• The Korean Journal of Physiology and Pharmacology
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• v.22 no.4
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• pp.437-445
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• 2018

${\alpha}$-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vascular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic ${\alpha}$-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC). In aortic rings isolated from C57BL/6J mice, ICB significantly attenuated the contraction induced by phenylephrine (PE) and norepinephrine (NE), whereas ICB had no effects on KCl (60 mM)-induced contraction. In vasculatures precontracted with PE, ICB caused marked relaxation of aortic rings with or without endothelium, suggesting a direct effect on VSMC. In cultured rat VSMC, PE or NE increased MLC phosphorylation and increased cytosolic calcium levels. Both of these effects were significantly suppressed by ICB. In conclusion, our results showed that ICB regulated vascular tone by inhibiting MLC phosphorylation and calcium flux into VSMC, and suggest that ICB has anti-hypertensive properties and therapeutic potential for cardiovascular disorders related to vascular hypertension.

• Nuclear Engineering and Technology
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• v.41 no.8
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• pp.995-1004
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• 2009

The Advanced Power Reactor 1400 (APR1400) is an evolutionary advanced light water reactor (ALWR) based on the Optimized Power Reactor 1000 (OPR1000), which is in operation in Korea. The APR1400 incorporates a variety of engineering improvements and operational experience to enhance safety, economics, and reliability. The advanced design features and improvements of the APR1400 design include a pilot operated safety relief valve (POSRV), a four-train safety injection system with direct vessel injection (DVI), a fluidic device (FD) in the safety injection tank, an in-containment refueling water storage tank (IRWST), an external reactor vessel cooling system, and an integrated head assembly (IHA). Development of the APR1400 started in 1992 and continued for ten years. The APR1400 design received design certification from the Korean nuclear regulatory body in May of2002. Currently, two construction projects for the APR1400 are in progress in Korea.

• Nuclear Engineering and Technology
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• v.28 no.6
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• pp.551-562
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• 1996

This paper introduces the five-step methodology for identifying information needs and assessing instrument availability during the course of severe accidents in nuclear power plants. The methodology is applied to the Yonggwang (YGN) 3&4 to shed light on accident management. It constructs three safety objective trees to prevent the reactor vessel failure, to prevent the containment failure, and to mitigate the fission product release from the containment. The study assesses information needs and instrument availability under severe conditions for preventing the reactor vessel failure of YGN 3&4, and recommends additional instrument that m8y prove to be of vital importance in managing the accident.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.10a
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• pp.176-177
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• 2011

현재, 해양 선박의 경우 주간에는 육안을 통하여 쉽게 항구를 찾아 쉽게 선박을 정박시키거나 출항을 할 수 있지만, 사람의 시야를 확보할 수 없는 야간의 경우에는 선박의 전자 장비에 의존하거나 해상위에 떠 있는 해상 유도 표시등을 이용하여 선박을 정박시키거나 출항을 하고 있다. 또한, 현재의 많은 해상 유도 표시등은 GPS를 사용하여 제품을 설계하고 있지만, 시간에 따른 점멸 제어에 대한 오차가 누적되어 일정시간의 경과 후에는 유도등의 동기화에 많은 문제가 발생하고 있는 실정이다. 본 논문에서는 야간에 선박의 안전한 출항과 정박의 안내를 위하여 해상 유도 표시등의 동시 점멸에 관한 논문으로 PGS 시간 정보 데이터를 이용하여 일정시간이 흘러간 뒤에도 유도등의 점멸 제어 누적 오차를 제거할 수 있는 알고리즘을 개발하여 기존의 제품을 보완할 수 있는 알고리즘을 제안하고 그 성능을 실험을 통하여 제시하고자 한다.

• Journal of the Korean Society of Safety
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• v.23 no.5
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• pp.15-21
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• 2008

The bus using compressed natural gas(CNG) trend to be extended in use internationally as optimal counter-plan for reducing discharge gas of light oil due to high concern about environment. But, Composit pressure vessels(CPV) to be equipped with CNG bus is always involved in the point that safety accidents happen due to having compressed natural gas. In this report, we analysis the cause of CPV bursting accident by reviewing design and manufacture factor and suggest preventive measure through this case.

• International Journal of Stem Cells
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• v.17 no.1
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• pp.15-29
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• 2024

The development and differentiation of endothelial cells (ECs) are fundamental processes with significant implications for both health and disease. ECs, which are found in all organs and blood vessels, play a crucial role in facilitating nutrient and waste exchange and maintaining proper vessel function. Understanding the intricate signaling pathways involved in EC development holds great promise for enhancing vascularization, tissue engineering, and vascular regeneration. Hematopoietic stem cells originating from hemogenic ECs, give rise to diverse immune cell populations, and the interaction between ECs and immune cells is vital for maintaining vascular integrity and regulating immune responses. Dysregulation of vascular development pathways can lead to various diseases, including cancer, where tumor-specific ECs promote tumor growth through angiogenesis. Recent advancements in single-cell genomics and in vivo genetic labeling have shed light on EC development, plasticity, and heterogeneity, uncovering tissue-specific gene expression and crucial signaling pathways. This review explores the potential of ECs in various applications, presenting novel opportunities for advancing vascular medicine and treatment strategies.

• Journal of Plant Biotechnology
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• v.31 no.2
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• pp.133-138
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• 2004

Growth of M.9 (Malus domestica Bark. cv) and M.26 (Malus domestica Bark. cv) of dwarf apple rootstock, cultured on MS agar medium in a vessel with ventilating stopper (VS) and then in vivo rooting and acclimatization under combined-treatment by some materials with IBA, were investigated. Concentration of $CO_2$ and ethylene in the vessel with VS was lower then in the vessel with non-VS. Change of temperature and humidity in the vessel with VS was repeated by light condition. Stomatal pares of tissue in the vessel with VS were immediately closed after plantlets were exposed to room humidity but those in the vessel with non-VS were opened after 20 minutes exposure to room humidity. Leaf area and chloroplast index of tissue in the vessel with VS was higher then in the vessel with non-VS. In vivo rooting ratio and acclimatization ratio of M.9 and M.26 was highest in 300mg/L IBA＋3％ sucrose dip-treatment among other combined- treatments.

• Resources Recycling
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• v.7 no.3
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• pp.42-51
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• 1998

Hydrogen in atmosphere can easily dissolve in melt of light metal alloys. Increasing demand for recycling of light metal a alloys has, therefore, focused attention on the removal of hydrogen gas, and alloy addition in melt has become an imporLant r refining process. For this purpose behaviors of mixing and hydrogen degassing in impeller agitated refming vessel with/without barnes were investigated. Flow patterns, mixing time behavior and kinetics of degassing in various agitating conditions were analysed in watet model experiments. And, numerical analysis on turbulent flow pattern in impeller agitated vessels was performed.

• The korean journal of orthodontics
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• v.14 no.1
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• pp.65-81
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• 1984

In order to observe the responses of the periodontal tissue on the tension side following the experimental tooth movement, 35 Guinea pigs were divided into the control group (5 animals) and 6 experimental groups (3 movement groups and 3 retention groups) consisting of each 5 animals. The experimental tooth movement of Guinea pig's upper incisors installing open helical loop were carried out by rendering continuous force : 5g (1st groups) 35g (2nd groups), 100g (3rd groups), respectively for 7 days. 3 movement groups (15 animals) were sacrificed soon after the continuous force, and 3 retention groups (15 animals) were sacrificed after the retention period of another 7 days. The following results were obtained from the observation of the surrounding tissues of teeth on the tension side through light microscopy any transmission electron microscopy. 1. The vessel walls in the experimental groups were thinner than those of the control group, the number of blood vessel had the tendency to increase. The greater the strong force applied to each group, the more the destruction of cells and fibers was found and the more the number of the red blood cell of vessel outside appeared. 2. New collagen fibers were produced from fibroblasts in the 1st groups (light force), but were produced rather less in the 2nd groups (medium force) and the 3rd groups (heavy force). 3. In the forming patterns of the new alveolar bone of the 3rd groups (heavy force), the bone trabeculae were formed towards the direction of the force to be applied, but the new alveolar bone in the 1st groups (light force) was produced evenly throughout the all surfaces of the alveolar bone rather than the patterns of bone trabeculae ; therefore, the patterns of new alveolar bone were observed differently according to the magnitude of the force applied. 4. In the retention group, it was observed that the collagen fibers were produced from the osteoblasts in the marginal areas of the periodontal ligaments being widely opened and were deposited on the alveolar bone surface but the production of collagen fibers from the osteoblasts in the other area of the periodontal ligaments was almost ceased, and a rest line on the new alveolar bone surface was found.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.42 no.1
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• pp.7-12
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• 2010

Morphological characteristics of hemp fiber were investigated using a light microscope in order to provide fundamental data for the use of hemp as a papermaking law material. Phloem of hemp is composed of cortical parenchyma cells and bast fiber with thick walls while xylem is composed of vessel, wood fiber and ray parenchyma cells. Also there are solitary pore and radial pore multiple which exist in diffuse porous pattern. Ray cells consist of uniseriate rays and thin walled ray parenchyma cells. Wood fibers are composed of three types: a large diameter fiber with longer length; a large diameter fiber with shorter length; a small diameter fiber with medium length. Vessel elements are composed of: a medium length one; a longer length one; the one whose both end walls have ligules or tails. Parenchyma cells in xylem and pit parenchyma cells have completely different size and shape. For bast fiber, the average length is about 4.4 mm and the width is about $30.5\;{\mu}m$; for vessel element, $600.0\;{\mu}m$ in length and $493.6\;{\mu}m$ in width; for wood fiber, $1000\;{\mu}m$ and $38.9\;{\mu}m$; for parenchyma cell, $50\;{\mu}m$ and $26.4\;{\mu}m$.