• 한국식품저장유통학회지
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• 제20권3호
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• pp.429-434
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• 2013

매실주의 숙성 중 에틸카바메이트의 발생을 알아보고자 일반 가정에서 담그는 방식으로 매실주와 복분자주를 담아 저장하면서 발생량을 측정하였다. 매실주는 매실과 설탕 및 $19.5^{\circ}{\sim}35^{\circ}$ 담금주의 담금비를 달리하여 담아, 15일부터 180일까지 15~30일 간격으로 에틸카바메이트의 함량을 분석한 결과 숙성 90일 까지 매실을 설탕만으로 숙성한 경우와 복분자주에서 에틸카바메이트는 발생하지 않았으나 매실의 알코올의 농도가 높을수록 에틸카바메이트의 생성량이 증가하였다. 매실과 담금주의 비율을 달리한 결과, 매실보다는 알코올 함량이 에틸카바메이트 발생에 더 큰 영향을 미치는 것을 확인하였으며 120~150일 숙성기간이 지나면서 에틸카바메이트 발생량은 점차 감소하는 경향을 보였으나 90일 숙성 후 여과처리 하였을 경우 여과하지 않았을 경우보다 180일까지 2배가량 높은 에틸카바메이트가 발생하였으나 이들 모두 안전한 수준이었다.

• KEPCO Journal on Electric Power and Energy
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• 제2권2호
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• pp.285-291
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• 2016

In chemical-looping combustion, pure oxygen is transferred to fuel by solid particles called as oxygen carrier. Chemical-looping combustion process usually utilizes a circulating fluidized-bed process for fuel combustion and regeneration of the reduced oxygen carrier. The performance of an oxygen carrier varies with the active metal oxide and the raw support materials used. In this work, spraydried Mn-based oxygen carriers were prepared with different raw support materials and their physical properties and oxygen transfer performance were investigated to determine that the raw support materials used are suitable for spray-dried manganese oxide oxygen carrier. Oxygen carriers composed of 70 wt% $Mn_3O_4$ and 30 wt% support were produced using spray dryer. Two different types of $Al_2O_3$, ${\gamma}-Al_2O_3$ and ${\alpha}-Al_2O_3$, and $MgAl_2O_4$ were applied as starting raw support materials. The oxygen carrier prepared from ${\gamma}-Al_2O_3$ showed high mechanical strength stronger than commercial fluidization catalytic cracking catalyst at calcination temperatures below $1100^{\circ}C$, while the ones prepared from ${\alpha}-Al_2O_3$ and $MgAl_2O_4$ required higher calcination temperatures. Oxygen transfer capacity of the oxygen carrier prepared from ${\gamma}-Al_2O_3$ was less than 3 wt%. In comparison, oxygen carriers prepared from ${\alpha}-Al_2O_3$ and $MgAl_2O_4$ showed higher oxygen transfer capacity, around 3.4 and 4.4 wt%, respectively. Among the prepared Mn-based oxygen carriers, the one made from $MgAl_2O_4$ showed superior oxygen transfer performance in the chemical-looping combustion of $CH_4$, $H_2$, and CO. However, it required a high calcination temperature of $1400^{\circ}C$ to obtain strong mechnical strength. Therefore, further study to develop new support compositions is required to lower the calcination temperature without decline in the oxygen transfer performance.

• 한국통신학회논문지
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• 제40권10호
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• pp.1994-2005
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• 2015

다양한 기술들이 하나로 융합된 VoIP(Voice over Internet Protocol) 서비스는 IP 망을 통해 음성뿐만 아니라 멀티미디어 서비스와 각종 부가서비스를 제공한다. 현재 대역폭 사용효율과 저비용성 등의 장점들 때문에 기존 PSTN 전화에서 VoIP 시스템으로 비즈니스가 전환되고 있다. 이러한 것이 가능한 이유는 기존의 회선교환 네트워크를 대신하여 디지털화된 정보가 IP 패킷 형태로 여러 계층의 컴퓨터로 구성된 패킷교환망을 통해 전달되기 때문이다. 반면에 이러한 형태의 시스템들이 기존 IP네트워크 환경에서의 취약점과 융합되어 발생되는 신규 취약점 등에 의해서 각종 Fraud가 발생하고 있다. 2012년 상반기 Fraud call의 46%가 VoIP 전화기에서 만들어지고 있다는 조사 결과도 있듯이 Fraud Call의 피해는 상당하다. 따라서 Fraud에 대한 손실예방을 위해 대책마련이 필요하다. 특히, Fraud Call의 피해는 주로 국제 통화를 이용할 때 과금 피해로 나타나고 있어, 이와 관련된 SIM Box에 의한 Toll Bypass Fraud에 대한 분석과 이를 검출할 수 있는 방안마련이 요구된다. 일반적으로는 DPI(Deep Packet Inspection)를 기반으로 주요 Signature 또는 통계정보를 이용한 다양한 검출 방안이 제안되었으나, Fraudster 역시 이를 회피하기 위해 다양한 방법을 사용하고 있다. 특히, VoIP에서 Call Setup과 Termination과정을 수행하는 SIP Signal을 암호화 하거나 여러 경로로 전송하는 방식을 사용함으로써 감지를 회피하고 있다. 본 논문은 Fraud call의 감지 회피를 효과적으로 방지할 수 있도록 VoIP 트래픽의 특성과 VoIP Fraud 중 SIM Box Fraud의 행위분석을 결합한 방법론을 제안한다. 또한 제안된 방법론을 적용하여 Toll Bypass Fraud와 관련된 VoIP 서비스 제공자의 장비를 검출하는 방법을 제시한다.

• 한국식품과학회지
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• 제37권5호
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• pp.838-843
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• 2005

살균소독제의 살균소독력 평가를 위한 표준시험법을 확립하기 위하여 세균현탁액 시험법(bacterial suspension test)에 대해 연구하였다. 살균소독력은 G(-)인 E. coli ATCC 10536과 G(+)인 S. aureus ATCC 6538에 대하여 $20{\pm}1^{\circ}C$에서 $5min{\pm}10^{\circ}sec$간 반응하였을 때 초기근수를 5 log이상 감소시키고, 또한, 시험검증조건을 만족하는지를 검토하여 시험법을 확립하였다. 유통 중인 살균소독제 제품 36종에 대하여 확립된 시험법으로 살균소독력을 시험한 결과 모든 살균소독제는 제조자가 제시한 사용농도에서 살균소독력을 나타내었으며, 주요 식중독 균에 대한 살균효과도 관찰되었다. 확립된 시험법은 살균소독력을 측정하는 국가표준시험법으로서 살균소독제의 살균소독력 평가에 적합하였다.

• 대한족부족관절학회지
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• 제18권4호
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• pp.165-172
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• 2014

Purpose: We evaluated the correlation of postoperative clinical outcomes and radiologic findings using computed tomography and simple X-ray in intra-articular calcaneal fractures. Materials and Methods: The current study is based on 41 feet, 38 patients with displaced intra-articular fracture who underwent surgical treatment with at least one year of follow-up. Evaluation of clinical outcome included American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, visual analogue scale (VAS) score, and subjective satisfaction. A simple X-ray was used in evaluation of preoperative and postoperative Gissane angle, B${\ddot{O}}$hler angle, and calcaneal fracture width. Computed tomography scan was performed for evaluation of preoperative and postoperative articular step-off and articular gap in all cases. Finally, we evaluated the correlation of the postoperative clinical outcomes and radiologic findings based on the measurement. Results: The average postoperative AOFAS score and VAS score was $84.1{\pm}8.5$ and $2.2{\pm}2.2$. Subjective satisfaction was excellent in 15 cases, good in 19 cases, and fair in seven cases. The average B${\ddot{O}}$hler angle was restored from $11.1^{\circ}$ to $24.7^{\circ}$(p<0.05), Gissane angle was changed from $121.0^{\circ}$ to $119.0^{\circ}$ (p>0.05), and the average width was restored from 45.8 to 35.0 mm (p<0.05). The average articular step-off and gap were decreased from 6.3 to 2.0 mm and from 11.1 to 4.6 mm, respectively (p<0.05). No significant correlations were observed between the clinical outcome and Gissane angle, B${\ddot{O}}$hler angle, and width, and there was no significant correlation between the clinical outcome and Sanders classification. However, postoperative articular step-off showed correlation with VAS and AOFAS score and articular gap showed correlation with VAS score. Conclusion: The clinical outcome did not show correlation with B${\ddot{O}}$hler angle and Gissane angle but did show correlation with anatomical reduction of the posterior facet joint.

• 대한원격탐사학회지
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• 제23권2호
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• pp.131-135
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• 2007

조간대의 조류로 발달은 조간대 퇴적물종류, 입도, 조성 및 조류의 세기 등 에 많은 영향을 받는다. 따라서 조류로의 발달 특성, 밀도, 형태 등은 조간대의 특징을 분석하는데 활용될 수 있다. 그러나 아직 갯벌의 조류로에 대한 정량적 분석은 매우 미흡한 실정이다. 이 연구에서는 조류로의 정량적 분류기준으로 프랙탈 분석방법을 제시하고, 발달 정도가 다른 두 지역의 조류로에 대한 적용결과에 대한 정량적 비교를 제시한다. 시험 적용지역인 강화도 남단 조간대에서 얻어진 IKONOS 영상으로부터 조류로를 추출한 뒤, 프랙탈 분석방법 중 2차원 분석에 많이 사용되는 box counting 방법을 적용하여 프랙탈 차원을 구하였다. 분석 결과 강화도 남단 전체 조간대 지역에 대한 프랙탈 차원 값은 약 1.31로 나타났다. 조류로의 지선이 단순하며 남북으로 수직방향으로 발달한 지역은 프랙탈 차원 값이 $1.0563\sim1.0672$로 비교적 적은 값을 나타내는 반면, 조류로의 지선이 발달하고 매우 복잡한 형태를 보이는 곳은 프랙탈 차원 값이 $1.2550\sim1.3016$로 나타났다. 즉, 조류로의 발달정도에 따라 프랙탈 차원 값이 약 0.2 정도로 매우 뚜렷한 차이를 나타내며, 따라서 조류로의 정량적 구분이 프랙탈 분석에 의하여 가능하다는 결론을 얻을 수 있다. 향후 다른 특성을 갖는 다양한 조간대 지역에 적용하면 조류로의 발달정도와 환경 인자에 대한 정량적 분석이 가능할 것으로 사료된다.

• Korean Journal of Acupuncture
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• 제38권3호
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• pp.140-150
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• 2021

Objectives : The increase of osteoclasts could cause osteoporosis and bone-related diseases. Also, the inhibition of osteoclast differentiation is important in treating bone-related diseases. Traditionally, Psoraleae Semen has been used for geriatric diseases, aging and musculoskeletal diseases. The purpose of this study is to investigate the effect of Psoraleae Semen ethanol extract (PS) on osteoclast differentiation and its function. Methods : To confirm the effect of PS on osteoclastogenesis and bone resorption activity, various levels of concentrations of PS (5, 10, 20 and 40 ㎍/ml) were tested on RAW 264.7 cells cultured with RANKL. We measured tartarate-resistant acid phosphatase (TRAP)-positive cells, TRAP activity, pit formation and F-actin ring formation. The expressions of nuclear factor of activated T-cells (NFATc1) and c-Fos were confirmed through western blot and reverse transcription- polymerase chain reaction (RT-PCR). Also, the expression of bone resorption and fusion-related genes in osteoclast was confirmed by RT-PCR. Results : PS decreased the number of TRAP-positive cells and the TRAP activity. In addition, PS significantly inhibited the formation of pit and F-actin ring. Furthermore, PS decreased the expression of osteoclast related genes. Conclusions : PS inhibits osteoclast differentiation and bone resorption ability through inhibition of the expression of osteoclast-related genes. This indicates that PS may be a potential therapeutic agent to osteoporosis by suppressing osteoclastogenesis.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.111-111
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• 2019

Glycyrrhizae radix is one of the most frequently prescribed ingredients in Oriental medicine, and G. radix extract has been shown to exert anti-cancer effects. However, the cellular and molecular mechanisms of apoptosis by G. radix are poorly defined. In the present study, it was examined the biochemical mechanisms of apoptosis by water extract of G. radix (WEGR) in human bladder T24 cancer cells. It was found that WEGR could inhibit the cell growth of T24 cells in a dose-dependent manner, which was associated with the induction of apoptotic cell death, as evidenced by the formation of apoptotic bodies, DNA fragmentation and increased populations of annexin-V positive cells. The induction of apoptotic cell death by WEGR was connected with an up-regulation of pro-apoptotic Bax protein expression and down-regulation of anti-apoptotic Bcl-2 and Bcl-xL proteins, and inhibition of apoptosis family proteins (XIAP, cIAP-1 and cIAP-2). In addition, apoptosis-inducing concentrations of WEGR induced the activation of caspase-9, an initiator caspase of the mitochondrial-mediated intrinsic pathway, and caspase-3, accompanied by proteolytic degradation of poly (ADP-ribose)-polymerase. WEGR also induced apoptosis via a death receptor-mediated extrinsic pathway by caspase-8 activation, resulting in the down-regulation of total Bid and suggesting the existence of cross-talk between the extrinsic and intrinsic pathways. Taken together, the present results suggest that WEGR may be a potential chemotherapeutic agent for the control of human bladder cancer cells.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.112-112
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• 2019

Baicalein is one of the main flavonoids derived from roots of Scutellaria baicalensis Georgi, a traditional Oriental medicine. Although baicalein has high antitumor effect on several human carcinomas, the mechanism responsible for this property is not unclear. In this study, the data revealed that baicale-ininduced growth inhibition was associated with the induction of apoptosis connecting with cytochrome c release, down-regulation of anti-apoptotic Bcl-xl and increased the percentage of cells with a loss of mitochondria membrane permeabilization. Baicalein also induced the proteolytic activation of caspases and cleavage of PARP; however, blockage of caspases activation by z-VAD-fmk inhibited baicalein-induced apoptosis. In addition, baicalein enhanced the formation of autophagosomes and up-regulated LC3-II/LC3-I ratio. Interestingly, the pretreatment of bafilomycin A1 recovered baicalein-induced cell death suggesting that autophagy by baicalein roles as protective autophagy. Taken together, our results indicated that this flavonoid induces apoptosis and cell protective autophagy. These data means combination treatment with baicalein and autophagy inhibitor might be a promising anticancer drug.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 춘계학술대회
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• pp.113-113
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• 2019

Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic. Although certain studies have demonstrated that DATS possesses strong anti-inflammatory activity, the underlying molecular mechanisms remain largely unresolved. In this study, we examined whether DATS exerts anti-inflammatory activity and investigated the possible mechanisms. Our results indicated that DATS significantly suppressed the lipopolysaccharide (LPS)-induced release of nitric oxide (NO) and prostaglandin E2 by inhibiting inducible NO synthase and cyclooxygenase-2 expression at the transcriptional and post-transcriptional levels in RAW 264.7 macrophages. DATS also down-regulated Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 expression, and inhibited nuclear translocation of nuclear transcription factor-kappa B (NF-${\kappa}B$) in LPS-stimulated 264.7 macrophages. Furthermore, we found that these inhibitory effects of DATS were associated with the inhibition of chemokine receptor (CXCR4) and ligand (CXCL12) expression, and reactive oxygen species generation. Overall, the present data indicated that DATS had anti-inflammatory effects on LPS-activated macrophages, possibly via inhibiting the TLR4/NF-kB and/or chemokine signaling pathways, and DATS could be a potential drug therapy for inflammation and its associated diseases.