• Title/Summary/Keyword: Linear best-fitting

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Evaluation of micronucleus frequency in cytokinesis-blockedlymphocytes of cattle in the vicinity of Uljin nuclear power station (세포질 분열 차단 림프구를 이용한 울진원자력발전소 주변 소의 미소핵 발생 평가)

  • Kim, Se-ra;Kang, Chang-mo;Kim, Sung-ho
    • Korean Journal of Veterinary Research
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    • v.44 no.3
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    • pp.343-348
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    • 2004
  • Cytogenetic and hematological analysis was performed in peripheral blood of cattle in the vicinity of Uljin nuclear power station and control area. The frequency of micronuclei(MN) in peripheral blood lymphocytes from cattle was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the bovine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. MN ratio in lymphocytes of cattle from Uljin nuclear power station and control area were 8.90/1,000 and 9.60/1,000, respectively. There were no significant differences in MN frequencies and hematological values in cattle between Uljin and control area.

A Baseline Correction for Effective Analysis of Alzheimer’s Disease based on Raman Spectra from Platelet (혈소판 라만 스펙트럼의 효율적인 분석을 위한 기준선 보정 방법)

  • Park, Aa-Ron;Baek, Sung-June
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.49 no.1
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    • pp.16-22
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    • 2012
  • In this paper, we proposed a method of baseline correction for analysis of Raman spectra of platelets from Alzheimer's disease (AD) transgenic mice. Measured Raman spectra include the meaningful information and unnecessary noise which is composed of baseline and additive noise. The Raman spectrum is divided into the local region including several peaks and the spectrum of the region is modeled by curve fitting using Gaussian model. The additive noise is clearly removed from the process of replacing the original spectrum with the fitted model. The baseline correction after interpolating the local minima of the fitted model with linear, piecewise cubic Hermite and cubic spline algorithm. The baseline corrected models extract the feature with principal component analysis (PCA). The classification result of support vector machine (SVM) and maximum $a$ posteriori probability (MAP) using linear interpolation method showed the good performance about overall number of principal components, especially SVM gave the best performance which is about 97.3% true classification average rate in case of piecewise cubic Hermite algorithm and 5 principal components. In addition, it confirmed that the proposed baseline correction method compared with the previous research result could be effectively applied in the analysis of the Raman spectra of platelet.

Identifying Factors for Corn Yield Prediction Models and Evaluating Model Selection Methods

  • Chang Jiyul;Clay David E.
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.50 no.4
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    • pp.268-275
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    • 2005
  • Early predictions of crop yields call provide information to producers to take advantages of opportunities into market places, to assess national food security, and to provide early food shortage warning. The objectives of this study were to identify the most useful parameters for estimating yields and to compare two model selection methods for finding the 'best' model developed by multiple linear regression. This research was conducted in two 65ha corn/soybean rotation fields located in east central South Dakota. Data used to develop models were small temporal variability information (STVI: elevation, apparent electrical conductivity $(EC_a)$, slope), large temporal variability information (LTVI : inorganic N, Olsen P, soil moisture), and remote sensing information (green, red, and NIR bands and normalized difference vegetation index (NDVI), green normalized difference vegetation index (GDVI)). Second order Akaike's Information Criterion (AICc) and Stepwise multiple regression were used to develop the best-fitting equations in each system (information groups). The models with $\Delta_i\leq2$ were selected and 22 and 37 models were selected at Moody and Brookings, respectively. Based on the results, the most useful variables to estimate corn yield were different in each field. Elevation and $EC_a$ were consistently the most useful variables in both fields and most of the systems. Model selection was different in each field. Different number of variables were selected in different fields. These results might be contributed to different landscapes and management histories of the study fields. The most common variables selected by AICc and Stepwise were different. In validation, Stepwise was slightly better than AICc at Moody and at Brookings AICc was slightly better than Stepwise. Results suggest that the Alec approach can be used to identify the most useful information and select the 'best' yield models for production fields.

Statistical Modelling and Forecasting of Cervix Cancer Cases in Radiation Oncology Treatment: A Hospital Based Study from Western Nepal

  • Sathian, Brijesh;Fazil, Abul;Sreedharan, Jayadevan;Pant, Sadip;Kakria, Anjali;Sharan, Krishna;Rajesh, E.;Vishrutha, K.V.;Shetty, Soumya B.;Shahnavaz, Shameema;Rao, Jyothi H.;Marakala, Vijaya
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.2097-2100
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    • 2013
  • Background: To estimate the numbers and trends in cervix cancer cases visiting the Radiotherapy Department at Manipal Teaching Hospital, Pokhara, Nepal, statistical modelling from retrospective data was applied. Materials and Methods: A retrospective study was carried out on data for a total of 159 patients treated for cervix cancer at Manipal Teaching Hospital, Pokhara, Nepal, between $28^{th}$ September 2000 and $31^{st}$ December 2008. Theoretical statistics were used for statistical modelling and forecasting. Results: Using curve fitting method, Linear, Logarithmic, Inverse, Quadratic, Cubic, Compound, Power and Exponential growth models were validated. Including the constant term, none of the models fit the data well. Excluding the constant term, the cubic model demonstrated the best fit, with $R^2$=0.871 (p=0.004). In 2008, the observed and estimated numbers of cases were same (12). According to our model, 273 patients with cervical cancer are expected to visit the hospital in 2015. Conclusions: Our data predict a significant increase in cervical cancer cases in this region in the near future. This observation suggests the need for more focus and resource allocation on cervical cancer screening and treatment.

Estimation of Leak Frequency Function by Application of Non-linear Regression Analysis to Generic Data (비선형 회귀분석을 이용한 Generic 데이터 기반의 누출빈도함수 추정)

  • Yoon, Ik Keun;Dan, Seung Kyu;Jung, Ho Jin;Hong, Seong Kyeong
    • Journal of the Korean Society of Safety
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    • v.35 no.5
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    • pp.15-21
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    • 2020
  • Quantitative risk assessment (QRA) is used as a legal or voluntary safety management tool for the hazardous material industry and the utilization of the method is gradually increasing. Therefore, a leak frequency analysis based on reliable generic data is a critical element in the evolution of QRA and safety technologies. The aim of this paper is to derive the leak frequency function that can be applied more flexibly in QRA based on OGP report with high reliability and global utilization. For the purpose, we first reviewed the data on the 16 equipments included in the OGP report and selected the predictors. And then we found good equations to fit the OGP data using non-linear regression analysis. The various expectation functions were applied to search for suitable parameter to serve as a meaningful reference in the future. The results of this analysis show that the best fitting parameter is found in the form of DNV function and connection function in natural logarithm. In conclusion, the average percentage error between the fitted and the original value is very small as 3 %, so the derived prediction function can be applicable in the quantitative frequency analysis. This study is to contribute to expand the applicability of QRA and advance safety engineering as providing the generic equations for practical leak frequency analysis.

Animal Model Versus Conventional Methods of Sire Evaluation in Sahiwal Cattle

  • Banik, S.;Gandhi, R.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.9
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    • pp.1225-1228
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    • 2006
  • A total of 1,367 first lactation records of daughters of 81 sires, having 5 or more progeny were used to evaluate sires by 3 different methods viz., least squares (LS), best linear unbiased prediction (BLUP) and derivative free restricted maximum likelihood (DFREML) method. The highest and lowest overall average breeding value of sires for first lactation 305 days or less milk yield was obtained by BLUP (1,520.72 kg) and LS method (1,502.22 kg), respectively. The accuracy, efficiency and stability of different sire evaluation methods were compared to judge their effectiveness. The error variance of DFREML method was lowest ($191,112kg^2$) and its coefficient of determination of fitting the model was highest (33.39%) revealing that this method of sire evaluation was most efficient and accurate as compared to other methods. However, the BLUP method was most stable amongst all the methods having coefficient of variation (%) very near to unadjusted data (18.72% versus 19.89%). The higher rank correlations (0.7979 to 0.9568) between different sire evaluation methods indicated that there was higher degree of similarity of ranking sires by different methods ranging from about 80 to 96 percent. However, the DFREML method seemed to be the most effective sire evaluation method as compared to other methods for the present set of data.

Evaluation of Micronucleus Frequency in Cytokinesis-blocked Bovine Lymphocytes from Regions around Wolsong Nuclear Power Plant (세포질 분열 차단 림프구를 이용한 월성원자력발전소 주변 소의 미소핵 발생 평가)

  • Kim, Se-ra;Kim, Tae-hwan;Kim, Sung-ho
    • Korean Journal of Veterinary Research
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    • v.43 no.3
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    • pp.333-338
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    • 2003
  • Cytogenetic and hematological analysis was performed in bovine peripheral blood from the regions around Wolsong nuclear power plant and control area. The frequency of micronuclei (MN) in peripheral blood lymphocytes from cattle was used as a biomarker of radiobiological effects resulting from exposure to environmental radiation. An estimated dare of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the bovine lymphocytes exposed in vitro to radiation over the range from 0 Gy to 4 Gy. MN rates in lymphocytes of cattle from Wolsong nuclear power plant and control area were 9.87/1,000 and 9.60/1,000, respectively. There were no significant differences in MN frequencies and hematological values in cattle between Wolsong and control area. The study indicates that the MN assay is a rapid, sensitive and accurate method that can be used to monitor a large population exposed to radiation.

A Study on the Optimal Design of Automotive Gas Spring (차량용 가스스프링의 최적설계에 관한 연구)

  • Lee, Choon Tae
    • Journal of Drive and Control
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    • v.14 no.4
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    • pp.45-50
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    • 2017
  • The gas spring is a hydropneumatic adjusting element, consisting of a pressure tube, a piston rod, a piston and a connection fitting. The gas spring is filled with compressed nitrogen within the cylinder. The filling pressure acts on both sides of the piston and because of area difference it produces an extension force. Therefore, a gas spring is similar in function compare to mechanical coil spring. Conversely, optimization is a process of finding the best set of parameters to reach a goal while not violating certain constraints. The AMESim software provides NLPQL (Nonlinear Programming by Quadratic Lagrangian) and GA (genetic algorithm) for optimization. The NLPQL method builds a quadratic approximation to the Lagrange function and linear approximations to all output constraints at each iteration, starting with the identity matrix for the Hessian of the Lagrangian, and gradually updating it using the BFGS method. On each iteration, a quadratic programming problem is solved to find an improved design until the final convergence to the optimum design. In this study, we conducted optimization design of the gas spring reaction force with NLPQL.

An advanced technique to predict time-dependent corrosion damage of onshore, offshore, nearshore and ship structures: Part I = generalisation

  • Kim, Do Kyun;Wong, Eileen Wee Chin;Cho, Nak-Kyun
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.12 no.1
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    • pp.657-666
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    • 2020
  • A reliable and cost-effective technique for the development of corrosion damage model is introduced to predict nonlinear time-dependent corrosion wastage of steel structures. A detailed explanation on how to propose a generalised mathematical formulation of the corrosion model is investigated in this paper (Part I), and verification and application of the developed method are covered in the following paper (Part II) by adopting corrosion data of a ship's ballast tank structure. In this study, probabilistic approaches including statistical analysis were applied to select the best fit probability density function (PDF) for the measured corrosion data. The sub-parameters of selected PDF, e.g., the largest extreme value distribution consisting of scale, and shape parameters, can be formulated as a function of time using curve fitting method. The proposed technique to formulate the refined time-dependent corrosion wastage model (TDCWM) will be useful for engineers as it provides an easy and accurate prediction of the 1) starting time of corrosion, 2) remaining life of the structure, and 3) nonlinear corrosion damage amount over time. In addition, the obtained outcome can be utilised for the development of simplified engineering software shown in Appendix B.

Gamma and neutron shielding properties of B4C particle reinforced Inconel 718 composites

  • Gokmen, Ugur
    • Nuclear Engineering and Technology
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    • v.54 no.3
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    • pp.1049-1061
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    • 2022
  • Neutron and gamma-ray shielding properties of Inconel 718 reinforced B4C (0-25 wt%) were investigated using PSD software. Mean free path (MFP), linear and mass attenuation coefficients (LAC,MAC), tenth-value and half-value layers (TVL,HVL), effective atomic number (Zeff), exposure buildup factors (EBF), and fast neutron removal cross-sections (FNRC) values were calculated for 0.015-15 MeV. It was found that MAC and LAC increased with the decrease in the content of B4C compound by weight in Inconel 718. The EBFs were computed using G-P fitting method for 0.015-15 MeV up to the penetration depth of 40 mfp. HVL, TVL, and FNRC values were found to range between 0.018 cm and 3.6 cm, between 2.46 cm and 12.087 cm, and between 0.159 cm-1 and 0.194 cm-1, respectively. While Inconel 718 provides the maximum photon shielding property since it offered the highest values of MAC and Zeff and the lowest value of HVL, Inconel 718 with B4C(25 wt%) was observed to provide the best shielding material for neutron since it offered the highest FNRC value. The study is original in terms of several aspects; moreover, the results of the study may be used in nuclear technology, as well as other technologies including nano and space technologies.