• Biomolecules & Therapeutics
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• 제2권3호
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• pp.247-255
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• 1994

As a series of safety studies of DA-3030, a new rhO-CSF, its local irritancy was examined in the rabbits after the following treatment; application into the conjunctival sac of the eye(single), subcutaneous injection(single), intramuscular injection(single), and intravenous injection(8-day repeated). In addition, paravenous irritation of DA-3030 was investigated in mice. The results obtained were as follows. 1. In the result of ocular irritation test, 0.03% solution of DA-3030 could be considered as a non-irritating material. 2. The local irritation of DA-3030 by an injection of 0.5mι of its solution subcutaneously or intramuscularly was negligible and not so much different from that of saline. 3. In the vascular irritancy test, macro- and microscopic observations revealed that the irritating activity of DA-3030 in blood vessels was not different from that of saline when they were injected once a day into vein retroauricularis of rabbits for 8 days.4. The paravenous administration of DA-3030 did not induce any abnormal changes at injection sites except mild swelling in 1 mouse at 3 hours after injection which was thought to be due to slow absorption. The above-mentioned results suggest that DA-3030 has no irritating activity when injected through intravenous or subcutaneous route for clinical practice as 0.03% solution.

• Journal of Advanced Marine Engineering and Technology
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• 제15권4호
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• pp.46-53
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• 1991

In the present study, Navier-Stokes equation is numerically solved by use of a Finite analytic method to obtain the 2-dimensional flow field in the square cavity. The basic idea of F.A.M. is the incorporation of local analytic solutions in the numerical solution of linear or non-linear partial differential equations. In the F.A.M., the total problem is subdivided into a number of all elements. The local analytic solution is obtained for the small element in which the governing equation, if non-linear, to be linearized. The local analytic solutions are then expressed in algebraic form and are overlapped to cover the entire region of the problem. The assembly of these local analytic solutions, which still preserve the overall nonlinearity of the governing equations, results in a system of linear algebraic equations. The system of algebraic equations is then solved to provide the numerical solutions of the total problem. The computed flow field shows the same characteristics to physical concept of flow phenomena.

• 한국정밀공학회지
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• 제23권8호
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• pp.89-99
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• 2006

In this paper a new shape reconstruction method that allows us to construct surface models from very large sets of points is presented. In this method the global domain of interest is divided into smaller domains where the problem can be solved locally. These local solutions of subdivided domains are blended together according to weighting coefficients to obtain a global solution using partition of unity function. The suggested approach gives us considerable flexibility in the choice of local shape functions which depend on the local shape complexity and desired accuracy. At each domain, a quadratic polynomial function is created that fits the points in the domain. If the approximation is not accurate enough, other higher order functions including cubic polynomial function and RBF(Radial Basis Function) are used. This adaptive selection of local shape functions offers robust and efficient solution to a great variety of shape reconstruction problems.

• 디지털콘텐츠학회 논문지
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• 제10권3호
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• pp.401-411
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• 2009

본 논문은 지역을 근간으로 하는 지역민영방송이 처한 경영위기를 분석하고 정책적 대안을 모색해 봄으로써 미래 지역민방의 발전 가능성을 예측해보고자 한다. 지역민방은 95년 첫 서비스를 개시한 이래로 지금까지 서울을 중심으로 하는 SBS와의 네트워크 체제를 유지하면서 비교적 빠른 시기에 안정된 경영성과를 이루어왔다. 그러나 이러한 독특한 네트워크 시스템은 지역민방의 고질적 문제로 자리잡았고, IMF와 같은 외부 환경의 영향에 매우 취약한 구조를 만들 수밖에 없었다. 최근의 방송환경은 더욱 빠르게 급변하고 있다. 다매체 다채널의 무한경쟁 시대에 진입하고 있으며 더 이상 특정한 매체를 보호 육성할 수 없음을 시사하고 있다. 다만 지역민방은 지역성 구현을 목적으로 하는 공공성과 시장논리에서 살아남아야 하는 상업방송으로서의 성격을 모두 가지고 있는 특수성이 존재한다. 존폐의 위기에 까지 몰린 지역민방을 더 이상 방치할 수만은 없다. 본 논문에서는 먼저 개국 후 지금까지 지역민방의 경영성과를 분석해보고, 최근 지역민방의 경영에 악재로 등장한 몇 가지 정책적 쟁점을 진단해 본다. 특히 민영미디어랩의 도입과 방송법 개정에 따른 지역민방에의 영향을 중점으로 분석해보고자 한다. 결론적으로 위기에 처한 지역민방의 활성화를 위한 정책적 대안을 모색해 보고자 한다.

• 대한기계학회논문집A
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• 제22권2호
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• pp.278-288
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• 1998

An efficient and useful method to improve the local stress field in a displacement-formulated finite element solution has been proposed using the theory of conjugate approximations for a stress field and the Loubignac's iterative method for a displacement field. Validity of the proposed method has been tested through three test examples, to improve the stress field and displacement field in the whole domain and the local regions. As a result of analysis on the test examples, it is found that the stress field in the local regions are approximated to those in the whole domain within a few iterations which have satisfied the original finite element equilibrium equation. In addition, it is found that the local stress field are by far better approximated to the exact stress field than the displacement-based stress field with the reduction of the finite-element mesh-size.

• 대한수학회보
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• 제40권4호
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• pp.603-611
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• 2003

In this paper we extend the definition of K-positive definite operators from linear to Frechet differentiable operators. Under this setting, we derive from the inverse function theorem a local existence and approximation results corresponding to those of Theorems land 2 of the authors [8], in an arbitrary real Banach space. Furthermore, an asymptotically K-positive definite operator is introduced and a simplified iteration sequence which converges to the unique solution of an asymptotically K-positive definite operator equation is constructed.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 22-24 Oct. 1991
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• pp.601-605
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• 1991

In this paper an approximate solution method for the large-scale Traveling Salesman Problem(TSP) is presented. The method start with the subdivision of the problem domain into a number of clusters by considering their geometries. The clusters have limited number of nodes so as to get local solutions. They are linked to give the least path which covers the whole domain and become TSPs with start- and end-node. The approximate local solutions in each cluster are obtained by using geometrical property of the cluster, and combined to give an overall-approximate solution for the large-scale TSP.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1990년도 한국자동제어학술회의논문집(국내학술편); KOEX, Seoul; 26-27 Oct. 1990
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• pp.36-40
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• 1990

Conventional back propagation learning is generally characterized by slow and rather inaccurate learning which makes it difficult to use in control applications. A new multilayer perception architecture and its learning algorithm is proposed that consists of a Kohonen front layer followed by a back propagation network. The Kohonen layer selects a subset of the hidden layer neurons for local tuning. This architecture has been tested on the inverse kinematic solution of robot manipulator while demonstrating its fast and accurate learning capabilities.

• Kyungpook Mathematical Journal
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• 제55권2호
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• pp.301-311
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• 2015

In this paper, we present the error control techniques for the error correction methods (ECM) which is recently developed by P. Kim et al. [8, 9]. We formulate the local truncation error at each time and calculate the approximated solution using the solution and the formulated truncation error at previous time for achieving uniform error bound which enables a long time simulation. Numerical results show that the error controlled ECM provides a clue to have uniform error bound for well conditioned problems [1].

• Archives of Plastic Surgery
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• 제43권3호
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• pp.272-277
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• 2016

Background One-per-mil tumescent solution, which contains 0.2% lidocaine with 1:1,000,000 epinephrine, has been reported to be clinically effective for hand surgery under local anesthesia. However, it was lacking in its basic pharmacokinetics profile in regard to the onset of action (OOA) and duration of action (DOA). Methods A randomized, double-blind study was conducted on 12 volunteers who met the inclusion criteria from October to November 2014. All volunteers had their right and left ring finger pulps injected with either one-per-mil solution or 2% lidocaine. Semmes-Weinstein and two-point discrimination tests were used to test sensation. Visual analogue scale was recorded at the time when the finger lost its sensation and when it regained normal sensation to measure the OOA and DOA. The data were then analyzed with a paired t-test and a Wilcoxon signed-rank test. Results The OOA and DOA of 2% plain lidocaine were 1 minute and 99.67 minutes, respectively. Meanwhile, 0.2% lidocaine in a one-per-mil tumescent solution showed an OOA of 5 minutes and a DOA of 186.83 minutes. The OOA of 0.2% lidocaine in a one-per-mil tumescent solution is statistically shorter than 2% plain lidocaine (P=0.04); while its DOA is statistically longer than 2% plain lidocaine (P<0.001). Conclusions The 0.2% lidocaine in a one-per-mil tumescent solution is statistically and clinically superior to 2% plain lidocaine in achieving longer duration of local anesthesia.