended together according to weighting coefficients to obtain a global solution using partition of unity function. The suggested approach gives us considerable flexibility in the choice of local shape functions which depend on the local shape complexity and desired accuracy. At each domain, a quadratic polynomial function is created that fits the points in the domain. If the approximation is not accurate enough, other higher order functions including cubic polynomial function and RBF(Radial Basis Function) are used. This adaptive selection of local shape functions offers robust and efficient solution to a great variety of shape reconstruction problems.

• Journal of Digital Contents Society
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• v.10 no.3
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• pp.401-411
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• 2009

This study focused on the crisis of local private broadcasting and political solution. The local private broadcasting has launched in 1995. Until now, local private broadcasting is successful in stable management and ensuring profit but it is attributed to a role of transmission pipe of SBS. However, this kind of syndication system has been a major problem of local private broadcasting and local private broadcasting has become weak and weak from outside impact. Presently broadcasting market has been changed very fast. It enters into unlimited competition era of multimedia and multichannel. However, especially local private broadcasting has both of public and private characteristics. Thus, local private broadcasting should not be hung by the wall any more. In this study administrative outcome of local private broadcasting will be analyzed and some hot political issues will be analyzed also then the political solution might be looked up at the same time. Now local private broadcasting also should be changed to totally new broadcasting company pursuing creative local contents and new digital concept.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.2
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• pp.278-288
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• 1998

An efficient and useful method to improve the local stress field in a displacement-formulated finite element solution has been proposed using the theory of conjugate approximations for a stress field and the Loubignac's iterative method for a displacement field. Validity of the proposed method has been tested through three test examples, to improve the stress field and displacement field in the whole domain and the local regions. As a result of analysis on the test examples, it is found that the stress field in the local regions are approximated to those in the whole domain within a few iterations which have satisfied the original finite element equilibrium equation. In addition, it is found that the local stress field are by far better approximated to the exact stress field than the displacement-based stress field with the reduction of the finite-element mesh-size.

• Bulletin of the Korean Mathematical Society
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• v.40 no.4
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• pp.603-611
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• 2003

In this paper we extend the definition of K-positive definite operators from linear to Frechet differentiable operators. Under this setting, we derive from the inverse function theorem a local existence and approximation results corresponding to those of Theorems land 2 of the authors [8], in an arbitrary real Banach space. Furthermore, an asymptotically K-positive definite operator is introduced and a simplified iteration sequence which converges to the unique solution of an asymptotically K-positive definite operator equation is constructed.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10a
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• pp.601-605
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• 1991

In this paper an approximate solution method for the large-scale Traveling Salesman Problem(TSP) is presented. The method start with the subdivision of the problem domain into a number of clusters by considering their geometries. The clusters have limited number of nodes so as to get local solutions. They are linked to give the least path which covers the whole domain and become TSPs with start- and end-node. The approximate local solutions in each cluster are obtained by using geometrical property of the cluster, and combined to give an overall-approximate solution for the large-scale TSP.

• 제어로봇시스템학회:학술대회논문집
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• 1990.10a
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• pp.36-40
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• 1990

Conventional back propagation learning is generally characterized by slow and rather inaccurate learning which makes it difficult to use in control applications. A new multilayer perception architecture and its learning algorithm is proposed that consists of a Kohonen front layer followed by a back propagation network. The Kohonen layer selects a subset of the hidden layer neurons for local tuning. This architecture has been tested on the inverse kinematic solution of robot manipulator while demonstrating its fast and accurate learning capabilities.

• Kyungpook Mathematical Journal
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• v.55 no.2
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• pp.301-311
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• 2015

In this paper, we present the error control techniques for the error correction methods (ECM) which is recently developed by P. Kim et al. [8, 9]. We formulate the local truncation error at each time and calculate the approximated solution using the solution and the formulated truncation error at previous time for achieving uniform error bound which enables a long time simulation. Numerical results show that the error controlled ECM provides a clue to have uniform error bound for well conditioned problems [1].

• Archives of Plastic Surgery
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• v.43 no.3
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• pp.272-277
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• 2016

Background One-per-mil tumescent solution, which contains 0.2% lidocaine with 1:1,000,000 epinephrine, has been reported to be clinically effective for hand surgery under local anesthesia. However, it was lacking in its basic pharmacokinetics profile in regard to the onset of action (OOA) and duration of action (DOA). Methods A randomized, double-blind study was conducted on 12 volunteers who met the inclusion criteria from October to November 2014. All volunteers had their right and left ring finger pulps injected with either one-per-mil solution or 2% lidocaine. Semmes-Weinstein and two-point discrimination tests were used to test sensation. Visual analogue scale was recorded at the time when the finger lost its sensation and when it regained normal sensation to measure the OOA and DOA. The data were then analyzed with a paired t-test and a Wilcoxon signed-rank test. Results The OOA and DOA of 2% plain lidocaine were 1 minute and 99.67 minutes, respectively. Meanwhile, 0.2% lidocaine in a one-per-mil tumescent solution showed an OOA of 5 minutes and a DOA of 186.83 minutes. The OOA of 0.2% lidocaine in a one-per-mil tumescent solution is statistically shorter than 2% plain lidocaine (P=0.04); while its DOA is statistically longer than 2% plain lidocaine (P<0.001). Conclusions The 0.2% lidocaine in a one-per-mil tumescent solution is statistically and clinically superior to 2% plain lidocaine in achieving longer duration of local anesthesia.