• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.88-88
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• 1995

Tetrahydroisoquinoline (THI) compounds have various pharmacological actions in the cardiovascular system. Recently, we have synthesized 1-${\alpha}$-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, YS 49. In the present study, we evaluated the effect of YS-49 on positive inotropic and chronotropic action using isolated rat heart and on blood pressure and heart rate using anesthesized rabbit. Vasodilating action was also assessed in isolated rat thoracic aorta. YS 49, concentration-dependently relaxed rat aorta precontracted with phenylephrine (PE, 0.3 ${\mu}$M) and high potassium (high K$\^$+/, 65.4 mM). The 50% inhibitory concentration (IC$\sub$50/) of YS 49 in PE-induced and high K$\^$+/-induded contraction was 5.36 ${\mu}$M and 2.52 ${\mu}$M, respectively. In isolated rat atria, YS 49 increased both heart rate and force, and in anesthesized rabbit it decreased blood pressure but increased heart rate. In addition, to know the mechanism of action of the compound, propranolol, nonselective ${\beta}$-antagonist, and phentolamine, ${\alpha}$-blocker, were used. Furthermore, a comparison with the effect of higenamine, trimetoquinol on the vasodilating action in rat thoracic aorta was also made. The action of YS 49 was inhibited by the presence of propranolo, not pentolamine. These results indicate that cardiotonic and vasodilatory action of YS 49 is attributable, at least in part, for ${\beta}$-receptor stimulation.

• Smart Structures and Systems
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• v.32 no.6
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• pp.393-402
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• 2023

Recently, hybrid and electric vehicles have been actively developed to replace internal combustion engine (ICE) vehicles. However, their vibrations and noise with complex spectra cause discomfort to drivers. To reduce the vibrations transmitted through primary excitation sources such as powertrains, structural changes have been introduced. However, the interference among different parts is a limitation. Thus, active mounting systems based on smart materials have been actively investigated to overcome these limitations. This study focuses on diminishing the source movement when a structure with two active mounting systems is excited to a single sinusoidal and a multi-frequency signal, which were investigated for source movement reduction. The overall structure was modeled based on the lumped parameter method. Active vibration control was implemented based on the modeled structure, and a multi-normalization least mean square (NLMS) algorithm was used to obtain the control input for the active mounting system. Furthermore, the performance of the NLMS algorithm was compared with that of the quantification method to demonstrate the performance of active vibration control. The results demonstrate that the vibration attenuation performance of the source component was improved.

• Journal of the Korea Society of Computer and Information
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• v.25 no.3
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• pp.11-17
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• 2020

In this paper, we propose practical results for cache replacement policy by measuring cache hit and search time for each replacement algorithm through cache simulation. Thus, the structure of each cache memory and the four types of alternative policies of FIFO, LFU, LRU and Random were implemented in software to analyze the characteristics of each technique. The paper experiment showed that the LRU algorithm showed hit rate and search time of 36.044% and 577.936ns in uniform distribution, 45.636% and 504.692ns in deflection distribution, while the FIFO algorithm showed similar performance to the LRU algorithm at 36.078% and 554.772ns in even distribution and 45.662% and 489.574ns in bias distribution. Then LFU followed, Random algorithm was measured at 30.042% and 622.866ns at even distribution, 36.36% at deflection distribution and 553.878ns at lowest performance. The LRU replacement method commonly used in cache memory has the complexity of implementation, but it is the most efficient alternative to conventional alternative algorithms, indicating that it is a reasonable alternative method considering the reference information of data.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.1A
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• pp.45-52
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• 2009

In conventional structural design, deterministic optimization which satisfies codified constraints is performed to ensure safety and maximize economical efficiency. However, uncertainties are inevitable due to the stochastic nature of structural materials and applied loads. Thus, deterministic optimization without considering these uncertainties could lead to unreliable design. Recently, there has been much research in reliability-based design optimization (RBDO) taking into consideration both the reliability and optimization. RBDO involves the evaluation of probabilistic constraint that can be estimated using the RIA (Reliability Index Approach) and the PMA(Performance Measure Approach). It is generally known that PMA is more stable and efficient than RIA. Despite the significant advancement in PMA, RBDO still requires large computation time for large-scale applications. In this paper, A new reliability-based design optimization (RBDO) method is presented to achieve the more stable and efficient algorithm. The idea of the new method is to integrate a response surface method (RSM) with PMA. For the approximation of a limit state equation, the moving least squares (MLS) method is used. Through a mathematical example and ten-bar truss problem, the proposed method shows better convergence and efficiency than other approaches.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.124-129
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• 2013

Embedding Therapy keep the stimulation to acupoint. Recently, Embedding Therapy is used for various disease and also studied in many different fields especially in China. In Korea, Embedding Therapy is studied and used for dermatology, face-lift, obesity, facial palsy most frequently. Chinese studies shows us Embedding Therapy could help musculoskeletal system disorder, lumbar herniated intervertebral disc, sprain, spinal canal stenosis. In Korea study concerning lumbar herniated intervertebral disc treatment used Embedding Therapy is few. This study's purpose is to ensure effect of Embedding Therapy at lumbar herniated intervertebral disc treatment. Four lumbar disc herniation patients had been treated with Embedding Therapy were described in this article. The patients(n=4) had been suffering from chronic lower back and leg pain that continued for more than 6 months. All patients had been diagnosed as lumbar disc herniation by MRI or CT, and treated with Embedding Therapy at least 2 times(7 days interval). 2 patients had been treated with concurrent treatment of acupuncture therapy, and the other 2 patients with concurrent treatment of acupuncture and herbal therapy. We observed 4 patients for more than 2 weeks, and their symptoms and quality of daily life had been improved. This suggests that lumbar disc herniation can be successfully recovered with Concurrent Embedding Therapy under conventional Korean Medical Treatment without side effects.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.1
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• pp.25-35
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• 2017

About 60% to 90% of a total population experience low back pain at least once of life, and about 35% to 79% among them experience a recurrent and chronic low back pain. thread-embedding therapy is mainly used to improve appearance or treat obesity in early stage, but recently it is also used to treat musculoskeletal pain. This study aimed to search Chinese study using thread-embedding therapy on low back pain and to analyse their methodology. Three Chinese database(CNKI(www.cnki.net), WANFANG(www.wanfangdata.com), WEIPU(www.cqvip.com)) were searched for clinical study of thread-embedding therapy up to March 2016. The characteristics of included studies and regimen of thread-embedding in those studies were analyzed. The total 21 studies (4 case studies, 16 non-randomized controlled trials, 1 randomized controlled trial) were included. All studies on thread embedding treatment of low back pain reported that its effectiveness was very good. The most frequently used acupoints was Ashi acupoints and acupoints on bladder meridian(BL) or governor vessel(GV). Thread-embedding therapy is considered very useful for low back pain in Traditional Chinese medicine. Further studies are needed to investigate the effect of thread-embedding therapy and to expand its application. This study is limited in that the literature search in the Chinese database were restricted.

• Journal of Broadcast Engineering
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• v.25 no.1
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• pp.36-47
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• 2020

The improved belief-propagation-based algorithms, such as normalized min-sum algorithm (NMSA) or offset min-sum algorithm (OMSA), are widely used to decode LDPC(Low-Density Parity-Check) codes because they are less computationally complex and work well even at low SNR(Signal-to-Noise Ratio). However, these algorithms work well only when an appropriate normalization factor or offset value is used. A new method that uses a CMD(Check Node Message Distribution) chart and least-square method, which has been recently proposed, has advantages on computational complexity over other approaches to get optimal coefficients. Furthermore, this method can be used to derive coefficients for each iteration. In this paper, we apply this method and propose an algorithm to derive a combination of normalization factor and offset value for a combined normalized and offset min-sum algorithm to further improve the decoding of LDPC codes. Simulations on the next-generation broadcasting standards, ATSC 3.0 LDPC codes, prove that a combined normalized and offset min-sum algorithm which takes the proposed coefficients as correction coefficients shows the best BER performance among other decoding algorithms.

• Genomics & Informatics
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• v.10 no.3
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• pp.194-199
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• 2012

In addition to single-nucleotide polymorphisms (SNP), copy number variation (CNV) is a major component of human genetic diversity. Among many whole-genome analysis platforms, SNP arrays have been commonly used for genomewide CNV discovery. Recently, a number of CNV defining algorithms from SNP genotyping data have been developed; however, due to the fundamental limitation of SNP genotyping data for the measurement of signal intensity, there are still concerns regarding the possibility of false discovery or low sensitivity for detecting CNVs. In this study, we aimed to verify the effect of combining multiple CNV calling algorithms and set up the most reliable pipeline for CNV calling with Affymetrix Genomewide SNP 5.0 data. For this purpose, we selected the 3 most commonly used algorithms for CNV segmentation from SNP genotyping data, PennCNV, QuantiSNP; and BirdSuite. After defining the CNV loci using the 3 different algorithms, we assessed how many of them overlapped with each other, and we also validated the CNVs by genomic quantitative PCR. Through this analysis, we proposed that for reliable CNV-based genomewide association study using SNP array data, CNV calls must be performed with at least 3 different algorithms and that the CNVs consistently called from more than 2 algorithms must be used for association analysis, because they are more reliable than the CNVs called from a single algorithm. Our result will be helpful to set up the CNV analysis protocols for Affymetrix Genomewide SNP 5.0 genotyping data.

• Journal of the Korea Society of Computer and Information
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• v.25 no.6
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• pp.99-107
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• 2020

In this paper, we analyze the characteristics of mobile cache, which is used to improve the data access speed when executing applications on mobile devices, and verify the importance of mobile cache through a cache data access experiment. The mobile device market has grown at a fast pace over the past decade; however, battery limitations and size, price considerations restrict the usage of fast hardware. Thus, their performance are supplemented by using a memory buffer structure such as the cache memory. The analysis mainly focuses on cache size, hierarchical structure of cache, cache replacement policy, and the effect these features has on mobile performance. For the experimental data, we applied a data set from a microprocessor system study, originally used to test the cache performance. In the experimental results, the average data access speed on a mobile device showed a performance improvement of up to 10 times with the presence of cache memory than without. Accordingly, the cache memory was helpful for the performance improvement of a mobile device when the specifications were identical.

• Clinical and Experimental Reproductive Medicine
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• v.28 no.3
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• pp.183-190
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• 2001

Objective: Recently, microdissection of tissue sections has been used increasingly for the isolation of morphologically identified homogeneous cell populations, thus overcoming the obstacle of tissue complexity for the analysis cell-specific expression of macromolecules. The aim of the present study was to establish the minimal conditions required for the RNA extraction and amplification from the cells captured by the laser captured microdissection. Methods : Mouse ovaries were fixed and cut into serial sections (7 im thickness). Oocytes were captured by laser captured microdissection (LCM) method by using PixCell $II^{TM}$ system. The frozen sections were fixed in 70% ethanol and stained with hematoxylin and eosin, while the paraffin sections were stained with Multiple stain. Sections were dehydrated in graded alcohols followed by xylene and air-dried for 20 min prior to LCM. All reactions were performed in ribonuclease free solutions to prevent RNA degradation. After LCM, total RNA extraction from the captured oocytes was performed using the guanidinium isothiocyanate (GITC) solution, and subsequently evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) for glyceraldehyde-3-phosphate-dehydrogenase (GAPDH). Results: With the frozen sections, detection of the GAPDH mRNA expression in the number of captured 25 oocytes were not repeatable, but the expression was always detectable from 50 oocytes. With 25 oocytes, at least 27 PCR cycles were required, whereas with 50 oocytes, 21 cycles were enough to detect GA PDH expression. Amount of the primary cDNA required for RT-PCR was reduced down to at least 0.25 $\grave{i}$ l with 50 oocytes, thus the resting 19.75 il cDNA can be used for the testing other interested gene expression. Tissue-to-slide, tissue-to-tissue forces were very high in the paraffin sections, thus the greater number of cell procurement was required than the frozen sections. Conclusion: We have described a method for analyzing gene expression at the RNA level with the homogeneously microdissected cells from the small amount of tissues with complexity. We found that LCM coupled with RT-PCR could detect housekeeping gene expression in 50 oocytes captured. This technique can be easily applied for the study of gene expression with the small amount of tissues.