• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.179-189
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• 2000

Clebopride malate(Cm) is a new benzamide drug which has a potent central antidopaminergic activity possessing antiemetic and anxiolytic properties. A purpose of this study was to assess the feasibility of formulating sustained release preparation by dispersing a drug in hydrophilic polymeric matrices and double layered tablets(DLT), using HPMC, carbopol, PEO, PVP/VA and other polymers as a rate controlling barrier. The matrix and DLT showed optimum dissolution pattern up to 8 hours and the contents of polymer were optimized at 30% level in this preparation. After an oral administration in beagle dog, Cm concentration was determined by use of GC-ECD and pharmacokinetic parameters were calculated by Vallner's method. The AUC of DLT showed similar results and the duration of action was increased 55% compared to that of regular release dosage form. The calculated absorption rate effectiveness(ARE) and controlled release effectiveness(CRE) for DLT increased 50% compared to that of matrix, the overall effectiveness(E) of this product appears to be about 70%. in vivo effectiveness test, DLT showed significant differences from control on antiemetic action of Cm. In consequence, it was possible to conclude that double layered tablet might be a good candidate for the sustained release dosage forms.

• Bulletin of the Korean Chemical Society
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• v.33 no.6
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• pp.1845-1850
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• 2012

Layered metal hydroxides (LMHs) containing calcium were synthesized by coprecipitation in solution having two different trivalent metal ions, iron and aluminum. Two mixed metal solutions ($Ca^{2+}/Al^{3+}$ and $Ca^{2+}/Fe^{3+}$ = 2/1) were added to sodium hydroxide solution and the final pH was adjusted to ~11.5 and ~13 for CaAl-and CaFe-LMHs. Powder X-ray diffraction (XRD) for the two LMH samples showed well developed ($00l$) diffractions indicating 2-dimensional crystal structure of the synthesized LMHs. Rietveld refinement of the X-ray diffraction pattern, the local structure analysis through X-ray absorption spectroscopy, and thermal analysis also confirmed that the synthesized precipitates show typical structure of LMHs. The chemical formulae, $Ca_{2.04}Al_1(OH)_6(NO_3){\cdot}5.25H_2O$ and $Ca_{2.01}Fe_1(OH)_6(NO_3){\cdot}4.75H_2O$ were determined by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). Particle morphology and thermal behavior for the synthesized LMHs were examined by field emission scanning electron microscopy and thermogravimetricdifferential scanning calorimetry.

• Journal of the korean society of oceanography
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• v.31 no.4
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• pp.173-182
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• 1996

A median-density fluid was injected into the upper layer of a two-layered fluid in a rotating cylindrical container. Several sets of the top and bottom boundary configurations were employed and the flow pattern of each layer including the injected fluid was observed to determine the factors that affect the path of the injected intermediate fluid. The axisymmetric path of the intermediate fluid when the upper layer had a free surface, changed into the asymmetric path with bulged-shape radial spreading whenever either the upper layer or the lower layer had ${\beta}$-effect. The internal Fronds number that controls the shape of the interface turned out to be the most important parameter that determines the radial spreading in terms of location and strength. When the upper and lower layer had the ${\beta}$-effect, convective overturning produced anticyclonic vortices at the frontal edge of the intermediate fluid, and that could enhance the vertical mixing of different density fluids. The intermediate fluid did not produce any topographic effect on the upper-layer motion during its spreading over the interface, since its thickness was very small. However, its anticyclonic motion within the bulged-shape produced a cyclonic motion in the lower layer just beneath the bulge.

• Archives of design research
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• v.13
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• pp.123-137
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• 1996

Weaving, is an ideal subject for study to designer who is concerned with interrelationship between art and technology. Double cloth is a two layered fabric that can be woven on the loom with more than 4 harnesses, is often used to produce special woven fabric such as double width fabric or reverse pattern fabric, etc, in textile industry. Because of the attractive characteristic of two layered structure, double cloth technique can be applied as expressive media in fiber art requiring aesthetics and creativty. in the work, the concept, types, and characteristics of double weave have been studied through literature survey and sample production and the potential characteristics of this technique is, especially, emphasized by analysing the representative works of artists specilized in a double weave. Double weave technique can provide various images or forms throught the variation of structures and expressive styles and therefore suggests another characteristic expression creative means for weaver to develope.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.6
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• pp.275-282
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• 2011

Current service discovery protocols such as UPnP, Jini, SLP provide the basic function which is message exchange pattern, service representation and description, in service discovery. They does not guarantee service interoperability among service discovery. Therefore, in this paper, we design and implement CLAM (Component-based Autonomic Layered Middleware) agent platform to enable an efficient service discovery through extension of DF agent function in FIPA-compliant specification. Also, we propose an efficient service discovery mechanism using DHT-Chord algorithm to guarantee scalability and interoperability in DF agent.

• Smart Structures and Systems
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• v.29 no.3
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• pp.513-522
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• 2022

Due to the importance of accurate analysis of bearing capacity in civil engineering projects, this paper studies the efficiency of two novel metaheuristic-based models for this objective. To this end, black hole algorithm (BHA) and multi-verse optimizer (MVO) are synthesized with an artificial neural network (ANN) to build the proposed hybrid models. Based on the settlement of a two-layered soil (and a shallow footing) system, the stability values (SV) of 0 and 1 (indicating the stability and failure, respectively) are set as the targets. Each model predicted the SV for 901 stages. The results indicated that the BHA and MVO can increase the accuracy (i.e., the area under the receiving operating characteristic curve) of the ANN from 94.0% to 96.3 and 97.2% in analyzing the SV pattern. Moreover, the prediction accuracy rose from 93.1% to 94.4 and 95.0%. Also, a comparison between the ANN's error decreased by the BHA and MVO (7.92% vs. 18.08% in the training phase and 6.28% vs. 13.62% in the testing phase) showed that the MVO is a more efficient optimizer. Hence, the suggested MVO-ANN can be used as a reliable approach for the practical estimation of bearing capacity.

• The Journal of the Korea Contents Association
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• v.21 no.3
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• pp.157-171
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• 2021

The purpose of this study is to assess the smart city for major cities in Korea. The assessment indicators are based on the STIM structure (Service, Technology, Infrastructure, and Management Layer Architecture) of the Multi-Layered Smart City Model. Assessment indicators are established through smart city concepts, case analysis, big data analysis, as well as weighted through expert AHP survey. For the assessment, seven major metropolitan cities are selected, including Seoul, and their data such as KOSIS, KISDISTAT from 2017 to 2019 is utilized for the smart city level assessment. The smart city level results show that the service, technology, infrastructure, and management levels were relatively high in Seoul and Incheon, which are metropolitan areas. Whereas, Busan, Daegu, and Ulsan, the Gyeongsang provinces are relatively moderate, while Daejeon and Gwangju, the South Chungcheong region and the Jeolla provinces, were relatively low. The overall STIM ranking shows a similar pattern, as the Seoul metropolitan area smart city level outperforms the rest of the analyzed areas with a large difference. Accordingly, balanced development strategies are needed to reduce gaps in the level of smart cities in South Korea, and respective smart city plans are needed considering the characteristics of each region. This paper will follow the literature review, assessment index establishment, weight analysis of assessment index, major cities assessment and result in analysis, and conclusion.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.1
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• pp.91-97
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• 2005

In the mobile antenna systems for satellite multimedia communications, the active way antenna having a low sidelobe antenna pattern is described in this paper. This designed and fabricated array antenna is satisfied with international beam pattern regulation on moving states. The subarray of the proposed mobile antenna system is arranged with a stair-planar structure and non-periodic array spacing. This subarray is designed with three-layered microstrip patch as both receiving and transmitting radiator of which are improved with antenna gain and bandwidth. Also, the optimum subarray spacing is designed to make the lowest sidelobe pattern by genetic algorithm. In addition, the characteristics of a GA-perturbed array are investigated from simulated and measured beam pattern results.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.07b
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• pp.653-656
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• 2002

In this paper, we present the simulation results of multi-layer VCO(voltage controlled oscillator), which is composed of resonator, oscillator, and buffer circuit, using EM simulator and nonlinear RF circuit simulator. EM simulator is used for obtaining the EM(Electromagnetic) characteristics of conductor pattern as well as designing the multi-layer VCO. Obtained EM characteristics were used as real components in nonlinear RF circuit simulation. Finally the overall VCO was simulated by the nonlinear RF circuit simulator. The material for the circuit pattern was Ag and the dielectric was DuPont 951AT, which will be applied for LTCC process. The structure of multi-layer VCO is constructed with 4 conducting layer. Simulated results showed that the output level was about 4.5 [dBm], the phase noise was -104 [dBc/Hz] at 30 [kHz] offset frequency, the harmonics -8 dBc, and the control voltage sensitivity of 30 [MHz/V] with a DC current consumption of 9.5 [mA]. The size of VCO is $6{\times}9{\times}2$ mm(0.11[cc]).

• Economic and Environmental Geology
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• v.16 no.4
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• pp.269-276
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• 1983

This paper describes three-dimensional (3-D) standard curves for single prismatic buried bodies in induced polarization (IP) method. Dipole-dipole IP responses for the bodies are calculated by the numerical modeling technique using an integral equation solution. The pattern of IP responses for conductive targets depends on the ratio of the width of body to the depth extent. The IP response of a body of six units in strike length approximates that of a two-dimensional body. In addition, if the strike length is long enough, a layered-earth interpretation is applicable for a body much longer than four units in width. Moving an IP line away from the center of a body alon gstrike produces an effect similar to that of increasing the depth. Moving the location of body along line has little effect to the pattern of IP responses.