• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4469-4475
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• 2012

Background: The potential use of hypomethylation of Long INterspersed Element 1 (LINE-1) and Alu elements (Alu) as a biomarker has been comprehensively assessed in several cancers, including head and neck squamous cell carcinoma (HNSCC). Failure to detect occult metastatic head and neck tumors on radical neck lymph node dissection can affect the therapeutic measures taken. Objective: The aim of this study was to investigate the LINE-1 and Alu methylation status and determine whether it can be applied for detection of occult metastatic tumors in HNSCC cases. Methods: We used the Combine Bisulfite Restriction Analysis (COBRA) technique to analyse LINE-1 and Alu methylation status. In addition to the methylation level, LINE-1 and Alu loci were classified based on the methylation statuses of two CpG dinucleotides in each allele as follows: hypermethylation ($^mC^mC$), hypomethylation ($^uC^uC$), and 2 forms of partial methylation ($^mC^uC$ and $^uC^mC$). Sixty-one lymph nodes were divided into 3 groups: 1) non-metastatic head and neck cancer (NM), 2) histologically negative for tumor cells of cases with metastatic head and neck cancer (LN), and 3) histologically positive for tumor cells (LP). Results: Alu methylation change was not significant. However, LINE-1 methylation of both LN and LP was altered, as demonstrated by the lower LINE-1 methylation levels (p<0.001), higher percentage of $^mC^uC$ (p<0.01), lower percentage of $^uC^mC$ (p<0.001) and higher percentage of $^uC^uC$ (p<0.001). Using receiver operating characteristic (ROC) curve analysis, $%^uC^mC$ and $%^mC^uC$ values revealed a high level of AUC at 0.806 and 0.716, respectively, in distinguishing LN from NM. Conclusion: The LINE-1 methylation changes in LN have the same pattern as that in LP. This epigenomic change may be due to the presence of occult metastatic tumor in LN cases.

• Journal of the Korean Applied Science and Technology
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• v.32 no.3
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• pp.405-411
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• 2015

Carbon composites for flexible fiber heating element were examined to improve the electrical conductivity in this study. Carbon composites using carbon black, denka black, super-c, super-p with/without CNF or dispersant such as BCS03 and Sikament-nn were prepared. Carbon composite slurry was coated on plane film and yarns(cotton, polyester) and the performances of prepared heating materials were investigated by checking electrical surface resistance, adhesion strength. The plane heating element using carbon black under natural drying condition($25^{\circ}C$) had better physical properties such as surface resistance(185.3 Ohm/sq) and adhesion strength(above 90%) than those of other carbon composite heating elements. From these results, polyester heating element coated by carbon black showed better electrical line resistance(33.2 kOhm/cm) than cotton heating element. Then, it was found that polyester heating element coated by carbon black with CNF(3 wt%) and BCS03(1 wt%) appeared best properties(0.604 kOhm/cm).

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2012.10a
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• pp.630-635
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• 2012

Nearfield acoustic holography method predicts an unmeasured sound field, therefore it depends on its prediction methods. In particular, if one has radiators or scatters, which cannot be expressed by simple geometry, then inverse boundary element method (BEM) is normally employed to reconstruct the sound field induced by sound sources with irregular profiles. The characteristics of boundary element, including the element shape, characteristic length, order of shape function and others, affect the reconstruction error. Investigating the errors by means of changing these factors will provide a guide line for selecting appropriate factors, associated with the elements of BEM. These factors are investigated by numerical simulations, and the accuracies with respect to the variant factors are compared. Novel suggestions for selecting appropriate boundary element factors are described based on the simulation results.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.2
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• pp.69-76
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• 2018

The paper presents preliminary investigation results for the effect of the baseline correction in the acceleration excitation method on finite element seismic analysis results (such as accumulated equivalent plastic strain, equivalent plastic strain considering cyclic plasticity, von Mises effective stress, etc) of nuclear safety Class I components. For investigation, finite element elastic-plastic time-history seismic analysis is performed for a surge line including a pressurizer lower head, a pressurizer surge nozzle, a surge piping, and a hot leg surge nozzle using the Chaboche hardening model. Analysis is performed for various seismic loading methods such as acceleration excitation methods with and without the baseline correction, and a displacement excitation method. Comparing finite element analysis results, the effect of the baseline correction is investigated. As a result of the investigation, it is identified that finite element analysis results using the three methods do not show significant difference.

• Nuclear Engineering and Technology
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• v.54 no.7
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• pp.2550-2563
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• 2022

This study performed a precise dynamic finite element time history elastic-plastic seismic analysis considering the welds, which have been not considered in design stage, on the nuclear components subjected to severe seismic loadings such as beyond-design basis earthquakes for sustainable nuclear power plants. First, the dynamic finite element elastic-plastic seismic analysis was performed for a general design practice that does not take into account the welds of the pressurizer surge line system, one of safety class I components in nuclear power plants, and then the reference values for the accumulated equivalent plastic strain, equivalent plastic strain, and von Mises effective stress were set. Second, the dynamic finite element elastic-plastic seismic analyses were performed for the case of considering only the mechanical strength over-mismatch of the welds as well as for the case of considering both the strength over-mismatch and welding residual strain. Third, the effects of the strength over-mismatch and welding residual strain were analyzed by comparing the finite element analysis results with the reference values. As a result of the comparison, it was found that not considering the strength over-mismatch may lead to conservative assessment results, whereas not considering the welding residual strain may be non-conservative.

• Restorative Dentistry and Endodontics
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• v.18 no.2
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• pp.291-316
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• 1993

Restorative procedures can lead to tooth fracture due to the relatively small amount of the remaining tooth structure. It is essential to prevent fractures by having a clear concept of the designs for cavity preparations. Among the several parameters in cavity designs, profound understanding of isthmus width factor would facilitate selection of the appropriate cavity preparation for a specific clinical situation. In this study, MO amalgam cavity were prepared on maxillary first premolar and filled with amalgam. Three dimensional, model with 1365 8-node brick elements was made by serial photographic method. In this model, isthmus was varied in width at 1/4, 1/3, 1/2 and 2/3 of intercuspal width and material properties were given for three element groups, i.e., enamel, dentin and amalgam. A load of 500 N was applied vertically on amalgam and enamel. In case of enamel loading, 2 model (with and without amalgam) was compared to consider the possibility of play at the interface between tooth material and amalgam. These models were analyzed with three dimensional finite element method. The results were as follows: 1. The stress was concentrated on the facio-pulpal line angle and distal marginal ridge of the cavity. 2. With the increase of the isthmus width, the stress spread around the facio-pulpal line angle and the area of stress concentration moved toward the proximal box. 3. In case of narrow isthmus width, the initiation point of crack would be in the area of isthmus corner of the cavity, and with the increase of the isthmus width, it would move toward the proximal box and at the same time the possibility of crack increase at the distal marginal ridge. 4. The direction of crack progressed outward and downward from the facio-pulpal line angle, and with the increase of the isthmus width, it approximated vertical direction. At the marginal ridge, it occurred in vertical direction. 5. It would be favorable to make the isthmus width narrower than a third of the intercuspal width, and to cover the cusp if isthmus width were wider than half of the intercuspal width. 6. It is necessary to apply the possibility of play to the finite element analysis.

• Restorative Dentistry and Endodontics
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• v.24 no.1
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• pp.67-75
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• 1999

The use of composite restorative materials is established due to continuing improvements in the materials and restorative techniques. Composite resins are widely used for the restoration of cervical lesions because of esthetics, good physical properties and working time. There are several types of cavity design for class V composite resin filling, but inappropriate cavity form may affect bonding failure, microleakage and fracture during mastication. Cavity preparations for composite materials should be as conservative as possible. The extent of the preparation is usually determined by the size, shape, and location of the defect. The design of the cavity preparation to receive a composite restoration may vary depending on several factors. In this study, 5 types of class V cavity were prepared on each maxillary central incisor. The types are; 1) V-shape, 2) round(U) shape, 3) box form, 4) box form with incisal bevel and 5) box form with incisal bevel and grooves for axial line angles. After restoration, in order to observe the concentration of stress at bonding surfaces of teeth and restorations, developing a 2-dimensional finite element model of labiopalatal section in tooth, surrounding bone, periodontal ligament and gingiva, based on the measurements by Wheeler, loading force from direction of 45 degrees from lingual side near the incisal edge was applied. This study analysed Von Mises stress with SuperSap finite element analysis program(Algor Interactive System, Inc.). The results were as follows : 1. Stress concentration was prevalent at tooth-resin bonding surface of cervical side on each model. 2. In model 2 without line angle, stress was distributed evenly. 3. Preparing bevel eliminated stress concentration much or less at line angle. 4. Model with round-shape distributed stress concentration more evenly than box-type model with sharp line angle, therefore decreased possibility of fracture. 5. Adding grooves to line angles had no effect of decreasing stress concentration to the area.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.41-44
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• 2003

We propose portable equipment that monitors current and voltage of high-potential power transmission lines. In the equipment, a current and voltage sensor are attached to an insulator that supports a power transmission line: A clamped to the power line and the detected current signal is transmitted to the ground station by a wireless optical link using transmission line is detected by a high resistance element, zinc oxide (ZnO). That acts as a potential divider between the power line and ground. We make an experimental device for 66kV power line and demonstrate that it can monitor currents proposed equipment is small-sized, light, and inexpensive in comparison with the conventional CT (current transformer) and PT (potential transformer) since it does not require high potential insulators and magnetic cores, further, the equipment is easily installed owing to its small size and its simple structure.

• Journal of Hydrospace Technology
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• v.2 no.1
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• pp.41-54
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• 1996

Sculptured surface structures such as ship hulls are traditionally formed up to the required double curved shape by line heating method. The nature of the line heating process is a transient thermal process, followed by a thermo-elastic-plastic stress field. The permanant shape is dependent on many factors involved in the process, Among them are torch speed and path, supplied heat type and amount , and plate size. Thus, the work is essentially leaded by experts with lots of experiences. However, in order to effectively improve productivity through automation, each factor should be clearly examined how much it affects the final shape. This can not be done only by experiments, but can be achieved by a mechanics-based approach. In this paper, we propose a conceptual configuration for plate forming system, and then present simulations of the line heating process with numerical data in practices and suggest a computerized process of the line heating for practical applications. The modeling of heating torch, water cooling, and the plate to be formed is proposed for the finite element analysis after the mechanics of line heating is studied. Parametric studies are given and discussed for the effects of plate thickness, torch speed and initial curvature in forming a saddle typed surface.

• Journal of Ocean Engineering and Technology
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• v.31 no.4
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• pp.299-307
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• 2017

The design of the mooring line to maintain the position of an offshore structure in rough marine environments is recognized as a very important consideration. Conventional fatigue evaluation of a mooring line was performed by considering the tensile force acting on the mooring line, but the mooring line broke after 238 days in the girassol area even though the expected fatigue life was expected to be longer. The causes of this event are known to be due to OPB/IPB (out-of-plane bending/in-plane bending) caused by chain link friction due to the excessive tensile strength of the mooring line. In this study, three models with different boundary conditions were proposed for fatigue analysis of a mooring line considering OPB/IPB. Interlink stiffness was calculated by nonlinear structure analysis and a stress concentration factor was derived. In addition, the sensitivity of interlink stiffness according to the magnitude of tensile force, large deformation effect, and coefficient of friction was analyzed, and the effect of critical elastic slip and bending moment calculation position on interlink stiffness was confirmed.