• 제목/요약/키워드: LPE

검색결과 131건 처리시간 0.022초

Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells

  • Lee, Jung-Min;Park, Soo-Jin;Im, Dong-Soon
    • Biomolecules & Therapeutics
    • /
    • 제25권2호
    • /
    • pp.194-201
    • /
    • 2017
  • Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular $Ca^{2+}$ through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs for lysophosphatidic acid (LPA) were not implicated in the LPE-mediated activities in LPA GPCR overexpression systems or in SK-OV3 ovarian cancer cells. In the present study, in human SH-SY5Y neuroblastoma cells, experiments with $LPA_1$ antagonists showed LPE induced intracellular $Ca^{2+}$ increases in an $LPA_1$ GPCR-dependent manner. Furthermore, LPE increased intracellular $Ca^{2+}$ through pertussis-sensitive G proteins, edelfosine-sensitive-phospholipase C, 2-APB-sensitive $IP_3$ receptors, $Ca^{2+}$ release from intracellular $Ca^{2+}$ stores, and subsequent $Ca^{2+}$ influx across plasma membranes, and LPA acted on $LPA_1$ and $LPA_2$ receptors to induce $Ca^{2+}$ response in a 2-APB-sensitive and insensitive manner. These findings suggest novel involvements for LPE and LPA in calcium signaling in human SH-SY5Y neuroblastoma cells.

MBE, LPE와 $\mu$ - PD 기술에 의한 산화물재료의 개선된 단결정 성장방법 (Improved single crystal growth methods for oxide materials by MBE, LPE and $\mu$ - PD techniques)

  • 윤대호
    • 한국결정성장학회지
    • /
    • 제5권4호
    • /
    • pp.378-385
    • /
    • 1995
  • 분자션 에피텍시얼(MBE)법, 액상 에피텍시열(LPE)법과 마이크로 인상($\mu$ - PD)법 에 의한 단결정 성장에 있어서의 새로운 접근을 논의하였다. 재료로써는 Bi-Sr-Ca-Cu계, $K_3Li_2Nb_5O_{15}$계의 산화물을 사용하였으며, 비평형영역으로 부터의 고품질(균일 조성 및 저결함 밀도) 결정성장은 원자수준의 계면제어에 의해 가능함을 고찰할 수 있였다.

  • PDF

LPE에 의한 1.3$\mu$m GaInAsP/InP DH 레이저의 제작 및 발진특성 (Lasing characteristics of 1.3??m GaInAsP/InP DH Lasers Grown By LPE)

  • 신동혁;유태환
    • 대한전자공학회논문지
    • /
    • 제22권4호
    • /
    • pp.72-75
    • /
    • 1985
  • Double-heterostructure 구조의 1.3μm GalnAsP/lnP 웨이퍼를 LPE 기술로 성장시키고, 전면전극(broad contact)레이저 다이오드를 제작, 실온에서 펄스 발진시켜 전기적 및 광학적 특성을 조사하였다. 발진 개시전류는 2Amp. 이하, 발진개시전류밀도 3∼6 KAmp./㎠였으며, 파장 1.315μm에서 발진하는 것을 확인하였다.

  • PDF

Lattice strain effects on superconductivity in $La_{2-x}Sr_{x}CuO_{4}$ single-crystalline films grown by IR-LPE technique

  • Tanaka, I.;Islam, A.T.M.N.;Wataudhi, S.
    • 한국결정성장학회지
    • /
    • 제13권4호
    • /
    • pp.172-175
    • /
    • 2003
  • We have investigated effects of the lattice mismatch between the LPE films and the substrates. We have grown $La_{2-x}Sr_{x}CuO_{4}$(x=0.1 to 0.15) single crystalline films on single crystalline substrates having different lattice parameter ratio c/a e.g., $La_{2-x}Sr_{x}Cu_{1-y}Zn_{y}O_{4},\;La_{2-x}Ba_{x}CuO_{4},\; LaSrAlO_{4}\;and\;La_{2-x}Sr_{x}Cu_{1-y}Al_{y}O_{4}$ etc., using the IR-LPE technique. The superconducting properties of the grown films were found to vary significantly depending on the lattice mismatch with different substrates.

단결정 성장을 위한 수직형 LPE 장치의 제작 (The Development of Fertical type LPE System for Single Crystal Growth)

  • 오종환
    • 한국광학회:학술대회논문집
    • /
    • 한국광학회 1989년도 제4회 파동 및 레이저 학술발표회 4th Conference on Waves and lasers 논문집 - 한국광학회
    • /
    • pp.201-205
    • /
    • 1989
  • In this study, the vertical type LPE system has been developed by fully hand-made. The temperature fluctuation and minimum cooling rate of this LPE system are within $\pm$0.05$^{\circ}C$ and 0.15$^{\circ}C$/min, respectively. It is considered that these properties are enough to grow III-V semiconductor compounds single crystals by liquid phase epitaxy method. Futhermore in this study. 1.3${\mu}{\textrm}{m}$ GaInAsP/InP single crystal growing has been carried out by this system. It has been obtained that the growing rate was about 0.72${\mu}{\textrm}{m}$/min for InP binary layer and 0.36${\mu}{\textrm}{m}$/min for GaInAsP quarternary layer under 0.6$^{\circ}C$/min cooling rate condition.

  • PDF

LPE법으로 성장시킨 Bi2Sr2Ca(Cu1-xNix)2O8+δ 막(film)의 초전도특성 및 터널링 분광 (Superconducting Properties and Tunneling Spectroscopy of Bi2Sr2Ca(Cu1-xNix)2O8+δ Film by LPE Method)

  • 이민수
    • 한국세라믹학회지
    • /
    • 제40권5호
    • /
    • pp.455-459
    • /
    • 2003
  • LPE(Liquid Phase Epitaxial)법을 이용하여 성장시킨 B $i_2$S $r_2$Ca(C $u_{1-x}$ N $i_{x}$ )$_2$ $O_{8+}$$\delta$/ 막(film)을 break junction 법을 이용하여 터널링 분광을 측정하였다. Ni 조성비 $\chi$$_{L}$의 증가에 따라 에너지 간격 2$\Delta$의 크기는 증가하였다. 에너지 간격 2$\Delta$(4.2 K)는 54.4~64 meV, 2$\Delta$/ $k_{B}$ $T_{c}$ $^{zero}$는 7.36~10.14로 BCS 이론에 의한 값 보다 큰 결과를 얻었다. 융액(melting solution) 속의 Ni 조성비 $\chi$$_{L}$의 증가에 따라, 임계온도 $T_{c}$ $^{zero}$와 격자상수 c-축의 길이는 감소하는 경향을 보였다.을 보였다.$^{zero}$와 격자상수 c-축의 길이는 감소하는 경향을 보였다.

Effects of Dietary Supplementation of Aqueous Extracts of Liriopeplatyphylla and Akebiaquinata on Breast Meat Qualities of Broiler Chickens

  • Park, Jae Hong;Kang, Suk-Nam;Jin, Sang-Keun
    • 한국축산식품학회지
    • /
    • 제33권4호
    • /
    • pp.456-462
    • /
    • 2013
  • The present study investigated the effects of Liriopeplatyphylla extract (LPE) and Akebiaquinata extract (AQE) on breast meat properties when used as dietary supplements of broiler chickens. First, the identification and quantification of phenolic acids and flavonoids were carried out by HPLC. As a result, the total amount of phenolic acids and flavonoids was higher in AQE than LPE. These extracts were added at a rate of 0.2% to the broiler diets, and a feeding trial was conducted in battery cages for 35 d. At the end of the experiment (d 35), six carcasses from each treatments were used for evaluating meat quality. The experimental results indicate that color shades, pH levels, volatile basic nitrogen, thiobarbituric acid reactive substance (TBARS), cooking loss and drip loss of breast meat fed with 2 extracts were not different as compared with the controls at d 0 and d 10 of storage. However, TBARS values of breast meat fed with either the control diet or the LPE supplementation was increased as the storage period increased (from d 0 to d 10) (p<0.05), while AQE-fed groups were not different between d 0 to d 10 of storage. In textural properties, the addition of LPE and AQE decreased shear force values at d 10 of storage (p<0.05). Cohesiveness, gumminess and chewiness of breast meat were increased in AQE-fed groups when compared with the control at d 0 of storage (p<0.05). Dietary additions of AQE and LPE only increased the linoleic acid contents of chicken breast meat (p<0.05). In conclusion, supplementation of these extracts in broiler diets may potentially influence meat qualities including the TBARS, textural properties and linoleic acid levels in broiler chicken meats.