• Journal of Aerospace System Engineering
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• v.16 no.5
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• pp.17-25
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• 2022

The pintle injector has many advantages in the key characteristics of a liquid rocket engine, such as combustion stability, combustion efficiency, and wide range of comprehensive thrust control, design and manufacture, and test fired under supercritical conditions. The pintle injector is manufactured with a rectangular, single-row orifice for thrust control and production considerations. In order to verify the combustion performance of the pintle injector and its potential as a commercial injector, the combustion characteristics were analyzed by varying the TMR (Total Momentum Ratio) and BF (Blockage Factor). The result of the hot firing test showed that the heat flux increased as TMR increased, and it confirmed that the characteristic velocity efficiency was more affected by BF than TMR. Suppose a single-row pintle injector with efficiency characteristics insensitive to changes in TMR can achieve high efficiency at low fuel differential pressure conditions. In that case, the variable pintle injector's design flexibility can be increase.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.331-336
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• 2010

In rapidly growing tumors, hypoxia commonly develops due to the imbalance between $O_2$ consumption and supply. Hypoxia Inducible Factor (HIF)-$1{\alpha}$ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-$1{\alpha}$-targeting drugs. When treating various cancer cells with the inhibitors, we found that a CamKII inhibitor, KN-62, effectively suppressed HIF-$1{\alpha}$ specifically in hepatoma cells. To examine the effect of KN-62 on HIF-$1{\alpha}$-driven gene expression, we analyzed the EPO-enhancer reporter activity and mRNA levels of HIF-$1{\alpha}$ downstream genes, such as EPO, LOX and CA9. Both the reporter activity and the mRNA expression were repressed by KN-62. We also found that KN-62 suppressed HIF-$1{\alpha}$ by impairing synthesis of HIF-$1{\alpha}$ protein. Based on these results, we propose that KN-62 is a candidate as a HIF-$1{\alpha}$-targeting anticancer agent.

• Aerospace Engineering and Technology
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• v.6 no.1
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• pp.120-127
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• 2007

Performance dispersion in the engine should be considered to predict the flight accuracy of a launch vehicle. A dispersion estimation method was presented with a LOx/Kerosene gas generator cycle engine. The orifices in the propellant supply lines in the engine were assumed to be used for calibration of the performance and the required pressure drops were acquired. The dispersions after calibration were quantified also.

• Korean Journal of Microbiology
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• v.26 no.2
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• pp.113-121
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• 1988

Ozone, an atmospheric pollutant, can damage similar UV and X-rays DNA and its components. It is possible then that the KNA damage produced by this gas are similar, to some extent, to those of radiations and that they could be repaired by the same DNA repair mechanisms. It has been observed in Escherichia coli that radiosensitive strains such as lex A, rec A and pol A, all deficient to some extent for DNA repair, are more sensitive to ozone than a wild type strain. We have thendetermined the ozone resistance and host-cell reactivation of ozone-damaged T3 phages for the E. coli double mutants pol A, lex A, uvr B, lex A, uvr A, rec A and rec A lox A. According to the results, the DNA polymerase 1 plays a key role in ozone resistance and Type 11 mechanism and/or shory patch excision repair are the most important for it. The interactions between the different DNA repair mechanisms are secondary. There is a strong correlation between ozone resistance and the capacity to reactivate T3 phages damaged by ozone.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2004.11a
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• pp.195-200
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• 2004

To avoid an unexpected explosion occurring from a mixture of LOx and fuel, Inter-Propellant Seal (IPS) is used in a Turbopump. This paper presents a brief theoretical backgrounds of IPS and also reports preliminary test results. Tests were performed up to 1.5 MPa and 20,000 rpm and leakage performance of IPS was evaluated. As a result it was verified that leakage flow rate of IPS satisfied its design requirement.

• Proceedings of the KSME Conference
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• 2008.11b
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• pp.3154-3158
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• 2008

A liquid rocket engine performance has been analyzed as a function of combustion pressure with LOx/RP-1R. The present method is verified by comparing the specific impulse for various combustion pressure with given pump head model. The optimal combustion pressure is between 150 bar and 200 bar for given efficiencies. Both the optimal combustion pressure and the specific impulse increase for increased turbine efficiency. The optimal combustion pressure decreases and the specific impulse increases for increased combustion efficiency. The pump efficiency and the turbine inlet temperature have the same qualitative effect as the turbine efficiency.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1998.04a
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• pp.16-16
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• 1998

로켓의 추진제에는 고체 추진제와 액체 추진제를 사용하는 두 경우로 나눌 수 있는데, 액체 추진제를 사용하는 경우, 액체 연료와 액체 산화제를 다양한 방법으로 연소실내로 분사하게 된다. 이때 사용되는 injector들 중에 impingement type이 있다. 이 type은 injector의 가공이 비교적 용이하고, 혼합성능이 좋기 때문에 LOX/RP-1(Kerosin-based hydrocarbon fuel)을 사용하는 액체 로켓엔진에서 주로 사용되어 왔다. 두 액체 jet의 충돌에 의해 액막이 형성되는데, 이 액막은 가장자리로 갈수록 두께가 얇아지며 액막표면의 파는 충돌점으로부터 멀어질수록 그 진폭의 증가를 이루어 액체의 표면장력과 관성력의 균형을 깨트리며, 이 순간 액막은 rim의 형태로 분열하여 결국에는 액적을 생성하게 된다. 현재까지의 연구내용은 충돌 jet의 형태 laminar jet과 turbulent jet으로 구분된 인젝트에 관해 연구되어왔고, 특히 국내에는 이러한 구분된 충돌 jet의 분열현상에 관한 연구결과가 미흡하다. 동일한 오르피스의 경우에도 laminar jet과 turbulent jet으로 구분되어 지며, 각각의 jet의 형태에 따라 생성되는 액막의 형상 또는 다르게 생성되어 진다. 그러므로 본 연구에서는 두 구분된 jet의 경우의 분열현상을 실험적으로 분석하였다.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.560-564
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• 2004

The optimal design and combustion analysis of the gas generator for Liquid Rocket Engine (LRE) were performed. A fuel-rich gas generator in open cycle turbopump system was designed for 10ton$_{f}$ in thrust with RP-1/Lox propellant. The optimal design was done for maximizing specific impulse of main combustion chamber with constraints of combustion temperature and power matching required by turbopump system. Design variables were selected as total mass flow rate to gas generator, O/F ratio in gas generator, turbine injection angle, partial admission ratio, and turbine rotational speed. Results of optimal design show the dimension of length, diameter, and contraction ratio of gas generator. Also, the combustion test was conducted to evaluate the performance of injector and combustion chamber. And the effect of the turbulence ring was investigated on the mixing enhancement in the chamber.r.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 1999.04a
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• pp.6-6
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• 1999

국가우주개발의 중장기 계획에 따른 우주 발사체 개발의 일환으로, 한반도 대기상태측정 등을 위한 고성능 과학관측로켓의 국산화를 위하여 항공우주연구소를 중심으로 여러 기관에서 연구가 진행되고 있다. 액체로켓을 주 추진체으로 삼고 있기 때문에 로켓의 안정적인 연소와 성능 향상이야말로 발사체 개발에 핵심이라고 할 수 있다. 액체로켓의 경우, 초기점화는 고체시동장치 또는 액체시동장치에 의한 방법 등으로 구분될 수 있다. 본 연구는 액체시동장치 중 hypergolic으로 초기점화를 하고 뒤이어 주추진제(LOX/kerosene)를 내보내어 주연소를 할 수 있는 Unlike impinging Quadlet injector(3 on 1)의 연소성능 이해와 예측을 위해 Cold flow test를 기초로 수행되었다.

• Journal of Industrial and Engineering Chemistry
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• v.67
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• pp.80-91
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• 2018

Here, we engineered spheroids by using ECM mimicking nano-fragments (NFs) with fibroblasts and investigated their effect on proliferation and cell/ECM interactions. NF incorporation resulted in formation of a stable spheroid, which improved proliferation and viability of cells by assisting oxygen transport confirmed by LOX-1 staining. In addition, hypoxic and apoptotic genes were significantly downregulated in spheroids with PD-NFs. Furthermore, ECM and cell junction proteins were highly expressed. Overall, our findings suggest that incorporation of NFs within spheroids for assembly with various cell types can be an alternative approach for 3D cell culture in many applications.