• Journal of Mushroom
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• v.10 no.1
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• pp.9-14
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• 2012

This study was carried out to investigated optimum mixing ratio of Korean natural Lindera glauca for production of functional oyster mushroom. Total nitrogen and carbon source of Lindera glauca was 0.16% and 40.9%, respectively and C/N ratio was 215. Total nitrogen source and pH of substrate mixed with Lindera glauca was 2.8~3.0 and 4.8~5.0, respectively. The contents of $P_2O_5$, CaO, MgO and $Na_2O$ were increased by increasing Lindera glauca, but there was no significant difference in $K_2O$ content. Mycerial growth was faster at Lindera glauca treatments than that of control. Yields of fruiting body was the highest at Lindera glauca 20%, and dimeter and thick of pileus were increased according to increase of Lindera glauca addition ratio. The L value of pileus was the highest at the Lindera glauca 10% during mushroom harvest, but there was no significant difference in the a-value and the b-value.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.4
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• pp.635-640
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• 2015

Various medicinal plants were collected, air-dried, and subjected to extraction with ethanol. Ethanol extracts were screened for their efficacies as antioxidative and antiproliferative agents against cancer cells. Among the 15 species, extract of Lindera glauca Blume stem with a total polyphenolic content of $70.99{\pm}1.88{\mu}g/TAE\;{\mu}g$, was found to possess high DPPH radical scavenging ($IC_{50}=30.54{\pm}0.62{\mu}g/mL$), nitrite scavenging ($IC_{50}=787.94{\pm}89.28{\mu}g/mL$), and reducing power activities ($595.76{\pm}1.90{\mu}g/mL$). The antiproliferative activities of plant extracts were determined using MTT assay in human colorectal cancer cells. Extracts of stems and roots from L. glauca Blume were found to possess high anti-proliferative activities in HT-29 and HCT116 cells ($IC_{50}=711.52{\pm}40.27{\mu}g/mL$ and $IC_{50}=85.07{\pm}4.06{\mu}g/mL$, respectively). These results suggest that L. glauca Blume extract could be a useful natural antioxidant and anticancer resource.

• Journal of Applied Biological Chemistry
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• v.54 no.4
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• pp.309-312
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• 2011

Chipped stem wood from Lindera glauca was extracted repeatedly with 80% aqueous methanol at room temperature, and the concentrated methanolic extract was successively partitioned with ethyl acetate (EtOAc), n-butyl alcohol, and $H_2O$. From the EtOAc fraction, four sterols were isolated through a repeated silica gel and octadecyl silica gel column chromatography. The chemical structures of the sterols were elucidated as ${\beta}$-sitosterol (1), 7-ketositosterol (2), 7${\beta}$-hydroxysitosterol (3), and daucosterol (4). Among them, compounds 2 and 3 were isolated for the first time from the stem woods of this plant.

• Journal of the Korean Society of Food Culture
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• v.36 no.2
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• pp.235-245
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• 2021

Lindera glauca Blume has been used in Korean traditional medicine to treat the symptoms of paralysis, abdominal pain, speech disorders, extravasations, contusions, and pain caused by rheumatoid arthritis. We investigated the effect of L. glauca Blume extracts on the proliferation of colorectal cancer cells in vitro using HCT116 human colorectal cancer cell lines. We also investigated its mechanism of action. For this purpose, we used the MTT assay, western blotting, DNA fragmentation analysis, and flow cytometry. HCT116 cells were cultured in several concentrations of ethanol extracts of L. glauca Blume root (0, 50, 100 ㎍/mL). In this study, colon cancer cell growth was inhibited by L. glauca Blume root extract in a dose-dependent manner. It was associated with induction of apoptosis as assessed by nuclear fragmentation and cell cycle analysis. Apoptosis was assessed using western blotting for TNF-α, IL-6, NF-κB, Caspase-3, PARP, Bax, Bcl-2, and SIRT1. The extract also dose-dependently upregulated the expression Bax, the pro-apoptotic gene and downregulated the expression of the anti-apoptotic gene Bcl-2. Furthermore, the extract enhanced Caspase-3 activity in a dose-dependent manner. Our findings provide evidence that L. glauca Blume extract may mediate its anti-proliferative effect via the modulation of apoptosis.

• 한국약용작물학회:학술대회논문집
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• 2010.10a
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• pp.463-464
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• 2010

• Korean Journal of Pharmacognosy
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• v.53 no.1
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• pp.49-56
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• 2022

The present study was designed to evaluate the anti-inflammatory and anti-nociceptive potential of the ethyl acetate fraction of Lindera glauca (ELG). We found that ELG significantly suppressed NO production through decreased enzyme activity and expression of iNOS in the IFN-γ/LPS-activated murine peritoneal macrophages. The treatment of ELG also down-regulated the expression of COX-2. Our western blot data revealed that inhibitory effects of ELG on these pro-inflammatory mediators were attributed to inactivation of NF-κB. In addition, ELG-fed mice showed a marked decrease in paw edema induced by subplantar injection of trypsin, suggesting in vivo anti-inflammatory potential of ELG. We further investigated the anti-nociceptive properties of ELG using thermal and chemical nociception model. We found that ELG has a strong anti-nociceptive activities in both central and peripheral mechanism. An additional combination test with naloxone revealed that opioid receptor was not involved in the ELG-mediated anti-nociception. In conclusion, ELG may possibly be used as valuable anti-inflammatory and anti-nociceptive agent for the treatment of inflammatory diseases and pains.

• Journal of Plant Biology
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• v.27 no.1
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• pp.15-24
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• 1984

Leaf venation of 12 species of Lauraceae in Korea, native or introduced, was investigated and described by the use of Soft X-Ray. They could be grouped by the venation types, such as, 1. Actinodromous; Lindera obtusiloba, 2. Acrodromous; Cinnamomum camphora, C. japonicum, C. loureirii, 3. Brochidodromous having strongly developed basal secondary vein; Neolitsea aciculata, N. sericea, 4. Brochidodromous hoving irregulary branched secondary vein; Lindera erythrocarpa, L. glauca, 5. Brochidodromous having weak marginal loop; Machilus thunbergii, M.Japonica, 6. Brochidodromous having typical venation; Iozoste lancifolia, Litsea japonicum. This grouping corresponded with current classifying system at genus level except for genus Lindera, and supported Nakai's system at Tribe level. They also showed a gradual transition from brochidodromous to actinodromous types, but to certify the systematic value of this transition warrented more study. Identifying key for the species could be made by the venation type.

• Korean Journal of Plant Taxonomy
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• v.52 no.2
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• pp.114-117
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• 2022

Lindera angustifolia is mainly distributed in the temperate climate zone of China but shows an extraordinary distribution, disjunctively isolated on the western coastal islands of Korea. We therefore present the complete chloroplast genome of Korean L. angustifolia. The complete plastome was 152,836 bp in length, with an overall GC content of 39.2%. A large single copy (93,726 bp) and a small single copy (18,946 bp) of the genome were separated by a pair of inverted repeats (20,082 bp). The genome consists of 125 genes, including 81 protein-coding, eight ribosomal RNA, and 36 transfer RNA genes. While five RNA editing genes (psbL, rpl2, ndhB×2, and ndhD) were identified in L. angustifolia from China, the "ndhD" gene was not recognized as an RNA editing site in the corresponding Korean individual. A phylogenetic analysis revealed that Korean L. angustifolia is most closely related to the Chinese L. angustifolia with strong bootstrap support, forming a sister group of L. glauca.

• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.359-386
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• 2003

The vascular plants in Baekdudaegan of the South Korea were recorded of 1,477 taxa; 126 families, 641 genus, 1,248 species, 3 subspecies, 204 varieties, 22 forma. From the floristic point of view, Jirisan, Backunsan and Duckyusan District in the Baekdudaegan belongs to the southern province in Korea, appeared to Cephalotaxus koreana, Lindera obtusiloba, Lindera erythrocarpa, Lindera glauca, Izex macropoda, Meliosma myriantha, Melisoma oldhami and Stewartia koreana. But on the top regions of these mountains more than 1,000m above the sea level were contained many alpine plants. And on the top regions and ridgeline parts of Duckyusan and Jirisan were the middle province, owing to Betula costata, Betula ermani, Ulmus laciniata, Isopyrum raddeanum, Hylomecon vemale, Viola diamantica, Vaccinium koreanum, Heloniopsis orientalis, Disporum ovale, Symplocarpus renifolius and Veronica arvensis. These results were epresented that plant species of the middle province moved to the South along the ridgeline of Baekdudaegan, on the other hand plants of southern province had biological niche of low ground according to go toward the North.

• Korean Journal of Environment and Ecology
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• v.29 no.3
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• pp.454-461
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• 2015

This study aims to classify the biotope types based on the vegetation community in built-up areas by different land use and to map the plant communities. By classifying biotopes according to a taxonomic system, the characteristics of a biological community can be well-represented. The biotope classification indexes for the target area include human behavioral factors such as land use intensity, land-use patterns and land-cover types. The type classification was divided into four hierarchic ranks starting with Biotope Class, next by Biotope Group and Biotope Type and lastly by Biotope Sub-Type. The Biotope Class was first divided into two areas: the areas improved by humans and the areas unimproved by humans. The improved areas were again divided into permeable and non-permeable regions on the Biotope Group level. In the Biotope Type level, permeable paving areas were divided into areas with wide gap pavers and those with narrow gap pavers. The differential species of each biotope type are Lindera glauca, Conyza canadensis, Mazus pumilus, Vicia tetrasperma, Crepidiastrum sonchifolium, Zoysis japonica, Potentilla supina and Festuca arundinacea. The results of this study suggest that the biotope classification methodology, using a subjective phytosociological approach, is a useful and valuable tool and the results also suggest the possibility of applying more objective and scientific methods in mapping and classifying various environments.