• Journal of Microbiology and Biotechnology
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• 제18권8호
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• pp.1377-1385
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• 2008

The uracil-sensing domain in archaeal family B-type DNA polymerases recognizes pro-mutagenic uracils in the DNA template, leading to stalling of DNA polymerases. Here, we describe our new findings regarding the molecular, mechanism underpinning the stalling of polymerases. We observed that two successive deaminated bases were required to stall TNA1 and KOD1 DNA polymerases, whereas a single deaminated base was enough for stalling Pfu DNA polymerase, in spite of the virtually identical uracil-sensing domains. TNA1 and KOD1 DNA polymerases have a much higher extension rate than Pfu DNA polymerase; decreasing the extension rate resulted in stalling by TNA1 and KOD1 DNA polymerases at a single deaminated base. These results strongly suggest that these polymerases require two factors to stop DNA polymerization at a single deaminated base: the presence of the uracil-sensing domain and a relatively slow extension rate.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4191-4197
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• 2012

The aim of this study was to identify breast cancer risk factors and reasons for having mammography of the women who applied for mammography, as well as to determine their level of knowledge about risk factors and level of risk perception, and anxiety concerning breast cancer. This cross-sectional descriptive study was conducted from June 15, 2010 through September 10, 2010, in a university hospital in Ankara, Turkey. A questionnaire prepared by the researchers was used to collect the data. The mean age of the women was $52.1{\pm}9.98$ years. Sixteen percent of the women had a family history of breast cancer. The majority of participants had mammograms (75.8%) before and had gained knowledge about breast cancer and its screening (73.7%). The leading source of information about breast cancer was physicians (46.2%). Physician recommendations, having breast-related complaints, and family history of breast cancer were important reasons to obtain mammography. The mean knowledge score about risk factors of breast cancer was $4.15{\pm}2.73$ and the mean anxiety score was $1.65{\pm}1.61$. It was found that some socio-demographic and obstetrical characteristics of women, their family history, and risk perceptions about breast cancer affect their knowledge and anxiety scores about breast cancer. In conclusion, the present study identified a number of factors affecting mammography participation for women. The results of this study can be helpful in promoting screening for breast cancer.

• Journal of Preventive Medicine and Public Health
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• 제38권1호
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• pp.38-44
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• 2005

Objective : To compare the mortality rate of Korean medical doctors to that of the general Korean population for the period 1992-2002. Methods : The membership records of the Korean Medical Association were linked to the 1992-2002 death certificate data of Korea s National Statistical Office using 13-digit unique personal identification numbers. The study population consisted of 61,164 medical doctors with a follow-up period of 473,932 person-years. Standardized mortality ratios(SMRs) were calculated to compare cause-specific mortality rates of medical doctors to those of the general population. Results : We confirmed 1,150 deaths at ages from 30 to 75 years from 1 January 1992 to 31 December 2002. The SMR for all-cause of death was 0.47(95% CI : $0.44{\sim}0.50$). The SMRs for smoking-related diseases such as cerebrovascular accidents and chronic obstructive pulmonary disease were smaller than the SMR of all-cause of death. However, the SMRs for colorectal and pancreatic cancers were not significantly lower than those of the general population. Transport accidents and suicides accounted for 72% (94 of 131) of external causes of death. The SMR for suicide was 0.51 (95% CI : $0.38{\sim}0.68$). Conclusions : The mortality rate of South Korean medical doctors was less than 50% that of the general population of South Korea. Cause-specific analysis showed that mortality rates in leading causes of death were lower among medical doctors although differences in mortality rates between medical doctors and the general population varied with the causes of death. These health benefits found among medical doctors may be attributable to the lower level of health damaging behaviors (e.g., lower smoking rates) and better working conditions.

• Clinical and Experimental Pediatrics
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• 제62권5호
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• pp.193-197
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• 2019

Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (${\alpha}3$, ${\alpha}4$, and ${\alpha}5$). ATS is characterized by persistent microscopic hematuria that starts during infancy, eventually leading to either progressive nephritis or end-stage renal disease. There are 3 known genetic forms of ATS, namely X-linked ATS, autosomal recessive ATS, and autosomal dominant ATS. About 80% of patients with ATS have X-linked ATS, which is caused by mutations in the type IV collagen ${\alpha}5$ chain gene, COL4A5. Although an 80% mutation detection rate is observed in men with X-linked ATS, some difficulties do exist in the genetic diagnosis of ATS. Most mutations are point mutations without hotspots in the COL4A3, COL4A4, and COL4A5 genes. Further, there are insufficient data on the detection of COL4A3 and COL4A4 mutations for their comparison between patients with autosomal recessive or dominant ATS. Therefore, diagnosis of ATS in female patients with no apparent family history can be challenging. Therefore, in this study, we used whole-exome sequencing (WES) to identify mutations in type IV collagen in 2 girls with glomerular basement membrane structural changes suspected to be associated with ATS; these patients had no relevant family history. Our results revealed de novo c.4688G>A (p.Arg1563Gln) and c.2714G>A (p.Gly905Asp) mutations in COL4A5. Therefore, we suggest that WES is an effective approach to obtain genetic information in ATS, particularly in female patients without a relevant family history, to detect unexpected DNA variations.

• 한국가족관계학회지
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• 제22권3호
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• pp.47-72
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• 2017

Objectives: Do husbands with working wives share domestic labor more equally than husbands with unemployed housewives? Is the husband's contribution sufficient enough to satisfy his wife? These questions have long inspired many researchers to find ways to more accurately estimate husband's domestic contributions and narrow the emotional gap following the different threshold of satisfaction within couples, but not without some limits. This study attempted to figure out an answer to the above-mentioned subject by using time diaries of Korean married couples with a preschooler as their first-born child and relying on the typology of husbands' sharing of housework and childcare, which allowed me to overcome some limitations of prior research. Method: I analyzed a total of 1,716 diaries of 858 married couples from 2014 Korea Time Use Survey with descriptive statistics, t-test, cluster analysis, and multinomial logit. Results: Analytic results showed that husbands in dual-earner households did share domestic labor more equally than husbands in single-earner households, but there were different types of husband's contribution depending on time they spent in housework and childcare. While more than half of husbands with employed wives shared more or less than ten percent of domestic labor, the rest were divided into one group of husbands who shared both housework and childcare more heavily and evenly, and another group who were mainly involved in childcare duties. It is interesting that husbands who made the least contributions to domestic labor were not the ones with the lowest level of satisfaction with their sharing of household labor, whereas their wives were deeply dissatisfied, leading to a huge emotional gap within couples. Conclusion: Identifying factors associated with the three different types allowed me to find a point of intervention to narrow the emotional gap that is likely to harm the marital relationship if left unattended to.

• 건축역사연구
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• 제30권3호
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• pp.45-54
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• 2021

In 2020, Yi Hunwoo was discovered as one of the earliest modern architects in Korea. However, his personal life was yet mostly unknown, including the time of his death. The research team ('the team' hereafter) searched for the records of his personal life and professional career. First, his family genealogical chart revealed that he died in 1937. Having located and contacted Yi's direct descendents, the team was able to clarify his family background with the descendants' testimonies. They possess the photographs of him and his family members, including Yi's picture when he was a freshman at the Nagoya Higher Technical School in Japan. The team also identifies his birthplace and the location of his grave as Hadong, Gyeongsangnamdo, Korea. The team visited his project site in Jinju, Gyeonsangnamdo, Korea and obtained more detailed information about the Ilshin Girls' High School, which he designed in 1928. Gyohoan, the congregation records of Cheondogyo, one of the leading religions in Korea during Yi's times, confirmed that he was one of the congregation members. The field research also discovered the house he designed and built in his hometown of Hadong, probably the only surviving architectural project by him. This paper is to report the result of the research on Yi's life and career with the aim of providing materials for further studies in identifying and positioning him more properly in the early 20th century Korean architectural scene.

• 임상간호연구
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• 제16권1호
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• pp.131-143
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• 2010

Purpose: The purpose of this survey was to identify a set of performance indicators for Korean APNs (Advanced Practice Nurses). Methods: A convenience sample of 78 APNs working in 2 leading hospitals in south Korea participated in the three-round Delphi survey. In the first round, subjects were asked to propose performance indicators to evaluate the effectiveness of their practice. They rated the relevancy of each indicator during the second round. In the final round of survey, subjects rated the relevancy of indicators again in the light of second round's overall results and they also were asked to check on current and future use of indicators. Results: After 5 months of three-round Delphi survey, 60 performance indicators were identified. In regard to relevancy, the 10 highly ranked indicators were patient satisfaction, self-care ability, expertise of service, family satisfaction, nurse satisfaction, satisfaction in nursing education, advanced nursing service count, education for patient/ family, education for nurse, and compliance. Advanced nursing service count, education for patient/ family, and education for nurse are currently used as indicators by more than 70% of respondents. Conclusion: Additional research is needed to identify subsets of performance indicators for specialized areas and to determine the validity and sensitivity of indicators.

• 한국실내디자인학회논문집
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• 제28호
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• pp.3-10
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• 2001

The purpose of this study is to identify the cognition differences of home interior remodeling and preference of mass media among consumers and analyze relationship between remodeling perception and mass communication. The data are collected through questionnaire surveys, which included demographic information and preference of remodeling, mass communication from adult consumers who live in Seoul. 223 samples are collected, and are analyzed by using SPSS-WIN program. The major results are as follows: Most of the media are preferences above the average. TV media is a leading mass communication, which has an effect of most consumers. Internet business preference is found at young, male, white color business group and small family. Remodeling has been a strange word with consumers, but now on its needs are spread among the public that is provide to solve the problem which were found in their home on the influence of mass communication.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 2003년도 봄 학술발표회 논문집
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• pp.33-35
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• 2003

Over the last 30 years, water-swellable and water-insoluble hydrogels have been extensively investigated and developed, leading to a large family of materials which have found use in a wide range of biomedical applications such as carriers of soft tissues, wound healing, ophthalmological applications, membranes for artificial kidney, and materials for blood compatible and other medical devices[1-3]. (omitted)

• Journal of Chest Surgery
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• 제47권2호
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• pp.155-159
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• 2014

Cardiac tamponade due to purulent pericarditis with a characteristic greenish fluid is rare in this antibiotic era. It is highly fatal despite early diagnosis and advanced treatment. Gram-positive cocci are the leading cause of purulent pericarditis, which usually results from a direct or hematogenous spread of organisms to the pericardium from the primary foci of infection. We describe an index case of rapidly developing pericardial tamponade caused by oropharyngeal polymicrobial infection in the absence of a primary source of infection in a 62-year-old man, who was successfully managed with emergency large-volume pericardiocentesis followed by pericardiectomy.