• Korean Chemical Engineering Research
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• 제45권5호
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• pp.479-486
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• 2007

BCB 수지를 이용하여 본딩한 웨이퍼의 BCB 두께, 본딩 촉진제의 사용여부 및 이웃하는 적층 물질의 종류에 따른 본딩 결합력에 대한 영향을 4-점 굽힘방법을 이용하여 규명한다. 실험결과 본딩 결합력은 BCB 두께에 선형 비례하는데, 이는 BCB의 소성 변형의 정도가 두께에 비례하는 반면에 BCB의 항복 강도에는 영향을 미치지 않기 때문이다. 본딩한 BCB의 두께가 각각 $2.6{\mu}m$ 및 $0.4{\mu}m$인 경우에 대하여 본딩 촉진제를 사용 했을 때, 본딩 촉진제와 본딩된 물질의 표면에서는 공유 결합이 형성되기 때문에 본딩 결합력이 증가한다. 산화 규소막이 증착된 실리콘 웨이퍼와 BCB 사이 계면에서의 본딩 결합력은 글래스 웨이퍼와 BCB 사이의 계면에서 보다 약 3배 정도 높다. 이러한 본딩 결합력의 차이는 각 계면에서 Si-O 본드의 본딩 밀도 및 본드 파단 에너지의 차이에 기인한다. PECVD 산화 규소막을 증착한 실리콘 웨이퍼와 BCB 사이 계면의 경우, 기 측정된 $18J/m^2$ 및 $22J/m^2$의 본드 파단 에너지를 얻기 위해 각각 약 $12{\sim}13bonds/nm^2$ 및 $15{\sim}16bonds/nm^2$의 Si-O 본드 밀도가 필요하다. 반면에, 글래스 웨이퍼와 BCB 사이 계면의 경우에는 기 측정된 $5J/m^2$의 본드 파단 에너지를 얻기 위해 약 $7{\sim}8bonds/nm^2$의 Si-O 본드 밀도가 필요하다.

• Asian Journal of Atmospheric Environment
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• 제7권4호
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• pp.191-198
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• 2013

Cryptomeria japonica pollen is the most common pollen, which are scattering during each spring season in Japan. Japanese cedar (Cryptomeria japonica) pollinosis is one of seasonal allergic rhinitis that mainly occurs in Japan. In addition, long range transportation of Yellow Sand from the East Asian continent was also found during the pollen scattering seasons in Japan. Therefore, the interaction or impact between pollen and Yellow Sand should be concerned. In this study, our objective was to investigate the airborne behaviour of Cryptomeria japonica pollen grains and its size-segregated allergenic (Cry j 1) particles as the airborne tracer of Cryptomeria japonica pollen during the Yellow Sand events. Airborne Cryptomeria japonica pollen grains and its size-segregated allergenic particles were collected at roadside of urban residential zones of Saitama city during the pollination periods from February to March in two year investigation of 2009 and 2010. The overlap of Yellow Sand events and dispersal peak of pollen grains was observed. According to the Meteorological data, we found that the peaks of airborne pollen grains appeared under higher wind speed and temperature than the previous day. It was thought that Yellow Sand events and airborne pollen counts were related to wind speed. From the investigation of the airborne behavior of the size-segregated allergen particles by determining Cry j 1 with Surface Plasmon Resonance (SPR), the higher concentrations of the allergenic Cry j 1 were detected in particle size equal to or less than $1.1{\mu}m$($PM_{1.1}$) than other particle sizes during Yellow Sand events, especially in the rainy day. We conclude that rainwater trapping Yellow Sand is one of the important factors that affect the release of allergenic pollen species of Cry j 1. Therefore, it is very important to clarify the relationships between Cryptomeria japonica pollen allergenic species and chemical contents of the Yellow Sand particles in further studies.

• 한방재활의학과학회지
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• 제15권2호
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• pp.141-154
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• 2005

Objectives : This study was planned to evaluate clinical status of the alopecia patients who had visited oriental medicine clinic. Methods : 80 patients with alopecia, who had visited oriental medicine clinic from January 2004 to August 2004, were examined. Results & Conclusions : 1. The kinds and incidences of Alopecia : androgenetic alopecia 57.5%(46/80), alopecia areatea 20.0%(16/80), telogen effluvium 16.3%(13/80), seborrheic alopecia 6.3%(5/80). 2. In distribution of sex, the rate of male to female was 1:1 and most patients belonged to 20-30 year old group. 3. The most common onset of age was adolescence(63.8%) and the most common duration of hair loss was 1 to 3 years. 4. Among the 30 male androgenetic alopecia patients, Hamilton's type 4 was most common and among the 16 female androgenetic alopecia patients, Ludwig's type II and III were most common. 5. Family history of baldness in Androgenetic alopecia and alopecia areata were 56.5% and 25.0%, respectively. 6. Self-conscious causes of hair loss : stress(48.8%), irregular eating habits(21.3%), and lack of sleep(20.0%). 7. Associated diseases with alopecia patients : chronic neck pain(58.8%), temporomandibular disorders(55.0%) and seborrheic dermatitis(20.0%). 8. Associated symptoms with alopecia Patients : stress(78.8%), sleep disorders(68.8%), irregular eating habits(55.0%), Hot flush(43.8%), Stool disorders(43.8%), cold hands and feet(37.5%) and menstruation disorders(31.3%). 9. The most common scalp type was oily scalp(70.0%) and the symptoms of scalp were iching, dandruff, pain, inflammation. 10. $Bi{\grave{a}}n$ $zh{\grave{e}}ng$(辨證) of alopecia patients : $xu{\grave{e}}-r{\grave{e}}-f{\bar{e}}ng-z{\grave{a}}u$(血熱風燥) (25.0%), $g{\bar{a}}n-sh{\grave{e}}n-b{\grave{u}}-z{\acute{u}}$(肝腎不足) (23.8%), $shi-r{\grave{e}}-sh{\grave{a}}ng-zh{\bar{e}}ng$(濕熱上蒸) (16.3%), $xu{\grave{e}}-r{\grave{e}}-sh{\bar{e}}ng-f{\bar{e}}ng$(血熱生風) (13.8%), $xu{\grave{e}}-x{\bar{u}}-f{\bar{e}}ng-z{\grave{a}}u$(血熱風燥) (13.8%), $y{\bar{u}}-xu{\grave{e}}-z{\check{u}}-lu{\grave{o}}$(瘀血阻絡) (7.5%).

• Bulletin of the Korean Chemical Society
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• 제30권3호
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• pp.543-550
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• 2009

The single-crystal structure of largely ammonium-exchanged zeolite Y dehydrated at room temperature (293 K) and 1 ${\times}\;10^{-6}$ Torr. has been determined using synchrotron X-radiation in the cubic space group $Fd\overline{3}m\;(a=24.9639(2)\AA)$ at 294 K. The structure was refined to the final error index $R_1$ = 0.0429 with 926 reflections where $F_o>4\sigma(F_o)$; the composition (best integers) was identified as |$(NH_4)_{60}Na_{11}$|[$Si_{121}Al_{71}O_{384}$]-FAU. The 11 $Na^{+}$ ions per unit cell were found at three different crystallographic sites and 60 ${NH_4}^{+}$ ions were distributed over three sites. The 3 $Na^{+}$ ions were located at site I, the center of the hexagonal prism ($Na-O\;=\;2.842(5)\;\AA\;and\;O-Na-O\;=\;85.98(12)^{\circ}$). The 4 $Na^{+}$ and 22 ${NH_4}^{+}$ ions were found at site I' in the sodalite cavity opposite the double 6-rings, respectively ($Na-O\;=\;2.53(13)\;\AA,\;O-Na-O\;=\;99.9(7)^{\circ},\;N-O\;=\;2.762(11)\;\AA,\;and\;O-N-O =\;89.1(5)^{\circ}$). About 4 $Na^{+}$ ions occupied site II ($(Na-O\;=\;2.40(4)\;\AA\;and\;O-Na-O\;=\;108.9(3)^{\circ}$) and 29 ${NH_4}^{+}$ ions occupy site II ($N-O\;=\;2.824(9)\;\AA\;and\;O-N-O\;=\;87.3(3)^{\circ}$) opposite to the single 6-rings in the supercage. The remaining 9 ${NH_4}^{+}$ ions were distributed over site III' ($N-O\;=\;2.55(3),\;2.725(13)\;\AA\;and\;O-N-O\;=\;94.1(13),\;62.16(15),\;155.7(14)^{\circ}$).

• Journal of Microbiology and Biotechnology
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• 제26권6호
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• pp.989-998
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• 2016

Acidic endo-polygalacturonases are the major part of pectinase preparations and extensively applied in the clarification of fruits juice, vegetables extracts, and wines. However, most of the reported fungal endo-polygalacturonases are active and stable under narrow pH range and low temperatures. In this study, an acidic endo-polygalacturonase (EPG4) was purified and characterized from a mutant strain of Penicillium oxalicum. The N-terminal amino acid sequence of EPG4 (ATTCTFSGSNGAASASKSQT) was different from those of reported endo-polygalacturonases. EPG4 displayed optimal pH and temperature at 5.0 and 60-70℃ towards polygalacturonic acid (PGA), respectively, and was notably stable at pH 2.2-7.0. When tested against pectins, EPG4 showed enzyme activity over a broad acidic pH range (>15.0% activity at pH 2.2-6.0 towards citrus pectin; and >26.6% activity at pH 2.2-7.0 towards apple pectin). The K_m and V_max values were determined as 1.27 mg/ml and 5,504.6 U/mg, respectively. The enzyme hydrolyzed PGA in endo-manner, releasing oligo-galacturonates from PGA, as determined by TLC. Addition of EPG4 (3.6 U/ml) significantly reduced the viscosity (by 42.4%) and increased the light transmittance (by 29.5%) of the papaya pulp, and increased the recovery (by 24.4%) of the papaya extraction. All of these properties make the enzyme a potential application in the beverage industry.

• Asian-Australasian Journal of Animal Sciences
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• 제32권4호
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• pp.541-547
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• 2019

Objective: This study investigated the effects of photoperiod on nutrient digestibility, hair follicle (HF) activity and cashmere quality in Inner Mongolia white cashmere goats. Methods: Twenty-four female (non-pregnant) Inner Mongolia white cashmere goats aged 1 to 1.5 years old with similar live weights (mean, $20.36{\pm}2.63kg$) were randomly allocated into two groups: a natural daily photoperiod group (NDPP group:10 to 16 h light, n = 12) and a short daily photoperiod group (SDPP group: 7 h light:17 h dark, n = 12). All the goats were housed in individual pens and fed the same diets from May 15 to October 15, 2015. The digestibility of crude protein (CP), dry matter (DM), and neutral detergent fiber (NDF) were measured in different months, along with secondary hair follicle (SHF) activity, concentration of melatonin (MEL), and cashmere quality. Results: Although there was no significant difference in the live weights of goats between the SDPP and NDPP groups (p>0.05), the CP digestibility of goats in the SDPP group was significantly increased compared to the NDPP group in July, September, and October (p<0.05). For the DM and NDF digestibility of goats, a significant increase (p<0.05) was found during in September in the SDPP group. Furthermore, compared to the NDPP group, the SHF activity in July, the MEL concentration in July, and the cashmere fiber length and fiber weight in October were significantly increased in the SDPP group (p<0.05). Conclusion: The cashmere production of Inner Mongolia white cashmere goats was increased without obvious deleterious effects on the cashmere fibers in the SDPP group (metabolizable energy, 8.34 MJ/kg; CP, 11.16%; short daily photoperiod, 7 h light:17 h dark).

• 핵의학기술
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• 제26권2호
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• pp.37-42
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• 2022

Purpose Since 1985, the Korean society of nuclear medicine technology (KSNMT) has been engaged in academic activities related to nuclear medicine imaging. From 2017 to 2021, the papers published in the journal were classified by the specific fields to examine the trends in the research and the direction of nuclear medicine in comparison with the papers submitted to the Korean Society of Nuclear Medicine (KSNM) during the same period. Materials and Methods From 2017 to 2021, papers submitted to KSNMT and KSNM were classified and databaseization using the Excel program by submission type, examination equipment, and examination field. Through this data, the number of papers published in journals by year, the number of papers submitted by detailed fields, and key words by era were analyzed and compared. Results The papers included by journal was 57 KSNMT and 280 KSNM. The major large classification of equipment, PET, Planar and SPECT was 26.3%, 21.1%, 19.3% in the KSNMT, KSNM was 49.6%, 6.4%, and 9.3%, with 66.7% and 65.3%, respectively. the major medium classification of equipment, industrial safety, urogenital system, nervous system, and quality control accounted for 54.4% of the total papers of the total ratio in the KSNMT, while the medium classification of oncology, endocrine system, urogenital system, therapy, and nervous system accounted for 61.1% of KSNM. In the major small classification of image acquisition, improvement effect, and exposure management accounted for 70.2% in KSNMT, while the items of image acquisition, report, and improvement effect accounted for 60.7% in KSNM. The major keywords except for equipment-related keywords such as PET/CT, PET/MR, and SPECT were SUV, Planar Image, and Respiration Gating Method in KSNMT and Ga68, Thyroid, and Lymphoma in the KSNM. Conclusion When checking the last 5 years of submissions, we can see that KSNMT is mainly concerned with image acquisition using existing radiotracers, while KSNM has focused on new radiotracers such as ⁶⁸Ga, ¹⁷⁷Lu, etc., and new medical technologies of theranostic. It has been confirmed that more PET-related papers than other examination equipment will account for a greater number of papers, and it is believed that future submissions will also account for a higher proportion of PET-related papers than other equipment.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.246-246
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• 2021

본 연구는 강우 발생시 유량을 추정하는 것에 목적이 있다. 이를 위해 본 연구는 선행연구의 모형 개발방법론에서 벗어나 딥러닝 알고리즘 중 하나인 합성곱 신경망 (convolution neural network)과 수문학적 이미지 (hydrological image)를 이용하여 강우 발생시 유량을 추정하였다. 합성곱 신경망은 일반적으로 분류 문제 (classification)을 해결하기 위한 목적으로 개발되었기 때문에 불특정 연속변수인 유량을 모의하기에는 적합하지 않다. 이를 위해 본 연구에서는 합성곱 신경망의 완전 연결층 (Fully connected layer)를 개선하여 연속변수를 모의할 수 있도록 개선하였다. 대부분 합성곱 신경망은 RGB (red, green, blue) 사진 (photograph)을 이용하여 해당 사진이 나타내는 것을 예측하는 목적으로 사용하지만, 본 연구의 경우 일반 RGB 사진을 이용하여 유출량을 예측하는 것은 경험적 모형의 전제(독립변수와 종속변수의 관계)를 무너뜨리는 결과를 초래할 수 있다. 이를 위해 본 연구에서는 임의의 유역에 대해 2차원 공간에서 무차원의 수문학적 속성을 갖는 grid의 집합으로 정의되는 수문학적 이미지는 입력자료로 활용했다. 합성곱 신경망의 구조는 Convolution Layer와 Pulling Layer가 5회 반복하는 구조로 설정하고, 이후 Flatten Layer, 2개의 Dense Layer, 1개의 Batch Normalization Layer를 배열하고, 다시 1개의 Dense Layer가 이어지는 구조로 설계하였다. 마지막 Dense Layer의 활성화 함수는 분류모형에 이용되는 softmax 또는 sigmoid 함수를 대신하여 회귀모형에서 자주 사용되는 Linear 함수로 설정하였다. 이와 함께 각 층의 활성화 함수는 정규화 선형함수 (ReLu)를 이용하였으며, 모형의 학습 평가 및 검정을 판단하기 위해 MSE 및 MAE를 사용했다. 또한, 모형평가는 NSE와 RMSE를 이용하였다. 그 결과, 모형의 학습 평가에 대한 MSE는 11.629.8 m3/s에서 118.6 m3/s로, MAE는 25.4 m3/s에서 4.7 m3/s로 감소하였으며, 모형의 검정에 대한 MSE는 1,997.9 m3/s에서 527.9 m3/s로, MAE는 21.5 m3/s에서 9.4 m3/s로 감소한 것으로 나타났다. 또한, 모형평가를 위한 NSE는 0.7, RMSE는 27.0 m3/s로 나타나, 본 연구의 모형은 양호(moderate)한 것으로 판단하였다. 이에, 본 연구를 통해 제시된 방법론에 기반을 두어 CNN 모형 구조의 확장과 수문학적 이미지의 개선 또는 새로운 이미지 개발 등을 추진할 경우 모형의 예측 성능이 향상될 수 있는 여지가 있으며, 원격탐사 분야나, 위성 영상을 이용한 전 지구적 또는 광역 단위의 실시간 유량 모의 분야 등으로의 응용이 가능할 것으로 기대된다.

• Korean Journal of Radiology
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• 제24권12호
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• pp.1221-1231
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• 2023

Objective: To clinically validate the feasibility and accuracy of cine images acquired through the multitasking method, with no electrocardiogram gating and free-breathing, in measuring left ventricular (LV) function indices by comparing them with those acquired through the balanced steady-state free precession (bSSFP) method, with multiple breath-holds and electrocardiogram gating. Materials and Methods: Forty-three healthy volunteers (female:male, 30:13; mean age, 23.1 ± 2.3 years) and 36 patients requiring an assessment of LV function for various clinical indications (female:male, 22:14; 57.8 ± 11.3 years) were enrolled in this prospective study. Each participant underwent cardiac magnetic resonance imaging (MRI) using the multiple breath-hold bSSFP method and free-breathing multitasking method. LV function parameters were measured for both MRI methods. Image quality was assessed through subjective image quality scores (1 to 5) and calculation of the contrast-to-noise ratio (CNR) between the myocardium and blood pool. Differences between the two MRI methods were analyzed using the Bland-Altman plot, paired t-test, or Wilcoxon signed-rank test, as appropriate. Results: LV ejection fraction (LVEF) was not significantly different between the two MRI methods (P = 0.222 in healthy volunteers and P = 0.343 in patients). LV end-diastolic mass was slightly overestimated with multitasking in both healthy volunteers (multitasking vs. bSSFP, 60.5 ± 10.7 g vs. 58.0 ± 10.4 g, respectively; P < 0.001) and patients (69.4 ± 18.1 g vs. 66.8 ± 18.0 g, respectively; P = 0.003). Acceptable and comparable image quality was achieved for both MRI methods (multitasking vs. bSSFP, 4.5 ± 0.7 vs. 4.6 ± 0.6, respectively; P = 0.203). The CNR between the myocardium and blood pool showed no significant differences between the two MRI methods (18.89 ± 6.65 vs. 18.19 ± 5.83, respectively; P = 0.480). Conclusion: Multitasking-derived cine images obtained without electrocardiogram gating and breath-holding achieved similar image quality and accurate quantification of LVEF in healthy volunteers and patients.

• Korean Journal of Radiology
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• 제22권10호
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• pp.1619-1627
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• 2021

Objective: This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) with those of patients with essential hypertension (EH) and healthy controls (HCs). Materials and Methods: This prospective study enrolled 35 patients with PA, in addition to 35 age- and sex-matched patients with EH, and 35 age- and sex-matched HCs, all of whom underwent comprehensive clinical and cardiac MRI examinations. The analysis of variance was used to detect the differences in the characteristics of left ventricular remodeling among the three groups. Univariable and multivariable linear regression analyses were used to determine the relationships between left ventricular remodeling and the physiological variables. Results: The left ventricular end-diastolic volume index (EDVi) (mean ± standard deviation [SD]: 85.1 ± 13.0 mL/m² for PA, 75.9 ± 14.3 mL/m² for EH, and 77.3 ± 12.8 mL/m² for HC; p = 0.010), left ventricular end-systolic volume index (ESVi) (mean ± SD: 35.2 ± 9.8 mL/m² for PA, 30.7 ± 8.1 mL/m² for EH, and 29.5 ± 7.0 mL/m² for HC; p = 0.013), left ventricular mass index (mean ± SD: 65.8 ± 16.5 g/m² for PA, 56.9 ± 12.1 g/m² for EH, and 44.1 ± 8.9 g/m² for HC; p < 0.001), and native T1 (mean ± SD: 1224 ± 39 ms for PA, 1201 ± 47 ms for EH, and 1200 ± 44 ms for HC; p = 0.041) values were higher in the PA group compared to the EH and HC groups. Multivariable linear regression demonstrated that log (plasma aldosterone-to-renin ratio) was independently correlated with EDVi and ESVi. Plasma aldosterone was independently correlated with native T1. Conclusion: Patients with PA showed a greater degree of ventricular hypertrophy and enlargement, as well as myocardial fibrosis, compared to those with EH. Cardiac MRI T1 mapping can detect left ventricular myocardial fibrosis in patients with PA.