• 한국컴퓨터정보학회논문지
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• 제26권10호
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• pp.157-165
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• 2021

최근 대량의 텍스트 분석을 위해 딥 러닝(Deep Learning)을 활용하는 연구들이 활발히 수행되고 있으며, 특히 대량의 텍스트에 대한 학습 결과를 특정 도메인 텍스트의 분석에 적용하는 사전 학습 언어 모델(Pre-trained Language Model)이 주목받고 있다. 다양한 사전 학습 언어 모델 중 BERT(Bidirectional Encoder Representations from Transformers) 기반 모델이 가장 널리 활용되고 있으며, 최근에는 BERT의 MLM(Masked Language Model)을 활용한 추가 사전 학습(Further Pre-training)을 통해 분석 성능을 향상시키기 위한 방안이 모색되고 있다. 하지만 전통적인 MLM 방식은 신조어와 같이 새로운 단어가 포함된 문장의 의미를 충분히 명확하게 파악하기 어렵다는 한계를 갖는다. 이에 본 연구에서는 기존의 MLM을 보완하여 신조어에 대해서만 집중적으로 마스킹을 수행하는 신조어 표적 마스킹(NTM: Newly Coined Words Target Masking)을 새롭게 제안한다. 제안 방법론을 적용하여 포털 'N'사의 영화 리뷰 약 70만 건을 분석한 결과, 제안하는 신조어 표적 마스킹이 기존의 무작위 마스킹에 비해 감성 분석의 정확도 측면에서 우수한 성능을 보였다.

• Journal of Ginseng Research
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• 제47권2호
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• pp.291-301
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• 2023

Introduction: Non-small cell lung cancer (NSCLC) patients are particularly vulnerable to the Coronavirus Disease-2019 (COVID-19). Currently, no anti-NSCLC/COVID-19 treatment options are available. As ginsenoside Rg3 is beneficial to NSCLC patients and has been identified as an entry inhibitor of the virus, this study aims to explore underlying pharmacological mechanisms of ginsenoside Rg3 for the treatment of NSCLC patients with COVID-19. Methods: Based on a large-scale data mining and systemic biological analysis, this study investigated target genes, biological processes, pharmacological mechanisms, and underlying immune implications of ginsenoside Rg3 for NSCLC patients with COVID-19. Results: An important gene set containing 26 target genes was built. Target genes with significant prognostic value were identified, including baculoviral IAP repeat containing 5 (BIRC5), carbonic anhydrase 9 (CA9), endothelin receptor type B (EDNRB), glucagon receptor (GCGR), interleukin 2 (IL2), peptidyl arginine deiminase 4 (PADI4), and solute carrier organic anion transporter family member 1B1 (SLCO1B1). The expression of target genes was significantly correlated with the infiltration level of macrophages, eosinophils, natural killer cells, and T lymphocytes. Ginsenoside Rg3 may benefit NSCLC patients with COVID-19 by regulating signaling pathways primarily involved in anti-inflammation, immunomodulation, cell cycle, cell fate, carcinogenesis, and hemodynamics. Conclusions: This study provided a comprehensive strategy for drug discovery in NSCLC and COVID-19 based on systemic biology approaches. Ginsenoside Rg3 may be a prospective drug for NSCLC patients with COVID-19. Future studies are needed to determine the value of ginsenoside Rg3 for NSCLC patients with COVID-19.

• KIEE International Transactions on Electrophysics and Applications
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• 제4C권1호
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• pp.10-14
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• 2004

A large area electron beam generator has been developed for industrial applications, for example, waste water cleaning, flue gas treatment, and food pasteurization. The operational principle is based on the emission of secondary electrons from the cathode when ions in the plasma contact the cathode, which are accelerated toward the exit window by the gradient of the electric potential. Conventional electron beam generators require an electron beam scanning mechanism because a small area thermal electron emitter is used. The electron beam of the large area electron beam generator does not need to be scanned over target material because the beam area is considerable. We have fabricated a large area electron beam generator with peak energy of 200keV, and a beam diameter of 200mm. The electron beam current has been investigated as a function of accelerating voltage and distance from the extracting window while its radial distribution in front of the extracting window has been also measured.

• 한국물환경학회지
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• 제37권3호
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• pp.175-189
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• 2021

In this study, 48 streams in the Sapgyo Watershed were selected, and the Load Duration Curves (LDC) were drawn up for each stream using water quality and flow monitoring over the last three years (2018-2020), and it was evaluated whether the target water quality was achieved for each flow section. As a result of evaluating whether or not the target water quality exceeded according to the LDC, it was found that 22 rivers exceeded the target water quality. Five rivers exceeded the target water quality due to point pollutant sources, 13 rivers exceeded the target water quality due to non-point pollutant sources, and 4 rivers exceeded the target water quality due to both point and non-point pollutant sources. Among the rivers that exceeded the target water quality due to point pollutant sources, which included domestic sewage of the untreated population, there is a need to reduce the influx of polluted loads by the untreated population. The use of eco-friendly fertilizers is recommended for rivers with a relatively high farmland ratio among rivers exceeding the target water quality due to non-point pollutant sources, and installation of boiling point reduction facilities that can reduce the amount of polluted load introduced during rainfall or manage water shores. In rivers with a large number of livestock breeding heads, the livestock houses located in these rivers need to be preferentially transferred to livestock manure treatment plants. Due to the high ratio of land area because of urbanization, initial rainwater treatment facilities are required to reduce the amount of pollutant load flowing into the river through the impermeable layer during rainfall.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 1997년도 학술발표회
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• pp.9-10
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• 1997

Calmodulin: very large conformation change of helix uncoiling, hinge-bending and domain rotation. Calmodulin (CaM) is the principal Ca$\^$2＋/ -dependent regulator of a variety of important eukaryotic cellular processes. In many of these processes, calmodulin activates a plethora of target enzymes, and the calmodulin-binding domains in several targets have been shown to residue in a region of about 18-residue peptide segment.(omitted)

• BMB Reports
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• 제47권8호
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• pp.417-423
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• 2014

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators, which are 21-24 nt in length and play a role in a wide variety of biological processes in eukaryotes. The past few years have seen rapid progress in our understanding of miRNA biogenesis and the mechanism of action, which commonly entails a combination of target degradation and translational repression. The target degradation mediated by Argonaute-catalyzed endonucleolytic cleavage exerts a significant repressive effect on target mRNA expression, particularly during rapid developmental transitions. This review outlines the current understanding of the mechanistic aspects of this important process and discusses several different experimental approaches to identify miRNA cleavage targets.

• 한국농공학회논문집
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• 제56권4호
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• pp.29-39
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• 2014

In this study, we performed a non-stationary frequency analysis using a power model and the model was applied for Seoul, Daegu, Daejeon, Mokpo sites in Korea to estimate the probable precipitation amount at the target years (2020, 2050, 2080). We used the annual maximum precipitation of 24 hours duration of precipitation using data from 1973 to 2009. We compared results to that of non-stationary analyses using the linear and logistic regression. The probable precipitation amounts using linear regression showed very large increase in the long term projection, while the logistic regression resulted in similar amounts for different target years because the logistic function converges before 2020. But the probable precipitation amount for the target years using a power model showed reasonable results suggesting that power model be able to reflect the increase of hydrologic extremes reasonably well.

• 한국군사과학기술학회지
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• 제9권3호
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• pp.95-100
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• 2006

The pulse compression technique using Linear FM signal is commonly used for improving the performance of both the detection range and range resolution in radar system. In general, the compressed LFM waveform has relatively large sidelobe level which may prevent a target from being detected when strong jammer or clutter signal is near the target signal. In this paper, we propose a new weighting method which uses the square-root weight to suppress the sidelobe level. Typical applications are missile seekers and tracking radar systems where target tracking range is available prior to the signal processing. By computer simulation, we show that the performance of the proposed method is better than that of the conventional weighting methods in terms of sidelobe suppression.

• 제어로봇시스템학회논문지
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• 제8권1호
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• pp.60-66
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• 2002

In this paper, a new target pointing guidance algorithm is proposed by combining the optimal target pointing solution and a simple time-to-Go estimator. Also investigated are some properties of the guidance algorithm which include a relation to conventional PNG, convergence region and convergence trajectories of error states according to the time-to-go estimator gain. Some guidelines for designing the pointing guidance law are commented based on the convergence properties. A design example in the case of large initial heading errors is presented and its performance is investigated by simulation.

• 한국정보통신학회논문지
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• 제18권12호
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• pp.3063-3068
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• 2014

표적의 RCS(Radar Cross Section)는 레이더 탐지 성능을 결정하는데 중요한 요소이므로 표적을 효율적으로 탐지하기 위해 RCS가 크게 나타나는 위치에 레이더를 배치하는 것이 유리하다. 그러나 표적의 RCS와 함께 표적과 레이더 간의 거리 또한 레이더에 수신되는 신호의 강도를 결정하는 중요한 요소이다. 본 논문에서는 탄도미사일을 대상으로 동일한 횡축 선상에서 위치를 변경하면서 표적을 관측하였을 때 레이더에 수신되는 전력을 계산하고, 탐지 효율을 높이기 위한 레이더 배치 방안에 대해 연구하였다.