• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.399-408
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• 2022

Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.

• Transactions of the Korean hydrogen and new energy society
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• v.17 no.1
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• pp.117-124
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• 2006

By calcining at $750^{\circ}C$ for 30 h in $O_2$ stream after milling, $LiNi_{1-y}In_yO_2$(y = 0.005, 0.01, 0.025, 0.05, and 0.1) were synthesized and their electrochemical properties were investigated. All the samples had the $R{\bar{3}}m$ structure. In addition, they contained $LiInO_2$ phase and the intensities of the peaks for the $LiInO_2$ phase increased as the value of y increased. The sample with y = 0.01 had the largest first discharge capacity (140.2 mAh/g), but the sample with y = 0.005 had a better cycling performance. The samples with y $\geq$ 0.025 had a bad cycling performance irrespective of the first discharge capacity. The sample with y = 0.005 had the largest value of $I_{003}/I_{104}$ and the smallest value of R-factor. Among all the samples, $LiNi0_{0.995}In_{0.005}O_2$ had the best electrochemical properties. This sample had a smaller first discharge capacity than $LiNiO_2$, but it showed a better cycling performance than $LiNiO_2$.

• Korean Journal of Acupuncture
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• v.25 no.4
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• pp.73-88
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• 2008

Objective : The aim of this research was to investigate the effect on five element constitutional acupuncture(Sa-am acupuncture) at 4 acupoints by needle manipulation to sedate Six Fu-Organ on hyperlipidemia induced by high fat diet in rats. Method : We recorded data of weight gain, food intake, food efficiency, weight of liver, heart, spleen, lung, kidney, levels of total cholesterol, triglyceride, HDL-cholesterol, AST, ALT in serum of rats fed high fat diet for 5 weeks. Spraque Dawley rats were divided into eight groups(normal; normal diet and non-acupuncture group, control; non-acupuncture group, Acu-LI; acupuncture at $SI_5{\cdot}LI_5{\cdot}BL_{66}{\cdot}LI_2$ group, Acu-ST; acupuncture at $GB_{41}{\cdot}ST_{43}{\cdot}LI_1{\cdot}ST_{45}$, Acu-SI; acupuncture at $BL_{66}{\cdot}SI_2{\cdot}ST_{36}{\cdot}SI_8$, Acu-BL; acupuncture therapy at $ST_{36}{\cdot}BL_{40}{\cdot}GB_{41}{\cdot}BL_{65}$, Acu-TE; acupuncture at $BL_{66}{\cdot}TE_2{\cdot}ST_{36}{\cdot}TE_{10}$, Acu-GB; acupuncture at $LI_1{\cdot}GB_{44}{\cdot}SI_5{\cdot}GB_{38}$. After needles inserted, it was rotated clockwise and anticlockwise 12 times on rats fed high fat diet. Results : The body weight was decreased in Acu-SI, Acu-TE, Acu-GB group, /the food intake was decreased in Acu-TE, / the food efficiency was decreased in Acu-SI, /serum triglyceride was decreased in Acu-LI, Acu-ST, Acu-BL, Acu-GB, /serum total cholesterol was decreased in Acu-LI, Acu-BL, serum ALP was decreased in Acu-LI, Acu-ST, Acu-BL, Acu-TE, Acu-GB. While the relative weight of heart was increased in Acu-LI, Acu-SI, the relative weight of kidney was increased in Acu-SI, Acu-GB. Conclusion : These results suggest that five element constitutional acupuncture(Sa-am acupuncture) may be having an therapeutic influence on hyperlipidemia induced by high fat diet. Further researches of acupuncture manipulation are needed in the future based on our study.

• Journal of architectural history
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• v.28 no.1
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• pp.25-34
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• 2019

"Stupa of Buddhist Monk, YeomGeo"(844) is known as the earliest Seon-stupa relic remains in Korean peninsula, from which, during late Silla and ealy Goryeo period, there were more than 30 of stupa was built on such canon. and became the well-known material culture in Seon Buddhism in late Silla period. In $9^{th}$ century, with the JeonDeong(delivering the light of Seon)from Tang to Silla, the culture of "GeonTapIpBi(building the pagoda and erecting stele)" was also moved in. And it was right after the style of monk's stupa had been methodically changed in china, from having the room in stupa for the corpse, named as "QuanShenSheLi", to the lessened stupa that contain the cremated. Analyzing the "Master ChengGuang's stupa"（807）and its stele, it can be found the correspondences of octagonal plan and the subjects of ornamentation to that of Stupas built in Silla, reveals they were made by the same canon. By the document in the stele, surmising the historical cause of alteration in Chan stupa, there was the most famous zen master ShenHui at the time, who has the most important role of making the NanZongChan to get the authenticity in Chan Buddhism. His reliqury was the first ${\acute{s}}ar{\bar{i}}ra$ casket discovered among Chan monks' relics, consequentially it was to influence to Chan cuture and size the monks 'stupa for his ${\acute{s}}ar{\bar{i}}ra$. The stupa of master ChengGuang, by its shape and geological location, is the lost piece in the Puzzle of Chan stupa culture between Silla and Tang.

• Spatial Information Research
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• v.18 no.5
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• pp.37-45
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• 2010

AT(Aerial Triangulation) is the essential procedure for creating orthophoto and transforming coordinates on the photographs into the real world coordinates utilizing GCPs (Ground Control Point) which is obtained by field survey and the external orientation factors from GPS/INS as a reference coordinates. In this procedure, all of the GCPs can be collected from field survey using GPS and Total Station, or obtained from digital maps. Collecting GCPs by field survey is accurate than GCPs from digital maps; however, lots of manpower should be put into the collecting procedure, and time and cost as well. On the other hand, in the case of obtaining GCPs from digital maps, it is very difficult to secure the required accuracy because almost things at each stage in the collecting procedure should rely on the subjective judgement of the performer. In this study, the results from three methods have been compared for the accuracy assessment in order to know if the results of each case is within the allowance error: for the perceivable objects such as road boarder, speed bumps, constructions etc., 1) GCPs selection utilizing the unique LiDAR intensity value reflected from such objects, 2) using LiDAR DSM and 3) GCPs from field survey. And also, AT and error analysis have been carried out w ith GCPs obtained by each case.

• Journal of the Mineralogical Society of Korea
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• v.22 no.1
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• pp.63-72
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• 2009

Carbon-coated lithium iron phosphate ($LiFePO_4/C$) composites are synthesized by the modified mechanical activation method (modified MA process) and studied by the Rietveld structural refinement. Rietveld indices of $LiFePO_4/C$ indicate good fitting with $R_p=8.14%,\;R_{wp}=11.1%,\;R_{exp}=9.09%,\;R_B=3.88%$, and S (GofF, Goodness of fit) = 1.2, respectively. $LiFePO_4/C$ with a space group Pnma shows a = 10.3229(3)${\AA}$, b = 6.0052(2) ${\AA}$, c = 4.6939(1) ${\AA}$, and V = 290.98(1) ${\AA}^3$ in dimension, indicating good agreements with those of previous works. Synthetic powders are nano-sized ($65{\sim}90nm$) homogeneous particles with high purity. Thus the modified MA method will be an efficient process to get a high quality cathode material for commercial lithium batteries.

• BMB Reports
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• v.42 no.1
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• pp.59-64
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• 2009

Hepatitis B virus (HBV) infection is highly prevalent worldwide. The major challenge for current antiviral treatment is the elevated drug resistance that occurs via rapid viral mutagenesis. In this study, we developed AAV vectors to simultaneously deliver two or three shRNAs targeting different HBV-related genes. These vectors showed markedly better antiviral effects than ones that delivered a single shRNA in vitro. A dual shRNA expression vector (AAV-157i/1694i), which simultaneously expressed two shRNAs targeted the S and X genes of HBV, reduced HBsAg, HBeAg and HBV DNA levels by $87{\pm}4$, $80.3{\pm}2.6$ and $86.2{\pm}7%$ respectively, eight days post-transduction. In a mouse model of prophylactic treatment, HBsAg and HBeAg were reduced to undetectable levels and the serum HBV DNA level was reduced by at least 100 fold. These results indicate that AAV-157i/1694i generates potent anti-HBV effects and that the strategy of constructing multi-shRNA expression vectors may lead to enhanced anti-HBV efficacy and overcome the evading mechanism of the virus and thus the development of drug resistance.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2008.11a
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• pp.306-307
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• 2008

• Structural Engineering and Mechanics
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• v.6 no.5
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• pp.517-527
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• 1998

This paper describes an exact method of analysis for natural vibration of diagonal networks by considering an equivalent cyclic periodic structure and adopting the double U-transformation technique. Both a lumped mass system and a distributed mass system are considered to investigate the diagonal networks. The exact solution for the frequency equations and the natural modes of the networks can be derived. As numerical examples, square diagonal cable networks with different meshes are worked out.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1147-1151
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• 2009

The synthetic route of novel 3′-C-methyl carbodine analogue is described. The construction of tertiary alcohol at 3′- position of carbodine analogues was successfully made via sequential [3,3]-sigmatropic rearrangement, ring-closing metathesis (RCM) and stereoselective dihydroxylation reactions starting from ethyl glycolate.