• Journal of Technologic Dentistry
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• v.32 no.3
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• pp.221-232
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• 2010

Purpose: It is necessary for dental technicians exposed to hazardous chemicals in the dental laboratories to be informed of the various harmful effects of chemicals for their health and safety. The purposes of this study was to investigate the actual condition of the use of MSDS in dental laboratories and the recognition rate of MSDS for dental technicians. Methods: 231 dental technicians who were self-written questionnaire. The results were analyzed by SPSS 12.0. The answers to the questionnaire underwent frequency analysis, chi-square test and correlation analysis were performed to investigate association between health effects and recognition rate of chemical information. Results: The results from the effects of damage caused by chemicals 60.7%, and when it was less than 2 years working experience 47.6%. Currently any dental laboratories(rooms) was not furnished MSDS(0%) and even similar data furnishing rate was only 17.3%. Answer rate of 'Do not know about MSDS' was 73.6%. In addition to, education in the types and characteristics of chemicals(74.5%) does not receive all the higher education. For the question of 'To prevent human risks and accidents, is to provide chemical information needed', the answer rate of 'needed' was 87.2%. Moreover, the answer rate of 'To provide chemical information that could prevent accidents' was 76.6%. Therefore it was found that dental technicians need to be provided for chemical information. In addition, they wanted to get education related to chemicals used in the workplace(80.5%), and 90.9% was answered that they was willing to keep MSDS in they workplace. Conclusion: This study investigated the current dental laboratories(rooms) and the MSDS for the awareness and recognition of workers was very low, education was not being conducted properly. The dental laboratories(rooms) of the compact characteristics of the MSDS was not reasonably accessible and the furnishing location, dental laboratories(rooms) for the real item was needed for improvement. MSDS for dental technicians through education and promotion of information about chemicals and chemicals was to prevent health problems caused by the MSDS that will raise awareness of the necessity.

• Archives of Pharmacal Research
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• v.26 no.6
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• pp.493-498
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• 2003

In this study we have investigated the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. Plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min after intravenous injection in mice. After intramuscular injection, plasmid DNA concentration in the injection site rapidly declined to less than 1 ％ of the initial concentration by 90 min post-injection. However, sub-picogram levels (per mg tissue) were occasionally detected for several days after injection. The relative proportions of the individual plasm ids of GX-12 remained relatively constant at the injection site until 90 min post-injection. The concentration of plasmid DNA in tissues other than the injection site peaked at 90 min post-injection and decreased to undetectable levels at 8 h post-injection. The rapid in vivo degradation of GX-12 and absence of persistence in non-target tissues suggest that the risk of potential gene-related toxicities by GX-12 administration, such as expression in non-target tissues, insertional mutagenesis and germline transmission, is minimal.

• Journal of Technologic Dentistry
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• v.38 no.1
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• pp.23-36
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• 2016

Purpose: The purpose of this study is to suggest direction for dental technicians and management of dental laboratories to contribute to the improvement of oral health of citizens with high-quality dental prosthesis by researching operational status and management satisfaction of dental laboratories. Methods: In order to investigate operational status and management satisfaction of dental laboratories, this study conducted a questionnaire survey by mailing questionnaires to heads of dental laboratories designated as clinical training workshops of Department of Dental Technology of G University and a total of 158 questionnaires were used for analysis. Results: As for gender, males were 142 persons (89.9%) and females were 16 persons (10.1%). For location of the laboratories, number of laboratories in metropolitan cities was 94 (59.5%) while small and that in mid-sized cities was 64 (40.5%). As for the satisfaction with job, those who have managed dental laboratories for 23-30 years ($1.92{\pm}77$), transact with 7-12 dental clinics ($1.70{\pm}75$), had monthly income of 4-8 million won ($1.74{\pm}.80$) and had 8-10 employees ($2.33{\pm}.68$) were the highest in their satisfaction. As for satisfaction with management, those who have managed their business for 15-20 years ($2.86{\pm}.52$), transact with more than 20 dental clinics ($2.00{\pm}.04$), had monthly income of less than 4 million won ($2.00{\pm}.85$) and had less than 3 employees ($2.00{\pm}.62$) were the highest in their satisfaction. As for monthly income, those with less than 2 million won were 24 persons (15.2%), 2-4 million were 64 persons (40.5%), 4-6 million were 40 (25.3%), 6-8 million were 14 (8.9%) and over 8 million won were 16 persons (10.2%). As for number of employees, those with less than 3 employees were 32perosns (20.3%), 4-7 were 82 (51.9%), 8-10 were 26 (16.5%) and more than 11 were 10 persons (6.3%). As for severance payment, 84 persons practiced it according to Labor Standard Act (53.2%) and 34 practice it to a proper degree (21.5%) while 20 did not practice it at all (12.7%) and 20 persons did not respond to the question (12.7%). Conclusion: Although dental laboratories have rapidly expanded in number from 473 in 1986 to 2,400 in 2015, dental technician circles are facing difficulty in their management due to fierce competition and low profitability. Therefore, in order to improve this problem, it is necessary to readjust prices for dental prosthesis to realistic ones.

• Korean Journal of Pharmacognosy
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• v.36 no.2 s.141
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• pp.97-101
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• 2005

Saussureae Radix, the dried root of Saussurea lappa Clarke, has traditionally used for alleviating pain in abdominal distention and tenesmus, indigestion with anorexia, dysentery, nausea, and vomiting. Here we observed that methanol extracts of Saussurea Radix inhibited CDK2 activities in vitro. This inhibitory compound was isolated and identified as dehydrocostuslactone, one of the major constituents of Saussurea Radix. It is well known that dehydrocostuslactone induces apoptotic cell death. In this study, we also showed that dehydrocosruslactone inhibited cellular Rb phosphorylation and blocked cell growth at the concentration below $12\;{\mu}g/ml$ at which apoptotic cell death was not observed. Taken together, these results indicated that dehydrocostuslactone showed its anti-proliferative effects through the inhibition of CDK2 activity as well as the induction of apoptotic cell death.

• Journal of Veterinary Science
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• v.23 no.2
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• pp.21.1-21.7
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• 2022

Newcastle disease (ND), infectious laryngotracheitis (ILT) and avian metapneumovirus (aMPV) can be similar making it critical to quickly differentiate them. Herein, we adapted pre-existing molecular-based diagnostic assays for NDV and ILTV, and developed new assays for aMPV A and B, for use under synchronized thermocycling conditions. All assays performed equivalently with linearity over a 5 log₁₀ dynamic range, a reproducible (R² > 0.99) limit of detection of ≥ 10 target copies, and amplification efficiencies between 86.8%-98.2%. Using biological specimens for NDV and ILTV showed 100% specificity. Identical amplification conditions will simplify procedures for detection in diagnostic laboratories.

• 한국정보디스플레이학회:학술대회논문집
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• 2008.10a
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• pp.627-628
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• 2008

We have studied the optical performance of flexible polymer network liquid crystal (PNLC) films at various bending states. Different measurement setups, wide and narrow opening angles of detector, were used to collect scatting light of PNLC films. The optical and dynamic properties of bent PNLC implied the change of LC domains.

• Journal of the Korean Society of Safety
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• v.25 no.1
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• pp.72-78
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• 2010

Laboratory accidents have happened incidently. However, laboratory safety management has been out of concerns for a long time. At last, the Korean government established an act called Establishment of safe environment of laboratories in 2005. To support the act and to establish policies on laboratory safety management，a national-wide survey was conducted for the 74 research organizations sampled and their 201 laboratories. For the survey, a safety management checklist with 114 items grouped into 20 categories was developed By using this checklist, safety expert groups investigated the laboratories and evaluated them on the five-point Likert scale. A statistical analysis was conducted to compare the safety management status between different research organization types and between different research fields. The resultsmanaw that the universities are in significant lower level on safety institution and safety education than the public research organizations and theare poration research organizations. In terms of research field, chemistry/chemical engineering laboratories generallymanaw higher level compared with theaothers. Conversely, biology/life science laboratories marked low levels in a number of checklist items.

• International Journal of Safety
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• v.5 no.1
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• pp.33-36
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• 2006

In laboratories, researchers frequently work using new methods with new tools and materials. So the workers in laboratories are exposed to risk from dangerous articles all the time. In the case of university laboratories, testing is done by the individual at night. Because of that, the risks in university laboratories are higher than in other places. In addition, students and managers in universities generally have little concern for laboratory safety. So students are sometimes injured or killed in laboratory accidents. In this study, 1,000 university students answered questions about university laboratory safety. Their answers have been analyzed to determine the state of actual conditions and to formulate countermeasures. The results indicate that we need to change the safety awareness of the universities and the students. Adequate safety training and safe practice must be implemented by each university to decrease accidents. Development of systematic safety training program suited to the specific conditions of the individual laboratory and formulation of specific counter plans should accidents occur are required.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2005.05a
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• pp.12-18
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• 2005

• Proceedings of the Zoological Society Korea Conference
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• 1997.10b
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• pp.292.2-292
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• 1997

No Abstract, See Full Text