Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Left Ventricular Remodeling in Patients with Primary Aldosteronism: A Prospective Cardiac Magnetic Resonance Imaging Study

  • Tao Wu (Department of Radiology, West China Hospital, Sichuan University) ;
  • Yan Ren (Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) ;
  • Wei Wang (Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) ;
  • Wei Cheng (Department of Radiology, West China Hospital, Sichuan University) ;
  • Fangli Zhou (Department of Endocrinology and Metabolism, West China Hospital, Sichuan University) ;
  • Shuai He (Department of Radiology, West China Hospital, Sichuan University) ;
  • Xiumin Liu (Department of Radiology, West China Hospital, Sichuan University) ;
  • Lei Li (Department of Radiology, West China Hospital, Sichuan University) ;
  • Lu Tang (Department of Radiology, West China Hospital, Sichuan University) ;
  • Qiao Deng (Department of Radiology, West China Hospital, Sichuan University) ;
  • Xiaoyue Zhou (MR Collaboration, Siemens Healthcare) ;
  • Yucheng Chen (Department of Cardiology, West China Hospital, Sichuan University) ;
  • Jiayu Sun (Department of Radiology, West China Hospital, Sichuan University)
  • Received : 2020.11.02
  • Accepted : 2021.04.25
  • Published : 2021.10.01
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Abstract

Objective: This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) with those of patients with essential hypertension (EH) and healthy controls (HCs). Materials and Methods: This prospective study enrolled 35 patients with PA, in addition to 35 age- and sex-matched patients with EH, and 35 age- and sex-matched HCs, all of whom underwent comprehensive clinical and cardiac MRI examinations. The analysis of variance was used to detect the differences in the characteristics of left ventricular remodeling among the three groups. Univariable and multivariable linear regression analyses were used to determine the relationships between left ventricular remodeling and the physiological variables. Results: The left ventricular end-diastolic volume index (EDVi) (mean ± standard deviation [SD]: 85.1 ± 13.0 mL/m2 for PA, 75.9 ± 14.3 mL/m2 for EH, and 77.3 ± 12.8 mL/m2 for HC; p = 0.010), left ventricular end-systolic volume index (ESVi) (mean ± SD: 35.2 ± 9.8 mL/m2 for PA, 30.7 ± 8.1 mL/m2 for EH, and 29.5 ± 7.0 mL/m2 for HC; p = 0.013), left ventricular mass index (mean ± SD: 65.8 ± 16.5 g/m2 for PA, 56.9 ± 12.1 g/m2 for EH, and 44.1 ± 8.9 g/m2 for HC; p < 0.001), and native T1 (mean ± SD: 1224 ± 39 ms for PA, 1201 ± 47 ms for EH, and 1200 ± 44 ms for HC; p = 0.041) values were higher in the PA group compared to the EH and HC groups. Multivariable linear regression demonstrated that log (plasma aldosterone-to-renin ratio) was independently correlated with EDVi and ESVi. Plasma aldosterone was independently correlated with native T1. Conclusion: Patients with PA showed a greater degree of ventricular hypertrophy and enlargement, as well as myocardial fibrosis, compared to those with EH. Cardiac MRI T1 mapping can detect left ventricular myocardial fibrosis in patients with PA.

Keywords

Acknowledgement

This work was supported by grants from the Key R & D projects in Sichuan Province (No. 2020YFS0123) and 1·3·5 Project for Disciplines of Excellence-Clinical Research Incubation Project (2018HXFH009).

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