• Korean Journal of Acupuncture
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• 제31권2호
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• pp.90-97
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• 2014

Objective : The objective of this study is to investigate the effects of smoking on the skin bioelectrical capacitance at specific acupoints of lung meridian. Methods : Bioelectrical capacitance was measured on bilateral six source points(bilateral LU10, LU9, LU7, LU6, LU5, LU1), and the changes with time and between left and right side were analyzed. Results : The skin bioelectrical capacitance at specific acupoints of lung meridian was significantly increased after smoking. And it recovered as time passed. The change of the skin bioelectrical capacitances at specific acupoints of lung meridian with time were similar between left and right. Conclusion : Smoking increases the bioelectrical capacitance at specific acupoints of lung meridian. There is no difference between the effects of smoking on the bioelectrical capacitance at left and right specific acupoints of lung meridian.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2000년도 2nd Korea-China Congress of Nuclear Medicine and 39th Annual Spring Meeting if the Korea SOciety Nuclear Medicine
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• pp.67.2-67.2
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• 2000

• Korean Journal of Acupuncture
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• 제24권3호
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• pp.205-221
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• 2007

Objectives : Aims of this study is to investigate the effects of $LU8{\cdot}KI7$ in rat induced by experimental focal ischemia. Materials and methods : The focal ischemia was induced by intraluminal filament insertion into middle cerebral artery. The groups divided into 6groups, control; no therapy group after ischemia-induced, AT1; acupuncture therapy group at $LU8{\cdot}KI7$ after ischemia-induced, AT2; acupuncture therapy at $LU8{\cdot}KI7$ bilaterally and the needle was twirled and rotated forward with the thumb of the right hand 9times, AT3; acupuncture therapy at $LU8{\cdot}KI7$ bilaterally and the needle was twirled and rotated forward with the forefinger of the right hand 9times, AT4; acupuncture therapy at$LU8{\cdot}KI7$ bilaterally and the needle was inserted to the direction following the flowing route of the meridian(digital direction), AT5; acupuncture therapy at $LU8{\cdot}KI7$ bilaterally, the needle was inserted to the direction following the flowing route of the meridian(digital direction) and the needle was twirled and rotated forward with the thumb of the right hand 9times. Acupuncture therapy was carried out 7times during 2weeks after focal ischemia-induced. The anti-apoptotic and neuroprotective effects of acupuncture are observed by Bax, Bcl-2, mGluR5, cytochrome c, Cresyl violet and ChAT-stain. Results : The intensity of Bax was decreased in AC1, AC4, AC5 group, was increased in AC2, AC3 group. The intensity of Bcl-2 was increased in AC2, AC3, AC4, AC5 group. The intensity of mGluR5 was decreased in AC1 group, was increased in AC4, AC5 group. The intensity of Cytochrome c was increased in ACI, AC2 group, was decreased in AC4, AC5 group. The density of neurons stained by Cresyl violet was increased in all group without control group. The density of ChAT was increased in AC2, ACS group. Conclusions : Our study suggests that AC5 group show anti-apoptotic and neuroprotective effects on cholinergic neuron in focal cerebral ischemia of the stroke in rats.

• 동의생리병리학회지
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• 제20권4호
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• pp.807-813
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• 2006

The purpose of this study is to investigate the acupuncture points and the The Meridians and Collaterals which are often applicable to Allergic Rhinitis treatment and to help us do a clinical diagnosis. In my discretion, to study Allergic Rhinitis, investigating rhinitis, syuffy nose and nasal mucus is essential. And 1 investigated the acupuncture points and The Meridians and Collaterals and dialectic patterns which are useful for the acupuncture and moxibustion treatment. 1 also investigated the correlation of the acupuncture points, and The Meridians and Collaterals and other dialectic patterns. The order of frequency in use of The Meridians and Collaterals is The Governor Vessel, The Large Intestine Meridian of Hand-Yangming, The Bladder Meridian of Foot-Taiyang and the order of frequency in moxibustion is The Governor Vessel, The Large Intestine Meridian of Hand-Yangming. In the acupuncturation of stuffy nose, there are 33 points, and the order of frequency in use is LU2O, GV23, LU4, GBI 5, GV2O, BL7, GV22. In the acupuncturation of nasal mucus, there are 21 points, and the order of frequency in use is LU2O,, GV23, GVl6, GV26, BLl2, GV2O, GB2O. It is thought that acupuncture points LU2O, GV23, LU4 can go through the nasal cavity and remove wind fever. And those are used for the face and the five sensory organs diseases. It means that those acupuncture points have similar efficacy. It is thought that The Meridians and Collaterals of The Governor Vessel, The Large Intestine Meridian of Hand-Yangming, The Bladder Meridian of Foot-Taiyang go on a patrol near nose and cure nose disease.

• 대한방사성의약품학회지
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• 제9권1호
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• pp.17-21
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• 2023

In this study, we evaluated the targeting of prostate cancer (PCa) using [¹⁸F]Florastamin in non-clinical study, for the purpose of therapeutic monitoring of [¹⁷⁷Lu]Ludotadipep, a therapeutic radiopharmaceutical for PCa, [¹⁸F]Florastamin/[¹⁷⁷Lu]Ludotadipep was co-administered to a single-individual prostate tumor bearing mouse model, mimicking clinical condition. Considering the difference in half-life of the two isotopes (¹⁸F or ¹⁷⁷Lu), image scan of whole-body autoradiography was performed at 24 or 48 h after preparation of frozen section, respectively. Then, it was confirmed whether they showed the same targeting efficiency for the area of tumor. A tumor xenograft model was prepared using PSMA-overexpressing PC3-PIP prostate cancer cells. [¹⁸F]Florastamin [111 MBq (3 mCi) in 100 µL]/¹⁷⁷Lu]Ludotadipep [3.7 MBq (100 µCi) in 100 µL] was co-administered through the tail vein, and 2 hours after administration, the mice were frozen, and after freezing for 24 hours, whole-body cryosection was performed at 24 h after freezing. Image scanning using cryosection was performed after 24 or 48 hours after freezing, respectively. In the scan image after 24 hours, tumor uptake of [¹⁸F] Florastamin/[¹⁷⁷Lu]Ludotadipep were simultaneously observed specific uptake in the tumor. In the scan image after 48 hours in the same section, signal of ¹⁸F was lost by decay of radioisotope, and specific uptake image for [¹⁷⁷Lu]Ludotadipep was observed in the tumor. Uptake of [¹⁷⁷Lu]Ludotadipep was specific to the same tumor region where [¹⁸F]Florastamin/[¹⁷⁷Lu]Ludotadipep was uptake. These results suggested that [¹⁸F]Florastamin showed the same tumor uptake efficiency to PCa as [¹⁷⁷Lu]Ludotadipep, and effective therapeutic monitoring is expected to be enable using [¹⁸F]Florastamin during [¹⁷⁷Lu]Ludotadipep therapy for PCa.

• 대한방사성의약품학회지
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• 제3권2호
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• pp.59-64
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• 2017

It has been reported that $^{64}Cu$ was radiolabeled with bombesin (BBN) peptide binding to the gastrin releasing peptide receptor expressed in human prostate cancer cells (PC3), confirming tumor target efficacy in mouse model. In this study, we developed the kit for the diagnosis and treatment of prostate cancer that can be used clinically using bombesin peptide available of $^{64}Cu$ and $^{177}Lu$ radioisotope labeling. The NODAGA-galacto-BBN peptide containing the NODAGA chelator and galactose was dispensed into a sterilized glass vial and lyophilized to prepare a kit. The stability of the kit after long-term storage in the $4^{\circ}C$ cold chamber and the radiolabeling efficiency after $^{64}Cu$ or $^{177}Lu$ labeling were confirmed by thin layer chromatography. When labeling with $^{64}Cu$ at the initial stage of storage, labeling efficiency of NODAGA-galacto-BBN peptide kit was over 96%, labeling efficiency was over 90% when $^{177}Lu$ was labeled. At 11 months after storage, the radiolabeling efficiency of kit against $^{64}Cu$ and $^{177}Lu$ was each over 95% and 90%. The cell viability was significantly reduced in the $^{177}Lu$-NODAGA-galacto-BBN treated group compared with the control and $^{177}Lu$ alone treated group in clonogenic assay. In conclusion, the NODAGA-galacto-BBN kit prepared by the lyophilization showed high stability over time and high yield of radioisotope labeling. Also $^{177}Lu$-NODAGA-galacto-BBN confirmed high cytotoxicity to prostate cancer cells. Therefore, the NODAGA-galacto-bombesin kit is expected to be useful for the diagnosis and treatment of prostate cancer patients.

• 한국재료학회지
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• 제28권6호
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• pp.355-360
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• 2018

$LuNbO_4:0.2Yb^{3+},xTm^{3+}$ powders were prepared using a solid-state reaction process. The effects of the amount of Tm on up-conversion(UC) and down-conversion(DC) luminescence properties are investigated. X-ray diffraction patterns confirm that $Yb^{3+}$ and $Tm^{3+}$ ions are successfully incorporated into Lu sites. Under 980 nm excitation, the UC spectra of the powders predominantly exhibit strong near-infrared emission bands that peak at 805 nm, whereas weak 480 nm emission bands are observed as well. The emission bands are assigned to the $^1G_4{\rightarrow}^3H_6$ (480 nm) and 3 $^3H_4{\rightarrow}^3H_6$ (805 nm) transitions of the $Tm^{3+}$ ions via an energy transfer from $Yb^{3+}$ to $Tm^{3+}$; two- and three-photon UC processes are responsible for the 805 and 480 nm emissions, respectively. The DC emission spectra exhibit blue emission ($^1D_2{\rightarrow}^3F_4$) of $Tm^{3+}$ at 458 nm. The amount of Tm affects the emission intensity with the strongest emissions at x = 0.007 and 0.02 for the UC and DC luminescence, respectively. The results demonstrate that $LuNbO_4:Yb^{3+},Tm^{3+}$ phosphors are suitable for bio-applications.

• 한국항공우주학회지
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• 제30권7호
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• pp.68-80
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• 2002

최신 마이크로프로세서에서 성능 최적화된 수치 코드를 작성하는 접근법을 제시하였다. 국소화로 지칭한 이 코드 최적화 방법은 모든 최신 마이크로프로세서에서 채용되는 2차 캐시의 사용을 최대화하고 시스템의 주기억장치에 대한 접근을 최소화하는 개념이다. 본 연구에서는 유체역학 문제의 해결을 위한 LU-SGS 해법을 3 단계에 걸쳐 국소화 하였으며, 요즈음 널리 이용되고 있는 여러 가지 마이크로프로세서들에 대해 시험을 수행하였다. 국소 최적화 개념의 시험 결과는, 컴퓨터 시스템에 따라서는, 같은 컴퓨터에서 완전히 동일한 해를 기본 알고리즘에 비해 7.35배까지 빨리 얻을 수 있는 주목할 만한 성능을 보여 주었다.

• 방사선산업학회지
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• 제7권2_3호
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• pp.127-134
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• 2013

Bombesin receptors are overexpressed in many kinds of human tumors. In particular, the gastrin releasing peptide receptor (GRPR) which is also called bombesin receptor subtype 2, has been identified in prostate cancer. In the present study, we developed a bombesin antagonist-based $^{177}Lu$-labeled peptide, $^{177}Lu$-DOTA-$Ala(SO_3H)$-Aminooctanoyl-Gln-Trp-Ala-Val-N methyl Gly-His-Statine-Leu-$NH_2$ (DOTA-sBBNA). DOTA-sBBNA was prepared using a solid phase synthesis method. It was labeled with $^{177}Lu$ by a high radiolabeling yield (>98%), and its Log P value was -2.05. The radiolabeled peptide was highly stable in serum incubation at $37^{\circ}C$ for 48 hr. A competitive displacement of $^{125}I-[Tyr^4]$-Bombesin on the PC-3 human prostate carcinoma cells revealed that the $IC_{50}$ value of the peptide was 6.76 nM indicating a highly nanomolar binding affinity for GRPR. These results suggest that $^{177}Lu$-DOTA-sBBNA can be a potential candidate for targeting prostate cancer, and further studies to evaluate its biological characteristics are needed.

• 한국조경학회지
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• 제19권2호
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• pp.1-11
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• 1991

The style of "Lu$.$Chong" was analyzed to investigate the characteristics of korean traditional garden style or planning theories of garden. To carry out this study more effectively, a combinded approach was introduced. This approach consisted of two processes. One was the review of old literature and the other was field survey. About 65-80% of Lu$.$Chong were named after natural landscape elements or techniques of natural landscape treatment. The techniques was summarrized 'conversing-scape(聚景)', 'surround-scape', 'multiland-scape(多景)', 'far-off-scape(遠景)', and 'emptiness of Lu$.$ Chong or landscape'. The results were proved through the analysis of visual boundary, locational pattern and 'Palkyeong(eight-sceneries)'.