• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3911-3916
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• 2016

Background: Triple negative (TN) and triple positive (TP) breast cancers both are aggressive types but TN generally has a shorter survival. Objectives: To compare the clinical characteristics and treatment outcomes for patients with TN versus TP breast cancer and to assess various prognostic factors affecting overall survival. Materials and Methods: A retrospective audit of 85 breast cancer patients was conducted in the Department of Radiation Oncology and Medical Oncology on patients from 2006 to 2013 for whom IHC for ER, PgR and Her-2 neu were available. The patients were stratified into: ER-, PR- and Her-2 neu- (Arm A, n=47) and ER+, PgR+ and Her-2 neu+ (Arm B, n=38). Results: TN subtype had higher numbers of premenopausal and advanced stage patients as compared to TP subtype. The locoregional recurrence (LRR) and distant metastatic rate was also higher in TN subtype but there was no definite pattern in both the arms. Among the prognostic factors, patients with premenopausal status and advanced stage in TN breast cancer had inferior survival (P=0.07) whereas for those with postmenopausal status and early stage there was no survival difference between the two arms. Conclusions: TN subtype tends to be more aggressive in terms of younger age and advanced stage at presentation, higher tumour grade, LRR and metastasis, suggesting need for future research efforts on providing aggressive treatment to these patients. We could attribute better outcome for TP subtype to receptor positivity enabling role of hormonal treatment and targeted therapy, although less number of patients received targeted therapy.

• Journal of Plant Biotechnology
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• 제44권3호
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• pp.208-219
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• 2017

Heterosis or hybrid vigor describes a phenomenon that superior phenotypes compared to the two parents are observed in the heterozygous $F_1$-hybrid plants. Identification and characterization of heterosis-related genes (HRGs) will facilitate hybrid breeding in crops. To identify HRGs in Brassica rapa, we analyzed transcriptome profiling using a Br300K microarray in non-heading Chinese cabbage at three developmental stages. A large number of genes were differentially expressed in $F_1$ hybrids and non-additive expression was prominent. Genes that are expressed specifically for $F_1$ hybrid at all three stages were Brassica-specific uncharacterized genes and several defense-related genes. Expression of several photosynthesis- and stress-related genes were also $F_1$ hybrid-specific. Thirteen NBS-LRR class genes showed high and specific expression in $F_1$ hybrid Shulu: some of them were characterized as defense genes in Arabidopsis, but most have not been. Further characterization of these defense-related genes in Brassica species and its application will be helpful for understanding the role of defense responses in heterosis. In addition, results obtained in this study will be valuable to develop molecular markers for heterosis and disease resistance in B. rapa.

• Molecules and Cells
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• 제42권7호
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• pp.503-511
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• 2019

As sessile organisms, plants have developed sophisticated system to defend themselves against microbial attack. Since plants do not have specialized immune cells, all plant cells appear to have the innate ability to recognize pathogens and turn on an appropriate defense response. The plant innate immune system has two major branches: PAMPs (pathogen associated molecular patterns)-triggered immunity (PTI) and effector-triggered immunity (ETI). The ability to discriminate between self and non-self is a fundamental feature of living organisms, and it is a prerequisite for the activation of plant defenses specific to microbial infection. Arabidopsis cells express receptors that detect extracellular molecules or structures of the microbes, which are called collectively PAMPs and activate PTI. However, nucleotidebinding site leucine-rich repeats (NB-LRR) proteins mediated ETI is induced by direct or indirect recognition of effector molecules encoded by avr genes. In Arabidopsis, plasmamembrane localized multifunctional protein RIN4 (RPM1-interacting protein 4) plays important role in both PTI and ETI. Previous studies have suggested that RIN4 functions as a negative regulator of PTI. In addition, many different bacterial effector proteins modify RIN4 to destabilize plant immunity and several NB-LRR proteins, including RPM1 (resistance to Pseudomonas syringae pv. maculicola 1), RPS2 (resistance to P. syringae 2) guard RIN4. This review summarizes the current studies that have described signaling mechanism of RIN4 function, modification of RIN4 by bacterial effectors and different interacting partner of RIN4 in defense related pathway. In addition, the emerging role of the RIN4 in plant physiology and intercellular signaling as it presents in exosomes will be discussed.

• 한국융합학회논문지
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• 제10권5호
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• pp.79-84
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• 2019

20대 무용전공자들을 대상으로 트레드밀 보행운동이 유산소 운동능력에 미치는 영향을 알아보고자 하였다. 20대 한국무용 전공자 10명과 일반 여대생 10명을 대상으로 트레드밀 보행운동을 실시하였다. 측정은 실험 전과 후에 심박수 회복율, 최대산소섭취량, 최대환기량, 젖산 회복율을 측정하였다. 이렇게 얻어진 자료는 SPSS win 16.0을 이용하여 분석하였다. 실험 후 유산소 운동능력의 변화를 비교해 보면 대조군보다 실험군에서 심박수 회복율과 젖산 회복율에서 유의한 증진의 효과가 나타났으며, 최대환기량과 최대산소섭취량에서는 유의하게 증가하지 않았다. 실험전후 집단 간 검증에는 심박수 회복율에서 유의한 수준으로 높게 나타났다. 한국무용 전공자의 트레드밀 훈련을 통해 유산소성 운동능력을 증진시켜 기초체력의 향상에 도움이 줄 수 있으며 과학적인 운동처방의 근거가 되는 기초자료를 제시하는데 많은 도움이 될 것으로 사료된다.

• 한국전자통신학회논문지
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• 제19권1호
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• pp.11-18
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• 2024

본 논문에서는 Chebyshev 다항식을 이용해서 차량용 근거리 레이다에서 사용하는 70GHz 대역 배열안테나를 최적 설계하였다. SRR(: Short Range Radar)에서는 근거리 내에 물표를 검출하면서 높은 FoV(: Field of View)를 확보하기 위한 빔폭과 낮은 SLL(: Side lobe level)을 가져야 한다. 최적 설계된 안테나는 76~81GHz에서 동작하며 안테나의 크기를 소형으로 하기 위해 12개의 패치를 직렬로 배열하여 구성하였고, 78GHz에서 SLL - 10dB이하, 안테나의 이득 15.4dB를 만족하고 빔폭 112.5o, 입력반사계수 -10dB이하의 성능을 갖는다. 본 논문에서는 Chebyshev 다항식을 이용해서 SRR을 위한 안테나의 설계를 진행하고 이를 기반으로 MRR과 LRR에 사용될 안테나 구조 설계를 위한 최적 설계법을 제시한다.

• 대한공간정보학회지
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• 제18권1호
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• pp.21-29
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• 2010

낙동강 하구는 세계적 철새 서식지로 부산의 관광명소인 해운대와 광안리의 모래 공급지로 다양한 역할을 하고 있다. 본 연구는 낙동강 하구(진우도, 신자도, 도요등, 다대포) 해안의 장기간 지형변화를 탐지 해석 하였다. 34년간의 위성영상 분석 결과 진우도의 전면과 후면의 중간부분이 증가하고, 신자도는 1970년 띠 형태로 양분, 80년대 이후 하나의 섬으로 형성하여 서쪽 방향으로 길게 형성된다. 1990년대 이후 백합등 전면의 소규모 섬들이 급격히 발달하여 90년대 후반 도요등을 형성하여 성장하고 있었다. 낙동강 하구역 해안지도 제작을 위해 1975년부터 2009년간 Landsat 영상 112매 중 조위가 $99{\pm}13cm$인 영상 12매를 선택하고 NDVI값을 이용해 수역과 육역을 구분하였다. 그리고 GIS의 DSAS 4.0(Digital Shoreline Analysis System)과 MATLAB을 이용해 EPR(End Point Rate), LRR(Linear Regression Rate)등 해안선 변화율을 산정하였다. 지형변화탐지결과 EPR은 진우도 전면과 후면은 -0.93~2.56m/yr로 남진하고 해안선과 면적변화는 적고 안정적이며 신자도 전면과 후면은 1~4m/yr로 북진하나 서측은 2~3m/yr로 안정되고 동측은 10m/yr이상 북진하고 있다. 도요등 전면과 후면은 18~27m/yr로 북진, 면적은 증가하고 다대포해안은 7m/yr로 서진하며 확대되었다. LRR 또한 EPR과 유사한 경향을 나타내었다. 위성영상과 GIS 분석을 통해 지형변화 탐지와 자연현상의 정량적 분석이 가능하였지만 자연현상의 지속적인 관찰과 다양한 분석 방법이 필요함을 알 수 있었다.

• Animal cells and systems
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• 제13권1호
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• pp.1-8
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• 2009

Toll-like receptor (TLR) family proteins, type I transmembrane proteins, play a central role in human innate immune response by recognizing common structural patterns in diverse molecules from bacteria, viruses and fungi. Recently four structures of the TLR and ligand complexes have been determined by high resolution x-ray crystallographic technique. In this review we summarize reported structures of TLRs and their proposed activation mechanisms. The structures demonstrate that binding of agonistic ligands to the extracellular domains of TLRs induces homo- or heterodimerization of the receptors. Dimerization of the TLR extracellular domains brings their two C-termini into close proximity. This suggests a plausible mechanism of TLR activation: ligand induces dimerization of the extracellular domains, which enforces juxtaposition of intracellular signaling domains for recruitment of intracellular adaptor proteins for signal initiation.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2002년도 총회 및 추계학술발표회
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• pp.78.1-78
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• 2002

• 한국안전학회지
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• 제11권3호
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• pp.66-74
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• 1996

Numerical simulations were carried out using standard Reynolds stress turbulence model(LRR model) and modified RSM(Janicka model ) to validate these models in combustion flow fields. Two flames were selected for use as a benchmark data for model testing. One is a conventional jet diffusion flame that has the effect of suppression of turbulence by combustion. The other is a triple jet diffusion flame that designed to give high turbulence to the periphery of the flame and to remove the low Reynolds-number flow fields. As a result, it was found that the modification of standard RSM model is indispensable in the modelling of flames with low turbulence region. And it is also necessary to improve the existing modified models for the universal use.

• 전기학회논문지
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• 제64권5호
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• pp.786-791
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• 2015

This paper presents a signal processing method for calibrating an antenna array to solve the inaccuracy of Direction of Arrival(DOA). Using reference data quantifying amplitude and phase distortion levels for each angles, we compensate each radar array’s amplitude and phase distortion. The proposed method is applied to the Bartlett, Capon and MUSIC algorithms, Using 77 GHz Frequency Modulated Continuous Wave(FMCW) Long Range Radar(LRR) signal, we experimentally demonstrate the performance improvement after the proposed compensation.