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http://dx.doi.org/10.22889/KJP.2022.53.1.49

Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Lindera glauca  

Kim, Jong Soo (College of Pharmacy, Woosuk University)
Kang, Bo Hye (College of Pharmacy, Woosuk University)
Park, Seung Ju (College of Pharmacy, Woosuk University)
Yang, Woo In (College of Pharmacy, Woosuk University)
Kim, Myung Soo (College of Pharmacy, Woosuk University)
Lee, Byung Soo (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Lee, Se Youn (College of Pharmacy, Woosuk University)
Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Welfare)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.53, no.1, 2022 , pp. 49-56 More about this Journal
Abstract
The present study was designed to evaluate the anti-inflammatory and anti-nociceptive potential of the ethyl acetate fraction of Lindera glauca (ELG). We found that ELG significantly suppressed NO production through decreased enzyme activity and expression of iNOS in the IFN-γ/LPS-activated murine peritoneal macrophages. The treatment of ELG also down-regulated the expression of COX-2. Our western blot data revealed that inhibitory effects of ELG on these pro-inflammatory mediators were attributed to inactivation of NF-κB. In addition, ELG-fed mice showed a marked decrease in paw edema induced by subplantar injection of trypsin, suggesting in vivo anti-inflammatory potential of ELG. We further investigated the anti-nociceptive properties of ELG using thermal and chemical nociception model. We found that ELG has a strong anti-nociceptive activities in both central and peripheral mechanism. An additional combination test with naloxone revealed that opioid receptor was not involved in the ELG-mediated anti-nociception. In conclusion, ELG may possibly be used as valuable anti-inflammatory and anti-nociceptive agent for the treatment of inflammatory diseases and pains.
Keywords
Lindera glauca; Anti-inflammatory; Anti-nociceptive;
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