• Title/Summary/Keyword: Life cycle

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Change of Protein Patterns in Uterine Fluid during Estrus Cycle in Pigs (돼지에서 발정 주기 동안 자궁액 내의 단백질 패턴의 변화)

  • Lee, Yeon-Ju;Song, Eun-Ji;Lee, Sang-Hee;Cheong, Hee-Tae;Yang, Boo-Keun;Park, Choon-Keun
    • Reproductive and Developmental Biology
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    • v.37 no.3
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    • pp.103-108
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    • 2013
  • An uterus is female reproductive tract organ that affected estrus cycle. During a various changes occur at uterus in estrus cycle, one of them is body fluids secretion be called uterine fluid. Therefore, the objective of this study was to investigate the changes of protein patterns using two-dimensional gel electrophoresis in uterus fluids during the follicular and luteal phases in estrus cycle of pigs. In changes of protein spots were confirmed during the follicular and luteal phases. The 136 spots were expressed in follicular phase, the 57 spots of them showed reproducibility. On the other hand, the 140 spots were expressed in luteal phase, the 73 spots of them showed reproducibility. Also, spots expressed in follicular phase were number 69 and 94 spots and spots expressed in luteal phase only were number 156, 157, 184~187, 190 and 191 spots. The spots which of higher expression levels in the luteal phase than in follicular phase were number 76 and 79 spots. In conclusion, the spots expressed in follicular and luteal phases were confirmed with difference levels and these differences are function of RNA resolving, protein synthesis and cytoskeletal architecture.

A Study on the Analysis for Life-cycle of Quasi-Market Oriented SOC Public Enterprise and Effective Management (준시장형 SOC 공기업의 수명주기 분석과 효율적 관리방안에 관한 연구)

  • Park, Dong-Sun;Kang, Myung-Soo;Kim, Nam-Jung
    • Land and Housing Review
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    • v.6 no.4
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    • pp.165-175
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    • 2015
  • This study is focusing on the needs to introduce policy decision making based on identification of the definition for 'business life cycle' and 'public enterprises' for proper public enterprises management. For this purpose, the study is planning to define categorical variables for enterprise life cycle and provide basic data for public enterprises management policy. This study explored 'Korea Expressway Corporation', 'K-water', 'Korea Railroad', 'Korea Land and Housing Corporations', because of they are the public institutions recently underwent 'management normalization policy' due to rapidly increasing debt. First, there follows the analysis on priority and standard of categorical variables for quasi-market oriented SOC public enterprise life cycle by using AHP and frequency study on expert survey. Next, this study investigated and analyzed the enterprises management plan for expected 'declining period' through forecasting 'declining period' by conducting 2nd expert survey.

A Life Cycle-Based Performance-Centric Business Process Management Framework For Continuous Process Improvement (지속적 프로세스 개선을 위한 성과 중심의 생애 주기 기반 비즈니스 프로세스 관리 프레임워크)

  • Han, Kwan Hee
    • The Journal of the Korea Contents Association
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    • v.17 no.7
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    • pp.44-55
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    • 2017
  • Many enterprises have recently been pursuing process innovation or improvement to attain their performance goal. To comprehensively support business process execution, the concept of business process management (BPM) has been widely adopted. A life cycle of BPM is composed of process diagnosis, (re)design, and enactment. For aligning with enterprise strategies, all BPM activities must be closely related to performance metrics because the metrics are the drivers and evaluators of business process operations. The objective of this paper is to propose a life cycle-based BPM framework integrated with the process-based performance measurement model, in which business processes are systematically interrelated with key performance indicators (KPIs) during an entire BPM life cycle. By using the proposed BPM framework, company practitioners involved in process innovation projects can easily and efficiently find the most influencing processes upon enterprise performance in the process diagnosis phase, evaluate the performance of newly designed process in the process (re)design phase, monitor the KPIs of new business process, and adjust business process activities in the process execution phase through the BPM life cycle.

Life Cycle Impacts of Flexible-fiber Deep-bed Filter Compared to Sand-Filter including Coagulation and Sedimentation in Water Treatment Plant

  • Uh, Soo-Gap;Kim, Ji-Won;Han, Ki-Back;Kim, Chang-Won
    • Environmental Engineering Research
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    • v.13 no.1
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    • pp.1-7
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    • 2008
  • Recently a new technology called the flexible-fiber deep-bed filter (FDF) claimed to replace the conventional sand filter including coagulation and sedimentation filter (CSF) processes in the water treatment plant. Therefore the life cycle assessment (LCA) approach was applied for evaluating the life cycle impacts of FDF compared with those of CSF. The used LCA softwares were the Simapro 6 and PASS and their life cycle impact assessment (LCIA) methodologies were the Eco-indicator 99 and the Korean Eco-indicator, respectively. The goal of this LCA was to identify environmental loads of CSF and FDF from raw material to disposal stages. The scopes of the systems have been determined based on the experiences of existing CSF and FDF. The function was to remove suspended solids by filtration and the functional unit was $1\;m^3$/day. Both systems showed that most environmental impacts were occurred during the operation stage. To reduce the environmental impacts the coagulants and electricity consumptions need to be cut down. If the CSF was replaced with the FDF, the environmental impacts would be reduced in most of the impact categories. The LCA results of Korean Eco-indicator and Eco- indicator99 were quite different from each other due to the indwelling differences such as category indicators, impact categories, characterization factors, normalization values and weighting factors. This study showed that the life cycle assessment could be a valuable tool for evaluating the environmental impact of the new technology which was introduced in water treatment process.

Macro-level Methodology for Estimating Carbon Emissions, Energy Use, and Cost by Road Type and Road Life Cycle (도로 종류와 도로생애주기별 탄소배출량, 에너지소모량 및 비용에 대한 거시적 분석방법)

  • Hu, Hyejung;Baek, Jongdae
    • International Journal of Highway Engineering
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    • v.17 no.2
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    • pp.143-150
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    • 2015
  • PURPOSES : The authors set out to estimate the related carbon emissions, energy use, and costs of the national freeways and highways in Korea. To achieve this goal, a macro-level methodology for estimating those amounts by road type, road structure type, and road life cycle was developed. METHODS : The carbon emissions, energy use, and costs associated with roads vary according to the road type, road structure type, and road life cycle. Therefore, in this study, the road type, road structure type, and road life cycle were classified into two or three categories based on criteria determined by the authors. The unit amounts of carbon emissions and energy use per unit road length by classification were estimated using data gathered from actual road samples. The unit amounts of cost per unit road length by classification were acquired from the standard cost values provided in the 2013 road business manual. The total carbon emissions, energy use, and cost of the national freeways and highways were calculated by multiplying the road length by the corresponding unit amounts. RESULTS: The total carbon emissions, energy use, and costs associated with the national freeways and highways in Korea were estimated by applying the estimated unit amounts and the developed method. CONCLUSIONS: The developed method can be employed in the road planning and design stage when decision makers need to consider the impact of road construction from an environmental and economic point of view.

The Model to Generate Optimum Maintenance Scenario for Steel Bridges considering Life-Cycle Cost and Performance (강교량의 최적 유지관리 시나리오 선정 모델)

  • Park, Kyung Hoon;Lee, Sang Yoon;Kim, Jung Ho;Cho, Hyo Nam;Kong, Jung Sik
    • Journal of Korean Society of Steel Construction
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    • v.18 no.6
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    • pp.677-686
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    • 2006
  • In this paper, a more practical and realistic method is proposed to establish the lifetime optimum maintenance strategies of the deteriorating bridges considering the life-cycle performance as well as life-cycle cost. The genetic algorithm is applied to generate the set of maintenance scenarios that is the multi-objective combinatorial optimization problem related to lifetime performance and cost as separate objective functions, and the technique to select optimum tradeoff maintenance scenario is presented. Optimum maintenance scenarios could be generated not only at the individual member level but also at the system level of the bridge. Through the analytical results of applying the proposed methodology to the existing bridge, it is expected that the methodology will be effectively used to determine the optimum maintenance strategy for introducing a real preventive maintenance system and overcoming the limits of existing maintenance methods.

An Analysis of Potential Environmental Impact Reduction for Combined Sewer Overflow Project using a LCA Methodology (LCA 기법을 활용한 합류식 하수도 월류수 사업의 잠재적 환경영향 저감효과 분석)

  • Jo, Hyun-Jung;Song, Jang-Hwan;Hwang, Yong-Woo;Park, Ji-Hyoung
    • Journal of Korean Society of Water and Wastewater
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    • v.25 no.6
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    • pp.885-892
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    • 2011
  • In this study, LCA(Life Cycle Assessment) on 'Saemangum CSO Project' was carried out to evaluate environmental impact which occurred during the construction and operation periods and the potential environmental impact reduction was analyzed by comparing production and reduction level of pollution loads. LCA was conducted out according to the procedure of ISO14040 which suggested Goal and Scope Definition, Life Cycle Inventory Analysis, Life Cycle Impact Assessment and Interpretation. In the Goal and Scope Definition, the functional unit was 1 m3 of CSO, the system boundary was construction and operation phases, and the operation period was 20 years. For the data collection and inventory analysis, input energies and materials from civil, architecture, mechanical and electric fields are collected from design sheet but the landscape architecture field is excepted. LCIA(Life Cycle Impact Assessment) was performed following the procedure of Eco-Labelling Type III under 6 categories which were resource depletion, eutrophication, global warming, ozone-layer destruction, and photochemical oxide formation. In the result of LCA, 83.4% of environmental impact occurred in the construction phase and 16.6% in the operation phase. Especially 78% of environmental impact occurred in civil works. The Global warming category showed the highest contribution level in the environmental impact categories. For the analysis on potential environmental impact reduction, the reduction and increased of environmental impact which occurred on construction and operation phases were compared. In the case of considering only the operation phase, the result of the comparison showed that 78% of environmental impact is reduced. On the other hand, when considering both the construction and operation phases, 50% of environmental impact is increase. Therefore, this study showed that eco-friendly material and construction method should be used for reduction of environmental impact during life cycle, and it is strongly necessary to develop technology and skills to reduce environmental impact such as renewable energies.

Risk Factors for Falls in the Elderly by Life-cycle (노인생애주기에 따른 낙상요인)

  • Kim, Jong-Min;Suh, Hye-Kyung
    • Korean Journal of Health Education and Promotion
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    • v.27 no.1
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    • pp.21-34
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    • 2010
  • Objectives: The objective of this study was to investigate risk factors for falls in the elderly by life-cycle. Methods: This study used the data on 435 male and female elderly generated from a survey taken at 21 Welfare Centers for the Elderly in Seoul. The incidence of demographic characteristics, physical changes brought about with ageing, health-related behavior, chronic diseases, and environmental characteristics on falls in the elderly was analyzed. Hierarchical Logistic Regression analysis was also conducted to investigate the incidence by life-cycle (early-mid-late stage) and the results were used for predicting falls. Results: The incidence of risk factors on falls varied across life-cycle. Among the elderly in the early (ages from 65 through 74), marital status, the existence of a companion, the quality of sleep, the chronic diseases, and the condition of the bathroom floor were found to be related to falls. Among those in the mid-stage (ages from 75 through 84), sex, marital status, the existence of a companion, hearing capacity, sense of balancing, chronic diseases, the exclusive use of rooms, and the side bar with bath tub were found to affect falls. Finally, for the elderly in their late stage (85 years of age and older), drinking and vision were found to be related to falls. Conclusion: The incidence of risk factors on falls was found to vary according the stage in the elderly. A key implication of this finding is that falls prevention programs and interventions must be catered to specific age sub-groups.

Changes in Plasminogen Activity in Uterus Tissue during the Estrous Cycle in the Pigs

  • Kim, Kang-Hyun;Lee, Yong-Seung;Gu, Ha-Na;Yang, Boo-Keun;Cheong, Hee-Tae;Park, Choon-Keun
    • Reproductive and Developmental Biology
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    • v.35 no.4
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    • pp.463-468
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    • 2011
  • This study investigated the changes of plasminogen activators (PAs) activity, expression and localization of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) during the estrous cycle in pigs. Estrous cycle was sorted into three group by pre-ovulation (Pre-Ov), post-ovulation (Post-Ov) and early to mid-luteal stages (Early to mid-L). Analysis for immunohistochemistry was confirmed by location of tPA and uPA. Porcine uterus tissue was cut into $1{\times}1$ cm squares, and were incubated in DMEM/F-12 medium for 1 h at $38^{\circ}C$, 5% $CO_2$ for measurement of PA activity. Western blotting was implemented for measurement of PA quantity. In results, the blood vessels and secretory glands were increased in Post-Ov stage than Pre-Ov and Early to mid-L stages. The tPA and uPA was located mainly within lumen of blood vessels and secretory glands. The PA activity in Post-Ov ($0.99{\pm}0.03$) stage were significantly (p<0.01) higher than Pre-Ov stage ($0.51{\pm}0.03$) and Early to mid-L stage ($0.21{\pm}0.04$). Expression of PAs were significantly (p<0.05) higher in Early to mid-L stage than other stages. These results indicate that PAs activity and expression may change in uterus tissue during the estrous cycle in pigs.

A Study on the Effects on Low Cycle Fatigue Life of a High Pressure Turbine Nozzle due to the Perturbation of Crystal Orientation of Grain of DS Materials (일방향 응고 재료의 결정립 성장 방향 섭동이 고압터빈 노즐 저주기 피로 수명에 미치는 영향에 대한 연구)

  • Huh, Jae Sung;Kang, Young Seok;Rhee, Dong Ho
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.7
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    • pp.653-658
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    • 2016
  • High pressure components of a gas turbine engine are generally made of nickel-base superalloys, using precision casting process due to complicated geometries with intricate channels and cooling holes. Turbine components manufactured from directionally solidified and single crystal materials have columnar grains; however, it is found that the crystals do not grow in its preferred direction, although the orientation can be controlled. This anisotropy can lead to the variations of elastic and Hill's parameters in constitutive equations, and they alter stress distributions and the low cycle fatigue life. We aims to evaluate the effects of perturbed crystal orientations on the structural integrity of a directionally solidified nozzle using low cycle fatigue life. We also attempt to show the necessity for the control of allowed manufacturing errors and stochastic analysis. Our approaches included conjugate heat transfer and structural analysis, along with low cycle fatigue life assessment.