• Clinical and Experimental Reproductive Medicine
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• v.46 no.4
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• pp.206-210
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• 2019

Mucopolysaccharidosis type II (MPS II) is a rare X-linked recessive lysosomal storage disease caused by mutation of the iduronate-2-sulfatase gene. The mutation results in iduronate-2-sulfatase deficiency, which causes the progressive accumulation of heparan sulfate and dermatan sulfate in cellular lysosomes. The phenotype, age of onset, and symptoms of MPS II vary; accordingly, the disease can be classified into either the early-onset type or the late-onset type, depending on the age of onset and the severity of the symptoms. In patients with severe MPS II, symptoms typically first appear between 2 and 5 years of age. Patients with severe MPS II usually die in the second decade of life although some patients with less severe disease have survived into their fifth or sixth decade. Here, we report the establishment of a preimplantation genetic diagnosis (PGD) strategy using multiplex nested polymerase chain reaction, direct sequencing, and linkage analysis. Unaffected embryos were selected via the diagnosis of a single blastomere, and a healthy boy was delivered by a female carrier of MPS II. This is the first successful application of PGD in a patient with MPS II in Korea.

• Journal of architectural history
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• v.10 no.2 s.26
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• pp.35-54
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• 2001

This study concerns especially Choryang-Weagwan which was the largest Japanese House left in Pusan through Chosun Dynasty. Choryang-Waegwan was known to have been jointly constructed by Korean and Japanese carpenters. Therefore, Weagwan was a place for exchange of architectural tradition (special features such as sliding door and straw mat) between Korean and Japan. Judging from this point of view, It is certain that mutual influences helped to shape architecture of Choryang-Weagwan. After establishment Choryang- Weagwan was gradually extended, owing to the prosperity of trade with Japan. But since late 18th century government of Chosun did not give as much care to maintaining Choryang- Weagwan as a result of deteriorating condition of commercial and diplomatic relations with Japan. From the beginning of Choryang- Weagwan construction, Superintendents of the construction were called Hun-do and Byl-cha, who acted as official interpreters as well. And, during construction works, they were called Gamdong-gwan, At the start of construction, Weagwan was built partly in Japanese-style by the carpenters from Tokugawa Shogunate. But as time passed, the participation rate of Japanese carpenters diminished gradually. After 1831, Japanese technician vanished extremely and repairing construction was continued by the Korean workers only.

• Korean Journal of Oriental Medicine
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• v.14 no.3
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• pp.1-10
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• 2008

This paper treats with transitional development of medico-hygienical situation in district Yanbian along with the evolution in specific field of medicine. This work is particularly important in shaping TKM identity as TCM embraces Chao medicine asserting it as one included in TCM. This research deals with themes of migration of Chao minorities to this territory and their medico-hygienical situation. Lifted bans on immigration in late Qing dynasty with uncertainty of Korea(Chosun) triggered the immigration to this district. The flow was heavily strengthened under the influence of Westerners and Japanese imperialism into china which consequently provoked the ruin of Qing dynasty, the civil war between republicans and communist and the socio-political changes in Korea. As population growths, the establishment of hospitals and immigration of healthcare professionals were also increased. Though this district is located in Chinese mainland the influence of Japanese was also relevant which lead to medical practice reflection both sides. Mutual combination and influence of western(contemporary) medicine, TCM and TKM practices made the particularity of chao medicine.

• Journal of Technology Innovation
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• v.5 no.1
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• pp.113-149
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• 1997

This paper, searching for the origin of the science and technology policy, is one of the research series on the original form of current S&T policy such as origin, evolution and changing patterns. Without understanding the origin, it is very difficult to understand the evolution and the current change of the policy. To answer this question, 2 kinds of conditions are set: 4 concepts for the origin of a policy and also 4 conditions for the S&T policy itself. As the origin of a policy, 4 concepts are set such as independence, continuance, diffusion and modern state as a policy body. Also as conditions for S&T policy, there may be 4 conditions such as policy targets, policy functions, administration body and the usage of the name of the policy. S&T can be distinguished as science, technology and S&T along it's development path. There, hence, are 2 origins of science and technology policy. French policy for modern science at the late 18th century and the establishment of the Agency of Science and Technology Policy of Japan in 1956 can be pointed out as the origin of the policy. The former can be called as the origin for natural science, and the latter as the origin for S&T. This study implies that new paradigm of S&T policy is a reflection for both the needs of new S&T and social needs. When there were big problems in a society and when there appeared new S&T, they exploited new S&T vigorously. This has been remained as a rememberable monuments in the history of the S&T policy.

• Journal of the Korean Society of Safety
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• v.32 no.2
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• pp.21-26
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• 2017

According to the data of Korea Occupational Safety and Health Agency, electric shock accidents during recent 11 years exceeded more than 60% in architecture/other and construction work, the countermeasures for safety are required in the harsh environment of a construction site where moving electric machines and equipments are widely used. The establishment of countermeasure for insulation degradation and defect is required, in consideration of increasing trend for accidents caused by defective insulation among low voltage electrical installation each year. The aim of this study is to propose the policy about portable electrical tool standards and/or worker's safety standards for preventing electric shock accidents on safety workings, and is to develop the technology and the safety device to prevent electric shock for accident prevention reduction through experiments. It obtained the followings through this study; statistical data analysis of late about 10 years of electric shock-related industrial accidents analysis and portable electric tools; safety device development of 'device for testing continuous grounding and power shut-down' to prevent electric shock from portable electric tools. Furthermore, developed results and proposal in this study will help to prevent the electric shock accidents from portable electric tools and will be expected the utilization of policy formulation, educational data and field supplement of the safety device, and etc.

• Korean Journal Plant Pathology
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• v.10 no.4
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• pp.284-291
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• 1994

In order to establish an appropriate spray schedule to reduce the infection, 11 kinds of chemicals were tested for their properties on the inhibition of spore germination at the surface of apple fruits and the duration of the inhibitory effect after spray of each chemical was examined from late June to early September with basically 10 day intervals. Actual control efficacy of each chemical by the 8 successive spray and the patterns of waterborne spore dispersals during that periods were also examined. Combining those results with the meteorological observation data, actual control efficacy of each chemical in the given periods could be estimated. It was revealed that folpet, Brodeaux mixture, mancozeb, oxine copper and imminoctadine-triacetate could be used at any time during the possible infection periods. Captan and dithianon could also be used except the rainy season due to the short duration of inhibitory efficacy against spore germination under heavy rain. However, the usefulness of propineb, benomyl and chlorothalonil against the apple white rot could not be demonstrated in this experiment. Thiram, even though has not been used for apple white rot, can also be used before or after the rainy season to control not only white rot but also alternaria blotch.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.1959-1962
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• 2009

In this paper, we derive the hazard which is a criterion of safety assurance by PHA for the ATP equipped in Korea Tilting Train. The ATP onboard equipment in Korea Tilting Train was introduced as ETCS Level l(which is ETCS specification). Also, the ATP trackside equipment was introduced as a ETCS SRS(System Requirement Specification) 2.2.2 and it has a target for commercial operation in 2009 late. In IEC 62278(EN50126), it recommend of PHA to derive a hazard of target system in concept establishment step and estimate if it can control as a tolerable level and then derive safety case to control the hazard by lifecycle. Therefore, we indicate the hazard using criterion of safety assurance by PHA using FRS (Functional Requirement Specification) 5.0. which is a upper criterion than SRS. The hazard of ATP onboard equipment derived in Korea Tilting Train will be able to use as ATP functional hazards of unified onboard equipment in G7 which is a multiple unit and preliminary hazards of ATP onboard equipment in NEL drived by Korail.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.542-548
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• 2003

This paper describes an overall Noise Assurance Plan(NAP) in the project for developing a new rolling stock. In this paper, the procedure for implementing noise control activities for each development stage on the basis of the NAP is also described. The NAP was developed by KITECH(Korea Institute of Industrial Technology) and ODS(${\Phi}$degaard ＆ Danneskiold-Samsoe in DENMARK). Generally, the main objective of NAP is that noise assurance plan applies to the establishment of organization and personnel's roles and responsibilities, set-up of overall procedure and internal audit program. Here, a few comments are made to the deviations of the actual procedure(G7 Project) relative to the suggested NAP presented. The major difference between the suggested NAP and the actual procedure was the late involvement of the noise consultant resulting in suggestions for design improvements could not be implemented due to the advanced stage of the design. Similarly, the important task of preparing sub-supplier specifications was performed. The proposed NAP will be an efficient tool for noise management in the R＆D project for new rolling stock. Specially, in case that several companies and institutes are involoved in the R＆D team

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.259-266
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• 2008

In the past, MSW (Municipal Solid Waste) disposal was typically done by recycling, incineration, or landfilling. In South Korea prior to the late 1950's, land burial was usually accomplished by disposal in an open dump. Currently, with increasing concerns and environmental recognition, MSW disposal and landfilling is more restricted. MSW landfill facilities have been developed with certain design and construction specifications. However, these methods have a space for improvement. MSW landfill facilities follow a step wise approach of design, construction, operation and closure management after use in agreement with established environmental and sanitary standards. This study intends to give a technical guidance for installation and consideration of newly established MSW landfill facilities, and also provide an establishment and regular inspection of MSW landfill facilities.

• Journal of Dairy Science and Biotechnology
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• v.32 no.2
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• pp.71-76
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• 2014

The Netherlands produce more than 11 million tonnes of milk per year, and approximately 60% of the milk is exported. Dutch milk production is five times higher than that of Korea, even though Korea comprises a land area three times greater than the Netherlands. Upscaling and intensification have characterized the Dutch way of dairy farming since 1960, and adverse effects of the intensification of dairy farming became evident from the late 1970s and early 1980s onwards. The transition toward a more sustainable farming system is a central element of the Dutch agenda for the reconstruction of the livestock production sector. The environmental problems in Dutch dairy farming in the 1980s have led to the establishment of the experimental dairy farm "De Marke" which aims at improving the utilization of fertilizers and feeds, through minimizing nutrient requirements, maximizing the use of nutrients in organic manure and homegrown feeds, and through the targeted use of fertilizers and feeds. 85 cows at "De Marke" produce 720 tonnes of milk per year, using 55 ha of pasture in a sustainable manner. That means, 150,000 ha of pasture are required to produce 2 million tonnes of milk, which the current milk production of Korea. It is urgent to provide sufficient pasture for sustainable milk production in Korea, and primarily the transition to pasture of surplus rice paddies, resulting from of a decrease in rice consumption, should be considered.