• Asian-Australasian Journal of Animal Sciences
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• 제21권9호
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• pp.1286-1295
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• 2008

Leptin is produced by adipocytes and its role in the regulation of lipid metabolism, feed intake, productive and reproductive performance of domestic animal species has been greatly stressed and extensively investigated in recent years. This study was conducted to develop a radioimmunoassay (RIA) for the estimation of plasma bovine leptin and to determine plasma leptin concentration in fattening Japanese Black cattle (Wagyu) and its crossbreds at commercial farms. Relationships of plasma leptin with plasma vitamin A and age of crossbred cattle were also determined. Recombinant bovine leptin (rbleptin) was produced by the E. coli overexpressed leptin as a GST (glutathione S-transferase)-fusion protein. Then antiserum against bovine leptin was obtained by its immunization in rabbits. Using this antiserum, a bovine specific RIA was developed and plasma leptin level was determined in 120 crossbred fattening cattle (WagyuHolstein, 50:50) at commercial farms. The plasma leptin level increased with the age of cattle and its level was greater in the crossbred heifers than in the steers. Plasma vitamin A level was negatively correlated with plasma leptin level in crossbred heifers and steers. This relationship was stronger in heifers than in steers. Plasma leptin was gradually increased with advancing age in fattening Wagyu cattle. In conclusion, development of a bovine specific RIA to estimate plasma leptin will contribute to better understanding of the role of leptin in cattle.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 추계종합학술대회 논문집
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• pp.416-420
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• 1999

This paper describes a 32-bit RISC processor, which has instruction level compatibility with the ARM7 microprocessor. The processor is fully synthesizable, and its performance is evaluated based on 0.35-${\mu}{\textrm}{m}$ CMOS library. This paper focuses on the implementation of the processor and the reliable verification strategy ensuring the complete instruction level compatibility. The processor has successfully verified using a FPGA chip.

• 약학회지
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• 제57권5호
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• pp.362-368
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• 2013

High performance liquid chromatograph (HPLC) is the most frequently used analytical instrument in analytical laboratories for pharmaceutical analysis. In order to provide a high level of assurance for reliable data generated from the HPLC analysis, the performance qualification of the HPLC system is required. For this purpose, the performance of HPLC system should be regularly monitored by examining the key functions of the typical HPLC system (solvent delivery system, injector system, column oven, UV-VIS detector system). We have investigated the validation guidelines of the performance verification of these key modules for HPLC system. And we proposed and evaluated its validation guidelines and the related verification methods for pharmaceutical analysis that could be practically applied in Korea.

• 한국산학기술학회논문지
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• 제14권7호
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• pp.3482-3486
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• 2013

페이딩 채널에서 야기되는 진폭 및 위상 왜곡을 예측하여 보상하는 PSAM(Pilot Symbol Assisted Modulation)방식의 경우에는 fast 페이딩 채널에서 도플러확산에 의해 심한 성능 저하를 갖는다. 이에 대한 문제점을 분석하고, 이를 개선하기 위한 페이딩 보상 방식을 제안한다. 도플러 확산은 BER 성능을 저하시키는 주된 원인이 된다. 기존의 PSAM 방식과 비교해 보면, 한 심벌 주기 이내의 지연파의 간섭이 있는 환경에서는 기존 PSAM 방식은 도플러확산에 의해 BER이 $10^{-1}$ 정도의 매우 심각한 성능저하를 보이지만 제안된 방식은 도플러 확산이 클수록 성능저하는 발생하지만 기존 방식에 비해 BER이 $10^{-2}$ 이하로 성능이 우수함을 알 수 있다.

• 근관절건강학회지
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• 제6권2호
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• pp.295-309
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• 1999

This study was done to Identify the relations between psychosocial factors and symptoms of patient with rheumatoid arthritis. Its subjects were 150 outpatients selected at H. Rheumatism clinic from July to August in 1998. Data were collected by means of questionnaires using interview. Those data were analyzed by Frequency, t-test, ANOVA, pearson's correlation using SPSS window 8.0. The results were as follows : 1) The level of family support was relatively high and the level of self-efficacy and performance of daily living activities were average. Among their symptoms, fatigue and pain were frequent problems. 2) Family support was different by educational level, self-efficacy and physical, psychological symptoms were different by performance of regular exercise. 3) The family support was inversely related to physical symptoms especially ADL, while it was not related to psychological symptoms except a reverse correlation between depression and anxiety, and family support. Self-efficacy held a reverse correlation with both physical and psychological symptoms. And there was a close relationship between symptoms. In conclusion it was found that the promotion of family support, self-efficacy and exercise-performance holds a key post in reducing symptoms of rheumatoid arthritis.

• 한국군사과학기술학회지
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• 제9권3호
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• pp.25-32
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• 2006

Weapon systems composed of several subsystems execute various engagement missions in distributed combat environments in cooperation with a large number of subordinate/adjacent weapon systems as well as higher echelons through tactical data links. Such distributed weapon systems require distributed real-time simulation test beds to integrate and test their operational software, analyze their performance and effects of cooperated engagement, and validate their requirement specifications. These demands present significant challenges in terms of real-time constraints, time synchronization, complexity and development cost of an engagement simulation test bed, thus necessitate the use of high-performance distributed real-time simulation architectures, and modeling and simulation techniques. In this paper, in order to meet these demands, we presented a distributed real-time simulation system based on High Level Architecture(HLA) and Discrete Event System Specification(DEVS). We validated its performance by using it as a test bed for developing the Engagement Control System(ECS) of a surface-to-air missile system. The proposed technique can be employed to design a prototype or model of engagement-level distributed real-time simulation systems.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.1125-1128
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• 2007

In order to improve the acoustic performance of a noise barrier without increasing its height, various type of acoustic devices are suggested but, there is no proper method to estimate the performance in Korea. For this, an outdoor test facility was established in Expressway and Transportation Technology Institute(ETTI) of Korea Expressway Corporation for testing the acoustical performance of noise reducing devices installed on the top of a noise barrier. Noise measurements before and after installation of the noise reducing devices were carried out by using sound pressure level for long distance range from the barrier, from 10m to 40m. For considering the directivity effects of noise reducing devices, multivariate regression analysis was attempted.

• Preventive Nutrition and Food Science
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• 제1권1호
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• pp.69-74
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• 1996

Capsaicin(CAP) is a pungent ingredient of hot pepper that has been used as a spicy food additive, pre-servative, and medicine. In this study, the effect of CAP on L-ascorbic acid(AsA)level in various tissues as well as its urinary excretion. and drug-metabolizing enzyme activity in rats were investigated. Rats fed AsA-deficient diets for 17days were injected intraperitoneally with 1mg of CAP in 0.5ml of ethanol-Tween 80-saline(20 :10 : 70, v/v/v). Control rats received the equal volume of the same solution without CAP. Urine was collected for 3 day after the CAP injection, and after 5 days tissues were removed; their AsA contents were measured by high performance liquid chromatography combined with and electrochemical detector. In addition, hepatic microsomal ethoxyresorfin O-deethylase(EROD) activity as measured. Urinary AsA excretion changed significantly following CAP injection. One and two days after CAP injection, the urinary AsA increased 2-and 3-fold in the CAP injected group, compared to the control, but the contents of adrenal glands and brain were lower than those of the control Dehydroascorbic acid contents in adrenal glands of the CAP injected group were higher than that of the control These results suggested that a single large dose of CAP could temporarily cause the redistribution of AsA in tissues accompanying by its urinary excretion, by affecting probably a biological system including mixed function oxygenase system(MFOS)

• Journal of Ship and Ocean Technology
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• 제8권2호
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• pp.41-60
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• 2004

Ship design process requires lots of complicated analyses for determining a large number of design variables. Due to its complexity, the process is divided into several tractable designs or analysis problems. The interdependent relationship requires repetitive works. This paper employs collaborative optimization (CO), one of the multidisciplinary design optimization (MDO) techniques, for treating such complex relationship. CO guarantees disciplinary autonomy while maintaining interdisciplinary compatibility due to its bi-level optimization structure. However, the considerably increased computational time and the slow convergence have been reported as its drawbacks. This paper proposes the use of an approximation model in place of the disciplinary optimization in the system-level optimization. Neural network classification is employed as a classifier to determine whether a design point is feasible or not. Kriging is also combined with the classification to make up for the weakness that the classification cannot estimate the degree of infeasibility. For the purpose of enhancing the accuracy of a predicted optimum and reducing the required number of disciplinary optimizations, an approximation management framework is also employed in the system-level optimization.

• 경영과정보연구
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• 제24권
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• pp.1-24
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• 2008

This paper examines the direct effects of board independence and also its interaction effects with CEO's firm specific experience on firm performance. The findings in an hierarchial regression analysis of multiyear sample of computer hardware companies indicate that independent, outsider directors are beneficial to firms' performance when CEO has high-level of firm specific experience whereas it is harmful when CEO has low-level of firm specific experience. However, separating the positions of board chair and chief executive officer that has been used as another means for increasing board independence does not influence to firms' performance. These findings imply that researchers in corporate governance should reconsider the relative weight placed on directors' monitoring and assistance role. Rather than focusing predominantly on directors' willingness or ability to control executives, in future research scholars should yield more productive results by focusing on the assistance directors provide in bringing valued resources to the CEOs and in serving as a source of advice and counsel especially for CEO's improvement of management technique. In addition, they should pay more attention on identifying intervening processes between board and firm performance in order to provide optimal governance mechanisms and configurations to practitioners.